Examples: histone, BN000065

Project: PRJNA972765

TOPBP1 and other DNA damage response proteins play an important role in meiotic sex chromosome inactivation. We investigate a mutant mouse with a mutation in the BRCT5 domain of TOPBP1 and use single-cell RNA-seq to investigate the effect of the mutation on XY silencing. Overall design: Single-cell suspensions were generated from mouse testes and sorted by fluorescence-activated cell sorting to enrich for spermatocytes and analyzed using scRNA-seq (10X Genomics Chromium).

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