ENSMUSG00000004931 (Apba3)

mus musculus

amyloid beta (A4) precursor protein-binding, family A, member 3

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Mus musculus
Organism part
Showing 52 experiments:
image/svg+xml aorta circulatory system blood vessel brown adipose tissue white adipose tissue skin stomach duodenum pancreas spleen adrenal gland kidney colon small intestine caecum jejunum ileum esophagus gall bladder parotid gland submandibular gland lymph node parathyroid gland tongue Peyer’s patch prostate gland vas deferens epididymis testis seminal vesicle penis urinary bladder thymus femur bone marrow cartilage quadriceps femoris spinal cord lung diaphragm peripheral nervous system trachea hindlimb trigeminal nerve eye sciatic nerve intestinal mucosa liver heart brain skeletal muscle
Created with Highcharts 6.2.0adrenal glandcentral neural epitheliumepidermal ectodermhippocampusmammary glandolfactory epitheliumsmall intestineuterusaxillary lymph nodebronchuscorpora quadrigeminadiencephalonfloor plateheartintestinal mucosalateral prominence neural epitheliummedial prefrontal cortexmuscle tissuepancreasprostate glandstriatumthymuswhite adipose tissue
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49 FANTOM5 project - adult
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49 FANTOM5 project - juvenile
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49 FANTOM5 project - neonate
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49 FANTOM5 project - embryonic day 18
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49 FANTOM5 project - embryonic day 16
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9 in 3 strains - DBA/2J
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9 in 3 strains - CD1
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9 in 3 strains - C57BL/6
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14 - embryonic day 10.5
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Mammalian Kaessmann
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49 FANTOM5 project - embryonic day 15
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4 Bonthuis et al - CastEiJ
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4 Bonthuis et al - (C57BL/6J X …
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Fat and muscle
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Developing gut
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3 Soumillon et al
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Sun et al., 2020 - Organism part
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Gregg et al - CAST/EiJ
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Gregg et al - C57BL/6J
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Gregg et al - (CAST/EiJ X C57BL/6J)F1
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Gregg et al - (C57BL/6J X CAST/EiJ)F1
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4 Bonthuis et al - C57BL/6J
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Mernberger et al 2019 - Organism Part
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49 FANTOM5 project - embryonic day 17.5
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4 Bonthuis et al - Idaho derived wild …
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Linscheid et al., 2021 - tissue - heart …
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Linscheid et al. 2019 - organism part
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Huttlin et al., 2010 - tissues - brain, …
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Deshmukh et al., 2015 - organism part
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Proteomics
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Regulation
Log2-fold changeSpeciesGene nameComparisonExperimental variablesExperiment name
Adjusted p-valueLog2-fold change
1.1288 × 10-192.4
Apba3'extracellular vesicle; non-stimulated culture medium' vs 'none'sampling site, stimulusCellular and extracellular vesicle RNA sequence for E-cadherin-RFP EMT reporter system expressing mouse breast cancer cell line Py2T during EMT/MET
Adjusted p-valueLog2-fold change
2.4246 × 10-62.3
Apba3'brown adipose tissue' vs 'white adipose tissue' in 'chow; 23 degree celsius'diet, organism part, temperatureRNA-seq of brown and white mouse adipose tissue at thermoneutrality and high-fat diet
Adjusted p-valueLog2-fold change
2.8149 × 10-7-1.8
Apba3'mir181a1/b1 Knockout' vs 'wild type'genotypeMouse CD4+/CD8+ thymocytes from miR-181a1/b1 KO vs WT
Adjusted p-valueLog2-fold change
2.1092 × 10-41.8
Apba3'myeloid lineage restricted progenitor cell' vs 'long term hematopoietic stem cell' in 'Elp3fl/fl'cell type, genotypeRNA-seq of long-term hematopoietic stem cells and myeloid progenitors of control mice or mice conditionally deficient for Trp53 or Elp3 or both genes in the hematopoietic system
Adjusted p-valueLog2-fold change
6.4956 × 10-4-1.7
Apba3'synovial sarcoma' vs 'normal'diseaseTranscription profiling by array of tumors excised from conditional mouse model of synovial sarcoma compared to skeletal muscle from wild type mice
Adjusted p-valueLog2-fold change
4.7529 × 10-10-1.6
Apba3'conditional Kras and p53 mutation induced soft tissue sarcoma' vs 'normal'diseaseTranscription profiling by array of mouse soft tissue sarcoma samples induced by conditional mutations of Kras and p53 against healthy muscles from mice of the same genotype but no induced sarcoma
Adjusted p-valueLog2-fold change
1.1208 × 10-8-1.6
Apba3'clear cell sarcoma; TATCre' vs 'control'disease, genotypeMouse Model of Clear Cell Sarcoma
Adjusted p-valueLog2-fold change
1.211 × 10-2-1.6
Apba3'co-transplanted with NOD-scid IL2Rgamma null HSCs' vs 'co-transplanted with wild type HSCs'growth conditionRNA-seq of mouse wildtype HSCs purified from recipient mice co-transplanted with wildtype or different types of lymphoid cell deficient HSCs
Adjusted p-valueLog2-fold change
3.6115 × 10-41.5
Apba3'smoke; 3000 microgram' vs 'control; 0 microgram' in 'Nrf2 knockout' at 'after 5 month exposure'compound, genotype, sampling time pointTranscription profiling by array of Nrf2 knockout mice exposed to cigarette smoke
Adjusted p-valueLog2-fold change
1.3777 × 10-11-1.3
Apba3'clear cell sarcoma; Rosa26CreER' vs 'control'disease, genotypeMouse Model of Clear Cell Sarcoma
Adjusted p-valueLog2-fold change
4.5721 × 10-101.3
Apba3'lung carcinoma' vs 'normal' in 'CD11b+Ly6G+ neutrophil'cell type, diseaseTranscriptome analysis of isolated stormal cells and tumor epithelial cells in mouse lung cancer by RNA-Seq
Adjusted p-valueLog2-fold change
5.8967 × 10-71.3
Apba3'MEF2A knockout' vs 'wild type genotype' in 'Hoxb8-FL; lipopolysaccharide; 10 nanogram per milliliter'cell line, compound, genotypeBulk RNA-seq of wild type and MEF2A or MEF2C/D knockout mouse bone marrow macrophages under different stimulation conditions
Adjusted p-valueLog2-fold change
5.0558 × 10-31.3
Apba3'PTEN null, P53-/-' vs 'wild type genotype'genotypeRNA seq of prostate gland from WT, PTEN pc -/- and PTEN pc-/-;P53 -/- mice
Adjusted p-valueLog2-fold change
1.8219 × 10-71.2
Apba3'extracellular vesicle; EMT cell culture medium' vs 'none'sampling site, stimulusCellular and extracellular vesicle RNA sequence for E-cadherin-RFP EMT reporter system expressing mouse breast cancer cell line Py2T during EMT/MET
Adjusted p-valueLog2-fold change
7.3278 × 10-6-1.2
Apba3'transplanted secondary tumors' vs 'normal' in 'kidney'clinical information, organism partPremature termination of in vivo reprogramming leads to cancer development through altered epigenetic regulation [array]
Adjusted p-valueLog2-fold change
1.9849 × 10-49-1.1
Apba3'Irx3 knockout' vs 'control' at '7 day'genetic modification, timeRNA-Seq of mouse Irx3-KO and Control ME3 cells on days 1 and 7 of adipogenic differentiation
Adjusted p-valueLog2-fold change
2.6649 × 10-101.1
Apba3'lipopolysaccharide; 10 nanogram per milliliter and prostaglandin E2; 1 micromolar' vs 'none' in 'primary cell line; MEF2C/D knockout'cell line, compound, genotypeBulk RNA-seq of wild type and MEF2A or MEF2C/D knockout mouse bone marrow macrophages under different stimulation conditions
Adjusted p-valueLog2-fold change
3.3198 × 10-7-1.1
Apba3'adipose tissue specific Cnot1 knockout' vs 'wild type phenotype' in 'brown adipose tissue'organism part, phenotypeRNA-seq to identify the role of mRNA decay in mouse adipose tissues
Adjusted p-valueLog2-fold change
3.8913 × 10-71.1
Apba3'induced neural stem cell' vs 'neural stem cell'cell typeGene expression profile of mouse induced neural stem cells
Adjusted p-valueLog2-fold change
7.5886 × 10-7-1.1
Apba3'acute graft vs. host disease; T-cell depleted bone marrow + T cells transplant' vs 'normal; T-cell depleted bone marrow transplant'disease, stimulusRNA-Seq of lymph node fibroblastic reticular cells isolated from bone marrow transplant recipient mice with or without acute Graft-versus-host disease on day 7 or untransplanted control mice
Adjusted p-valueLog2-fold change
2.6928 × 10-51.1
Apba3'AZD5069; 100 milligram per kilogram' vs 'none'compoundRNA-seq to investigate differentially expressed genes in KPC mouse PDAC treated with CSF-1R small molecule inhibitor AZD7507 and/or the CXCR2 small molecule inhibitor AZD5069
Adjusted p-valueLog2-fold change
1.015 × 10-4-1.1
Apba3'lipopolysaccharide; 10 nanogram per milliliter' vs 'none' in 'Hoxb8-FL; wild type genotype'cell line, compound, genotypeBulk RNA-seq of wild type and MEF2A or MEF2C/D knockout mouse bone marrow macrophages under different stimulation conditions
Adjusted p-valueLog2-fold change
4.5816 × 10-4-1.1
Apba3'adult definitive erythroid cell' vs 'primitive erythroid cell' in 'proerythroblast'cell type, phenotypeTranscription profiling by array of differentiating primary primitive and definitive mouse red blood cells
Adjusted p-valueLog2-fold change
2.9165 × 10-3-1.1
Apba3'swimming twice a day' at '4 week' vs 'control'time, treatmentTranscription profiling of heart ventricles from mice that have cardiac hypertrophy induced by swimming training
Adjusted p-valueLog2-fold change
6.6701 × 10-3-1.1
Apba3'malignant peritoneal mesothelioma; lo SV40 virus large TAg genotype (loTAg)' vs 'malignant peritoneal mesothelioma; wild type genotype'disease, genotypeGene expression profiles in MexTAg transgenic mouse and wild type mouse asbestos-induced mesothelioma
Adjusted p-valueLog2-fold change
1.6479 × 10-21.1
Apba3'Elp3fl/fl vav-iCreT/+' vs 'Elp3fl/fl' in 'polysome associated RNA'fraction, genotypePolysome profiling analysis of myeloid progenitors of control mice or mice conditionally deficient for Elp3 in the hematopoietic system
Adjusted p-valueLog2-fold change
1.938 × 10-61
Apba3'induced neural stem cell' vs 'mouse embryonic fibroblast cell'cell typeGene expression profile of mouse induced neural stem cells
Adjusted p-valueLog2-fold change
9.183 × 10-51
Apba3'Rb^{lox/lox}; p130^{lox/lox}; p107+/-' vs 'wild type'genotypeTranscription profiling by array of livers from the mouse model of human hepatocellular carcinoma
Adjusted p-valueLog2-fold change
2.512 × 10-3-1
Apba3'malignant peritoneal mesothelioma; int SV40 virus large TAg genotype (intTAag)' vs 'malignant peritoneal mesothelioma; wild type genotype'disease, genotypeGene expression profiles in MexTAg transgenic mouse and wild type mouse asbestos-induced mesothelioma
Adjusted p-valueLog2-fold change
3.1289 × 10-31
Apba3'Influenza A virus (A/Puerto Rico/8/1934(H1N1)); 4 day' vs 'mock' in 'C57BL/6J'infect, strain, timeGenomic profiling of collaborative cross founder mouse strains infected with respiratory viruses to discover novel transcripts and infection-related strain-specific gene and isoform expression
Adjusted p-valueLog2-fold change
4.9299 × 10-3-1
Apba3'high fat diet; 30 degree celsius' vs 'chow; 23 degree celsius' in 'brown adipose tissue'diet, organism part, temperatureRNA-seq of brown and white mouse adipose tissue at thermoneutrality and high-fat diet
Adjusted p-valueLog2-fold change
8.1355 × 10-3-1
Apba3'erythroblast' vs 'hematopoietic stem cell'cell typeTranscription profiling by array of primary megakaryocytes (MEG) and erythroblasts (ERY) developed from murine fetal liver hematopoietic stem cells
Adjusted p-valueLog2-fold change
1.8565 × 10-21
Apba3'brown adipose tissue' vs 'white adipose tissue' in 'high fat diet; 30 degree celsius'diet, organism part, temperatureRNA-seq of brown and white mouse adipose tissue at thermoneutrality and high-fat diet
Adjusted p-valueLog2-fold change
3.2366 × 10-2-1
Apba3'osteosarcoma' vs 'control'disease, genotypeMouse Model of Clear Cell Sarcoma
Synonym
X11gamma, Mint 3, Mint-3, neuronal munc18-1-interacting protein 3, lin-10, neuron-specific X11L2 protein
Ortholog
Gene ontology
InterPro
Ensembl gene
Ensembl transcript
Ensembl protein
Entrez
UniProt
MGI ID (Mouse)
MGI description
Gene biotype
Design element
A_55_P1980981, 4875852, 4982534, A_51_P285960, 5513362, 5281925, 5023831, 5432534, 102750_at, 4899361, 4898694, 4498616, 4442752, 4739163, 5006444, 10365056, aa016364_at, 1416182_at, 5041624, 4319627, ILMN_2660110, 5036651, 5205801, 4583194, 4514283, 5106610, A_55_P1977538