Abstract: The tissues of Avicennia marina cooperate to ensure its survival in harsh environmental conditions, including high salinity and heat. This feat is accomplished through elegantly orchestrated, idiosyncratic RNA expression. We extracted RNA from roots, stems, leaves, flowers, and seeds of A. marina to decipher tissue-specific transcriptomic profiles. The data shows key enriched and up-regulated functions in each tissue and yields insight into cooperative mechanisms that could promote the survival of A. marina in the face of heavy abiotic stress. For example, antioxidant functions were uniquely enriched in roots and salt exclusion transporters were uniquely expressed in leaves. In particular, the unique enrichment of lignin biosynthesis genes in root tissue outlines a genetic strategy for progressive cambia formation that helps explain the successful emigration and global domain of A. marina. We also observed tissue-specific expression of retrotransposable elements in coding and non-coding RNA sequences, and implications for response to abiotic stress is discussed. The tissue-specific transcriptomic profiles presented here help to explain the diversity of functions and stress resistance capacity, especially with regards to the systemic halotolerance and successful oceanic propagation of A. marina.