TRAP translational profiling is a method that allows investigators to genetically characterize specific cell types in complex tissues such as mouse brain. Using this technique we obtained RNA-Seq data from actively translating transcripts present in medium spiny neurons in the accumbens nucleus of adult Drd1-EGFP/Rpl10a (CP73) mice that were administered either saline or cocaine under long-access conditions Overall design: Long-access cocaine intravenous self-administration study; TRAP-Seq of medium spiny neurons in the accumbens nucleus of adult Drd1-EGFP/Rpl10a (CP73) mice administered either saline or cocaine