The purpose of this experiment was to determine the murine liver expression traits that were changed in response to diet induced obesity. Keywords: diet induced obesity signature Overall design: Liver tissue from five diet induced obesity (DIO) mice were arrayed against a pool of liver tissue from chow-fed wildtype B6 animals. All samples were hybridized as fluor-reverse pairs, and then the data between the pairs was combined to form a single experiment. Five repeats were performed to increase the power to detect expression changes and to reduce effects of experimental noise.