Examples: histone, BN000065

Project: PRJNA359756

Purpose: To asses changes in gene expression profiles from the P30 wild type littermate control olfactory bulbs and conditional double knockout olfactory bulbs of hGFAP-Cre; Sp8 Flox/Flox; Sp9 Flox/Flox mice. Methods: Total RNA was isolated and sequenced from the olfactory bulbs of the P30 wild type littermate controls or hGFAP-Cre; Sp8 Flox/Flox; Sp9 Flox/Flox mice in tetrad using an illumina high-seq 2500. Raw data was analyzed using TopHat. Genes were considered changed which performed fold-change>=2 and FDR<=0.05. Changed genes were then filtered to reveal the downstream targets of Sp8 and Sp9. Results: 31 genes were significantly increased and 74 genes were significantly decreased in expression level due to the loss of Sp9 and Sp8 expression. Overall design: Total RNA was isolated and sequenced from the olfactory bulbs of the P30 wild type littermate controls or hGFAP-Cre; Sp8 Flox/Flox; Sp9 Flox/Flox mice in tetrad using an illumina high-seq 2500.

Secondary Study Accession:
SRP095936
Study Title:
Transcription Factors Sp8 and Sp9 Coordinately Regulate Olfactory Bulb Interneuron Development [RNA-seq 2]
Center Name:
Fudan University
Study Name:
Mus musculus
ENA-REFSEQ:
N
PROJECT-ID:
359756
ENA-FIRST-PUBLIC:
2017-04-19
ENA-LAST-UPDATE:
2025-02-24

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Mus musculus
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Mus musculus
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Mus musculus
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Mus musculus
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Mus musculus
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Mus musculus
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Mus musculus
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Mus musculus
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PRJNA344717 Transcription Factors Sp8 and Sp9 Coordinately Regulate Olfactory Bulb Interneuron Development
This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Seri... See more
PRJNA9559 The laboratory mouse is a major model organism for basic mammalian biology, human disease, and genom... See more
The mouse is one of the major organisms for modeling human disease and comparative genome analysis. ... See more
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