ENSMUSG00000022156 (Gzme)

mus musculus

granzyme E

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Mus musculus
Organism part
Showing 56 experiments:
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Created with Highcharts 6.2.0adrenal glandcentral neural epitheliumepidermal ectodermhippocampuslungolfactory bulbskeletal muscle organtracheaaxillary lymph nodebronchuscorpora quadrigeminadiencephalonfloor plateheartintestinal mucosalateral prominence neural epitheliummedial nasal prominencemuscle (biceps femoris)oviductpreoptic areaspleensubventricular zonevesicular glandwhole organism
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49 FANTOM5 project - adult
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49 FANTOM5 project - neonate
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49 FANTOM5 project - juvenile
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49 FANTOM5 project - embryonic day 18
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49 FANTOM5 project - embryonic day 17
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49 FANTOM5 project - embryonic day 16
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49 FANTOM5 project - embryonic day 15
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49 FANTOM5 project - embryonic day 14
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49 FANTOM5 project - embryonic day 12
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9 in 3 strains - DBA/2J
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9 in 3 strains - CD1
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9
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14 - embryonic day 10.5
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9 in 3 strains - C57BL/6
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49 FANTOM5 project - embryonic day 13
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Mammalian Kaessmann
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GENCODE
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6
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Vertebrates
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14 - embryonic day 9.5
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14 - embryonic day 8.5
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4 Bonthuis et al - CastEiJ
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Developing gut
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49 FANTOM5 project - embryonic day 11
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3
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Gregg et al - CAST/EiJ
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Gregg et al - C57BL/6J
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Gregg et al - (CAST/EiJ X C57BL/6J)F1
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Gregg et al - (C57BL/6J X CAST/EiJ)F1
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4 Bonthuis et al - (CastEiJ X …
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4 Bonthuis et al - (C57BL/6J X …
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Mernberger et al 2019 - Organism Part
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49 FANTOM5 project - pregnant adult day …
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49 FANTOM5 project - pregnant adult day …
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3 Soumillon et al
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2
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Sun et al., 2020 - Organism part
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4 Bonthuis et al - C57BL/6J
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Fat and muscle
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49 FANTOM5 project - pregnant adult day …
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49 FANTOM5 project - pregnant adult day …
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49 FANTOM5 project - pregnant adult day …
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49 FANTOM5 project - lactating adult …
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49 FANTOM5 project - embryonic day 17.5
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49 FANTOM5 project - embryonic day 14.5
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49 FANTOM5 project - embryo
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4 Bonthuis et al - Idaho derived wild …
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Huttlin et al., 2010 - tissues - brain, …
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Linscheid et al., 2021 - tissue - heart …
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Duda et al., 2018 - organism part - …
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Duda et al., 2018 - organism part - …
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Linscheid et al. 2019 - organism part
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Deshmukh et al., 2015 - organism part
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Zhao et al., 2019 - tissue - lens
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Meierhofer et al., 2016 - organism part
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Proteomics
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Transcriptomics
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Species
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Experimental variables
Regulation
Log2-fold changeSpeciesGene nameComparisonExperimental variablesExperiment name
Adjusted p-valueLog2-fold change
2.8086 × 10-158.7
Gzme'clear cell sarcoma; TATCre' vs 'control'disease, genotypeMouse Model of Clear Cell Sarcoma
Adjusted p-valueLog2-fold change
2.2666 × 10-87
Gzme'acute graft vs. host disease; T-cell depleted bone marrow + T cells transplant' vs 'normal; T-cell depleted bone marrow transplant'disease, stimulusRNA-Seq of lymph node fibroblastic reticular cells isolated from bone marrow transplant recipient mice with or without acute Graft-versus-host disease on day 7 or untransplanted control mice
Adjusted p-valueLog2-fold change
2.6322 × 10-96.4
Gzme'Salmonella enterica serovar Typhimurium' vs 'control' in 'bone marrow macrophage from 129P2 mouse strain'clinical information, infectGene expression profiles of mouse embryonic stem cell derived macrophages infected with Salmonella typhimurium
Adjusted p-valueLog2-fold change
1.1309 × 10-10-6
Gzme'6 day; osteogenesis differentiation' vs ' 0 day; control' in '2C12-pMirn0'cell line, growth condition, timeEffect of Mirn378 overexpression on gene expression during C2C12 myogenic and BMP2-induced osteogenic differentiation
Adjusted p-valueLog2-fold change
7.1582 × 10-10-6
Gzme'3 day; osteogenesis differentiation' vs ' 0 day; control' in '2C12-pMirn0'cell line, growth condition, timeEffect of Mirn378 overexpression on gene expression during C2C12 myogenic and BMP2-induced osteogenic differentiation
Adjusted p-valueLog2-fold change
3.1738 × 10-11-5.9
Gzme'6 day; osteogenesis differentiation' vs ' 0 day; control' in '2C12-pMirn378'cell line, growth condition, timeEffect of Mirn378 overexpression on gene expression during C2C12 myogenic and BMP2-induced osteogenic differentiation
Adjusted p-valueLog2-fold change
4.4544 × 10-11-5.9
Gzme'3 day; osteogenesis differentiation' vs ' 0 day; control' in '2C12-pMirn378'cell line, growth condition, timeEffect of Mirn378 overexpression on gene expression during C2C12 myogenic and BMP2-induced osteogenic differentiation
Adjusted p-valueLog2-fold change
1.3009 × 10-85.9
Gzme'bronchoalveolar adenocarcinoma induced using doxycycline' vs 'normal'diseaseTranscription profiling by array of lung alveolar type II epithelial cells with bronchoalveolar adenocarcinoma
Adjusted p-valueLog2-fold change
1.061 × 10-9-5.2
Gzme'6 day; myogenesis differentiation' vs ' 0 day; control' in '2C12-pMirn0'cell line, growth condition, timeEffect of Mirn378 overexpression on gene expression during C2C12 myogenic and BMP2-induced osteogenic differentiation
Adjusted p-valueLog2-fold change
2.0633 × 10-12-4.8
Gzme'induced neural stem cell' vs 'mouse embryonic fibroblast cell'cell typeGene expression profile of mouse induced neural stem cells
Adjusted p-valueLog2-fold change
2.807 × 10-11-4.7
Gzme'3 day; myogenesis differentiation' vs ' 0 day; control' in '2C12-pMirn0'cell line, growth condition, timeEffect of Mirn378 overexpression on gene expression during C2C12 myogenic and BMP2-induced osteogenic differentiation
Adjusted p-valueLog2-fold change
3.632 × 10-11-4.7
Gzme'6 day; myogenesis differentiation' vs ' 0 day; control' in '2C12-pMirn378'cell line, growth condition, timeEffect of Mirn378 overexpression on gene expression during C2C12 myogenic and BMP2-induced osteogenic differentiation
Adjusted p-valueLog2-fold change
4.4397 × 10-23.9
Gzme'glioma' vs 'normal'diseaseGene expression profile between glioma associated macrophages and normal brain tissue associated macrophages
Adjusted p-valueLog2-fold change
4.5 × 10-43.8
Gzme'clear cell sarcoma; Rosa26CreER' vs 'control'disease, genotypeMouse Model of Clear Cell Sarcoma
Adjusted p-valueLog2-fold change
1.6876 × 10-93.6
Gzme'Kit ligand' vs 'none' in 'wasp knockout'compound, genotypeTranscription profiling of bone marrow–derived mast cells from WASP-deficient mice after stimulation with kit ligand
Adjusted p-valueLog2-fold change
4.0585 × 10-10-3.4
Gzme'3 day; myogenesis differentiation' vs ' 0 day; control' in '2C12-pMirn378'cell line, growth condition, timeEffect of Mirn378 overexpression on gene expression during C2C12 myogenic and BMP2-induced osteogenic differentiation
Adjusted p-valueLog2-fold change
3.7179 × 10-2-3.3
Gzme'induced extraembryonic endoderm stem cell; grown in XEN cell medium' vs 'mouse embryonic fibroblast; control'cell type, growth conditionOSKM induce extraembryonic endoderm stem (iXEN) cells in parallel to iPS cells
Adjusted p-valueLog2-fold change
2.6101 × 10-4-3.1
Gzme'undifferentiated' vs 'differentiated; rosiglitazone' in 'SWR/J'phenotype, stimulus, strainRNA-seq of mouse subcutaneous SVF cells before and after differentiation with a brown fat differentiation cocktail
Adjusted p-valueLog2-fold change
4.1043 × 10-2-3
Gzme'induced extraembryonic endoderm stem cell; grown in ES cell medium' vs 'mouse embryonic fibroblast; control'cell type, growth conditionOSKM induce extraembryonic endoderm stem (iXEN) cells in parallel to iPS cells
Adjusted p-valueLog2-fold change
1.0558 × 10-2-2.8
Gzme'undifferentiated' vs 'differentiated; rosiglitazone' in 'F1.B6x129'phenotype, stimulus, strainRNA-seq of mouse subcutaneous SVF cells before and after differentiation with a brown fat differentiation cocktail
Adjusted p-valueLog2-fold change
1.0327 × 10-132.6
Gzme'etoposide; 2.5 micromolar' vs 'none' in 'H2afj-∆7-KO'compound, genotypeRNA-seq of H2afj-ko and isogenic WT C57/Bl6-N mouse embryonic fibroblasts in proliferation and after etoposide-induced senescence.
Adjusted p-valueLog2-fold change
4.0353 × 10-9-2.6
Gzme'ATF5 knockdown' vs 'wild type' in 'DMSO'compound, genotypeMicroarray to find ATF5 dependent genes in response to proteasome inhibition
Adjusted p-valueLog2-fold change
2.3628 × 10-182.5
Gzme'etoposide; 2.5 micromolar' vs 'none' in 'wild type genotype'compound, genotypeRNA-seq of H2afj-ko and isogenic WT C57/Bl6-N mouse embryonic fibroblasts in proliferation and after etoposide-induced senescence.
Adjusted p-valueLog2-fold change
3.7424 × 10-72.5
Gzme'5-aza-2'-deoxycytidine; 5 micromolar' vs 'none'compoundTranscription profiling by array of mouse primary dermal fibroblasts after treatment with 5-aza-2'-deoxycytidine
Adjusted p-valueLog2-fold change
2.3849 × 10-3-2.5
Gzme'osteoblast culture 27 day' vs '0 day'timeTranscription profiling by array of mouse primary neonatal osteoblasts to study the regulation of bone mineralisation
Adjusted p-valueLog2-fold change
4.3714 × 10-22.5
Gzme'wormy, worm separated; Trichuris muris' vs 'control; non wormy' in 'caecum'environmental stress, infect, organism partRNA-seq of mouse intestinal mucosa to investigate infection by the parasitic nematode Trichuris muris
Adjusted p-valueLog2-fold change
2.5373 × 10-82.4
Gzme'Kit ligand' vs 'none' in 'wild type'compound, genotypeTranscription profiling of bone marrow–derived mast cells from WASP-deficient mice after stimulation with kit ligand
Adjusted p-valueLog2-fold change
4.6596 × 10-3-2.3
Gzme'osteoblast culture 9 day' vs '0 day'timeTranscription profiling by array of mouse primary neonatal osteoblasts to study the regulation of bone mineralisation
Adjusted p-valueLog2-fold change
1.2415 × 10-22.1
Gzme'transgenic C3(1)-SV40Tag; 20 week' vs 'wild type; 8 week'age, genotypePrevention of mammary tumor progression by silencing HoxA1 via intraductal injection of nanoparticle-formulated siRNA
Adjusted p-valueLog2-fold change
3.2238 × 10-2-2.1
Gzme'undifferentiated' vs 'differentiated; rosiglitazone' in 'A/J'phenotype, stimulus, strainRNA-seq of mouse subcutaneous SVF cells before and after differentiation with a brown fat differentiation cocktail
Adjusted p-valueLog2-fold change
6.6807 × 10-3-2
Gzme'19BL; differentiated 3factor-reprogrammed induced pluripotent stem cell' vs 'R1; differentiated embryonic stem cell' at '11 day'cell line, growth condition, timeNatural cardiogenesis-based template predicts cardiogenic potential of induced pluripotent stem cell lines
Adjusted p-valueLog2-fold change
1.9111 × 10-2-2
Gzme'doxycycline-induced inactivation of ErbB3' vs 'ErbB3 expression'phenotypeTranscription profiling by array of mouse mammary epithelial organoids after doxycyline-induced repression of ErbB3 expression
Adjusted p-valueLog2-fold change
1.4727 × 10-41.8
Gzme'interleukin-3 and interleukin-33' vs 'interleukin-3'growth conditionStem cell factor programs the mast cell activation phenotype
Adjusted p-valueLog2-fold change
2.0871 × 10-41.7
Gzme'SERF2-/-' vs 'SERF2+/+'genotypeRNA-seq of mouse embryonic fibroblasts(MEFs) with knock-out of SERF2 compared to control MEFs
Adjusted p-valueLog2-fold change
1.3196 × 10-31.7
Gzme'Foxd3 knockout' vs 'control'phenotypeExpression data from embryonic stem cells differentiation
Adjusted p-valueLog2-fold change
8.5815 × 10-121.6
Gzme'AZD8835; 50 milligram per kilogram' vs 'none' at '14 day'compound, timeRNAseq of tumor samples from CT26 syngeneic mouse treated with a PI3Ka/d inhibitor (AZD8835)
Adjusted p-valueLog2-fold change
1.6786 × 10-5-1.6
Gzme'5-azacytidine 10 micromolar' vs 'none'compoundTranscription profiling by array of mouse C2C12 cells treated with 5-azacytidine
Adjusted p-valueLog2-fold change
3.1104 × 10-31.6
Gzme'Cebpg-/-' vs 'wild type'genotypeWhole genome expression data comparison between WT and Cebpg-/- MEFs.
Adjusted p-valueLog2-fold change
2.0063 × 10-7-1.5
Gzme'mutant MyoD expression' at '24 hour' vs 'wild type MyoD expression' at '0 hour'phenotype, timeTranscription profiling of mouse embryoic fibroblasts expressing wild type MyoD or its non-acetylatable version MyoD RRR to investigate how MyoD acetylation may contribute to differential gene activation.
Adjusted p-valueLog2-fold change
1.0262 × 10-5-1.5
Gzme'none; XPF knockout' vs 'all-trans-retinoic acid; 10 micromolar; wild type genotype'compound, genotypeRNA-seq of mouse DNA repair endonuclease XPF knock out versus wild type and versus trans retinoic acid (tRA) treated wild type
Adjusted p-valueLog2-fold change
1.491 × 10-31.5
Gzme'AZD8835; 50 milligram per kilogram' vs 'none' at '7 day'compound, timeRNAseq of tumor samples from CT26 syngeneic mouse treated with a PI3Ka/d inhibitor (AZD8835)
Adjusted p-valueLog2-fold change
4.9039 × 10-2-1.5
Gzme'STAT5 double knocked in' vs 'wild type' in 'interleukin-2' at '17 hour'compound, genotype, timeGene expression profile of splenic T cells from STAT5 double knocked in mice treated with IL-2
Adjusted p-valueLog2-fold change
1.1155 × 10-51.4
Gzme'CDK4/6 inhibitor PD 0332991' vs 'vehicle'compoundGene expression profile of mouse breast cancer V720 cells treated with vehicle or PD 0332991
Adjusted p-valueLog2-fold change
2.371 × 10-31.4
Gzme'Kras G12D' vs 'wild type'genotypeLoss of Lkb1 and Pten Leads to Lung Squamous Cell Carcinoma with Elevated Pdl1 Expression: Epithelial Cells
Adjusted p-valueLog2-fold change
4.7211 × 10-2-1.4
Gzme'STAT5 double knocked in' vs 'wild type' in 'interleukin-2' at '6 hour'compound, genotype, timeGene expression profile of splenic T cells from STAT5 double knocked in mice treated with IL-2
Adjusted p-valueLog2-fold change
4.7382 × 10-21.4
Gzme'Sall4 homozygous knockout' vs 'wild type genotype'genotypeRNA-Seq of Sall4 mutants in mouse embryonic stem cells
Adjusted p-valueLog2-fold change
3.0498 × 10-71.3
Gzme'Kit ligand; wasp knockout' vs 'Kit ligand; wild type'compound, genotypeTranscription profiling of bone marrow–derived mast cells from WASP-deficient mice after stimulation with kit ligand
Adjusted p-valueLog2-fold change
1.4674 × 10-6-1.3
Gzme'mutant MyoD expression' at '12 hour' vs 'wild type MyoD expression' at '0 hour'phenotype, timeTranscription profiling of mouse embryoic fibroblasts expressing wild type MyoD or its non-acetylatable version MyoD RRR to investigate how MyoD acetylation may contribute to differential gene activation.
Adjusted p-valueLog2-fold change
3.6124 × 10-4-1.2
Gzme'mutant MyoD expression' at '6 hour' vs 'wild type MyoD expression' at '0 hour'phenotype, timeTranscription profiling of mouse embryoic fibroblasts expressing wild type MyoD or its non-acetylatable version MyoD RRR to investigate how MyoD acetylation may contribute to differential gene activation.
Adjusted p-valueLog2-fold change
4.1912 × 10-21.2
Gzme'anti-mPDL1; anti-mCTLA4; 10 milligram per kilogram' vs 'none' at '7 day'compound, timeRNAseq of tumor samples from CT26 syngeneic mouse treated with a PD-L1 and CTLA-4 immunotherapy combination
Adjusted p-valueLog2-fold change
4.3047 × 10-2-1.2
Gzme'total RNA; HRasV12 and c-Myc overexpression and Eif4e wild type' vs 'total RNA; wild type'fraction, genotypeRedefining the role of eIF4E dose in development, cancer, and protein synthesis
Adjusted p-valueLog2-fold change
1.5043 × 10-61.1
Gzme'Mycobacterium tuberculosis H37Rv' vs 'none' in 'TNF-alpha knockout'compound, genotype, infect4-week mouse comparative study on effect of neutralizing IL-17A, IL-17F and TNFa antibodies
Adjusted p-valueLog2-fold change
7.3575 × 10-5-1.1
Gzme'MG132; 1 micromolar' vs 'DMSO' in 'wild type'compound, genotypeMicroarray to find ATF5 dependent genes in response to proteasome inhibition
Adjusted p-valueLog2-fold change
3.7803 × 10-41.1
Gzme'IRAK1BP1 KO' vs 'wild type' in 'none'genotype, treatmentIdentification of TNFα-induced genes that are IRAK1BP1 dependent
Adjusted p-valueLog2-fold change
1.3825 × 10-31.1
Gzme'glioblastoma multiforme' vs 'normal'diseaseAnalysis of the expression profiles of glioma-associated microglia/macrophages and naive control cells in Mus musculus.
Adjusted p-valueLog2-fold change
3.6218 × 10-2-1.1
Gzme'STAT5 double knocked in' vs 'wild type' in 'interleukin-2' at '2 hour'compound, genotype, timeGene expression profile of splenic T cells from STAT5 double knocked in mice treated with IL-2
Adjusted p-valueLog2-fold change
7.4171 × 10-41
Gzme'IRAK1BP1 KO' vs 'wild type' in 'TNFα'genotype, treatmentIdentification of TNFα-induced genes that are IRAK1BP1 dependent
Adjusted p-valueLog2-fold change
1.3052 × 10-21
Gzme'parathyroid hormone; 10 nanomolar' vs 'none' in 'wild type'compound, genotypeTranscription profiling by array of mouse primary osteoblastic cells from arrb2 knockout treated with parathyroid hormone
Synonym
MCSP-2, Ctla-6, Ctla6, CCP3
Ortholog
ENSECAG00000041707 (Equus caballus), GZMB (Bos taurus), ENSECAG00000012766 (Equus caballus), ENSPPYG00000029446 (Pongo abelii), GZMB (Macaca mulatta), ENSECAG00000015137 (Equus caballus), ENSECAG00000022193 (Equus caballus), GZMB (Pongo abelii), GZMH (Pongo abelii), ENSOARG00020003470 (Pongo abelii), GZMB (Papio anubis), ENSOANG00000041457 (Ornithorhynchus anatinus), GZMH (Sus scrofa), GZMH (Oryctolagus cuniculus), ENSECAG00000029634 (Felis catus), ENSDNOG00000039933 (Dasypus novemcinctus), ENSOARG00020024695 (Pongo abelii), ENSECAG00000040795 (Equus caballus), ENSECAG00000041747 (Papio anubis), ENSOARG00020003394 (Ornithorhynchus anatinus), GZMB (Chlorocebus sabaeus), ENSDNOG00000044209 (Dasypus novemcinctus), Gzmn (Rattus norvegicus), GZMH (Chlorocebus sabaeus), ENSECAG00000039930 (Equus caballus), ctsg (Xenopus tropicalis), ENSBTAG00000010828 (Bos taurus), ENSDNOG00000043296 (Dasypus novemcinctus), ENSECAG00000042681 (Equus caballus), ENSECAG00000043572 (Equus caballus), ENSBTAG00000038291 (Bos taurus), ENSECAG00000043675 (Equus caballus), GZMB (Gorilla gorilla), GZMB (Pan troglodytes), GZMH (Gorilla gorilla), ENSECAG00000041556 (Mus musculus), GZMB (Homo sapiens), ENSECAG00000042862 (Ornithorhynchus anatinus), ENSBTAG00000038159 (Bos taurus), GZMH (Homo sapiens)
Gene ontology
InterPro
Ensembl gene
Ensembl transcript
Ensembl protein
Entrez
UniProt
MGI ID (Mouse)
MGI description
Gene biotype
Design element
A_51_P357592, 4692793, 1450171_x_at, ILMN_1224204, 1421227_at, 17306983, ILMN_2642942, 5528603, 10420268, A_55_P1971010, x12821_f_at, A_55_P1971009