ENSMUSG00000016526 (Dyrk3)

mus musculus

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3

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Mus musculus
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Showing 42 experiments:
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Log2-fold changeSpeciesGene nameComparisonExperimental variablesExperiment name
Adjusted p-valueLog2-fold change
2.3962 × 10-736.6
Dyrk3'Alb-Cre-ERT2 / Cnot1 flox/flox' vs 'Cnot1 flox/flox' in 'none'compound, genotype, timeRNA-seq of livers in control and Cnot1 tamoxifen-inducible liver-specific knockout mice
Adjusted p-valueLog2-fold change
7.2845 × 10-424.5
Dyrk3'liver-specific Cnot3 knockout' vs 'wild type'phenotypeRoles of mRNA decay in liver development
Adjusted p-valueLog2-fold change
1.5939 × 10-4-4.3
Dyrk3'lipopolysaccharide; 10 nanogram per milliliter and prostaglandin E2; 1 micromolar and interferon beta; 100 units per milliliter' vs 'none' in 'primary cell line; wild type genotype'cell line, compound, genotypeBulk RNA-seq of wild type and MEF2A or MEF2C/D knockout mouse bone marrow macrophages under different stimulation conditions
Adjusted p-valueLog2-fold change
1.0653 × 10-203.7
Dyrk3'liver-specific Cnot1 knockout' vs 'wild type'phenotypeRoles of mRNA decay in liver development
Adjusted p-valueLog2-fold change
2.4005 × 10-23.6
Dyrk3'dexamethasone; 10 microgram per milliliter' vs 'none'compoundRNA-seq of mouse sciatic peripheral nerve of injured mouse with implant: control (untreated) vs local delivery of MCC950 (NLRP3inh) vs standard FBR treatment dexamethasone (Dex). .
Adjusted p-valueLog2-fold change
1.2378 × 10-423.5
Dyrk3'epithelium-specific Apc knockout' vs 'wild type'phenotypeRNAseq of murine small intestinal tissue following epithelium-specific deletion of Bcl9/9l +/- Apc +/- mutant B-catenin
Adjusted p-valueLog2-fold change
2.6124 × 10-33.5
Dyrk3'adipose tissue specific Cnot1 knockout' vs 'wild type phenotype' in 'brown adipose tissue'organism part, phenotypeRNA-seq to identify the role of mRNA decay in mouse adipose tissues
Adjusted p-valueLog2-fold change
2.576 × 10-233.4
Dyrk3'Triple knockout (Zfp36-/-, TNFR1-/-, TNFR2-/-)' vs 'wild type'genotypeTranscription profiling by high throughput sequencing of douple (TNFR1-/-/TNFR2-/-) and triple (Zfp36-/-/TNFR1-/-/TNFR2-/-) knockout mouse spleens
Adjusted p-valueLog2-fold change
1.352 × 10-293.3
Dyrk3'α-GalCer; 2 microgram' vs 'none' in 'Cd1d homozyous knockout'compound, genotypeCD1d-dependent immune suppression mediated by regulatory B cells through modulations of iNKT cells
Adjusted p-valueLog2-fold change
1.0766 × 10-10-3.3
Dyrk3'10 day' vs '0 day'ageTranscription profiling of mouse embyronic stem cell line CGR8 during the first 10 days of differentiation into embryoid bodies
Adjusted p-valueLog2-fold change
1.9558 × 10-103.1
Dyrk3'H-Ras expression; c-Myc activation' vs 'wild type'phenotypeRNA-seq of heart tissue from 15 day old mice 4 hours post MycER activation compared to wild type controls. RNA-seq of heart tissues from adult mice that have expressed oncogenic H-Ras for 4 weeks followed by MycER activation for 4 hours compared to MycER negative controls.
Adjusted p-valueLog2-fold change
2.8585 × 10-10-3.1
Dyrk3'7 day' vs '0 day'ageTranscription profiling of mouse embyronic stem cell line CGR8 during the first 10 days of differentiation into embryoid bodies
Adjusted p-valueLog2-fold change
1.1944 × 10-11-3
Dyrk3'6 day' vs '0 day'ageTranscription profiling of mouse embyronic stem cell line CGR8 during the first 10 days of differentiation into embryoid bodies
Adjusted p-valueLog2-fold change
1.0115 × 10-6-3
Dyrk3'neurosphere in differentiation medium; 12 day' vs 'neurosphere; 0 day' in 'wild type genotype'genotype, growth condition, timeTranscriptome analysis of neurospheres derived from Cstb-KO mouse embryo brains during differentiation
Adjusted p-valueLog2-fold change
5.8389 × 10-92.9
Dyrk3'actinomycin D; 8 hour' vs 'none' in 'Cnot1 flox/flox'compound, genotype, timeRNA-seq of livers in control and Cnot1 tamoxifen-inducible liver-specific knockout mice
Adjusted p-valueLog2-fold change
4.6374 × 10-52.9
Dyrk3'PTEN null' vs 'wild type genotype'genotypeRNA seq of prostate gland from WT, PTEN pc -/- and PTEN pc-/-;P53 -/- mice
Adjusted p-valueLog2-fold change
1.9468 × 10-172.8
Dyrk3'tamoxifen induction at 2 months, wait 6 months' vs 'no tamoxifen induction' in 'basal cell of prostate epithelium; CK5-CreERT2 transgenic line'cell type, genotype, growth conditionTranscription profiling by high throughput sequencing of PIN/tumor lesions from basal or luminal origins at time points at which mice displayed similar histopathological phenotypes
Adjusted p-valueLog2-fold change
3.5935 × 10-32.8
Dyrk3'neoplasm' vs 'normal tissue adjacent to neoplasm'sampling siteTranscription profiling by array of Apc+/Delta716 mouse intestinal polyps vs normal intestinal mucosa
Adjusted p-valueLog2-fold change
1.629 × 10-262.7
Dyrk3'epithelium-specific mutant beta-catenin expression' vs 'wild type'phenotypeRNAseq of murine small intestinal tissue following epithelium-specific deletion of Bcl9/9l +/- Apc +/- mutant B-catenin
Adjusted p-valueLog2-fold change
1.7119 × 10-222.7
Dyrk3'epithelium-specific Apc; Bcl9; Bcl9l knockout' vs 'wild type'phenotypeRNAseq of murine small intestinal tissue following epithelium-specific deletion of Bcl9/9l +/- Apc +/- mutant B-catenin
Adjusted p-valueLog2-fold change
9.4727 × 10-62.7
Dyrk3'TGF-beta; 15 nanogram per milliliter' vs 'control'compoundTGF beta Dosage Experiment
Adjusted p-valueLog2-fold change
1.4311 × 10-5-2.7
Dyrk3'alpha-amanitin; maternal Ring1-Rnf+' vs 'none; maternal Ring1-Rnf+'compound, genotypePolycomb function during oogenesis is required for mouse early embryonic development (2-cell embryos)
Adjusted p-valueLog2-fold change
1.7021 × 10-52.7
Dyrk3'adult definitive erythroid cell' vs 'primitive erythroid cell' in 'basophilic erythroblast'cell type, phenotypeTranscription profiling by array of differentiating primary primitive and definitive mouse red blood cells
Adjusted p-valueLog2-fold change
1.6602 × 10-192.6
Dyrk3'tamoxifen induction at 2 months, wait 3 months' vs 'no tamoxifen induction' in 'luminal cell of prostate epithelium; Nkx3.1-CreERT2 targeted allele'cell type, genotype, growth conditionTranscription profiling by high throughput sequencing of PIN/tumor lesions from basal or luminal origins at time points at which mice displayed similar histopathological phenotypes
Adjusted p-valueLog2-fold change
6.2532 × 10-122.6
Dyrk3'tamoxifen induction at 2 months, wait 1 months' vs 'no tamoxifen induction' in 'luminal cell of prostate epithelium; Nkx3.1-CreERT2 targeted allele'cell type, genotype, growth conditionTranscription profiling by high throughput sequencing of PIN/tumor lesions from basal or luminal origins at time points at which mice displayed similar histopathological phenotypes
Adjusted p-valueLog2-fold change
9.3515 × 10-92.6
Dyrk3'undifferentiated' vs 'differentiated; rosiglitazone' in '129S6sv/ev'phenotype, stimulus, strainRNA-seq of mouse subcutaneous SVF cells before and after differentiation with a brown fat differentiation cocktail
Adjusted p-valueLog2-fold change
2.4268 × 10-82.6
Dyrk3'P60; insulin-expressing mature beta cells' vs 'E16.5; insulin-expressing nascent beta cells'age, cell typeTranscriptional profiling of nascent and mature pancreatic beta cells
Adjusted p-valueLog2-fold change
5.9469 × 10-4-2.6
Dyrk3'Helicobacter hepaticus' vs 'none' in 'wild type phenotype'infect, phenotypeWhole transcriptome profiling of the steady state and Hh-treated (8 hrs) Alpk1+/- (heterozygous) and Alpk1-/- (knockout) BMDMs using RNA-Sequencing approach
Adjusted p-valueLog2-fold change
1.4723 × 10-32.6
Dyrk3'AhCre Apc Floxed' vs 'control'genotypeCited-1 deficiency suppresses intestinal tumorigenesis through the repression of the Wnt pathway- evidence for the just right model of Wnt mediated tumorigenesis
Adjusted p-valueLog2-fold change
3.5861 × 10-3-2.6
Dyrk3'lipopolysaccharide' vs 'none' in 'bone marrow; wild type'cell type, compound, genotypeTranscription profiling by high throughput sequencing of spleens of GPR34 knockout and wild type mice
Adjusted p-valueLog2-fold change
1.4565 × 10-132.5
Dyrk3'tamoxifen induction at 2 months, wait 3 months' vs 'no tamoxifen induction' in 'basal cell of prostate epithelium; CK5-CreERT2 transgenic line'cell type, genotype, growth conditionTranscription profiling by high throughput sequencing of PIN/tumor lesions from basal or luminal origins at time points at which mice displayed similar histopathological phenotypes
Adjusted p-valueLog2-fold change
3.5324 × 10-10-2.5
Dyrk3'5 day' vs '0 day'ageTranscription profiling of mouse embyronic stem cell line CGR8 during the first 10 days of differentiation into embryoid bodies
Adjusted p-valueLog2-fold change
1.6089 × 10-82.5
Dyrk3'extraembryonic endoderm stem cell; grown in XEN cell medium' vs 'mouse embryonic fibroblast; control'cell type, growth conditionOSKM induce extraembryonic endoderm stem (iXEN) cells in parallel to iPS cells
Adjusted p-valueLog2-fold change
1.24 × 10-72.5
Dyrk3'induced extraembryonic endoderm stem cell; grown in XEN cell medium' vs 'mouse embryonic fibroblast; control'cell type, growth conditionOSKM induce extraembryonic endoderm stem (iXEN) cells in parallel to iPS cells
Adjusted p-valueLog2-fold change
2.1547 × 10-42.5
Dyrk3'AhCre Apc Floxed Cited1 knockout' vs 'control'genotypeCited-1 deficiency suppresses intestinal tumorigenesis through the repression of the Wnt pathway- evidence for the just right model of Wnt mediated tumorigenesis
Adjusted p-valueLog2-fold change
4.0912 × 10-112.4
Dyrk3'c-Myc activation' vs 'wild type'phenotypeRNA-seq of heart tissue from 15 day old mice 4 hours post MycER activation compared to wild type controls. RNA-seq of heart tissues from adult mice that have expressed oncogenic H-Ras for 4 weeks followed by MycER activation for 4 hours compared to MycER negative controls.
Adjusted p-valueLog2-fold change
5.9439 × 10-8-2.4
Dyrk3'Trp53 knockout' vs 'wild type genotype' in 'Nutlin-3a; 10 micromolar'compound, phenotypeResidual tumor suppressor activities of tumorigenic p53 mutants enhance survival under chemotherapy
Adjusted p-valueLog2-fold change
2.4133 × 10-32.4
Dyrk3'colitis' at '8 day' vs 'normal' at '0 day'disease, timeTemporal transcriptomic changes during DSS colitis development and resolution.
Adjusted p-valueLog2-fold change
2.0361 × 10-8-2.3
Dyrk3'4 day' vs '0 day'ageTranscription profiling of mouse embyronic stem cell line CGR8 during the first 10 days of differentiation into embryoid bodies
Adjusted p-valueLog2-fold change
5.871 × 10-7-2.3
Dyrk3'Zbtb10 knockdown' vs 'control' at '2 hour'genotype, timeRNA-seq of Zbtb10 Knockdown and Control cDC1 dendritic cells (Cd8+)
Adjusted p-valueLog2-fold change
7.2955 × 10-72.3
Dyrk3'AAV9-Ccnt1;Myh6-cre;LSL-R26CAG-c-MycERT2/+' vs 'AAV9-Ccnt1;LSL-R26CAG-c-MycERT2/+'genotypeRNA-seq of purified cardiomocytes from adult mice (+/- AAV-CCNT1) 4 hours post MycER activation compared controls.
Adjusted p-valueLog2-fold change
5.0695 × 10-62.3
Dyrk3'5 nanogram per milliliter; TGFbeta1' vs 'none' at '24 hour'compound, timeTranscription profiling by array of mouse hepatocytes following treatment with growth factor beta 1 in a time series
Adjusted p-valueLog2-fold change
1.3808 × 10-42.3
Dyrk3'undifferentiated' vs 'differentiated; rosiglitazone' in 'F1.129xB6'phenotype, stimulus, strainRNA-seq of mouse subcutaneous SVF cells before and after differentiation with a brown fat differentiation cocktail
Adjusted p-valueLog2-fold change
4.6495 × 10-42.3
Dyrk3'fetal definitive erythroid cell' vs 'primitive erythroid cell' in 'basophilic erythroblast'cell type, phenotypeTranscription profiling by array of differentiating primary primitive and definitive mouse red blood cells
Adjusted p-valueLog2-fold change
4.4808 × 10-22.3
Dyrk3'130 week' vs '13 week' in 'spleen'age, organism partTranscription profiling by array of liver, lung, spleen and kidney from young and old mice.
Adjusted p-valueLog2-fold change
1.1891 × 10-62.2
Dyrk3'confluent monolayer on collagen' at '7 day' vs 'freshly isolated' at '0 day'growth condition, timeTranscription profiling of primary mouse hepatocytes under different culture conditions
Adjusted p-valueLog2-fold change
3.3828 × 10-5-2.2
Dyrk3'myelocyte' vs 'hemopoietic stem cell'cell typeGene expression data from mouse hemopoietic stem cells (LSKs), promyelocytes, myelocytes and granulocytes.
Adjusted p-valueLog2-fold change
6.4639 × 10-52.2
Dyrk3'transgenic C3(1)-SV40Tag; 20 week' vs 'wild type; 8 week'age, genotypePrevention of mammary tumor progression by silencing HoxA1 via intraductal injection of nanoparticle-formulated siRNA
Adjusted p-valueLog2-fold change
5.7883 × 10-182.1
Dyrk3'doxycycline; 200 nanogram per milliliter; neoplasm; 5 day' vs 'none; normal; 0 day'compound, phenotype, timeRNA-seq of doxycycline induced tumor and residual mouse primary mammary epithelial cells grown in 3D cell cultures against non-induced controls
Adjusted p-valueLog2-fold change
2.4623 × 10-62.1
Dyrk3'subconfluent monolayer on collagen' at '7 day' vs 'freshly isolated' at '0 day'growth condition, timeTranscription profiling of primary mouse hepatocytes under different culture conditions
Adjusted p-valueLog2-fold change
2.6842 × 10-6-2.1
Dyrk3'granulocyte' vs 'hemopoietic stem cell'cell typeGene expression data from mouse hemopoietic stem cells (LSKs), promyelocytes, myelocytes and granulocytes.
Adjusted p-valueLog2-fold change
4.1089 × 10-3-2.1
Dyrk3'co-transplanted with NOD-scid IL2Rgamma null HSCs' vs 'co-transplanted with wild type HSCs'growth conditionRNA-seq of mouse wildtype HSCs purified from recipient mice co-transplanted with wildtype or different types of lymphoid cell deficient HSCs
Adjusted p-valueLog2-fold change
4.9537 × 10-8-2
Dyrk3'Trp53 Arg178Asp' vs 'wild type genotype' in 'Nutlin-3a; 10 micromolar'compound, phenotypeResidual tumor suppressor activities of tumorigenic p53 mutants enhance survival under chemotherapy
Adjusted p-valueLog2-fold change
1.7819 × 10-62
Dyrk3'Apc knockout in Villin1 positive cells' vs 'wild type'phenotypeTranscription profiling by array of Apc-deficient proximal colonic epithelium upon Msx1 transcription factor depletion
Adjusted p-valueLog2-fold change
8.079 × 10-6-2
Dyrk3'neurosphere in differentiation medium; 12 day' vs 'neurosphere; 0 day' in 'Cstb knockout'genotype, growth condition, timeTranscriptome analysis of neurospheres derived from Cstb-KO mouse embryo brains during differentiation
Adjusted p-valueLog2-fold change
2.077 × 10-42
Dyrk3'ulcer' vs 'distant normal tissue' in 'Bmp4 overexpression'genotype, sampling site, timeIntestinal ulcers from biopsy-wounded wild-type and Bmp4-overexpressing mice
Adjusted p-valueLog2-fold change
8.5271 × 10-42
Dyrk3'RAW264.7 macrophage cell line; control' vs 'bone marrow macrophage; control'cell type, growth conditionTranscription profiling of mouse bone marrow macrophages (BMM) compared to BMM co-cultured with 4T1.2 breast cancer cells, treated with tumour cell supernatant, or RAW macrophage cell line
Adjusted p-valueLog2-fold change
1.0964 × 10-22
Dyrk3'adipose tissue specific Cnot1 knockout' vs 'wild type phenotype' in 'inguinal fat pad'organism part, phenotypeRNA-seq to identify the role of mRNA decay in mouse adipose tissues
Adjusted p-valueLog2-fold change
1.1127 × 10-22
Dyrk3'undifferentiated' vs 'differentiated; rosiglitazone' in 'F1.B6x129'phenotype, stimulus, strainRNA-seq of mouse subcutaneous SVF cells before and after differentiation with a brown fat differentiation cocktail
Adjusted p-valueLog2-fold change
2.8708 × 10-12-1.9
Dyrk3'Salmonella enterica serovar Typhimurium' vs 'control' in 'bone marrow macrophage from 129P2 mouse strain'clinical information, infectGene expression profiles of mouse embryonic stem cell derived macrophages infected with Salmonella typhimurium
Adjusted p-valueLog2-fold change
5.5628 × 10-11-1.9
Dyrk3'SMRT shRNA' vs 'none' in 'none' at '0 hour'RNA interference, stimulus, timeRNA-seq of Control and SMRT KD CD8α+ DCs at 0hr and 6hr CpG stimulation
Adjusted p-valueLog2-fold change
5.9002 × 10-9-1.9
Dyrk3'Kit ligand' vs 'none' in 'wasp knockout'compound, genotypeTranscription profiling of bone marrow–derived mast cells from WASP-deficient mice after stimulation with kit ligand
Adjusted p-valueLog2-fold change
1.0515 × 10-61.9
Dyrk3'Apc and Msx1 knockout in Villin1 positive cells' vs 'wild type'phenotypeTranscription profiling by array of Apc-deficient proximal colonic epithelium upon Msx1 transcription factor depletion
Adjusted p-valueLog2-fold change
3.1537 × 10-51.9
Dyrk3'TGF-beta; 1.5 nanogram per milliliter' vs 'control'compoundTGF beta Dosage Experiment
Adjusted p-valueLog2-fold change
1.3199 × 10-2-1.9
Dyrk3'fetal definitive erythroid cell' vs 'primitive erythroid cell' in 'reticulocyte'cell type, phenotypeTranscription profiling by array of differentiating primary primitive and definitive mouse red blood cells
Adjusted p-valueLog2-fold change
1.5788 × 10-81.8
Dyrk3'Ink4a/Arf-/-; EGFRvIII' vs 'wild type genotype' in 'separate'genotype, growth conditionRNA-seq of wild-type and transformed Ink4a/Arf-/-; EGFRvIII neural stem cells in separate or co-culture conditions
Adjusted p-valueLog2-fold change
7.0779 × 10-5-1.8
Dyrk3'neurosphere in differentiation medium; 5 day' vs 'neurosphere; 0 day' in 'Cstb knockout'genotype, growth condition, timeTranscriptome analysis of neurospheres derived from Cstb-KO mouse embryo brains during differentiation
Adjusted p-valueLog2-fold change
2.0972 × 10-41.8
Dyrk3'extraembryonic endoderm stem cell; grown in ES cell medium' vs 'mouse embryonic fibroblast; control'cell type, growth conditionOSKM induce extraembryonic endoderm stem (iXEN) cells in parallel to iPS cells
Adjusted p-valueLog2-fold change
9.4474 × 10-4-1.8
Dyrk3'lipopolysaccharide; 10 nanogram per milliliter and prostaglandin E2; 1 micromolar' vs 'none' in 'primary cell line; MEF2C/D knockout'cell line, compound, genotypeBulk RNA-seq of wild type and MEF2A or MEF2C/D knockout mouse bone marrow macrophages under different stimulation conditions
Adjusted p-valueLog2-fold change
2.0959 × 10-31.8
Dyrk3'hypobaric hypoxia' vs 'control'growth conditionComparison of gene expression in whole blood of mice subjected to hypobaric hypoxia at Mt. Everest in vivo.
Adjusted p-valueLog2-fold change
8.6 × 10-61.7
Dyrk3'erythroblast' vs 'hematopoietic stem cell'cell typeTranscription profiling by array of primary megakaryocytes (MEG) and erythroblasts (ERY) developed from murine fetal liver hematopoietic stem cells
Adjusted p-valueLog2-fold change
2.0339 × 10-51.7
Dyrk3'collagen sandwich' at '1 day' vs 'freshly isolated' at '0 day'growth condition, timeTranscription profiling of primary mouse hepatocytes under different culture conditions
Adjusted p-valueLog2-fold change
2.3786 × 10-41.7
Dyrk3'Plasmodium chabaudi infection' vs 'no infection' in 'adjuvant only'infect, treatmentProtective vaccination against blood-stage malaria of Plasmodium chabaudi: differential gene expression in the liver of Balb/c mice towards the end of crisis phase
Adjusted p-valueLog2-fold change
6.1204 × 10-4-1.7
Dyrk3'AZD7507; AZD5069 (at same dosage); 100 milligram per kilogram' vs 'none'compoundRNA-seq to investigate differentially expressed genes in KPC mouse PDAC treated with CSF-1R small molecule inhibitor AZD7507 and/or the CXCR2 small molecule inhibitor AZD5069
Adjusted p-valueLog2-fold change
7.9075 × 10-41.7
Dyrk3'undifferentiated' vs 'differentiated; rosiglitazone' in 'AKR/J'phenotype, stimulus, strainRNA-seq of mouse subcutaneous SVF cells before and after differentiation with a brown fat differentiation cocktail
Adjusted p-valueLog2-fold change
1.1434 × 10-31.7
Dyrk3'Nix knock out' vs 'wild type'genotypeTranscription profiling by array of spleens from mice with Nix knocked out.
Adjusted p-valueLog2-fold change
2.4792 × 10-3-1.7
Dyrk3'renin-expression' vs 'control'phenotypeExpression data from mouse bone marrow cells expressing renin driven expression of green fluorescent protein.
Adjusted p-valueLog2-fold change
4.6403 × 10-3-1.7
Dyrk3'neurosphere in differentiation medium; 5 day' vs 'neurosphere; 0 day' in 'wild type genotype'genotype, growth condition, timeTranscriptome analysis of neurospheres derived from Cstb-KO mouse embryo brains during differentiation
Adjusted p-valueLog2-fold change
5.834 × 10-31.7
Dyrk3'19BL; differentiated 3factor-reprogrammed induced pluripotent stem cell' vs 'R1; differentiated embryonic stem cell' at '11 day'cell line, growth condition, timeNatural cardiogenesis-based template predicts cardiogenic potential of induced pluripotent stem cell lines
Adjusted p-valueLog2-fold change
8.0212 × 10-3-1.7
Dyrk3'Trp53 knockout' vs 'wild type genotype' in 'dimethyl sulfoxide; 0.1 microliter'compound, phenotypeResidual tumor suppressor activities of tumorigenic p53 mutants enhance survival under chemotherapy
Adjusted p-valueLog2-fold change
1.4398 × 10-2-1.7
Dyrk3'ABIN1[D485N] knock-in' vs 'wild type genotype' in 'neutrophil'cell type, genotypeRNA-seq of inflammatory monocytes, patrolling monocytes and neutrophils in wild type and ABIN1[D485N] mice
Adjusted p-valueLog2-fold change
1.2153 × 10-201.6
Dyrk3'TGFβ, 5 nanogram per milliliter' vs 'none'sampling site, stimulusCellular and extracellular vesicle RNA sequence for E-cadherin-RFP EMT reporter system expressing mouse breast cancer cell line Py2T during EMT/MET
Adjusted p-valueLog2-fold change
9.5474 × 10-18-1.6
Dyrk3'12 day' vs '5 day' in 'doxycycline; 200 nanogram per milliliter; neoplasm'compound, phenotype, timeRNA-seq of doxycycline induced tumor and residual mouse primary mammary epithelial cells grown in 3D cell cultures against non-induced controls
Adjusted p-valueLog2-fold change
1.0118 × 10-10-1.6
Dyrk3'CD4-positive T cell' vs 'CD8-positive T cell' in 'Egr2 and Egr3 knockout'cell type, genotype, phenotypeRNAseq analysis of CD4 and CD8 T cells in response to vaccinia virus infection
Adjusted p-valueLog2-fold change
2.9511 × 10-9-1.6
Dyrk3'interleukin-3 and interleukin-33' vs 'interleukin-3'growth conditionStem cell factor programs the mast cell activation phenotype
Adjusted p-valueLog2-fold change
1.7242 × 10-81.6
Dyrk3'gamma radiation; 8 Gray' vs 'none' in 'Lgr5-Cre-ERT2; Il22-/-'genotype, irradiateRNA Seq of colonic Lgr5+ epithelial stem cells in Il22+/+ and Il22-/- mice during homeostasis and 24h after irradiation with 8 Gy
Adjusted p-valueLog2-fold change
1.3075 × 10-7-1.6
Dyrk3'3 day; osteogenesis differentiation' vs ' 0 day; control' in '2C12-pMirn0'cell line, growth condition, timeEffect of Mirn378 overexpression on gene expression during C2C12 myogenic and BMP2-induced osteogenic differentiation
Adjusted p-valueLog2-fold change
2.5453 × 10-51.6
Dyrk3'spontaneous lung tumor' vs 'normal'disease state, diseaseTranscription profiling by array of spontaneous lung tumors in mice to compare to human non-small cell lung cancer
Adjusted p-valueLog2-fold change
2.8483 × 10-51.6
Dyrk3'subconfluent monolayer on collagen' at '5 day' vs 'freshly isolated' at '0 day'growth condition, timeTranscription profiling of primary mouse hepatocytes under different culture conditions
Adjusted p-valueLog2-fold change
1.1088 × 10-31.6
Dyrk3'heat-shocked at 42 degreeC' vs 'grown at 33 degreeC' in 'wild type'genotype, growth conditionTranscription profiling by array of mouse wild type and Htt mutant striatal cells upon heat shock
Adjusted p-valueLog2-fold change
1.6108 × 10-3-1.6
Dyrk3'lipopolysaccharide; 10 nanogram per milliliter' vs 'none' in 'primary cell line; MEF2C/D knockout'cell line, compound, genotypeBulk RNA-seq of wild type and MEF2A or MEF2C/D knockout mouse bone marrow macrophages under different stimulation conditions
Adjusted p-valueLog2-fold change
2.1247 × 10-3-1.6
Dyrk3'FusΔNLS/+' vs 'wild type genotype' at '12 hour'genotype, timeMutant FUS triggers age-dependent synaptic impairment in presymptomatic ALS-FUS mice (RNA-seq part2)
Adjusted p-valueLog2-fold change
7.7022 × 10-31.6
Dyrk3'actinomycin D; 4 hour' vs 'none' in 'Cnot1 flox/flox'compound, genotype, timeRNA-seq of livers in control and Cnot1 tamoxifen-inducible liver-specific knockout mice
Adjusted p-valueLog2-fold change
8.4783 × 10-31.6
Dyrk3'undifferentiated' vs 'differentiated; rosiglitazone' in 'SWR/J'phenotype, stimulus, strainRNA-seq of mouse subcutaneous SVF cells before and after differentiation with a brown fat differentiation cocktail
Adjusted p-valueLog2-fold change
1.1568 × 10-21.6
Dyrk3'Lymphocytic choriomeningitis mammarenavirus' vs 'none' in 'wild type genotype'genotype, infectComparison of Trail+/+ versus Trail-/- splenic NK cells from naïve and LCMV-infected mice
Adjusted p-valueLog2-fold change
1.6747 × 10-21.6
Dyrk3'heat-shocked at 42 degreeC' vs 'grown at 33 degreeC' in 'HdhQ111 knock-in'genotype, growth conditionTranscription profiling by array of mouse wild type and Htt mutant striatal cells upon heat shock
Adjusted p-valueLog2-fold change
2.0606 × 10-21.6
Dyrk3'22 to 23 month' vs '2 to 3 month'ageTranscription profiling by array of long-term haematopoietic stem cells from old and young mice
Adjusted p-valueLog2-fold change
4.6818 × 10-71.5
Dyrk3'α-GalCer; 2 microgram' vs 'none' in 'wild type genotype'compound, genotypeCD1d-dependent immune suppression mediated by regulatory B cells through modulations of iNKT cells
Adjusted p-valueLog2-fold change
4.305 × 10-5-1.5
Dyrk3'mutant MyoD expression' at '12 hour' vs 'control' at '12 hour'phenotype, timeTranscription profiling of mouse embryoic fibroblasts expressing wild type MyoD or its non-acetylatable version MyoD RRR to investigate how MyoD acetylation may contribute to differential gene activation.
Adjusted p-valueLog2-fold change
5.6884 × 10-51.5
Dyrk3'subconfluent monolayer on collagen' at '2 day' vs 'freshly isolated' at '0 day'growth condition, timeTranscription profiling of primary mouse hepatocytes under different culture conditions
Adjusted p-valueLog2-fold change
7.2462 × 10-5-1.5
Dyrk3'lipopolysaccharide; 10 nanogram per milliliter' vs 'none' in 'primary cell line; wild type genotype'cell line, compound, genotypeBulk RNA-seq of wild type and MEF2A or MEF2C/D knockout mouse bone marrow macrophages under different stimulation conditions
Adjusted p-valueLog2-fold change
1.1376 × 10-41.5
Dyrk3'confluent monolayer on collagen' at '1 day' vs 'freshly isolated' at '0 day'growth condition, timeTranscription profiling of primary mouse hepatocytes under different culture conditions
Adjusted p-valueLog2-fold change
1.1303 × 10-31.5
Dyrk3'myeloid lineage restricted progenitor cell' vs 'long term hematopoietic stem cell' in 'Elp3fl/fl'cell type, genotypeRNA-seq of long-term hematopoietic stem cells and myeloid progenitors of control mice or mice conditionally deficient for Trp53 or Elp3 or both genes in the hematopoietic system
Adjusted p-valueLog2-fold change
1.9943 × 10-3-1.5
Dyrk3'intravenous injection of 10-100 thousand B-ALL cells' vs 'none' in 'lentiviral expression of mTie2-IFN-mirT and Tie2-driven overexpression of IFNalpha'genotype, stimulusRNA-seq of mouse macrophages to investigate how interferon gene therapy reprograms the leukemia microenvironment
Adjusted p-valueLog2-fold change
1.3539 × 10-21.5
Dyrk3'undifferentiated' vs 'differentiated; rosiglitazone' in 'A/J'phenotype, stimulus, strainRNA-seq of mouse subcutaneous SVF cells before and after differentiation with a brown fat differentiation cocktail
Adjusted p-valueLog2-fold change
1.4238 × 10-21.5
Dyrk3'Cbs knockout' vs 'wild type'genotypeGene expression profile of CD4-positive T cells from mouse Cbs knockout
Adjusted p-valueLog2-fold change
2.3854 × 10-2-1.5
Dyrk3'Helicobacter hepaticus' vs 'none' in 'Alpk1 homozygous knockout'infect, phenotypeWhole transcriptome profiling of the steady state and Hh-treated (8 hrs) Alpk1+/- (heterozygous) and Alpk1-/- (knockout) BMDMs using RNA-Sequencing approach
Adjusted p-valueLog2-fold change
2.4967 × 10-21.5
Dyrk3'polysomal RNA; HRasV12 and c-Myc overexpression and Eif4e heterozygous knockout' vs 'polysomal RNA; wild type'fraction, genotypeRedefining the role of eIF4E dose in development, cancer, and protein synthesis
Adjusted p-valueLog2-fold change
2.531 × 10-21.5
Dyrk3"Evi1-GFP positive" vs "Evi1-GFP negative"phenotypeWhole genome expression profiling of Evi1-GFP positive and negative murine hematopoietic stem cell sub-populations.
Adjusted p-valueLog2-fold change
4.6743 × 10-291.4
Dyrk3'shear stressing' vs 'none'stimulusRNA seq of fluid shear stress treated mouse Pkd1-/- renal epithelial cells
Adjusted p-valueLog2-fold change
9.712 × 10-28-1.4
Dyrk3'upf3 knockout' vs 'wild type' in 'testis'cell type, genotypeUPF2 establishes testis-specific transcriptome enriched in transcripts with shorter 3’UTRs
Adjusted p-valueLog2-fold change
7.1626 × 10-14-1.4
Dyrk3'5 week' vs '1 week' in 'Jak2+/V617F; CRISPR/Cas9 mediated knockout of Dnmt3a'genotype, timeRNA-seq of Jak2VF LSK cells transduced with Dnmt3a-Cas9-GFP lentivirus vs. emp-Cas9-GFP controls one week and five weeks post methylcellulose plating
Adjusted p-valueLog2-fold change
2.2425 × 10-101.4
Dyrk3'Egr2 and Egr3 knockout' vs 'Egr2-GFP knockin; Egr2-GFP high' in 'CD8-positive T cell'cell type, genotype, phenotypeRNAseq analysis of CD4 and CD8 T cells in response to vaccinia virus infection
Adjusted p-valueLog2-fold change
3.9961 × 10-9-1.4
Dyrk3'336 hour' vs '0 hour' on 'Affymetrix Mouse430A_2 Array'timeTranscription profiling of murine V6.5 embryonic stem cells differentiating into embryoid bodies over a time-course to study changes in transcription during stem cell differentiation
Adjusted p-valueLog2-fold change
6.5425 × 10-7-1.4
Dyrk3'3 day; osteogenesis differentiation' vs ' 0 day; control' in '2C12-pMirn378'cell line, growth condition, timeEffect of Mirn378 overexpression on gene expression during C2C12 myogenic and BMP2-induced osteogenic differentiation
Adjusted p-valueLog2-fold change
7.038 × 10-7-1.4
Dyrk3'3 day' vs '0 day'ageTranscription profiling of mouse embyronic stem cell line CGR8 during the first 10 days of differentiation into embryoid bodies
Adjusted p-valueLog2-fold change
1.9409 × 10-6-1.4
Dyrk3'21 day' vs '1 day'ageTranscriptional profilling of female mice liver as a function of age
Adjusted p-valueLog2-fold change
2.6806 × 10-51.4
Dyrk3'14 days P. chabaudi infected' vs 'uninfected' in 'intact female'clinical information, disease, sex, timeTranscription profiling by array of mice infected with Plasmodium chabaudi after gonadectomization to investigate involvement of gonadal steroids
Adjusted p-valueLog2-fold change
5.7128 × 10-51.4
Dyrk3'14 days P. chabaudi infected' vs 'uninfected' in 'intact male'clinical information, disease, sex, timeTranscription profiling by array of mice infected with Plasmodium chabaudi after gonadectomization to investigate involvement of gonadal steroids
Adjusted p-valueLog2-fold change
1.1828 × 10-31.4
Dyrk3'SMAD2; TGF beta 1; 5 nanogram per milliliter' vs 'SMAD2; vehicle; 5 nanogram per milliliter'RNA interference, compoundtranscription profiling by array mouse mammary epithelial cells treated with TGF-beta to induce epithelial-to-mesenchymal transition
Adjusted p-valueLog2-fold change
1.3697 × 10-31.4
Dyrk3'3110043O21Rik knockout; spleen' vs 'wild type genotype; spleen'genotype, organism part, sampling siteRNAseq of coding RNA in the liver, spleen, kidney, abdominal muscle and gonadal adipose tissue of knock out mice and wild type controls.
Adjusted p-valueLog2-fold change
1.5921 × 10-31.4
Dyrk3'adult definitive erythroid cell' vs 'primitive erythroid cell' in 'proerythroblast'cell type, phenotypeTranscription profiling by array of differentiating primary primitive and definitive mouse red blood cells
Adjusted p-valueLog2-fold change
4.854 × 10-31.4
Dyrk3'Trichuris muris' vs 'control' in 'mesenteric lymph node'environmental stress, infect, organism partRNA-seq of mouse intestinal mucosa to investigate infection by the parasitic nematode Trichuris muris
Adjusted p-valueLog2-fold change
4.8726 × 10-31.4
Dyrk3'induced extraembryonic endoderm stem cell; grown in ES cell medium' vs 'mouse embryonic fibroblast; control'cell type, growth conditionOSKM induce extraembryonic endoderm stem (iXEN) cells in parallel to iPS cells
Adjusted p-valueLog2-fold change
9.8116 × 10-31.4
Dyrk3'wormy, worm separated; Trichuris muris' vs 'control; non wormy' in 'caecum'environmental stress, infect, organism partRNA-seq of mouse intestinal mucosa to investigate infection by the parasitic nematode Trichuris muris
Adjusted p-valueLog2-fold change
1.7272 × 10-21.4
Dyrk3'p60 subunit of CAF-1 siRNA knockdown' vs 'scrambled siRNA'RNA interferenceRNA-seq of control siRNA, p150 siRNA and p60 siRNA transfected mES cells
Adjusted p-valueLog2-fold change
4.2277 × 10-2-1.4
Dyrk3'uterine-specific Tsc2-null' vs 'wild type' in '17beta-estradiol'genotype, treatmentTranscription profiling by high throughput sequencing of uterine-specific Tsc2-null mice
Adjusted p-valueLog2-fold change
2.6949 × 10-201.3
Dyrk3'shear stressing' vs 'none'stimulusRNA seq of fluid shear stress treated mouse renal epithelial cells
Adjusted p-valueLog2-fold change
4.1515 × 10-18-1.3
Dyrk3'Stat5a (Stat5abnull/Stat5b-)' vs 'wild type' at 'pregnancy'genotype, sampling time pointTranscription profiling by high throughput sequencing of mouse wild type and Stat5-mutant mammary tissues at parturition and early pregnancy
Adjusted p-valueLog2-fold change
4.9418 × 10-171.3
Dyrk3'extracellular vesicle; EMT cell culture medium' vs 'none'sampling site, stimulusCellular and extracellular vesicle RNA sequence for E-cadherin-RFP EMT reporter system expressing mouse breast cancer cell line Py2T during EMT/MET
Adjusted p-valueLog2-fold change
5.2932 × 10-91.3
Dyrk3'10 Gy Gray; x-ray' vs 'none' in 'hematopoietic cell'cell type, irradiateRNA-seq of effector (CD43+) CD8+ T cells, CD45+ hematopoietic cells and CD45- tumor/stromal cells from mice bearing bilateral AT-3 tumors following radio-immunotherapy of which one tumor was irradiated
Adjusted p-valueLog2-fold change
3.2494 × 10-71.3
Dyrk3'14 days P. chabaudi infected' vs 'uninfected' in 'gonadectomized female'clinical information, disease, sex, timeTranscription profiling by array of mice infected with Plasmodium chabaudi after gonadectomization to investigate involvement of gonadal steroids
Adjusted p-valueLog2-fold change
6.0616 × 10-71.3
Dyrk3'K14-Cre-ERT2; none; UVB irradiation; 7 day' vs 'K14-Cre-ERT2; none; none'genotype, irradiate, timeAblation of casein kinase 1 in keratinocytes induces p53-dependent hyperpigmentation of the skin
Adjusted p-valueLog2-fold change
7.6802 × 10-7-1.3
Dyrk3'6 day; myogenesis differentiation' vs ' 0 day; control' in '2C12-pMirn0'cell line, growth condition, timeEffect of Mirn378 overexpression on gene expression during C2C12 myogenic and BMP2-induced osteogenic differentiation
Adjusted p-valueLog2-fold change
1.2801 × 10-6-1.3
Dyrk3'induced neural stem cell' vs 'neural stem cell'cell typeGene expression profile of mouse induced neural stem cells
Adjusted p-valueLog2-fold change
1.3622 × 10-6-1.3
Dyrk3'365 day' vs '1 day'ageTranscriptional profilling of female mice liver as a function of age
Adjusted p-valueLog2-fold change
1.9902 × 10-6-1.3
Dyrk3'30 day' vs '1 day'ageTranscriptional profilling of female mice liver as a function of age
Adjusted p-valueLog2-fold change
2.6374 × 10-6-1.3
Dyrk3'14 day' vs '1 day'ageTranscriptional profilling of female mice liver as a function of age
Adjusted p-valueLog2-fold change
6.9424 × 10-6-1.3
Dyrk3'Bcl6 +/+ BCR-ABL1-transformed B cell precursors; STI571 treated' vs 'Bcl6 +/+ BCR-ABL1-transformed B cell precursors; untreated'cell type, treatmentGene expression data of BCR-ABL1 transformed B cell precursors from BCL6 wild-type and BCL6 knockout mice
Adjusted p-valueLog2-fold change
8.012 × 10-51.3
Dyrk3'CpG; 6 hour' vs 'none; 0 hour' in 'SMRT shRNA'RNA interference, stimulus, timeRNA-seq of Control and SMRT KD CD8α+ DCs at 0hr and 6hr CpG stimulation
Adjusted p-valueLog2-fold change
1.2558 × 10-41.3
Dyrk3'subconfluent monolayer on collagen' at '3 day' vs 'freshly isolated' at '0 day'growth condition, timeTranscription profiling of primary mouse hepatocytes under different culture conditions
Adjusted p-valueLog2-fold change
1.9254 × 10-41.3
Dyrk3'confluent monolayer on collagen' at '5 day' vs 'freshly isolated' at '0 day'growth condition, timeTranscription profiling of primary mouse hepatocytes under different culture conditions
Adjusted p-valueLog2-fold change
3.8284 × 10-4-1.3
Dyrk3'recombinant human interleukin-2; 100 unit per milliliter; 4 hour' vs 'control; 0 hour'compound, timeTranscription profiling by array of mouse CTLL-2 cell line treated with recombinant human interleukin-2
Adjusted p-valueLog2-fold change
1.0462 × 10-3-1.3
Dyrk3'myeloid progenitor cell; FoxO1/3/4 triple knockout' vs 'myeloid progenitor cell; wild type genotype'cell type, genotypeTranscription profiling of bone marrow hematopoietic stem cells and myeloid progenitors from mice with conditional deletion of Forkhead O (FoxO) family of transcription factors
Adjusted p-valueLog2-fold change
1.2238 × 10-31.3
Dyrk3'total RNA; HRasV12 and c-Myc overexpression and Eif4e heterozygous knockout' vs 'total RNA; wild type'fraction, genotypeRedefining the role of eIF4E dose in development, cancer, and protein synthesis
Adjusted p-valueLog2-fold change
3.1913 × 10-3-1.3
Dyrk3'recombinant human interleukin-2; 100 unit per milliliter; 2 hour' vs 'control; 0 hour'compound, timeTranscription profiling by array of mouse CTLL-2 cell line treated with recombinant human interleukin-2
Adjusted p-valueLog2-fold change
8.7181 × 10-31.3
Dyrk3'undifferentiated' vs 'differentiated; rosiglitazone' in 'C57BL/6J'phenotype, stimulus, strainRNA-seq of mouse subcutaneous SVF cells before and after differentiation with a brown fat differentiation cocktail
Adjusted p-valueLog2-fold change
9.8691 × 10-31.3
Dyrk3'human-Mfn2 T111A/S442A-overexpressing (Mfn2AA)' vs 'wild type' in '5 week; left ventricle'age, genotype, organism partTranscription profiling by high throughput sequencing of a mitofusin 2 (Mfn2) mutant in mouse
Adjusted p-valueLog2-fold change
1.2547 × 10-21.3
Dyrk3'p150 subunit of CAF-1 siRNA knockdown' vs 'scrambled siRNA'RNA interferenceRNA-seq of control siRNA, p150 siRNA and p60 siRNA transfected mES cells
Adjusted p-valueLog2-fold change
1.3626 × 10-21.3
Dyrk3'wormy, worm left; Trichuris muris' vs 'control; non wormy' in 'caecum'environmental stress, infect, organism partRNA-seq of mouse intestinal mucosa to investigate infection by the parasitic nematode Trichuris muris
Adjusted p-valueLog2-fold change
1.3924 × 10-21.3
Dyrk3'19BL; differentiated 3factor-reprogrammed induced pluripotent stem cell' vs 'R1; differentiated embryonic stem cell' at '5 day'cell line, growth condition, timeNatural cardiogenesis-based template predicts cardiogenic potential of induced pluripotent stem cell lines
Adjusted p-valueLog2-fold change
1.6613 × 10-21.3
Dyrk3'clear cell sarcoma; Rosa26CreER' vs 'control'disease, genotypeMouse Model of Clear Cell Sarcoma
Adjusted p-valueLog2-fold change
2.0687 × 10-21.3
Dyrk3'Lymphocytic choriomeningitis mammarenavirus' vs 'none' in 'TRAIL homozygous knock out'genotype, infectComparison of Trail+/+ versus Trail-/- splenic NK cells from naïve and LCMV-infected mice
Adjusted p-valueLog2-fold change
2.5531 × 10-21.3
Dyrk3'Rb^{lox/lox}; p130^{lox/lox}; p107+/-' vs 'wild type'genotypeTranscription profiling by array of livers from the mouse model of human hepatocellular carcinoma
Adjusted p-valueLog2-fold change
4.4072 × 10-2-1.3
Dyrk3'Trp53 Arg178Asp' vs 'wild type genotype' in 'dimethyl sulfoxide; 0.1 microliter'compound, phenotypeResidual tumor suppressor activities of tumorigenic p53 mutants enhance survival under chemotherapy
Adjusted p-valueLog2-fold change
4.6078 × 10-21.3
Dyrk3'clear cell sarcoma; TATCre' vs 'control'disease, genotypeMouse Model of Clear Cell Sarcoma
Adjusted p-valueLog2-fold change
2.212 × 10-13-1.2
Dyrk3'interleukin-13 (Mus musculus); 10 nanogram per milliliter' vs 'none'compoundRNAseq of small intestinal organoids from mice treated with the cytokines IFNG, IL-13 and IL-22 for 24 hours
Adjusted p-valueLog2-fold change
1.0638 × 10-81.2
Dyrk3'K14-Cre-ERT2 / CK1α fl/fl; 4-hydroxytamoxifen; none; 14 day' vs 'K14-Cre-ERT2; none; none'genotype, irradiate, timeAblation of casein kinase 1 in keratinocytes induces p53-dependent hyperpigmentation of the skin
Adjusted p-valueLog2-fold change
1.2122 × 10-7-1.2
Dyrk3'6 day; osteogenesis differentiation' vs ' 0 day; control' in '2C12-pMirn378'cell line, growth condition, timeEffect of Mirn378 overexpression on gene expression during C2C12 myogenic and BMP2-induced osteogenic differentiation
Adjusted p-valueLog2-fold change
1.5925 × 10-61.2
Dyrk3'gamma radiation; 8 Gray' vs 'none' in 'Lgr5-Cre-ERT2'genotype, irradiateRNA Seq of colonic Lgr5+ epithelial stem cells in Il22+/+ and Il22-/- mice during homeostasis and 24h after irradiation with 8 Gy
Adjusted p-valueLog2-fold change
1.9258 × 10-61.2
Dyrk3'14 days P. chabaudi infected' vs 'uninfected' in 'gonadectomized male'clinical information, disease, sex, timeTranscription profiling by array of mice infected with Plasmodium chabaudi after gonadectomization to investigate involvement of gonadal steroids
Adjusted p-valueLog2-fold change
3.1566 × 10-6-1.2
Dyrk3'168 hour' vs '0 hour' on 'Affymetrix Mouse430A_2 Array'timeTranscription profiling of murine V6.5 embryonic stem cells differentiating into embryoid bodies over a time-course to study changes in transcription during stem cell differentiation
Adjusted p-valueLog2-fold change
4.0676 × 10-61.2
Dyrk3'control; streptozotocin-induced diabetes' vs 'control; control'diet, phenotypeHepatic gene expression in streptozotocin-induced diabetic mice fed a phloridzin diet
Adjusted p-valueLog2-fold change
4.9237 × 10-61.2
Dyrk3'S3 control; TGF beta 1; 5 nanogram per milliliter' vs 'S3 control; vehicle; 5 nanogram per milliliter'RNA interference, compoundtranscription profiling by array mouse mammary epithelial cells treated with TGF-beta to induce epithelial-to-mesenchymal transition
Adjusted p-valueLog2-fold change
6.2428 × 10-6-1.2
Dyrk3'730 day' vs '1 day'ageTranscriptional profilling of female mice liver as a function of age
Adjusted p-valueLog2-fold change
1.2615 × 10-5-1.2
Dyrk3'60 day' vs '1 day'ageTranscriptional profilling of female mice liver as a function of age
Adjusted p-valueLog2-fold change
1.3968 × 10-5-1.2
Dyrk3'90 day' vs '1 day'ageTranscriptional profilling of female mice liver as a function of age
Adjusted p-valueLog2-fold change
4.1795 × 10-41.2
Dyrk3'SMAD3; TGF beta 1; 5 nanogram per milliliter' vs 'SMAD3; vehicle; 5 nanogram per milliliter'RNA interference, compoundtranscription profiling by array mouse mammary epithelial cells treated with TGF-beta to induce epithelial-to-mesenchymal transition
Adjusted p-valueLog2-fold change
4.7067 × 10-41.2
Dyrk3'transplanted secondary tumors' vs 'normal' in 'kidney'clinical information, organism partPremature termination of in vivo reprogramming leads to cancer development through altered epigenetic regulation [array]
Adjusted p-valueLog2-fold change
6.9922 × 10-41.2
Dyrk3'V6.5; embryonic stem cell’ vs 'wild type; endothelial'cell line, cell type, genotypeCD47 Inhibits Self-renewal and Reprogramming by Regulating c-Myc and Other Stem Cell Transcription Factors
Adjusted p-valueLog2-fold change
9.1039 × 10-41.2
Dyrk3'db/db' vs 'wild type genotype' in 'control miRNA; fasted'RNA interference, diet, genotypeGene expression profiling of liver from C57BLKS/J and db/db 8 mice with an AAV harboring a control or GAbpa-specific miRNA under the LP1 promoter
Adjusted p-valueLog2-fold change
2.6174 × 10-31.2
Dyrk3'Ink4a/Arf-/-; EGFRvIII' vs 'wild type genotype' in 'co-culture'genotype, growth conditionRNA-seq of wild-type and transformed Ink4a/Arf-/-; EGFRvIII neural stem cells in separate or co-culture conditions
Adjusted p-valueLog2-fold change
5.4599 × 10-31.2
Dyrk3'adipose tissue specific Trim28 knockout' vs 'wild type genotype' in 'male'genotype, sexRNA-seq of gonadal adipose tissue from male and female Trim28-WT and Trim28 adipose specific KO mice
Adjusted p-valueLog2-fold change
6.5703 × 10-31.2
Dyrk3'Smad4f/f x CCSPicrePtenf/f' vs 'wild type' at '12 month'age, genotypeErbB2 Pathway Activation upon Smad4 Loss Promotes Lung Tumor Growth and Metastasis [expression]
Adjusted p-valueLog2-fold change
9.9592 × 10-3-1.2
Dyrk3'FusΔNLS/+' vs 'wild type genotype' at '24 hour'genotype, timeMutant FUS triggers age-dependent synaptic impairment in presymptomatic ALS-FUS mice (RNA-seq part2)
Adjusted p-valueLog2-fold change
1.5775 × 10-21.2
Dyrk3'Ccr2 knockout' vs 'wild type genotype'cell type, genotype, stimulusTranscriptomic profiling of lung monocytes and macrophages in mice
Adjusted p-valueLog2-fold change
2.621 × 10-21.2
Dyrk3'Tumor Necrosis Factor' vs 'none'stimulusTranscription profiling by high throughput sequencing of CD8 single positive thymocytes from F5 Rag1KO TCR transgenic mice stimulated with tumor necrosis factor
Adjusted p-valueLog2-fold change
7.8158 × 10-15-1.1
Dyrk3'Stat5b (Stat5abnull/Stat5a-)' vs 'wild type' at 'pregnancy'genotype, sampling time pointTranscription profiling by high throughput sequencing of mouse wild type and Stat5-mutant mammary tissues at parturition and early pregnancy
Adjusted p-valueLog2-fold change
1.5651 × 10-6-1.1
Dyrk3'artesunate and chloroquine (at same dosage); 30 milligram per kilogram' at '14 day' vs 'none' at '7 day' in 'Plasmodium berghei ANKA'compound, infect, sampling time pointRNA-seq analysis of anti-malarial drug chemotherapy of murine experimental Cerebral Malaria (ECM)
Adjusted p-valueLog2-fold change
1.7017 × 10-61.1
Dyrk3'carcinoma' vs 'normal'diseaseGene expression profile between normal mouse skin and carcinomas arising in the skin of RbF/F;K14creERTM;p107-/- mouse
Adjusted p-valueLog2-fold change
3.8732 × 10-6-1.1
Dyrk3'6 day; osteogenesis differentiation' vs ' 0 day; control' in '2C12-pMirn0'cell line, growth condition, timeEffect of Mirn378 overexpression on gene expression during C2C12 myogenic and BMP2-induced osteogenic differentiation
Adjusted p-valueLog2-fold change
7.5854 × 10-6-1.1
Dyrk3'MEF; transduced with NeuroD2 lentivirus' vs 'MEF; control'cell line, treatmentGenetic and epigenetic determinants of neurogenesis and myogenesis [expression profiling]
Adjusted p-valueLog2-fold change
7.9011 × 10-6-1.1
Dyrk3'180 day' vs '1 day'ageTranscriptional profilling of female mice liver as a function of age
Adjusted p-valueLog2-fold change
2.0361 × 10-51.1
Dyrk3'6 hour' vs '3 hour' in 'fetal bovine serum; 10 percent'growth condition, timeTranscriptomic changes in C3H10T1/2 cells exposed to lipid deprivation
Adjusted p-valueLog2-fold change
5.8317 × 10-5-1.1
Dyrk3'Salmonella enterica serovar Typhimurium' vs 'control' in 'derived macrophage from E14 cell line'clinical information, infectGene expression profiles of mouse embryonic stem cell derived macrophages infected with Salmonella typhimurium
Adjusted p-valueLog2-fold change
1.9995 × 10-4-1.1
Dyrk3'pre-B acute lymphoblastic leukemia 8093; nilotinib; 3 day' vs 'pre-B acute lymphoblastic leukemia 8093; nilotinib; 0 day'cell type, compound, timeDrug tolerance development of mouse Bcr/Abl pre-B ALL cells on irradiated MEFs
Adjusted p-valueLog2-fold change
4.3725 × 10-41.1
Dyrk3'collagen sandwich' at '2 day' vs 'freshly isolated' at '0 day'growth condition, timeTranscription profiling of primary mouse hepatocytes under different culture conditions
Adjusted p-valueLog2-fold change
4.5513 × 10-4-1.1
Dyrk3'mutant MyoD expression' at '6 hour' vs 'control' at '6 hour'phenotype, timeTranscription profiling of mouse embryoic fibroblasts expressing wild type MyoD or its non-acetylatable version MyoD RRR to investigate how MyoD acetylation may contribute to differential gene activation.
Adjusted p-valueLog2-fold change
5.1827 × 10-41.1
Dyrk3'5 nanogram per milliliter; TGFbeta1' vs 'none' at '6 hour'compound, timeTranscription profiling by array of mouse hepatocytes following treatment with growth factor beta 1 in a time series
Adjusted p-valueLog2-fold change
5.7042 × 10-41.1
Dyrk3'InsR, Igf1R double knockout' vs 'wild type' in 'postnatal day 5'developmental stage, genotypeTranscriptional profiling by array of mouse wild-type and Insulin receptor (InsR)/Igf1 receptor (Igf1R) double knockout mutant Sertoli cells from testis at embryonic day E17.5 and Postnatal day 5
Adjusted p-valueLog2-fold change
8.151 × 10-41.1
Dyrk3'collagen sandwich' at '3 day' vs 'freshly isolated' at '0 day'growth condition, timeTranscription profiling of primary mouse hepatocytes under different culture conditions
Adjusted p-valueLog2-fold change
2.3004 × 10-31.1
Dyrk3'acute myeloid leukemia' vs 'myeloproliferative disorder'diseaseTranscription profiling by high throughput sequencing of c-KIT+ splenocytes from murine acute myeloid leukemia and myeloproliferative neoplasm
Adjusted p-valueLog2-fold change
2.7862 × 10-3-1.1
Dyrk3'recombinant human interleukin-2; 100 unit per milliliter; 6 hour' vs 'control; 0 hour'compound, timeTranscription profiling by array of mouse CTLL-2 cell line treated with recombinant human interleukin-2
Adjusted p-valueLog2-fold change
3.7894 × 10-31.1
Dyrk3'Lsd1fl/fl Mx1Cre' vs 'Lsd1fl/fl'genotypeGene expression data of Lsd1fl/fl and Lsd1fl/fl Mx1Cre Gr1dim Mac1 granulocytic progenitor cells.
Adjusted p-valueLog2-fold change
1.8992 × 10-2-1.1
Dyrk3'lipopolysaccharide; 10 nanogram per milliliter' vs 'none' in 'Hoxb8-FL; MEF2A knockout'cell line, compound, genotypeBulk RNA-seq of wild type and MEF2A or MEF2C/D knockout mouse bone marrow macrophages under different stimulation conditions
Adjusted p-valueLog2-fold change
2.0736 × 10-21.1
Dyrk3'bone marrow macrophage; co-cultured with breast cancer cell line 4T1.2' vs 'bone marrow macrophage; control'cell type, growth conditionTranscription profiling of mouse bone marrow macrophages (BMM) compared to BMM co-cultured with 4T1.2 breast cancer cells, treated with tumour cell supernatant, or RAW macrophage cell line
Adjusted p-valueLog2-fold change
4.8162 × 10-2-1.1
Dyrk3'Runx3 knockout' vs 'wild type genotype' in 'IL-2'compound, genotypeRunx3 function in splenic NK cells (IL-2 or IL-15)
Adjusted p-valueLog2-fold change
1.1751 × 10-26-1
Dyrk3'neuron' vs 'differentiating progenitor'cell typeTranscription profiling by high throughput sequencing of proliferating neural stem cells, differentiating neurogenic progenitors and newborn neurons using a dual-reporter mouse line
Adjusted p-valueLog2-fold change
2.4317 × 10-81
Dyrk3'10 Gy Gray; x-ray' vs 'none' in 'tumor and stromal cell'cell type, irradiateRNA-seq of effector (CD43+) CD8+ T cells, CD45+ hematopoietic cells and CD45- tumor/stromal cells from mice bearing bilateral AT-3 tumors following radio-immunotherapy of which one tumor was irradiated
Adjusted p-valueLog2-fold change
2.1777 × 10-7-1
Dyrk3'Kit ligand' vs 'none' in 'wild type'compound, genotypeTranscription profiling of bone marrow–derived mast cells from WASP-deficient mice after stimulation with kit ligand
Adjusted p-valueLog2-fold change
3.736 × 10-7-1
Dyrk3'6 day; myogenesis differentiation' vs ' 0 day; control' in '2C12-pMirn378'cell line, growth condition, timeEffect of Mirn378 overexpression on gene expression during C2C12 myogenic and BMP2-induced osteogenic differentiation
Adjusted p-valueLog2-fold change
5.2807 × 10-7-1
Dyrk3'14 day' vs '0 day' on 'Affymetrix Mouse430A_2 Array'timeTranscription profiling of murine R1 embryonic stem cells differentiating into embryoid bodies over a time-course to study changes in transcription during stem cell differentiation
Adjusted p-valueLog2-fold change
6.2055 × 10-7-1
Dyrk3'3 day; myogenesis differentiation' vs ' 0 day; control' in '2C12-pMirn0'cell line, growth condition, timeEffect of Mirn378 overexpression on gene expression during C2C12 myogenic and BMP2-induced osteogenic differentiation
Adjusted p-valueLog2-fold change
1.2803 × 10-4-1
Dyrk3'TUT4 deficiency; TUT7 knockout' vs 'wild type'phenotypeMicroarray profiling of mouse pachytene cells deficient for UPF2 or both TUT4 and TUT7
Adjusted p-valueLog2-fold change
5.4215 × 10-41
Dyrk3'confluent monolayer on collagen' at '3 day' vs 'freshly isolated' at '0 day'growth condition, timeTranscription profiling of primary mouse hepatocytes under different culture conditions
Adjusted p-valueLog2-fold change
1.3381 × 10-31
Dyrk3'TGF-beta; 0.5 nanogram per milliliter' vs 'control'compoundTGF beta Dosage Experiment
Adjusted p-valueLog2-fold change
1.5281 × 10-31
Dyrk3'collagen sandwich' at '7 day' vs 'freshly isolated' at '0 day'growth condition, timeTranscription profiling of primary mouse hepatocytes under different culture conditions
Adjusted p-valueLog2-fold change
1.5315 × 10-31
Dyrk3'L-Pex5 knock-out' vs 'wild type'genotypeTranscription profiling by array of liver from L-Pex5 knock-out mice
Adjusted p-valueLog2-fold change
1.9196 × 10-3-1
Dyrk3'transgenic' vs 'wild type' in '160 day; C57BL/6'age, genotype, strainWhole genome transcriptome analysis identifies indices of fast and slow disease progression in two ALS mouse models
Adjusted p-valueLog2-fold change
2.1858 × 10-3-1
Dyrk3'etoposide; 2.5 micromolar' vs 'none' in 'wild type genotype'compound, genotypeRNA-seq of H2afj-ko and isogenic WT C57/Bl6-N mouse embryonic fibroblasts in proliferation and after etoposide-induced senescence.
Adjusted p-valueLog2-fold change
4.3663 × 10-3-1
Dyrk3'7 day' vs '1 day'ageTranscriptional profilling of female mice liver as a function of age
Adjusted p-valueLog2-fold change
8.0624 × 10-31
Dyrk3'SARS coronavirus MA15; 2 day' vs 'mock' in 'WSB/EiJ'infect, strain, timeGenomic profiling of collaborative cross founder mouse strains infected with respiratory viruses to discover novel transcripts and infection-related strain-specific gene and isoform expression
Adjusted p-valueLog2-fold change
1.9693 × 10-21
Dyrk3'total RNA; HRasV12 and c-Myc overexpression and Eif4e wild type' vs 'total RNA; wild type'fraction, genotypeRedefining the role of eIF4E dose in development, cancer, and protein synthesis
Adjusted p-valueLog2-fold change
2.6216 × 10-2-1
Dyrk3'B6.Sle1a.1' vs 'wild type'genotypeTranscription profiling by array of mouse CD4+ T cells mutant for Sle1a.1
Adjusted p-valueLog2-fold change
2.8478 × 10-21
Dyrk3'4 joule per square meter ultraviolet light' vs 'none' in 'wild type'genotype, irradiateTranscription profiling by array of mouse wild type and DNA-repair-deficient primary dermal fibroblasts after treatment with ultraviolet radiation
Adjusted p-valueLog2-fold change
4.1376 × 10-21
Dyrk3'synovial sarcoma' vs 'normal'diseaseTranscription profiling by array of tumors excised from conditional mouse model of synovial sarcoma compared to skeletal muscle from wild type mice
Ortholog
Gene ontology
InterPro
Ensembl gene
Ensembl transcript
Ensembl protein
Entrez
UniProt
MGI ID (Mouse)
MGI description
Gene biotype
Design element
5279617, 10357590, 4495982, 5249726, A_52_P232580, 5458846, 4763957, 5431513, 4835662, 163562_at, 4525703, 17226752, 1424229_at, ILMN_2699522, 5211303