HIF-metagene identifies hypoxic or constitutive HIF activation in scRNA-seq. Hypoxic normal cells have higher HIF-metagene scores than normoxic normal cells, and ccRCC tumour cells (harbouring VHL inactivation) have higher HIF-metagene score than normal cells. Overall design: Assess single cell HIF-metagene activation in primary cultures in hypoxic conditions and upon VHL inactivation >>>Submitter states that raw data are not available due to patient privacy concerns<<<