Purpose: RNA-Seq was used to detect the dwonstream genes after FASN knockdow. Method: Three chondrocyte total RNA profiles of Si-NC samples and Si-FASN samples were analyzed. Overall design: We collected three human knee joint samples and primary chondrocytes were cultured. Then, chondrocytes were transfected with FASN SiRNA or negetive SiRNA. After transfections, RNAs were collected and RNA-seq were performed