Axl+DC have been initially described through their ontogeny. Our lab reported for the first time an Axl+ DC functional specificity in the context of HV-1 capture, infection and in vitro transmission as a consequence of their constitutive expression of Siglec-1. However, Axl+DC immune responses to viral exposure remained to be studied. This study aim to decipher innate immune response of Axl+DC when exposed to HIV-1 in comparison to other DC subtypes. Overall design: cDC2 and Axl+DC cells were cultured with HIV-1 NL-AD8 complemented with Vpx for 24h. Cells cultured in mock medium were used as a control, as well as cells exposed to HIV-1 in the presence of azidothymidine (Azt) and neverapin (Nvp) to inhibit retrotranscription. Cells stimulated with TLR-L were also included .