We investigated the effect of IL-13 neutralization on COVID-19 disease progression in mice. Overall design: We analyzed the bulk lung tissue transcriptomes in Covid19 infected mice treated with anti-IL-13 or isotype (IgG) control antibodies and uninfected mice as an additional control group. 8-16 week-old male Tg(K18-hACE2) 2Prlmn (Jackson Laboratories) mice were challenged with 5000 plaque forming units (PFUs) of SARS-CoV-2 Hong Kong/VM20001061/2020 (BEI 14 Resources) in 50 μL by an intranasal route under 100 μL ketamine/xylazine sedation. Mice were given 150 μg of anti-IL-13(Thermofisher, clone eBio1316H; cat # 16-7135-85) or an isotype matched control IgG (Thermofisher, clone eBRG1; cat # 16-4301-85) administered on day 0, 2, and 4 pi. Mice were euthanzied at 5 days post-infection and lung tissue was resected for RNA-sequencing analysis.