The infant gut harbors a diverse microbial community consisting of several taxa whose persistence and succession depends on adaptation to the ecosystem and on environmental factors such as diet. In healthy breast-fed infants, the early infant gut microbiota is usually dominated by Bifidobacterium spp.. Cutibacterium avidum is among the initial colonizers, and isolates have been repeatedly obtained from feces. However, the phylogenetic relationship of infant fecal isolates to isolates from other body sites, and C. avidum carbon utilization related to the infant gut ecosystem have been little investigated.