Infection of B lymphocytes by HHV-8 is associated with the development of Primary Effusion Lymphoma (PEL). By microarray we identify differential expressions in three pro-inflammatory factors; LTA4H, TSP-1 and IL-16 in the BCBL-1 in comparison to BJAB (BL cell line) By microarray we identify differential expressions in three pro-inflammatory factors; LTA4H, TSP-1 and IL-16 in the BCBL-1 in comparison to L-428 a Classical Hodgkin’s disease cell line (cHD) as compared to BJAB a BL cell line. Keywords: Direct cell to cell comparison Overall design: Primary Effusion Lymphoma (PEL) was compared to BJAB (BL cell line). A direct comparison microarray was designed to reveal any differently expressed genes between those cell lines. Primary Effusion Lymphoma (PEL) BCBL-1 was compared to L-428 a Classical Hodgkin’s disease cell line (cHD). A direct comparison microarray was designed to reveal any differently expressed genes between those cell lines in comparison to BJAB, a BL cell line.