In this study, we aimed to assess if, and potentially how, changes associated with salmon farming discharged wastes are taking place in four sessile benthic organisms commonly found living on mixed and hard-substrate habitats of the Norwegian coast, namely the anemone Hormathia digitata, the soft coral Duva florida, and the sponges Craniella and Weberella bursa. Several specimens from each taxon were translocated along a distance gradient from a salmon farm located in the Sognefjord region (mid-west coast of Norway), and exposed for a period of seven months prior to being retrieved and thoroughly analysed. Specifically, specimens health and metabolism were assessed visually and through respirometry measurements, their epithelial microbiome characterised via 16S rRNA metabarcoding, their FA profile assessed via gas chromatography, and their carbon and nitrogen SI profile measured via mass spectrometry. We hypothesised that, for each of the benthic taxa, 1) specimens living further from the farm would present healthier physiology, 2) have a microbiome, FA and SI profile that significantly differs from those living in close proximity to the farm, and 3) that responses between benthic taxa would be substantially different due to their inherent specific physiology, ecology and reliance on their microbiome.