Salmonella is known to be the most widespread bacterial agent of acute diarrhea cases in the world. This bacteria has potential to cause food-born infection with small and large outbreaks. In Viet Nam, the prevalence of acute diarrhea in infants is 271 per 1000 children: among bacterial agents, Campylobacter (20.0%), Salmonella (18.0%), and Shigella (16.0%) were found. In Ho Chi Minh City, non-typhoid Salmonella were detected in 5.4% of acute diarrhea cases in children under 5 years old. High levels of contamination with Salmonella have been described in food-producing animals and poultry: in 50.0% of poultry farms and in 70.0% of pig breeding farms in Viet Nam. Most Salmonella strains (about 60.0%) examined in 2004-2017 in Viet Nam were resistant to "old" antibiotics (ampicillin, more than 40.0% of strains; tetracycline, more than 50.0%); trimethoprim/sulfamethoxazole (up to 60.0%); chloramphenicol (up to 50.0%); and ciprofloxacin (more than 30.0% of strains); from 17 to 52.2% of strains had multidrug resistance. The resistance to fluoroquinolones and cephalosporins observed, simultaneous with the loss of Salmonella susceptibility to "old" antimicrobials , crucially restrict the list of medicines potent to treat complicated salmonellosis. Antimicrobial usage in raising of farm livestock may account for the appearance of resistant Salmonella strains and their spread to humans. As such, resistance restriction requires prevention of resistance formation in strains circulating in farm livestock.