Amorphotheca resinae ZN1 has been used as one biodetoxification strain applied in the lignocellulose biorefinery process. It can degrade nearly all the inhibitors from lignocellulose pretreatment. RNA-Seq of A. resinae ZN1 was analyzed under various lignocellulose derived inhibitor conditions, to identify the important genes resposible for inhibitor degradation and to construct the inhibitor degradation pathways.