ENSMUSG00000010136 (Pifo)

mus musculus

primary cilia formation

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Mus musculus
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Showing 2 experiments:
Created with Highcharts 6.2.0adult CCAP neuronalpha’/beta’ middle Kenyon cellcentrifugal neuron C3distal medullary amacrine neuron Dm10distal medullary amacrine neuron Dm9dopaminergic PAM neuron 6gamma dorsal Kenyon celllamina monopolar neuron L2lobula columnar neuron LC10alobula columnar neuron LC6lobula-lobula plate columnar neuron LLPC1mushroom body output neuronproximal medullary amacrine neuron Pm3transmedullary neuron Tm1transmedullary neuron Tm4adult lamina marginal glial cellalpha/beta posterior Kenyon cellcolumnar neuron T1distal medullary amacrine neuron Dm3dopaminergic PAM neuron 3dopaminergic PAM neuron 9lamina intrinsic neuronlamina monopolar neuron L5lobula columnar neuron LC10dlobula plate tangential neuronmedullary intrinsic neuron Mi4photoreceptor cell R7T neurontransmedullary neuron Tm29
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Regulation
Log2-fold changeSpeciesGene nameComparisonExperimental variablesExperiment name
Adjusted p-valueLog2-fold change
1.4154 × 10-4-7.1
Pifo'neural stem cell' vs 'niche cell'cell typeTranscription profiling by high throughput sequencing of three populations of primary dentate gyrus cells
Adjusted p-valueLog2-fold change
2.5844 × 10-96.5
Pifo'hepatocyte-derived proliferative ducts (hepPDs)' vs 'hepatocyte'cell typeTranscription profiling by high throughput sequencing of hepatocyte-derived progenitors cells in a mouse model of oval cell activation
Adjusted p-valueLog2-fold change
1.796 × 10-8-5.9
Pifo'clear cell sarcoma; Rosa26CreER' vs 'control'disease, genotypeMouse Model of Clear Cell Sarcoma
Adjusted p-valueLog2-fold change
4.8276 × 10-7-5.8
Pifo'clear cell sarcoma; TATCre' vs 'control'disease, genotypeMouse Model of Clear Cell Sarcoma
Adjusted p-valueLog2-fold change
2.4566 × 10-8-5.4
Pifo'osteosarcoma' vs 'control'disease, genotypeMouse Model of Clear Cell Sarcoma
Adjusted p-valueLog2-fold change
9.8513 × 10-9-5.1
Pifo'synovial sarcoma' vs 'control'disease, genotypeMouse Model of Clear Cell Sarcoma
Adjusted p-valueLog2-fold change
3.575 × 10-45
Pifo'AZD7507; AZD5069 (at same dosage); 100 milligram per kilogram' vs 'none'compoundRNA-seq to investigate differentially expressed genes in KPC mouse PDAC treated with CSF-1R small molecule inhibitor AZD7507 and/or the CXCR2 small molecule inhibitor AZD5069
Adjusted p-valueLog2-fold change
4.4394 × 10-4-4.3
Pifo'neuron' vs 'differentiating progenitor'cell typeTranscription profiling by high throughput sequencing of proliferating neural stem cells, differentiating neurogenic progenitors and newborn neurons using a dual-reporter mouse line
Adjusted p-valueLog2-fold change
8.494 × 10-73.6
Pifo'doxycycline; 200 nanogram per milliliter; neoplasm; 5 day' vs 'none; normal; 0 day'compound, phenotype, timeRNA-seq of doxycycline induced tumor and residual mouse primary mammary epithelial cells grown in 3D cell cultures against non-induced controls
Adjusted p-valueLog2-fold change
1.0357 × 10-2-3.6
Pifo'cortical epithelial cell; Lin- Dapi-EpCAM+ CD31-UEA1-Ly51+ td-tomato+t vs 'medullary epithelial cell; Lin- Dapi-EpCAM+ CD31-UEA1+Ly51- td-tomato-'cell type, phenotypeThymic T-cell progenitor development is supported by membrane bound Kit ligand provided by a combined vascular endothelial and epithelial niche.
Adjusted p-valueLog2-fold change
3.4932 × 10-6-2.8
Pifo'spontaneous lung tumor' vs 'normal'disease state, diseaseTranscription profiling by array of spontaneous lung tumors in mice to compare to human non-small cell lung cancer
Adjusted p-valueLog2-fold change
1.4096 × 10-5-2.7
Pifo'acute graft vs. host disease' vs 'normal'compound, diseaseTranscription profiling by array of murine thymus medulla in the absence and presence of acute graft-versus-host disease
Adjusted p-valueLog2-fold change
1.2395 × 10-72.6
Pifo'hepatocyte-derived proliferative ducts (hepPDs)' vs 'biliary-derived proliferative ducts (bilDP)'cell typeTranscription profiling by high throughput sequencing of hepatocyte-derived progenitors cells in a mouse model of oval cell activation
Adjusted p-valueLog2-fold change
2.0878 × 10-4-2.5
Pifo'12 day' vs '5 day' in 'doxycycline; 200 nanogram per milliliter; neoplasm'compound, phenotype, timeRNA-seq of doxycycline induced tumor and residual mouse primary mammary epithelial cells grown in 3D cell cultures against non-induced controls
Adjusted p-valueLog2-fold change
9.1056 × 10-6-2.2
Pifo'Lkb1 -/- Pten-/-' vs 'wild type'genotypeLoss of Lkb1 and Pten Leads to Lung Squamous Cell Carcinoma with Elevated Pdl1 Expression: Epithelial Cells
Adjusted p-valueLog2-fold change
3.5316 × 10-2-2.2
Pifo'α-GalCer; 2 microgram' vs 'none' in 'Cd1d homozyous knockout'compound, genotypeCD1d-dependent immune suppression mediated by regulatory B cells through modulations of iNKT cells
Adjusted p-valueLog2-fold change
4.2294 × 10-62
Pifo'transplanted secondary tumors' vs 'normal' in 'kidney'clinical information, organism partPremature termination of in vivo reprogramming leads to cancer development through altered epigenetic regulation [array]
Adjusted p-valueLog2-fold change
1.6667 × 10-5-2
Pifo'Nrl-/-' vs 'wild type'genotypeNext Generation Sequencing Facilitates Quantitative Analysis of Wild Type and Nrl-/- Retinal Transcriptomes
Adjusted p-valueLog2-fold change
2.0749 × 10-3-1.9
Pifo'Kras G12D' vs 'wild type'genotypeLoss of Lkb1 and Pten Leads to Lung Squamous Cell Carcinoma with Elevated Pdl1 Expression: Epithelial Cells
Adjusted p-valueLog2-fold change
3.1834 × 10-31.6
Pifo'Smad4f/f x CCSPicrePtenf/f' vs 'wild type' at '12 month'age, genotypeErbB2 Pathway Activation upon Smad4 Loss Promotes Lung Tumor Growth and Metastasis [expression]
Adjusted p-valueLog2-fold change
2.4152 × 10-2-1.6
Pifo'induced neuronal cell' vs 'pluripotent embryonic stem cell'phenotypeTranscription profiling by high throughput sequencing of retinoic acid-differentiated neuronal cells compared to nondifferentiated pluripotent embryonic stem cells
Adjusted p-valueLog2-fold change
6.0773 × 10-31.5
Pifo'neuronal stem cell; positive staining for GFP and prominin' vs 'astrocyte; positive staining for GFP'cell type, phenotypeTranscription profiling by array of adult neural stem cells (hGFAP-GFP+/prominin1+ cells) compared to parenchymal astrocytes that are not neurogenic (hGFAP-GFP+ cells from the diencephalon)
Adjusted p-valueLog2-fold change
1.3706 × 10-2-1.5
Pifo'FusΔNLS/+' vs 'wild type genotype' at '8 hour'genotype, timeMutant FUS triggers age-dependent synaptic impairment in presymptomatic ALS-FUS mice (RNA-seq part2)
Adjusted p-valueLog2-fold change
2.6074 × 10-21.4
Pifo'Tumor Necrosis Factor' vs 'none'stimulusTranscription profiling by high throughput sequencing of CD8 single positive thymocytes from F5 Rag1KO TCR transgenic mice stimulated with tumor necrosis factor
Adjusted p-valueLog2-fold change
9.6009 × 10-10-1.3
Pifo'Rfx2 knock out' vs 'wild type genotype'genotypeNext Generation Sequencing Analysis of Wild Type and Rfx2-/- Testicular Transcriptomes at post natal day 30 [RNA-Seq P30]
Adjusted p-valueLog2-fold change
4.0695 × 10-5-1.2
Pifo'Mettl6 knockout clone D1' vs 'wild type genotype'genotypeMETTL6 is a tRNA m3C methyltransferase that regulates translation and tumor cell proliferation
Adjusted p-valueLog2-fold change
1.0336 × 10-4-1.2
Pifo'Influenza A virus (A/Puerto Rico/8/1934(H1N1)); 4 day' vs 'mock' in 'NOD/ShiLtJ'infect, strain, timeGenomic profiling of collaborative cross founder mouse strains infected with respiratory viruses to discover novel transcripts and infection-related strain-specific gene and isoform expression
Adjusted p-valueLog2-fold change
1.468 × 10-4-1.2
Pifo'MED23 knockout' vs 'wild type'genotypeMediator Med23-deficiency Enhances Neural Differentiation of Embryonic Stem Cells through Modulating BMP Signaling
Adjusted p-valueLog2-fold change
5.7543 × 10-41.2
Pifo'Smad4f/f x CCSPicrePtenf/f' vs 'wild type' at '7 month'age, genotypeErbB2 Pathway Activation upon Smad4 Loss Promotes Lung Tumor Growth and Metastasis [expression]
Adjusted p-valueLog2-fold change
2.8425 × 10-2-1.2
Pifo'FusΔNLS/+' vs 'wild type genotype' at '12 hour'genotype, timeMutant FUS triggers age-dependent synaptic impairment in presymptomatic ALS-FUS mice (RNA-seq part2)
Adjusted p-valueLog2-fold change
1.7306 × 10-5-1.1
Pifo'Rfx2 knock out' vs 'wild type genotype'genotypeNext Generation Sequencing Analysis of Wild Type and Rfx2-/- Testicular Transcriptomes at post natal day 21 [RNA-Seq P21]
Adjusted p-valueLog2-fold change
1.8238 × 10-41.1
Pifo'Ptenf/f x CCSPiCre' vs 'wild type' at '7 month'age, genotypeErbB2 Pathway Activation upon Smad4 Loss Promotes Lung Tumor Growth and Metastasis [expression]
Adjusted p-valueLog2-fold change
1.9482 × 10-3-1.1
Pifo'induction of polymicrobial sepsis' vs 'control' at '24 hour' in '1.5 to 3 month mice'age, time, treatmentAged Mice are Unable to Mount an Effective Myeloid Response to Sepsis
Adjusted p-valueLog2-fold change
3.5918 × 10-31.1
Pifo'Crx knockout' vs 'control' at '20 zeitgeber'genotype, timeTranscriptome in 129sv and Crx-/- pineal gland at ZT (Zeitgeber time) 6 and ZT20
Adjusted p-valueLog2-fold change
2.5723 × 10-2-1.1
Pifo'Egr2 and Egr3 knockout' vs 'Egr2-GFP knockin; Egr2-GFP high' in 'CD4-positive T cell'cell type, genotype, phenotypeRNAseq analysis of CD4 and CD8 T cells in response to vaccinia virus infection
Adjusted p-valueLog2-fold change
2.648 × 10-5-1
Pifo'PAI1 knockout; SARS MA15; 7 day' vs 'PAI1 knockout; mock'genotype, infect, timeSARS infection of C57BL6, TIMP1 and Serpine1 knock-out mice
Adjusted p-valueLog2-fold change
7.4906 × 10-41
Pifo'Crx knockout' vs 'control' at '6 zeitgeber'genotype, timeTranscriptome in 129sv and Crx-/- pineal gland at ZT (Zeitgeber time) 6 and ZT20
Adjusted p-valueLog2-fold change
7.9233 × 10-4-1
Pifo'SARS coronavirus MA15' vs 'none' at '7 day'infect, timeSM014 - SARS MA15 wild type, and SARS nsp16 mutant virus infections of C57BL6 mice - A time course
Adjusted p-valueLog2-fold change
1.5714 × 10-21
Pifo'Tgfbr2fl/fl;Wnt1-Cre' vs 'wild type'genotypeGene expression profiling of Tgfbr2 mutant mouse models of cleft palate
Adjusted p-valueLog2-fold change
2.1167 × 10-2-1
Pifo'induction of polymicrobial sepsis' vs 'control' at '24 hour' in '20 to 24 month mice'age, time, treatmentAged Mice are Unable to Mount an Effective Myeloid Response to Sepsis
Adjusted p-valueLog2-fold change
4.8083 × 10-2-1
Pifo'Sall4 -/-' vs 'wild type genotype'genotypeRNA-Seq of mouse embryonic stem cells in response to changes in Sall4
Synonym
pitchfork, 1700027A23Rik
Ortholog
ENSGALG00000023763 (Gallus gallus), PIFO (Dasypus novemcinctus), ENSAPLG00000008250 (Anas platyrhynchos), si:ch211-66i15.4 (Danio rerio), PIFO (Pongo abelii), ENSSSCG00000039977 (Sus scrofa), PIFO (Ornithorhynchus anatinus), PIFO (Chlorocebus sabaeus), Pifo (Rattus norvegicus), ENSOARG00020011762 (Salmo salar), PIFO (Oryctolagus cuniculus), ENSOARG00020011829 (Salmo salar), PIFO (Equus caballus), ENSMODG00000025691 (Monodelphis domestica), pifo (Xenopus tropicalis), ENSSSCG00000035204 (Sus scrofa), PIFO (Homo sapiens), ENSBTAG00000050402 (Bos taurus), ENSBTAG00000002489 (Bos taurus), ENSCSAVG00000007740 (Ciona savignyi), PIFO (Papio anubis), PIFO (Macaca mulatta), ENSCING00000005885 (Bos taurus), ENSACAG00000034763 (Anolis carolinensis), PIFO (Gorilla gorilla), PIFO (Pan troglodytes), ENSOARG00020010749 (Salmo salar)
Gene ontology
InterPro
Ensembl gene
Ensembl transcript
Ensembl protein
Entrez
UniProt
MGI ID (Mouse)
MGI description
Gene biotype
Design element
165845_at, 5299457, 4798886, A_55_P2054008, 5472180, 17408875, 4906168, A_55_P2142990, A_51_P258901, 5207142, 1453320_at, 4625952, 10500999, 4689211, ILMN_2736521, 4376672, 5495212, 5580642, 4525312, 5569300