The Center for Research on Influenza Pathogenesis and Transmission (CRIPT) focuses on basic and clinical influenza research to study the evolution, pathogenesis, and transmission of influenza viruses and other respiratory viruses with pandemic potential in humans, and at the zoonotic interfaces. The CRIPT research program will pursue basic research projects on virus and host determinates of virulence, host responses, antigenicity, tropism, transmission and pathogenesis. CRIPT will combine inter-related human studies to understand the factors contributing not only to zoonotic emergence, but also to disease severity, transmission, and immune protection and the impact of previous infections and/or vaccinations.