ENSMUSG00000022114 (Spry2)

mus musculus

sprouty RTK signaling antagonist 2

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Mus musculus
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Showing 42 experiments:
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Log2-fold changeSpeciesGene nameComparisonExperimental variablesExperiment name
Adjusted p-valueLog2-fold change
2.1133 × 10-105.3
Spry2'hepatocyte-derived proliferative ducts (hepPDs)' vs 'hepatocyte'cell typeTranscription profiling by high throughput sequencing of hepatocyte-derived progenitors cells in a mouse model of oval cell activation
Adjusted p-valueLog2-fold change
5.0197 × 10-40-4.3
Spry2'ABIN1[D485N] knock-in' vs 'wild type genotype' in 'neutrophil'cell type, genotypeRNA-seq of inflammatory monocytes, patrolling monocytes and neutrophils in wild type and ABIN1[D485N] mice
Adjusted p-valueLog2-fold change
1.3035 × 10-44.2
Spry2'adult definitive erythroid cell' vs 'primitive erythroid cell' in 'mix of orthochromatic and polychromatophilic erythroblast'cell type, phenotypeTranscription profiling by array of differentiating primary primitive and definitive mouse red blood cells
Adjusted p-valueLog2-fold change
2.1998 × 10-263.4
Spry2'Egr2 and Egr3 knockout' vs 'Egr2-GFP knockin; Egr2-GFP high' in 'CD4-positive T cell'cell type, genotype, phenotypeRNAseq analysis of CD4 and CD8 T cells in response to vaccinia virus infection
Adjusted p-valueLog2-fold change
1.3707 × 10-173.3
Spry2'Influenza A virus' vs 'none'infectRNA-seq of mouse alveolar macrophages from control and Influenza A virus infected animals
Adjusted p-valueLog2-fold change
3.3091 × 10-33.2
Spry2'4 hours after hCG treatment' vs 'control' in 'wild type'genotype, treatmentThe ISWI ATPase Snf2L is required for superovulation and regulates Fgl2 in differentiating mouse granulosa cells
Adjusted p-valueLog2-fold change
3.3905 × 10-33.1
Spry2'adult definitive erythroid cell' vs 'primitive erythroid cell' in 'basophilic erythroblast'cell type, phenotypeTranscription profiling by array of differentiating primary primitive and definitive mouse red blood cells
Adjusted p-valueLog2-fold change
5.1745 × 10-43
Spry2'human chorionic gonadotropin; 5 International Unit' vs 'none' in 'bER knockout'compound, genotypeLaser Capture Microdissection isolation of preovulatory granulosa cells from WT and bERKO ovaries
Adjusted p-valueLog2-fold change
5.9984 × 10-42.8
Spry2'adult definitive erythroid cell' vs 'primitive erythroid cell' in 'proerythroblast'cell type, phenotypeTranscription profiling by array of differentiating primary primitive and definitive mouse red blood cells
Adjusted p-valueLog2-fold change
1.674 × 10-111-2.7
Spry2'induced neuronal cell' vs 'pluripotent embryonic stem cell'phenotypeTranscription profiling by high throughput sequencing of retinoic acid-differentiated neuronal cells compared to nondifferentiated pluripotent embryonic stem cells
Adjusted p-valueLog2-fold change
3.7505 × 10-12-2.7
Spry2'CD4-positive T cell' vs 'CD8-positive T cell' in 'Egr2-GFP knockin; Egr2-GFP high'cell type, genotype, phenotypeRNAseq analysis of CD4 and CD8 T cells in response to vaccinia virus infection
Adjusted p-valueLog2-fold change
8.3791 × 10-5-2.7
Spry2'Mxd1 knockdown by siRNA' vs 'wild type' at '1 day'phenotype, time3' RNA-seq of differentiating (brown) mouse subcutaneous SVF cells upon knockdown of Zfp521, Fhl1, or Mxd1
Adjusted p-valueLog2-fold change
1.0402 × 10-4-2.7
Spry2'Fhl1 knockdown by siRNA' vs 'wild type' at '1 day'phenotype, time3' RNA-seq of differentiating (brown) mouse subcutaneous SVF cells upon knockdown of Zfp521, Fhl1, or Mxd1
Adjusted p-valueLog2-fold change
4.5584 × 10-92.6
Spry2'Id2_Id3_double knockout' vs 'wild type' in 'CD4+TCRb+CD8– cell; thymus'cell type, genotype, organism partTranscription profiling by high throughput sequencing of Id-proteins (Id2 and Id3) gene knockout cells
Adjusted p-valueLog2-fold change
7.5464 × 10-6-2.5
Spry2'trichostatin A and LIF' at '6 hour' vs 'none' at '0 hour'compound, timeTranscription profiling of mouse embryonic stem cell line CGR8 grown in presence of Leukemia Inhibitory Factor and treated with trichostatin A
Adjusted p-valueLog2-fold change
2.0279 × 10-22.4
Spry2'bER knockout' vs 'wild type' in 'human chorionic gonadotropin; 5 International Unit'compound, genotypeLaser Capture Microdissection isolation of preovulatory granulosa cells from WT and bERKO ovaries
Adjusted p-valueLog2-fold change
5.3339 × 10-6-2.3
Spry2'trichostatin A and LIF' at '12 hour' vs 'none' at '0 hour'compound, timeTranscription profiling of mouse embryonic stem cell line CGR8 grown in presence of Leukemia Inhibitory Factor and treated with trichostatin A
Adjusted p-valueLog2-fold change
1.9879 × 10-12-2.2
Spry2'lipopolysaccharide; 10 nanogram per milliliter' vs 'none' in 'primary cell line; MEF2C/D knockout'cell line, compound, genotypeBulk RNA-seq of wild type and MEF2A or MEF2C/D knockout mouse bone marrow macrophages under different stimulation conditions
Adjusted p-valueLog2-fold change
2.296 × 10-5-2.1
Spry2'Lkb1 -/- Pten-/-' vs 'wild type'genotypeLoss of Lkb1 and Pten Leads to Lung Squamous Cell Carcinoma with Elevated Pdl1 Expression: Epithelial Cells
Adjusted p-valueLog2-fold change
1.6792 × 10-42.1
Spry2'tumor' vs 'normal' in 'liver'clinical information, organism partPremature termination of in vivo reprogramming leads to cancer development through altered epigenetic regulation [array]
Adjusted p-valueLog2-fold change
9.4893 × 10-42.1
Spry2'renin-expression' vs 'control'phenotypeExpression data from mouse bone marrow cells expressing renin driven expression of green fluorescent protein.
Adjusted p-valueLog2-fold change
5.1708 × 10-8-2
Spry2'induced neural stem cell' vs 'neural stem cell'cell typeGene expression profile of mouse induced neural stem cells
Adjusted p-valueLog2-fold change
5.0664 × 10-7-2
Spry2'none; wasp knockout' vs 'none; wild type'compound, genotypeTranscription profiling of bone marrow–derived mast cells from WASP-deficient mice after stimulation with kit ligand
Adjusted p-valueLog2-fold change
2.9284 × 10-8-1.9
Spry2'MG132; 1 micromolar' vs 'DMSO' in 'CHOP-/-'compound, genotypeMicroarray to find CHOP dependent genes in response to proteasome inhibition
Adjusted p-valueLog2-fold change
8.4655 × 10-6-1.9
Spry2'pkd1 knockout' vs 'wild type' in 'presence of fluid flow'genotype, stimulusTranscription profiling by array of mouse kidney epithelial cells from pkd1 knockout and wild type in response to fluid flow
Adjusted p-valueLog2-fold change
3.6041 × 10-3-1.9
Spry2'damaged by neuropathy' vs 'control'sampling siteTranscriptional profiling of damaged and adjacent but intact dorsal root ganglia neurons against DRG cells from contralacteral control regions from mice with neuropathy
Adjusted p-valueLog2-fold change
3.7926 × 10-56-1.8
Spry2'PF-04691502–resistant cell; 1 micromolar; PF-04691502 removed for 48 hours' vs 'parental AKP cell; dimethyl sulfoxide'compound, phenotypeResistance to PI3K/mTOR inhibitor PF-04691502 in KRAS mutant colorectal cancer models reveals a sensitivity to combination with EGFR inhibition
Adjusted p-valueLog2-fold change
1.3025 × 10-13-1.8
Spry2'neurosphere in differentiation medium; 12 day' vs 'neurosphere; 0 day' in 'Cstb knockout'genotype, growth condition, timeTranscriptome analysis of neurospheres derived from Cstb-KO mouse embryo brains during differentiation
Adjusted p-valueLog2-fold change
2.0008 × 10-9-1.8
Spry2'lipopolysaccharide; 10 nanogram per milliliter and prostaglandin E2; 1 micromolar' vs 'none' in 'primary cell line; MEF2C/D knockout'cell line, compound, genotypeBulk RNA-seq of wild type and MEF2A or MEF2C/D knockout mouse bone marrow macrophages under different stimulation conditions
Adjusted p-valueLog2-fold change
7.2489 × 10-6-1.8
Spry2'granulocyte' vs 'hemopoietic stem cell'cell typeGene expression data from mouse hemopoietic stem cells (LSKs), promyelocytes, myelocytes and granulocytes.
Adjusted p-valueLog2-fold change
8.1001 × 10-16-1.7
Spry2'neurosphere in differentiation medium; 12 day' vs 'neurosphere; 0 day' in 'wild type genotype'genotype, growth condition, timeTranscriptome analysis of neurospheres derived from Cstb-KO mouse embryo brains during differentiation
Adjusted p-valueLog2-fold change
2.3588 × 10-11-1.7
Spry2'neurosphere in differentiation medium; 5 day' vs 'neurosphere; 0 day' in 'Cstb knockout'genotype, growth condition, timeTranscriptome analysis of neurospheres derived from Cstb-KO mouse embryo brains during differentiation
Adjusted p-valueLog2-fold change
2.8316 × 10-10-1.7
Spry2'neurosphere in differentiation medium; 1 day' vs 'neurosphere; 0 day' in 'wild type genotype'genotype, growth condition, timeTranscriptome analysis of neurospheres derived from Cstb-KO mouse embryo brains during differentiation
Adjusted p-valueLog2-fold change
1.8004 × 10-9-1.7
Spry2'neurosphere in differentiation medium; 1 day' vs 'neurosphere; 0 day' in 'Cstb knockout'genotype, growth condition, timeTranscriptome analysis of neurospheres derived from Cstb-KO mouse embryo brains during differentiation
Adjusted p-valueLog2-fold change
5.4604 × 10-71.7
Spry2'interferon alpha' vs 'none'compoundType I and II Interferon-Stimulated Genes in Murine Primary Bone Marrow Macrophages
Adjusted p-valueLog2-fold change
2.847 × 10-6-1.7
Spry2'adipogenic' vs 'non-adipogenic'phenotypeTranscription profiling by array of mouse sublines of Swiss 3T3 fibroblasts with varying potential for adipogenesis
Adjusted p-valueLog2-fold change
4.0871 × 10-61.7
Spry2'hepatocyte-derived proliferative ducts (hepPDs)' vs 'biliary-derived proliferative ducts (bilDP)'cell typeTranscription profiling by high throughput sequencing of hepatocyte-derived progenitors cells in a mouse model of oval cell activation
Adjusted p-valueLog2-fold change
1.676 × 10-5-1.7
Spry2'acute oropharyngeal candidiasis' vs 'healthy' in wild type micecompound, disease, genotype, sexTranscription profiling by array of antibody blockade of IL-17-family cytokines in immunity to acute murine oral mucosal candidiasis
Adjusted p-valueLog2-fold change
4.2119 × 10-77-1.6
Spry2'PF-04691502–resistant cell; 1 micromolar; PF-04691502' vs 'parental AKP cell; dimethyl sulfoxide'compound, phenotypeResistance to PI3K/mTOR inhibitor PF-04691502 in KRAS mutant colorectal cancer models reveals a sensitivity to combination with EGFR inhibition
Adjusted p-valueLog2-fold change
7.4975 × 10-57-1.6
Spry2'Nrl-/-' vs 'wild type'genotypeNext Generation Sequencing Facilitates Quantitative Analysis of Wild Type and Nrl-/- Retinal Transcriptomes
Adjusted p-valueLog2-fold change
6.147 × 10-191.6
Spry2'Salmonella enterica serovar Typhimurium' vs 'control' in 'derived macrophage from E14 Traf2 mutant cell line'clinical information, infectGene expression profiles of mouse embryonic stem cell derived macrophages infected with Salmonella typhimurium
Adjusted p-valueLog2-fold change
1.6465 × 10-17-1.6
Spry2'postnatal day 60' vs 'postnatal day 1' in 'insulin-expressing immature beta cell'cell type, developmental stageTranscription profiling by high throughput sequencing of murine beta cells at key stages of maturation
Adjusted p-valueLog2-fold change
6.2348 × 10-9-1.6
Spry2'neurosphere in differentiation medium; 5 day' vs 'neurosphere; 0 day' in 'wild type genotype'genotype, growth condition, timeTranscriptome analysis of neurospheres derived from Cstb-KO mouse embryo brains during differentiation
Adjusted p-valueLog2-fold change
1.4177 × 10-8-1.6
Spry2'interleukin-3 and interleukin-33' vs 'interleukin-3'growth conditionStem cell factor programs the mast cell activation phenotype
Adjusted p-valueLog2-fold change
3.0701 × 10-7-1.6
Spry2'induced neural stem cell' vs 'mouse embryonic fibroblast cell'cell typeGene expression profile of mouse induced neural stem cells
Adjusted p-valueLog2-fold change
7.7636 × 10-7-1.6
Spry2'beta(3)-adrenergic agonist Cl316,243' vs 'none' at '10 week'age, stimulusRNA-seq of age-associated transcriptome changes in brown adipose tissue
Adjusted p-valueLog2-fold change
5.7475 × 10-51.6
Spry2'clear cell sarcoma; Rosa26CreER' vs 'control'disease, genotypeMouse Model of Clear Cell Sarcoma
Adjusted p-valueLog2-fold change
6.6816 × 10-51.6
Spry2'methionine- and choline-deficient, high fat diet' vs 'normal'dietExpression data from mouse liver treated with metformin
Adjusted p-valueLog2-fold change
6.0737 × 10-4-1.6
Spry2'alpha-amanitin; maternal Ring1-Rnf+' vs 'none; maternal Ring1-Rnf+'compound, genotypePolycomb function during oogenesis is required for mouse early embryonic development (2-cell embryos)
Adjusted p-valueLog2-fold change
1.0119 × 10-31.6
Spry2'liver specific SMARCB1 knockout' vs 'wild type'phenotypeTP53 is a master regulator of proteostasis in SMARCB1-deficient malignant rhabdoid tumors
Adjusted p-valueLog2-fold change
2.5977 × 10-3-1.6
Spry2'cancer' vs 'normal' in 'lymph node medullary sinus macrophage'cell type, diseaseRNA Sequencing of CD169+ lymph node macrophages isolated from naïve or tumor-bearing mice
Adjusted p-valueLog2-fold change
2.7584 × 10-31.6
Spry2'lipopolysaccharide; 10 nanogram per milliliter and prostaglandin E2; 1 micromolar and interferon beta; 100 units per milliliter' vs 'none' in 'primary cell line; wild type genotype'cell line, compound, genotypeBulk RNA-seq of wild type and MEF2A or MEF2C/D knockout mouse bone marrow macrophages under different stimulation conditions
Adjusted p-valueLog2-fold change
3.2234 × 10-3-1.6
Spry2'Mxd1 knockdown by siRNA' vs 'wild type' at '3 day'phenotype, time3' RNA-seq of differentiating (brown) mouse subcutaneous SVF cells upon knockdown of Zfp521, Fhl1, or Mxd1
Adjusted p-valueLog2-fold change
5.0902 × 10-31.6
Spry2'thermal injury' vs 'none'injuryMicroarray profiling of post-injury and uninjured mouse lung neutrophils from a thermal injury model
Adjusted p-valueLog2-fold change
9.0431 × 10-3-1.6
Spry2'Stella maternal / zygotic knockout' vs 'wild type genotype' in '2-cell embryo'developmental stage, genotypeTranscription profiling of wild type and Stella knockout oocytes, wild type and Stella maternal/zygotic knockout embryos to study to the role of Stella in early mouse development
Adjusted p-valueLog2-fold change
1.8644 × 10-2-1.6
Spry2'MEF2C/D knockout' vs 'wild type genotype' in 'primary cell line; lipopolysaccharide; 10 nanogram per milliliter'cell line, compound, genotypeBulk RNA-seq of wild type and MEF2A or MEF2C/D knockout mouse bone marrow macrophages under different stimulation conditions
Adjusted p-valueLog2-fold change
1.9881 × 10-18-1.5
Spry2'Debaryomyces hansenii' at '12 hour' vs 'none' at '0 hour'stimulus, timeRNA seq of mouse bone marrow derived macrophages treated with Debaryomyces hansenii against untreated controls
Adjusted p-valueLog2-fold change
2.8808 × 10-111.5
Spry2'Ffar3 knockout' vs 'wild type'genotypeTranscription profiling by high throughput sequencing of pancreatic islets isolated from free fatty acid receptor 3 knockout (Ffar3 KO) and wild type (Ffar3 WT) male mice
Adjusted p-valueLog2-fold change
5.3289 × 10-10-1.5
Spry2'216 hour' vs '0 hour' on 'Affymetrix Mouse430A_2 Array'timeTranscription profiling of murine J1 embryonic stem cells undergoing a differentiation time course to study changes in transcription during stem cell differentiation
Adjusted p-valueLog2-fold change
7.5934 × 10-71.5
Spry2'K-ras mutant/Wt1-null' vs 'wild type'genotypeTranscription profiling by array of wild type, K-ras mutant, Wt1-null, and double K-ras mutant/Wt1-null mouse embryonic fibroblasts
Adjusted p-valueLog2-fold change
1.8089 × 10-51.5
Spry2'seizure-preconditioning followed by intra-amygdala kainic acid' vs 'sham-preconditioning followed by intra-amygdala vehicle'clinical treatmentTranscription profiling by array of mice with epileptic tolerance
Adjusted p-valueLog2-fold change
1.0226 × 10-41.5
Spry2'tumor' vs 'normal' in 'kidney'clinical information, organism partPremature termination of in vivo reprogramming leads to cancer development through altered epigenetic regulation [array]
Adjusted p-valueLog2-fold change
1.5731 × 10-41.5
Spry2'acute myeloid leukemia' vs 'myeloproliferative disorder'diseaseTranscription profiling by high throughput sequencing of c-KIT+ splenocytes from murine acute myeloid leukemia and myeloproliferative neoplasm
Adjusted p-valueLog2-fold change
7.3588 × 10-4-1.5
Spry2'acute graft vs. host disease; T-cell depleted bone marrow + T cells transplant' vs 'normal; T-cell depleted bone marrow transplant'disease, stimulusRNA-Seq of lymph node fibroblastic reticular cells isolated from bone marrow transplant recipient mice with or without acute Graft-versus-host disease on day 7 or untransplanted control mice
Adjusted p-valueLog2-fold change
1.045 × 10-2-1.5
Spry2'MEF2C/D knockout' vs 'wild type genotype' in 'primary cell line; lipopolysaccharide; 10 nanogram per milliliter and prostaglandin E2; 1 micromolar'cell line, compound, genotypeBulk RNA-seq of wild type and MEF2A or MEF2C/D knockout mouse bone marrow macrophages under different stimulation conditions
Adjusted p-valueLog2-fold change
2.5244 × 10-2-1.5
Spry2'Fhl1 knockdown by siRNA' vs 'wild type' at '3 day'phenotype, time3' RNA-seq of differentiating (brown) mouse subcutaneous SVF cells upon knockdown of Zfp521, Fhl1, or Mxd1
Adjusted p-valueLog2-fold change
1.6347 × 10-91.4
Spry2'5 week' vs '1 week' in 'Jak2+/V617F; CRISPR/Cas9 mediated knockout of Dnmt3a'genotype, timeRNA-seq of Jak2VF LSK cells transduced with Dnmt3a-Cas9-GFP lentivirus vs. emp-Cas9-GFP controls one week and five weeks post methylcellulose plating
Adjusted p-valueLog2-fold change
2.6222 × 10-9-1.4
Spry2'336 hour' vs '0 hour' on 'Affymetrix Mouse430A_2 Array'timeTranscription profiling of murine V6.5 embryonic stem cells differentiating into embryoid bodies over a time-course to study changes in transcription during stem cell differentiation
Adjusted p-valueLog2-fold change
8.8678 × 10-71.4
Spry2'anti-CD3/CSA' vs 'anti-CD3' in 'cyclosporine-sensitive'phenotype, treatmentActivating CD8 T cell clones via the T cell receptor complex in the absence and presence of cyclosporine A
Adjusted p-valueLog2-fold change
5.7312 × 10-61.4
Spry2'follicle stimulating hormone and epidermal growth factor' vs '293H control medium'growth conditionTranscription profiling by array of mouse cumulus cells after culture with growth differentiation factor 9 or follicle stimulating hormone and epidermal growth factor
Adjusted p-valueLog2-fold change
1.9067 × 10-51.4
Spry2'sham-preconditioning followed by intra-amygdala kainic acid' vs 'sham-preconditioning followed by intra-amygdala vehicle'clinical treatmentTranscription profiling by array of mice with epileptic tolerance
Adjusted p-valueLog2-fold change
2.6012 × 10-51.4
Spry2'K-ras mutant' vs 'wild type'genotypeTranscription profiling by array of wild type, K-ras mutant, Wt1-null, and double K-ras mutant/Wt1-null mouse embryonic fibroblasts
Adjusted p-valueLog2-fold change
5.1052 × 10-41.4
Spry2'calorie restricted diet' vs 'normal diet' at '15 month'age, dietTranscription profiling by array of cochleae from mice fed a calorie-restricted diet
Adjusted p-valueLog2-fold change
5.6766 × 10-4-1.4
Spry2'wild type; mature luminal' vs 'wild type; MaSC/basal'cell type, genotypeExpression data from sorted control and Pygo2-null mouse mammary stem/basal cells
Adjusted p-valueLog2-fold change
1.3581 × 10-31.4
Spry2'Taf10-/-' vs 'wild type'genotypeTranscription profiling by array of liver from Taf10 knock out mice
Adjusted p-valueLog2-fold change
1.3638 × 10-31.4
Spry2'16 week' vs '4 week'ageDifferential gene expression in the Lacrimal gland during development and onset of xerostomia in Sjogren's syndrome-like disease of the C57BL/6.NOD-Aec1Aec2 mouse.
Adjusted p-valueLog2-fold change
4.897 × 10-8-1.3
Spry2'96 hour' vs '0 hour' on 'Affymetrix Mouse430A_2 Array'timeTranscription profiling of murine V6.5 embryonic stem cells differentiating into embryoid bodies over a time-course to study changes in transcription during stem cell differentiation
Adjusted p-valueLog2-fold change
1.6011 × 10-7-1.3
Spry2'14 day' vs '0 day' on 'Affymetrix Mouse430A_2 Array'timeTranscription profiling of murine R1 embryonic stem cells differentiating into embryoid bodies over a time-course to study changes in transcription during stem cell differentiation
Adjusted p-valueLog2-fold change
3.7968 × 10-7-1.3
Spry2'4 day' vs '0 day' on 'Affymetrix Mouse430A_2 Array'timeTranscription profiling of murine R1 embryonic stem cells differentiating into embryoid bodies over a time-course to study changes in transcription during stem cell differentiation
Adjusted p-valueLog2-fold change
5.5941 × 10-7-1.3
Spry2'3 day; osteogenesis differentiation' vs ' 0 day; control' in '2C12-pMirn378'cell line, growth condition, timeEffect of Mirn378 overexpression on gene expression during C2C12 myogenic and BMP2-induced osteogenic differentiation
Adjusted p-valueLog2-fold change
5.6584 × 10-7-1.3
Spry2'MG132; 1 micromolar' vs 'DMSO' in 'wild type'compound, genotypeMicroarray to find CHOP dependent genes in response to proteasome inhibition
Adjusted p-valueLog2-fold change
5.7944 × 10-7-1.3
Spry2'9 day' vs '0 day' on 'Affymetrix Mouse430A_2 Array'timeTranscription profiling of murine R1 embryonic stem cells differentiating into embryoid bodies over a time-course to study changes in transcription during stem cell differentiation
Adjusted p-valueLog2-fold change
6.3347 × 10-61.3
Spry2'hypoxia' vs 'control'treatmentTranscription profiling of mouse Jardine SIDS Model
Adjusted p-valueLog2-fold change
2.8721 × 10-51.3
Spry2'Alb-Cre-ERT2 / Cnot1 flox/flox' vs 'Cnot1 flox/flox' in 'none'compound, genotype, timeRNA-seq of livers in control and Cnot1 tamoxifen-inducible liver-specific knockout mice
Adjusted p-valueLog2-fold change
4.58 × 10-5-1.3
Spry2'AZD7507; AZD5069 (at same dosage); 100 milligram per kilogram' vs 'none'compoundRNA-seq to investigate differentially expressed genes in KPC mouse PDAC treated with CSF-1R small molecule inhibitor AZD7507 and/or the CXCR2 small molecule inhibitor AZD5069
Adjusted p-valueLog2-fold change
9.3242 × 10-51.3
Spry2'Adjuvant System 03' vs 'PBS' in 'lymph node' at '4 hour'organism part, stimulus, timeExpression data from draining lymph node and muscle of mice immunised with AS03 or PBS
Adjusted p-valueLog2-fold change
7.1811 × 10-41.3
Spry2'anti-IL-17A and anti-IL-17F treatment' vs 'no treatment' in 'wild type mice with acute oropharyngeal candidiasis'compound, disease, genotype, sexTranscription profiling by array of antibody blockade of IL-17-family cytokines in immunity to acute murine oral mucosal candidiasis
Adjusted p-valueLog2-fold change
8.5098 × 10-4-1.3
Spry2'CD2314 and BIO' vs 'none' at '6 day'age, compoundTranscription profiling of mouse embryonic stem cell line CGR8 during differentiation to mesenchymal stem cells and then adipocyte precursors
Adjusted p-valueLog2-fold change
9.7589 × 10-41.3
Spry2'RA839; Nrf2 knockout' vs 'RA839; wild type genotype'RNA interference, compound, genotypeCharacterization of RA839, a non-covalent small-molecule binder to Keap1 and selective activator of Nrf2 signalling
Adjusted p-valueLog2-fold change
1.299 × 10-3-1.3
Spry2'48 hour' vs '0 hour' on 'Affymetrix Mouse430A_2 Array'timeTranscription profiling of murine J1 embryonic stem cells undergoing a differentiation time course to study changes in transcription during stem cell differentiation
Adjusted p-valueLog2-fold change
5.2084 × 10-3-1.3
Spry2'polarized with interleukin 4 and interleukin 13.' vs 'untreated'compound, treatmentExpression data from polarized macrophages: effect of p53
Adjusted p-valueLog2-fold change
8.2194 × 10-31.3
Spry2'p48-Cre;KrasG12D;Ela-Tgfa' vs 'wild type'genotypeTranscription profiling by array of pancreas from KrasG12D, Ela-Tgfa and KrasG12D Ela-Tgfa mice
Adjusted p-valueLog2-fold change
1.0682 × 10-2-1.3
Spry2'RAW264.7 macrophage cell line; control' vs 'bone marrow macrophage; control'cell type, growth conditionTranscription profiling of mouse bone marrow macrophages (BMM) compared to BMM co-cultured with 4T1.2 breast cancer cells, treated with tumour cell supernatant, or RAW macrophage cell line
Adjusted p-valueLog2-fold change
4.0167 × 10-21.3
Spry2'E14_STAT3_ER; leukemia inhibitor factor; 10000 unit per milliliter' vs 'E14_STAT3_ER; none; 'cell line, compoundTranscription profiling of mouse embryonic stem cells to identify genes regulated by STAT3 and NANOG, known differentiation inhibitors
Adjusted p-valueLog2-fold change
4.2042 × 10-2-1.3
Spry2'Tet2 knockout' vs 'wild type' in 'hematopoietic progenitor cell'cell type, genotypeTranscription profiling by high throughput sequencing of bone marrow stem and progenitor cells from Tet2 depleted mice
Adjusted p-valueLog2-fold change
1.5466 × 10-6-1.2
Spry2'doxorubicin; 17.5 milligram per kilogram body weight' vs 'vehicle' in 'scramble; podocyte'cell type, compound, genotypeTranscription profiling to identify the role of MOF in primary MEFs and differentiated podocytes in response to Adriamycin
Adjusted p-valueLog2-fold change
2.3664 × 10-51.2
Spry2'WT (VH81x transgenic Rag1-/-)' vs 'control'genotypePre-BCR Signaling induce IgK Locus Accessibility by functional redistribution of Enhancer-mediated chromatin Interactions
Adjusted p-valueLog2-fold change
4.3468 × 10-5-1.2
Spry2'Hmox1 homozygous knockout' vs 'wild type genotype'genotypeGlobal transcriptomic profiles of blood monocytes from Hmox1 homozygous knockout mice compared to wild type controls following Mtb infection
Adjusted p-valueLog2-fold change
8.8379 × 10-51.2
Spry2'NOD' vs 'C57BL/6' in 'PBS stimulation' at '18 hour'strain, time, treatmentExpression data from NOD and C57BL/6 mouse pancreas CD8α- Dendritic Cells (DCs) under steady-state and after in-vitro LPS stimulation
Adjusted p-valueLog2-fold change
1.5885 × 10-4-1.2
Spry2'36 hour' vs '0 hour' on 'Affymetrix Mouse430A_2 Array'timeTranscription profiling of murine J1 embryonic stem cells undergoing a differentiation time course to study changes in transcription during stem cell differentiation
Adjusted p-valueLog2-fold change
3.274 × 10-41.2
Spry2'doxycicline-mediated expression of c-Jun' vs 'control'phenotypeTranscription profiling by array of mouse whole bone marrow after c-Jun induction
Adjusted p-valueLog2-fold change
4.8033 × 10-41.2
Spry2'7-ketocholesterol' vs 'vehicle (cyclodextrin)'compound, timeArray results for differential gene expression in 661W, a mouse cone photoreceptor-derived cell line, comparing cells incubated with vehicle controls vs. those treated with either of two 7-dehdyrocholesterol-derived oxysterols or cholesterol
Adjusted p-valueLog2-fold change
5.6864 × 10-41.2
Spry2'3 hour' vs '1 hour' in 'fetal bovine serum; 10 percent'growth condition, timeTranscriptomic changes in C3H10T1/2 cells exposed to lipid deprivation
Adjusted p-valueLog2-fold change
7.2533 × 10-41.2
Spry2'methionine- and choline-deficient, high fat diet mixed with 0.1% metformin' vs 'normal'dietExpression data from mouse liver treated with metformin
Adjusted p-valueLog2-fold change
3.2562 × 10-3-1.2
Spry2'retinoic acid' vs 'none' in 'embryoid body' at '6 day'age, compound, phenotypeTranscription profiling of mouse embryonic stem cell line Sox1Tv2 during neuronal differentiation
Adjusted p-valueLog2-fold change
3.6522 × 10-31.2
Spry2'mutant MyoD expression' at '24 hour' vs 'wild type MyoD expression' at '24 hour'phenotype, timeTranscription profiling of mouse embryoic fibroblasts expressing wild type MyoD or its non-acetylatable version MyoD RRR to investigate how MyoD acetylation may contribute to differential gene activation.
Adjusted p-valueLog2-fold change
4.2084 × 10-31.2
Spry2'transgenic C3(1)-SV40Tag; 20 week' vs 'wild type; 8 week'age, genotypePrevention of mammary tumor progression by silencing HoxA1 via intraductal injection of nanoparticle-formulated siRNA
Adjusted p-valueLog2-fold change
4.434 × 10-2-1.2
Spry2'Ezh2 knockout' vs 'control'genotypeExpression profiling of secondary wild type (WT) and Ezh2-null murine MLL-AF9 AML
Adjusted p-valueLog2-fold change
1.5423 × 10-481.1
Spry2'Irx3 knockout' vs 'control' at '7 day'genetic modification, timeRNA-Seq of mouse Irx3-KO and Control ME3 cells on days 1 and 7 of adipogenic differentiation
Adjusted p-valueLog2-fold change
3.929 × 10-271.1
Spry2'129S1 allele at SNP rs50454566' vs 'wild type genotype'genotypeRNA-Seq of mouse embryonic stem cells derived from genetically diverse inbred mouse strains with varying alleles at Lifr gene
Adjusted p-valueLog2-fold change
1.3762 × 10-11-1.1
Spry2'Ddit4 knockout' vs 'wild type genotype' in 'high GLUT1 expression'genotype, phenotypeRNA-seq analysis of normoxic and hypoxic tumor-associated macrophages from wild type or REDD1 knockout mice
Adjusted p-valueLog2-fold change
3.6968 × 10-81.1
Spry2'undifferentiated' vs 'differentiated; rosiglitazone' in 'A/J'phenotype, stimulus, strainRNA-seq of mouse subcutaneous SVF cells before and after differentiation with a brown fat differentiation cocktail
Adjusted p-valueLog2-fold change
2.3959 × 10-71.1
Spry2'Influenza A virus (A/Puerto Rico/8/1934(H1N1)); 4 day' vs 'mock' in 'WSB/EiJ'infect, strain, timeGenomic profiling of collaborative cross founder mouse strains infected with respiratory viruses to discover novel transcripts and infection-related strain-specific gene and isoform expression
Adjusted p-valueLog2-fold change
1.1919 × 10-6-1.1
Spry2'6 day; osteogenesis differentiation' vs ' 0 day; control' in '2C12-pMirn378'cell line, growth condition, timeEffect of Mirn378 overexpression on gene expression during C2C12 myogenic and BMP2-induced osteogenic differentiation
Adjusted p-valueLog2-fold change
1.3302 × 10-5-1.1
Spry2'lung carcinoma' vs 'normal' in 'lung cell'cell type, diseaseTranscriptome analysis of isolated stormal cells and tumor epithelial cells in mouse lung cancer by RNA-Seq
Adjusted p-valueLog2-fold change
1.1102 × 10-41.1
Spry2'Adjuvant System 03' vs 'PBS' in 'lymph node' at '6 hour'organism part, stimulus, timeExpression data from draining lymph node and muscle of mice immunised with AS03 or PBS
Adjusted p-valueLog2-fold change
4.0403 × 10-4-1.1
Spry2'24 hour before induction of differentiation' vs 'induction of differentiation'compound, sampling time pointExpression Profiling of Early Myogenesis - Affymetrix Dataset
Adjusted p-valueLog2-fold change
4.2806 × 10-4-1.1
Spry2'lung carcinoma' vs 'normal' in 'Epcam+CD11b-CD11c- epithelial cell'cell type, diseaseTranscriptome analysis of isolated stormal cells and tumor epithelial cells in mouse lung cancer by RNA-Seq
Adjusted p-valueLog2-fold change
7.523 × 10-4-1.1
Spry2'R6/2 transgenic' vs 'wild type' in '12 week; striatum'age, genotype, organism partTranscription profiling by high throughput sequencing in wild type and R6/2 mutant mouse cortex and striatum at 8 and 12 weeks.
Adjusted p-valueLog2-fold change
8.2815 × 10-41.1
Spry2'undifferentiated' vs 'differentiated; rosiglitazone' in 'AKR/J'phenotype, stimulus, strainRNA-seq of mouse subcutaneous SVF cells before and after differentiation with a brown fat differentiation cocktail
Adjusted p-valueLog2-fold change
1.5055 × 10-3-1.1
Spry2'96 hour' vs '0 hour' on 'Affymetrix Mouse430A_2 Array'timeTranscription profiling of murine J1 embryonic stem cells undergoing a differentiation time course to study changes in transcription during stem cell differentiation
Adjusted p-valueLog2-fold change
2.1434 × 10-3-1.1
Spry2'myelocyte' vs 'hemopoietic stem cell'cell typeGene expression data from mouse hemopoietic stem cells (LSKs), promyelocytes, myelocytes and granulocytes.
Adjusted p-valueLog2-fold change
5.3618 × 10-31.1
Spry2'stromal cell; E2' vs 'stromal cell; vehicle'cell type, treatmentAffymetrix gene chip analysis for the whole mouse genome transcripts of epithelial and stromal cells from mouse uterine primary co-culture treated with either vehicle or E2
Adjusted p-valueLog2-fold change
7.709 × 10-31.1
Spry2'miR-1-133a_OSMR_tKO' vs 'miR-1-133a_dKO'compound, genotypeRepression of OSMR and FGFR1 by miR-1/133a prevents adult cardiomyocyte dedifferentiation and cell cycle entry in the adult heart
Adjusted p-valueLog2-fold change
1.0843 × 10-2-1.1
Spry2'nutlin-3a; polarized with interleukin 4 and interleukin 13.' vs 'untreated'compound, treatmentExpression data from polarized macrophages: effect of p53
Adjusted p-valueLog2-fold change
1.186 × 10-21.1
Spry2'vehicle control; Nrf2 knockout' vs 'vehicle control; wild type genotype'RNA interference, compound, genotypeCharacterization of RA839, a non-covalent small-molecule binder to Keap1 and selective activator of Nrf2 signalling
Adjusted p-valueLog2-fold change
3.4371 × 10-2-1.1
Spry2'extracellular vesicle; EMT cell culture medium' vs 'none'sampling site, stimulusCellular and extracellular vesicle RNA sequence for E-cadherin-RFP EMT reporter system expressing mouse breast cancer cell line Py2T during EMT/MET
Adjusted p-valueLog2-fold change
1.0913 × 10-12-1
Spry2'interferon gamma; 10 nanogram per milliliter and interleukin-13; 10 nanogram per milliliter' vs 'none'compoundRNAseq of small intestinal organoids from mice treated with the cytokines IFNG, IL-13 and IL-22 for 24 hours
Adjusted p-valueLog2-fold change
2.117 × 10-10-1
Spry2'co-cultured with hematopoietic stem cell for 9 days' vs 'non co-cultured for 9 days' in 'endothelial cell; expressing AKT1'cell type, growth condition, phenotypeTranscription profiling by high throughput sequencing of murine bone marrow endothelial cells and bone marrow stroma, in vitro and in vivo, with and without hematopoietic stem cells co-culture
Adjusted p-valueLog2-fold change
5.1255 × 10-10-1
Spry2'10 Gy Gray; x-ray' vs 'none' in 'tumor and stromal cell'cell type, irradiateRNA-seq of effector (CD43+) CD8+ T cells, CD45+ hematopoietic cells and CD45- tumor/stromal cells from mice bearing bilateral AT-3 tumors following radio-immunotherapy of which one tumor was irradiated
Adjusted p-valueLog2-fold change
7.1575 × 10-101
Spry2'Setd5 homozygous (null) knockout' vs 'Setd5 heterozygous knockout'genotypeTranscriptional profiling of Setd5 heterozygous and knockout mouse embryonic stem cells
Adjusted p-valueLog2-fold change
3.3373 × 10-8-1
Spry2'MG132; 1 micromolar' vs 'DMSO' in 'wild type'compound, genotypeMicroarray to find ATF5 dependent genes in response to proteasome inhibition
Adjusted p-valueLog2-fold change
4.7536 × 10-61
Spry2'CCl4 and diethylnitrosamine' vs 'none' in 'wild type genotype'genotype, treatmentGene expression accompanying the promotion of hepatocellular carcinoma by intestinal microbiota and Tlr4 in mice.
Adjusted p-valueLog2-fold change
4.821 × 10-6-1
Spry2'7 day' vs '0 day' on 'Affymetrix Mouse430A_2 Array'timeTranscription profiling of murine R1 embryonic stem cells differentiating into embryoid bodies over a time-course to study changes in transcription during stem cell differentiation
Adjusted p-valueLog2-fold change
5.6067 × 10-61
Spry2"tunicamycin; 2 microgram per milliliter" vs "DMSO" in "C57BL/6J x WSB/EiJ F1 cross"compound, strainTranscription profiling by high throughput sequencing of mouse embryonic fibroblasts treated with tunicamycin to study the transcriptional response to endoplasmic reticulum stress
Adjusted p-valueLog2-fold change
7.0358 × 10-6-1
Spry2'Duchenne muscular dystrophy' vs 'normal'diseaseRNA-seq comparison of immortalised myoblasts from dystrophic and WT mice
Adjusted p-valueLog2-fold change
7.4092 × 10-6-1
Spry2'168 hour' vs '0 hour' on 'Affymetrix Mouse430A_2 Array'timeTranscription profiling of murine V6.5 embryonic stem cells differentiating into embryoid bodies over a time-course to study changes in transcription during stem cell differentiation
Adjusted p-valueLog2-fold change
7.6953 × 10-6-1
Spry2'carcinoma' vs 'normal'diseaseGene expression profile between normal mouse skin and carcinomas arising in the skin of RbF/F;K14creERTM;p107-/- mouse
Adjusted p-valueLog2-fold change
8.3511 × 10-6-1
Spry2'Kit ligand' vs 'none' in 'wild type'compound, genotypeTranscription profiling of bone marrow–derived mast cells from WASP-deficient mice after stimulation with kit ligand
Adjusted p-valueLog2-fold change
1.0187 × 10-5-1
Spry2'24 hour' vs '0 hour' in 'WT1-KTS'genotype, timeEWS-WT1 Oncogene Activates a Neuronal Reprogramming Factor ASCL1 and Mediates Partial Neural Differentiation
Adjusted p-valueLog2-fold change
1.0749 × 10-51
Spry2'osteoblast culture 9 day' vs '0 day'timeTranscription profiling by array of mouse primary neonatal osteoblasts to study the regulation of bone mineralisation
Adjusted p-valueLog2-fold change
1.3418 × 10-51
Spry2'SARS coronavirus MA15; 2 day' vs 'mock' in 'CAST/EiJ'infect, strain, timeGenomic profiling of collaborative cross founder mouse strains infected with respiratory viruses to discover novel transcripts and infection-related strain-specific gene and isoform expression
Adjusted p-valueLog2-fold change
1.599 × 10-5-1
Spry2'336 hour' vs '0 hour' on 'Affymetrix Mouse430A_2 Array'timeTranscription profiling of murine J1 embryonic stem cells undergoing a differentiation time course to study changes in transcription during stem cell differentiation
Adjusted p-valueLog2-fold change
3.4493 × 10-5-1
Spry2'16 day' vs '0 day'ageGene expression profile of mouse differentiating embryonic stem cells (day 0, 6, 16, and 26)
Adjusted p-valueLog2-fold change
1.5859 × 10-4-1
Spry2'lung carcinoma' vs 'normal' in 'CD11b+Ly6G+ neutrophil'cell type, diseaseTranscriptome analysis of isolated stormal cells and tumor epithelial cells in mouse lung cancer by RNA-Seq
Adjusted p-valueLog2-fold change
1.5902 × 10-4-1
Spry2'KrasG12D extinction' vs 'sustained KrasG12D expression' in 'xenograft tumour'growth condition, phenotypeKras is required for pancreatic tumor maintenance through regulation of hexosamine biosynthesis and the non-oxidative pentose phosphate pathway
Adjusted p-valueLog2-fold change
1.6071 × 10-41
Spry2'Mkl1-RFP with a deletion of the SAP domain' vs 'full length Mkl1-RFP'genotypeTranscription profiling by array of HC11 mammary epithelial cell strains stably expressing different variants of the transcriptional regulator megakaryoblastic leukemia-1 (Mkl1)
Adjusted p-valueLog2-fold change
2.4214 × 10-41
Spry2'spontaneous lung tumor' vs 'normal'disease state, diseaseTranscription profiling by array of spontaneous lung tumors in mice to compare to human non-small cell lung cancer
Adjusted p-valueLog2-fold change
4.3956 × 10-41
Spry2'InsR, Igf1R double knockout' vs 'wild type' in 'postnatal day 5'developmental stage, genotypeTranscriptional profiling by array of mouse wild-type and Insulin receptor (InsR)/Igf1 receptor (Igf1R) double knockout mutant Sertoli cells from testis at embryonic day E17.5 and Postnatal day 5
Adjusted p-valueLog2-fold change
1.0918 × 10-3-1
Spry2'216 hour' vs '0 hour' on 'Affymetrix Mouse430A_2 Array'timeTranscription profiling of murine V6.5 embryonic stem cells differentiating into embryoid bodies over a time-course to study changes in transcription during stem cell differentiation
Adjusted p-valueLog2-fold change
1.3463 × 10-3-1
Spry2'MHC II overexpression'vs 'empty retroviral vector'phenotypeEffect of MHC II expression in pro-B cells: F6 leukaemic cell line
Adjusted p-valueLog2-fold change
2.3698 × 10-3-1
Spry2'CD2314' vs 'none' at '6 day'age, compoundTranscription profiling of mouse embryonic stem cell line CGR8 during differentiation to mesenchymal stem cells and then adipocyte precursors
Adjusted p-valueLog2-fold change
3.134 × 10-31
Spry2'anti-IL-17F treatment' vs 'no treatment' in wild type mice with acute oropharyngeal candidiasiscompound, disease, genotype, sexTranscription profiling by array of antibody blockade of IL-17-family cytokines in immunity to acute murine oral mucosal candidiasis
Adjusted p-valueLog2-fold change
7.712 × 10-31
Spry2'infarct and border region of left ventricle 1 day post-myocardial infarction; C57BL/6J' vs 'left ventricle at baseline (no myocardial infarction) in the same region as the infarct in post-myocardial infarction hearts; C57BL/6J'clinical information, strainExpression data from C57BL/6J and MRL/MpJ hearts following acute myocardial infarction
Adjusted p-valueLog2-fold change
8.2773 × 10-31
Spry2'mutant MyoD expression' at '12 hour' vs 'wild type MyoD expression' at '12 hour'phenotype, timeTranscription profiling of mouse embryoic fibroblasts expressing wild type MyoD or its non-acetylatable version MyoD RRR to investigate how MyoD acetylation may contribute to differential gene activation.
Adjusted p-valueLog2-fold change
9.0492 × 10-3-1
Spry2'pkd1 knockout' vs 'wild type' in 'absence of fluid flow'genotype, stimulusTranscription profiling by array of mouse kidney epithelial cells from pkd1 knockout and wild type in response to fluid flow
Adjusted p-valueLog2-fold change
1.0091 × 10-21
Spry2'high fat diet; 30 degree celsius' vs 'chow; 23 degree celsius' in 'white adipose tissue'diet, organism part, temperatureRNA-seq of brown and white mouse adipose tissue at thermoneutrality and high-fat diet
Adjusted p-valueLog2-fold change
3.479 × 10-21
Spry2'bone marrow macrophage; co-cultured with breast cancer cell line 4T1.2' vs 'bone marrow macrophage; control'cell type, growth conditionTranscription profiling of mouse bone marrow macrophages (BMM) compared to BMM co-cultured with 4T1.2 breast cancer cells, treated with tumour cell supernatant, or RAW macrophage cell line
Adjusted p-valueLog2-fold change
3.7358 × 10-2-1
Spry2'VEGF120 knock-in (VEGF164 deficient)' vs 'wild type'genotypeTranscription profiling by array of forebrain from mice expressing VEGF120 and deficient for VEGF164
Adjusted p-valueLog2-fold change
3.8336 × 10-21
Spry2'α-GalCer; 2 microgram' vs 'none' in 'wild type genotype'compound, genotypeCD1d-dependent immune suppression mediated by regulatory B cells through modulations of iNKT cells
Synonym
sprouty2
Ortholog
Gene ontology
InterPro
Ensembl gene
Ensembl transcript
Ensembl protein
Entrez
UniProt
MGI ID (Mouse)
MGI description
Gene biotype
Design element
4614956, A_55_P1952251, 1436584_at, A_52_P368532, 5518671, 17309340, 4777088, 1421656_at, 4420140, ILMN_2749464, 10422227, 4568952, 4899078, A_51_P445153
Reactome pathway ID