This study examined the miRNA expression level in exosomal derived from the plasma of first episode schizophrenia (FOS) patients and Healthy controls (HC), and explored the the potential of exosomes as biomarkers for schizophrenia. This study examined the lncRNA expression level in exosomal derived from the plasma of first episode schizophrenia (FOS) patients and Healthy controls (HC), and explored the the potential of exosomes as biomarkers for schizophrenia. This study examined the mRNA expression level in exosomal derived from the plasma of first episode schizophrenia (FOS) patients and Healthy controls (HC), and explored the the potential of exosomes as biomarkers for schizophrenia. Overall design: we recruited 10 FOS patients and healthy controls (HCs) respectively, examined the miRNA expression level of plasma exosome by high throughput sequencing we recruited 10 FOS patients and healthy controls (HCs) respectively, examined the lncRNA expression level of plasma exosome by high throughput sequencing we recruited 10 FOS patients and healthy controls (HCs) respectively, examined the mRNA expression level of plasma exosome by high throughput sequencing