GLI2 overexpression is a hallmark in SHH subgroup of medulloblastoma (SHH MB). Here we identify the targetome of Gli2 in two mouse models of SHH MB: SmoM2 overexpression and Sufu;Spop double knockout MB. Overall design: Examination of Gli2-bound DNA and H3K27ac- and H3K36me3-modified DNA in P13 Sufu;Spop double knockout and SmoM2 overexpression medulloblastoma in mice