To present, the only known inv*olvement of the gills in the immune response of shrimp is solely assisting the hemocytes in filtering out the harmful factors. This global expression of novel genes revealed several immune-related genes specifically expressed in high amounts only in gills. This data provide new insights on the immune defense of shrimp. Overall design: Expression analysis were done in all apparently healthy shrimp focusing on hemocyte, gills, hepatopancreas, lymphoid organ, muscle