To uncover whether aldosterone induces gene expression changes through mineralocorticoid or glucocorticoid receptors and determine if eplerenone and spironolactone could block aldosterone induced gene expression to the same extent Overall design: 12 total samples were analyzed. 3 biological replicates for each of the following treatment groups were included: 1) aldosterone; 2) spironolactone plus aldosterone; 3) eplerenone plus aldosterone; 4) mifepristone plus aldosterone. Pairwise comparison between groups were carried out and a fold-change ≥2 were selected.