ENSMUSG00000022226 (Mcpt2)

mus musculus

mast cell protease 2

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Mus musculus
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Showing 2 experiments:
Created with Highcharts 6.2.0adult CCAP neuronalpha’/beta’ middle Kenyon cellcentrifugal neuron C3distal medullary amacrine neuron Dm10distal medullary amacrine neuron Dm9dopaminergic PAM neuron 6gamma dorsal Kenyon celllamina monopolar neuron L2lobula columnar neuron LC10alobula columnar neuron LC6lobula-lobula plate columnar neuron LLPC1mushroom body output neuronproximal medullary amacrine neuron Pm3transmedullary neuron Tm1transmedullary neuron Tm4adult lamina marginal glial cellalpha/beta posterior Kenyon cellcolumnar neuron T1distal medullary amacrine neuron Dm3dopaminergic PAM neuron 3dopaminergic PAM neuron 9lamina intrinsic neuronlamina monopolar neuron L5lobula columnar neuron LC10dlobula plate tangential neuronmedullary intrinsic neuron Mi4photoreceptor cell R7T neurontransmedullary neuron Tm29
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Log2-fold changeSpeciesGene nameComparisonExperimental variablesExperiment name
Adjusted p-valueLog2-fold change
5.6298 × 10-98.4
Mcpt2'pre-B acute lymphoblastic leukemia 8093; nilotinib; 3 day' vs 'pre-B acute lymphoblastic leukemia 8093; nilotinib; 0 day'cell type, compound, timeDrug tolerance development of mouse Bcr/Abl pre-B ALL cells on irradiated MEFs
Adjusted p-valueLog2-fold change
6.8614 × 10-377.3
Mcpt2'wormy, worm left; Trichuris muris' vs 'control; non wormy' in 'caecum'environmental stress, infect, organism partRNA-seq of mouse intestinal mucosa to investigate infection by the parasitic nematode Trichuris muris
Adjusted p-valueLog2-fold change
6.2658 × 10-97.3
Mcpt2'trinitrobenzene sulfonic acid' vs 'none' in 'wild type'compound, genotypeChronic TNBS Colitis in the FN14 KO Mouse
Adjusted p-valueLog2-fold change
1.4063 × 10-77.1
Mcpt2'trinitrobenzene sulfonic acid' vs 'none' in 'Fn14 knockout'compound, genotypeChronic TNBS Colitis in the FN14 KO Mouse
Adjusted p-valueLog2-fold change
1.139 × 10-366.5
Mcpt2'wormy, worm separated; Trichuris muris' vs 'control; non wormy' in 'caecum'environmental stress, infect, organism partRNA-seq of mouse intestinal mucosa to investigate infection by the parasitic nematode Trichuris muris
Adjusted p-valueLog2-fold change
7.8445 × 10-226.5
Mcpt2'lung carcinoma' vs 'normal' in 'Epcam+CD11b-CD11c- epithelial cell'cell type, diseaseTranscriptome analysis of isolated stormal cells and tumor epithelial cells in mouse lung cancer by RNA-Seq
Adjusted p-valueLog2-fold change
1.1876 × 10-185.7
Mcpt2'Nippostrongylus brasiliensis' vs 'none'infectRNAseq of small intestinal epithelium extracted from mice infected with Nippostrongylus brasiliensis
Adjusted p-valueLog2-fold change
3.3283 × 10-10-5.5
Mcpt2'AZD7507; AZD5069 (at same dosage); 100 milligram per kilogram' vs 'none'compoundRNA-seq to investigate differentially expressed genes in KPC mouse PDAC treated with CSF-1R small molecule inhibitor AZD7507 and/or the CXCR2 small molecule inhibitor AZD5069
Adjusted p-valueLog2-fold change
8.9363 × 10-115.1
Mcpt2'Trichuris muris' vs 'control' in 'non wormy; caecum'environmental stress, infect, organism partRNA-seq of mouse intestinal mucosa to investigate infection by the parasitic nematode Trichuris muris
Adjusted p-valueLog2-fold change
3.3745 × 10-24.8
Mcpt2'extraembryonic endoderm stem cell; grown in XEN cell medium' vs 'mouse embryonic fibroblast; control'cell type, growth conditionOSKM induce extraembryonic endoderm stem (iXEN) cells in parallel to iPS cells
Adjusted p-valueLog2-fold change
2.3539 × 10-74.7
Mcpt2'lung carcinoma' vs 'normal' in 'lung cell'cell type, diseaseTranscriptome analysis of isolated stormal cells and tumor epithelial cells in mouse lung cancer by RNA-Seq
Adjusted p-valueLog2-fold change
7.6283 × 10-44.7
Mcpt2'hepatocyte-specific Pten and Tgfbr2 knockout' vs 'wild type'genotypeHepatocyte-specific knockout of Pten and of Pten and Tgfbr2 in mice
Adjusted p-valueLog2-fold change
2.6195 × 10-24.7
Mcpt2'expanded on HUVEC and m5GF in the presence of mD1R for 7 days' vs 'control'treatmentExpression data from cultured c-Kit+Sca-1+Lin- (KSL)cells
Adjusted p-valueLog2-fold change
8.4108 × 10-44.6
Mcpt2'pre-B acute lymphoblastic leukemia 8093; lonafarnib; 4 day' vs 'pre-B acute lymphoblastic leukemia 8093; lonafarnib; 0 day'cell type, compound, timeDrug tolerance development of mouse Bcr/Abl pre-B ALL cells on irradiated MEFs
Adjusted p-valueLog2-fold change
3.5209 × 10-24.6
Mcpt2'extraembryonic endoderm stem cell; grown in ES cell medium' vs 'mouse embryonic fibroblast; control'cell type, growth conditionOSKM induce extraembryonic endoderm stem (iXEN) cells in parallel to iPS cells
Adjusted p-valueLog2-fold change
4.716 × 10-9-4.3
Mcpt2'Runx1 knockdown; none' vs 'wild type; none'genotype, stimulusTranscription profiling by array of Mouse erythro-leukaemia cells during differentiation to investigate the influence of Runx1 transcription factor
Adjusted p-valueLog2-fold change
4.8516 × 10-7-3.8
Mcpt2'induce erythroid differentiation' vs 'none' in 'wild type'genotype, stimulusTranscription profiling by array of Mouse erythro-leukaemia cells during differentiation to investigate the influence of Runx1 transcription factor
Adjusted p-valueLog2-fold change
3.62 × 10-73.6
Mcpt2'18 week; Str/ort' vs '18 week; CBA'age, strainExpression data of cartiliage from CBA and STR/ORT mice
Adjusted p-valueLog2-fold change
5.8858 × 10-73.6
Mcpt2'8 week; Str/ort' vs '8 week; CBA'age, strainExpression data of cartiliage from CBA and STR/ORT mice
Adjusted p-valueLog2-fold change
4.7914 × 10-53.6
Mcpt2'40 week; Str/ort' vs '40 week; CBA'age, strainExpression data of cartiliage from CBA and STR/ORT mice
Adjusted p-valueLog2-fold change
2.1238 × 10-23.6
Mcpt2'clear cell sarcoma; Rosa26CreER' vs 'control'disease, genotypeMouse Model of Clear Cell Sarcoma
Adjusted p-valueLog2-fold change
2.9338 × 10-43.3
Mcpt2'fetal definitive erythroid cell' vs 'primitive erythroid cell' in 'reticulocyte'cell type, phenotypeTranscription profiling by array of differentiating primary primitive and definitive mouse red blood cells
Adjusted p-valueLog2-fold change
6.0931 × 10-43.3
Mcpt2'10 nanogram per milliliter; TGF-beta1' vs 'none' in 'multipotent progenitor' at '24 hour'cell type, compound, timeDynamic Gene Expression Response to TGF-b Stimulation in Multipotent Progenitors and Common Dendritic Cell Progenitors
Adjusted p-valueLog2-fold change
9.6026 × 10-20-3.2
Mcpt2'interferon gamma; 10 nanogram per milliliter and interleukin-22; 10 nanogram per milliliter' vs 'none'compoundRNAseq of small intestinal organoids from mice treated with the cytokines IFNG, IL-13 and IL-22 for 24 hours
Adjusted p-valueLog2-fold change
1.3335 × 10-103.1
Mcpt2'interleukin-3 and interleukin-33' vs 'interleukin-3'growth conditionStem cell factor programs the mast cell activation phenotype
Adjusted p-valueLog2-fold change
6.6904 × 10-72.8
Mcpt2'colitis' at '19 day' vs 'normal' at '0 day'disease, timeTemporal transcriptomic changes during DSS colitis development and resolution.
Adjusted p-valueLog2-fold change
8.8436 × 10-72.8
Mcpt2'dextran sodium sulfate' vs 'none' in 'wild type genotype'compound, genotypeRNA-seq analysis of colonic intestinal epithelial cells (IECs) isolated from naive wild-type C57BL/6 mice, DSS-treated wild-type C57BL/6 mice, Il10-/- C57BL/6 mice and Il10-/- C57BL/6 mice with IEC-specific Rabgef1 deletion
Adjusted p-valueLog2-fold change
2.5032 × 10-32.8
Mcpt2'dextran sodium sulphate induced colitis' vs 'normal' in 'water'compound, diseaseTranscription profiling by array of murine colon tissue after exposure to 4% dextran sodium sulphate (DSS) for 6 days followed by 4 days of water or 1% L-arginine to study the effect of L-arginine on DSS-induced colitis
Adjusted p-valueLog2-fold change
6.7433 × 10-52.7
Mcpt2'6 week' vs '0 week'timeTranscription profiling by array of mouse colon tissues with T cell transfer-induced colitis at week 0, 2, 4 and 6 post-transfer
Adjusted p-valueLog2-fold change
4.4785 × 10-32.7
Mcpt2'neoplasm' vs 'normal tissue adjacent to neoplasm'sampling siteTranscription profiling by array of Apc+/Delta716 mouse intestinal polyps vs normal intestinal mucosa
Adjusted p-valueLog2-fold change
8.8474 × 10-42.6
Mcpt2'chronic DSS-induced colitis; 1x DSS, recovery' vs 'none; none'clinical treatment, diseaseTranscription profiling by array of colon tissues isolated from mice with acute and chronic dextran sodium sulphate (DSS)-induced colitis
Adjusted p-valueLog2-fold change
1.5029 × 10-42.5
Mcpt2'missense mutation (T2996C) in Mucin 2 (Muc2)' vs 'wild type genotype'genotypeTranscription profiling of mouse intestine in ENU mutagenesis mouse strains with missense mutations in Muc2 mucin and ER stress
Adjusted p-valueLog2-fold change
4.5076 × 10-32.5
Mcpt2'lung carcinoma' vs 'normal' in 'CD11b+Ly6G+ neutrophil'cell type, diseaseTranscriptome analysis of isolated stormal cells and tumor epithelial cells in mouse lung cancer by RNA-Seq
Adjusted p-valueLog2-fold change
3.8178 × 10-32.4
Mcpt2'dextran sodium sulphate induced colitis' vs 'normal' in 'L-Arginine'compound, diseaseTranscription profiling by array of murine colon tissue after exposure to 4% dextran sodium sulphate (DSS) for 6 days followed by 4 days of water or 1% L-arginine to study the effect of L-arginine on DSS-induced colitis
Adjusted p-valueLog2-fold change
3.8746 × 10-2-2.4
Mcpt2'intravenous injection of 10-100 thousand B-ALL cells' vs 'none' in 'lentiviral expression of mTie2-IFN-mirT and Tie2-driven overexpression of IFNalpha'genotype, stimulusRNA-seq of mouse macrophages to investigate how interferon gene therapy reprograms the leukemia microenvironment
Adjusted p-valueLog2-fold change
3.4911 × 10-5-2.3
Mcpt2'10 Gy Gray; x-ray' vs 'none' in 'tumor and stromal cell'cell type, irradiateRNA-seq of effector (CD43+) CD8+ T cells, CD45+ hematopoietic cells and CD45- tumor/stromal cells from mice bearing bilateral AT-3 tumors following radio-immunotherapy of which one tumor was irradiated
Adjusted p-valueLog2-fold change
1.7112 × 10-72.2
Mcpt2'HDM allergen; IL-13 knockout' vs 'PBS control; IL-13 knockout' on 'Affymetrix MOE430A Array'compound, genotypeTranscription profiling of wild type and IL13 knock out mice treated with allergen vs. control to investigate the IL13 role in allergic asthma
Adjusted p-valueLog2-fold change
8.2487 × 10-42.2
Mcpt2'Tgfbeta 1 ligand 0.04 nanogram per milliliter' vs 'none'compoundExpression data from intestinal organoids altered for Tgfbeta signaling
Adjusted p-valueLog2-fold change
1.5928 × 10-14-2.1
Mcpt2'interleukin-22 (Mus Musculus); 10 nanogram per milliliter' vs 'none'compoundRNAseq of small intestinal organoids from mice treated with the cytokines IFNG, IL-13 and IL-22 for 24 hours
Adjusted p-valueLog2-fold change
9.1149 × 10-4-2.1
Mcpt2'acute graft vs. host disease' vs 'normal'compound, diseaseTranscription profiling by array of murine thymus medulla in the absence and presence of acute graft-versus-host disease
Adjusted p-valueLog2-fold change
2.1044 × 10-32.1
Mcpt2'TMEV infected' at '42 day' vs 'mock control' at '42 day'disease, timeTranscription profiling of mouse spinal cord from mock-infected and Theilers murine encephalomyelitis (TME)-virus infected animals - time series
Adjusted p-valueLog2-fold change
3.2472 × 10-22.1
Mcpt2'Vldlr knockout' vs 'wild type genotype' in 'house dust mite'genotype, treatmentTranscription profiling by array of lungs of Vldlr-/- mice and wild type (WT) B6129SF2/J mice that had received intranasal house dust mite (HDM) challenges to induce experimental asthma or saline
Adjusted p-valueLog2-fold change
9.1659 × 10-15-2
Mcpt2'interferon gamma; 10 nanogram per milliliter and interleukin-13; 10 nanogram per milliliter' vs 'none'compoundRNAseq of small intestinal organoids from mice treated with the cytokines IFNG, IL-13 and IL-22 for 24 hours
Adjusted p-valueLog2-fold change
4.8957 × 10-32
Mcpt2'chronic DSS-induced colitis; 2x DSS, additional recovery' vs 'none; none'clinical treatment, diseaseTranscription profiling by array of colon tissues isolated from mice with acute and chronic dextran sodium sulphate (DSS)-induced colitis
Adjusted p-valueLog2-fold change
2.685 × 10-51.9
Mcpt2'4 week' vs '0 week'timeTranscription profiling by array of mouse colon tissues with T cell transfer-induced colitis at week 0, 2, 4 and 6 post-transfer
Adjusted p-valueLog2-fold change
6.9534 × 10-51.9
Mcpt2'hypobaric hypoxia' vs 'control'growth conditionComparison of gene expression in whole blood of mice subjected to hypobaric hypoxia at Mt. Everest in vivo.
Adjusted p-valueLog2-fold change
2.2313 × 10-41.9
Mcpt2'chronic DSS-induced colitis; 3x DSS, recovery' vs 'none; none'clinical treatment, diseaseTranscription profiling by array of colon tissues isolated from mice with acute and chronic dextran sodium sulphate (DSS)-induced colitis
Adjusted p-valueLog2-fold change
2.3817 × 10-31.8
Mcpt2'chronic DSS-induced colitis; 2x DSS, recovery' vs 'none; none'clinical treatment, diseaseTranscription profiling by array of colon tissues isolated from mice with acute and chronic dextran sodium sulphate (DSS)-induced colitis
Adjusted p-valueLog2-fold change
4.2744 × 10-31.8
Mcpt2'colitis' at '12 day' vs 'normal' at '0 day'disease, timeTemporal transcriptomic changes during DSS colitis development and resolution.
Adjusted p-valueLog2-fold change
8.6111 × 10-31.8
Mcpt2'Influenza A virus' vs 'none'infectRNA-seq of mouse alveolar macrophages from control and Influenza A virus infected animals
Adjusted p-valueLog2-fold change
1.6265 × 10-21.8
Mcpt2'ulcer' vs 'distant normal tissue' in 'wild type genotype'genotype, sampling site, timeIntestinal ulcers from biopsy-wounded wild-type and Bmp4-overexpressing mice
Adjusted p-valueLog2-fold change
1.2818 × 10-5-1.7
Mcpt2'HDAC2 knockout' vs 'control'genotypeThe acetylome regulators Hdac1 and Hdac2 differently modulate intestinal epithelial cell dependent homeostatic responses in experimental colitis
Adjusted p-valueLog2-fold change
3.2367 × 10-2-1.7
Mcpt2'CKIαΔgut/p53R172H' vs 'CKIαΔgut/p53Δgut' in 'jejunum'compound, genotype, organism partRNAseq of enterocytes of the jejunum and Ileum from transgene C57BL/6 mice harboring a CKIαΔgut knock-out
Adjusted p-valueLog2-fold change
3.9436 × 10-11-1.6
Mcpt2'interferon gamma; 10 nanogram per milliliter' vs 'none'compoundRNAseq of small intestinal organoids from mice treated with the cytokines IFNG, IL-13 and IL-22 for 24 hours
Adjusted p-valueLog2-fold change
4.265 × 10-2-1.6
Mcpt2'social defeat stress' vs 'none'environmental stressTranscription profiling by array of ileum from mouse exposed to subchronic and mild social defeat stress
Adjusted p-valueLog2-fold change
2.014 × 10-4-1.5
Mcpt2'Aire knock out' vs 'wild type'genotypeTranscription profiling by array of mouse thymic medullary epithelial cells mutant for Aire
Adjusted p-valueLog2-fold change
3.3641 × 10-2-1.5
Mcpt2'Vldlr knockout' vs 'wild type genotype' in 'saline'genotype, treatmentTranscription profiling by array of lungs of Vldlr-/- mice and wild type (WT) B6129SF2/J mice that had received intranasal house dust mite (HDM) challenges to induce experimental asthma or saline
Adjusted p-valueLog2-fold change
8.4228 × 10-9-1.4
Mcpt2'interleukin-13 (Mus musculus); 10 nanogram per milliliter' vs 'none'compoundRNAseq of small intestinal organoids from mice treated with the cytokines IFNG, IL-13 and IL-22 for 24 hours
Adjusted p-valueLog2-fold change
2.7186 × 10-21.4
Mcpt2'TMEV infected' at '98 day' vs 'mock control' at '98 day'disease, timeTranscription profiling of mouse spinal cord from mock-infected and Theilers murine encephalomyelitis (TME)-virus infected animals - time series
Adjusted p-valueLog2-fold change
4.4725 × 10-21.4
Mcpt2'ulcer' vs 'distant normal tissue' in 'Bmp4 overexpression'genotype, sampling site, timeIntestinal ulcers from biopsy-wounded wild-type and Bmp4-overexpressing mice
Adjusted p-valueLog2-fold change
1.699 × 10-19-1.3
Mcpt2'LDB1 knock-down with Ldb1 delta 4/5 construct' vs 'control shRNA'RNA interferenceRole of LDB1 in the transition from chromatin looping to transcription activation
Adjusted p-valueLog2-fold change
2.923 × 10-41.3
Mcpt2'induce erythroid differentiation' vs 'none' in 'Runx1 knockdown'genotype, stimulusTranscription profiling by array of Mouse erythro-leukaemia cells during differentiation to investigate the influence of Runx1 transcription factor
Adjusted p-valueLog2-fold change
9.1972 × 10-41.3
Mcpt2'missense mutation (G9492A) in Mucin 2 (Muc2)' vs 'wild type genotype'genotypeTranscription profiling of mouse intestine in ENU mutagenesis mouse strains with missense mutations in Muc2 mucin and ER stress
Adjusted p-valueLog2-fold change
1.4035 × 10-31.3
Mcpt2'Apc and Msx1 knockout in Villin1 positive cells' vs 'wild type'phenotypeTranscription profiling by array of Apc-deficient proximal colonic epithelium upon Msx1 transcription factor depletion
Adjusted p-valueLog2-fold change
1.7303 × 10-2-1.3
Mcpt2'acute graft versus host disease' vs 'normal'diseaseTranscription profiling by array of intestinal tissues from mice receiving bone marrow transplantation with or without T-cell stimulation
Adjusted p-valueLog2-fold change
1.9569 × 10-21.3
Mcpt2'fetal definitive erythroid cell' vs 'primitive erythroid cell' in 'basophilic erythroblast'cell type, phenotypeTranscription profiling by array of differentiating primary primitive and definitive mouse red blood cells
Adjusted p-valueLog2-fold change
2.9552 × 10-21.3
Mcpt2'epithelium-specific Apc; Bcl9; Bcl9l knockout' vs 'wild type'phenotypeRNAseq of murine small intestinal tissue following epithelium-specific deletion of Bcl9/9l +/- Apc +/- mutant B-catenin
Adjusted p-valueLog2-fold change
1.4911 × 10-31.2
Mcpt2'Lkb1 -/- Pten-/-' vs 'wild type'genotypeLoss of Lkb1 and Pten Leads to Lung Squamous Cell Carcinoma with Elevated Pdl1 Expression: Epithelial Cells
Adjusted p-valueLog2-fold change
1.8254 × 10-41.1
Mcpt2'bronchoalveolar adenocarcinoma induced using doxycycline' vs 'normal'diseaseTranscription profiling by array of lung alveolar type II epithelial cells with bronchoalveolar adenocarcinoma
Adjusted p-valueLog2-fold change
5.8328 × 10-41.1
Mcpt2'acute DSS-induced colitis; 1x DSS, no recovery' vs 'none; none'clinical treatment, diseaseTranscription profiling by array of colon tissues isolated from mice with acute and chronic dextran sodium sulphate (DSS)-induced colitis
Adjusted p-valueLog2-fold change
4.8502 × 10-3-1.1
Mcpt2'active gastritis with low grade metaplasia; Helicobacter pylori' vs 'normal; none' at '12 month'disease, infect, timeTranscription profiling of gastric tissues from mice infected with H. pylori strain SS1 for 6 or 12 months
Adjusted p-valueLog2-fold change
2.1894 × 10-2-1.1
Mcpt2'aire knock out' vs 'wild type'genotypeTranscription profiling by array of mice mutant for aire
Adjusted p-valueLog2-fold change
3.9107 × 10-21.1
Mcpt2'azoxymethane and dextran sodium sulfate' vs 'control' in 'Myd88 knockout'compound, genotypeGene expression profiling of total colon in AOM/DSS-treated Myd88 knockout and wild type
Adjusted p-valueLog2-fold change
1.8957 × 10-31
Mcpt2'HDM allergen; IL-13 knockout' vs 'HDM allergen; wild type' on 'Affymetrix MOE430A Array'compound, genotypeTranscription profiling of wild type and IL13 knock out mice treated with allergen vs. control to investigate the IL13 role in allergic asthma
Adjusted p-valueLog2-fold change
1.3749 × 10-21
Mcpt2'UNC0638' vs 'control'compoundG9a-dependent gene expression in mouse AML cells
Adjusted p-valueLog2-fold change
2.168 × 10-21
Mcpt2'adult definitive erythroid cell' vs 'primitive erythroid cell' in 'basophilic erythroblast'cell type, phenotypeTranscription profiling by array of differentiating primary primitive and definitive mouse red blood cells