We tested it in an animal model of myocardial infarction to ensure whether early initiation of dapagliflozin (DAPA), or different orders of combination with sacubitril-valsartan would result in a greater improvement of heart function than sacubitril-valsartan alone in post-myocardial infarction heart failure. Overall design: Total RNA extractions of the left ventricles from cardiac tissues of sham group, MI group and DAPA group (3 biological replicates per group) were performed