We report gene expression data for zebrafish melanomas overexpressing human SATB2 and EGFP. Overall design: RNA-seq was performed on three biological replicates of primary zebrafish melanoma tumors that were excized from MCR:EGFP (control) and MCR:SATB2 overexpressing Tg(BRAF V600E);p53-/-; mitf-/- zebrafish.