To further understand the cellular function of HOTAIR, we have profiled RNA expression in breast cancer cell lines harboring tetracycline-inducible shRNA of human HOTAIR (Tet-shHOTAIR) or the control shRNA of scrambled sequence (Tet-shCtrl). Overall design: 3 independent biological repeats of MDA-MB-231/Tet-shHOTAIR and MDA-MB-231/Tet-shCtrl cells were performed with induction by 1 ug/ml doxycycline for 96hr