Kidney aging is an irreversible physiological process and some suggest that kidney aging is viewed as a pathological condition. To enhance understanding of the molecular nature of renal aging, we performed whole kidney RNA sequencing in young mice (2-month-old) fed with standard diet versus those with adenine-enriched diet, and this bulk transcriptome was then compared with transcriptional changes with aging. Overall design: Whole kidney RNA sequencing from 2-month-old mice fed with standard diet versus those with adenine-enriched diet