The dysfunction of endothelial nitric oxide synthase may be involved in development of atherosclerosis; however, the underlying molecular and cellular mechanisms of atherosclerosis are poorly understood. Here, we investigated gene expressionsin relation to atherosclerosis using endothelial nitric oxide synthase (eNOS)-deficient mice. Overall design: 3 samples of aorta from endothelial nitric oxide synthase (eNOS)-deficient mice were compared with 3 samples of aorta from age-matched normal mouse controls