To explore the role played by senescent cells in mice models of pulmonary hypertension we exposed young C57BL6/j mice to 8 days hypoxia or normoxia and treated with senolytic drug ABT-263 (50mg/kg/day) or its vehicule. We then performed lung gene expression profiling analysis using data obtained from RNA-seq of 4 groups of mice (Normoxia+Vehicule; Normoxia+ABT-263; Hypoxia+Vehicule; Hypoxia+ABT-263) Overall design: Comparative RNA-seq analysis has been performed on total RNA extracted from lungs of young C57BL6/j mice under hypoxia or normoxia conditions and treated with senolytic drug ABT-263 (50mg/kg/day) or its vehicule during 8 days. Mice under Normoxia condition and treated with vehicule is defined as the control condition.