-8.8 | | Lhx6 | 'Cox6a2 knockout' vs 'wild type' | phenotype | RNA-seq of PV+ interneurons in WT and Cox6a2-/- mice to unravel the molecular signaling that contributes to the increase in oxidative stress and metabolic dysregulation following Cox6a2 knockout. |
7.2 | | Lhx6 | 'neuron' vs 'differentiating progenitor' | cell type | Transcription profiling by high throughput sequencing of proliferating neural stem cells, differentiating neurogenic progenitors and newborn neurons using a dual-reporter mouse line |
-5.6 | | Lhx6 | '70 week' vs '6 week' in 'none; none; | age, irradiate | Pericyte induced reprogramming of the bone marrow microenvironment drives stem and cancer cell quiescence |
5.3 | | Lhx6 | 'soticlestat; 30 milligram per kilogram' vs 'none' in 'astrocyte; none' | cell type, compound, disease | RNA-seq profiling of three distinct cell populations in a murine model of epilepsia with and without drug treatment |
-4.6 | | Lhx6 | 'status epilepticus' vs 'none' in 'astrocyte; soticlestat; 30 milligram per kilogram' | cell type, compound, disease | RNA-seq profiling of three distinct cell populations in a murine model of epilepsia with and without drug treatment |
3.9 | | Lhx6 | 'induced extraembryonic endoderm stem cell; grown in ES cell medium' vs 'mouse embryonic fibroblast; control' | cell type, growth condition | OSKM induce extraembryonic endoderm stem (iXEN) cells in parallel to iPS cells |
3.9 | | Lhx6 | 'undifferentiated' vs 'differentiated; rosiglitazone' in 'SWR/J' | phenotype, stimulus, strain | RNA-seq of mouse subcutaneous SVF cells before and after differentiation with a brown fat differentiation cocktail |
3.7 | | Lhx6 | 'extraembryonic endoderm stem cell; grown in ES cell medium' vs 'mouse embryonic fibroblast; control' | cell type, growth condition | OSKM induce extraembryonic endoderm stem (iXEN) cells in parallel to iPS cells |
3.7 | | Lhx6 | 'colitis' at '8 day' vs 'normal' at '0 day' | disease, time | Temporal transcriptomic changes during DSS colitis development and resolution. |
3.1 | | Lhx6 | 'induced extraembryonic endoderm stem cell; grown in XEN cell medium' vs 'mouse embryonic fibroblast; control' | cell type, growth condition | OSKM induce extraembryonic endoderm stem (iXEN) cells in parallel to iPS cells |
3.1 | | Lhx6 | 'extraembryonic endoderm stem cell; grown in XEN cell medium' vs 'mouse embryonic fibroblast; control' | cell type, growth condition | OSKM induce extraembryonic endoderm stem (iXEN) cells in parallel to iPS cells |
3.1 | | Lhx6 | 'undifferentiated' vs 'differentiated; rosiglitazone' in 'AKR/J' | phenotype, stimulus, strain | RNA-seq of mouse subcutaneous SVF cells before and after differentiation with a brown fat differentiation cocktail |
2.9 | | Lhx6 | 'Salmonella enterica serovar Typhimurium' vs 'control' in 'derived macrophage from E14 Traf2 mutant cell line' | clinical information, infect | Gene expression profiles of mouse embryonic stem cell derived macrophages infected with Salmonella typhimurium |
2.8 | | Lhx6 | 'undifferentiated' vs 'differentiated; rosiglitazone' in 'F1.B6x129' | phenotype, stimulus, strain | RNA-seq of mouse subcutaneous SVF cells before and after differentiation with a brown fat differentiation cocktail |
2.8 | | Lhx6 | 'undifferentiated' vs 'differentiated; rosiglitazone' in '129S6sv/ev' | phenotype, stimulus, strain | RNA-seq of mouse subcutaneous SVF cells before and after differentiation with a brown fat differentiation cocktail |
2.7 | | Lhx6 | '10 Gy Gray; x-ray' vs 'none' in 'tumor and stromal cell' | cell type, irradiate | RNA-seq of effector (CD43+) CD8+ T cells, CD45+ hematopoietic cells and CD45- tumor/stromal cells from mice bearing bilateral AT-3 tumors following radio-immunotherapy of which one tumor was irradiated |
2.6 | | Lhx6 | 'undifferentiated' vs 'differentiated; rosiglitazone' in 'F1.129xB6' | phenotype, stimulus, strain | RNA-seq of mouse subcutaneous SVF cells before and after differentiation with a brown fat differentiation cocktail |
2.5 | | Lhx6 | 'synovial sarcoma' vs 'control' | disease, genotype | Mouse Model of Clear Cell Sarcoma |
2.5 | | Lhx6 | 'Alb-Cre-ERT2 / Cnot1 flox/flox' vs 'Cnot1 flox/flox' in 'none' | compound, genotype, time | RNA-seq of livers in control and Cnot1 tamoxifen-inducible liver-specific knockout mice |
2.5 | | Lhx6 | 'AZD7507; AZD5069 (at same dosage); 100 milligram per kilogram' vs 'none' | compound | RNA-seq to investigate differentially expressed genes in KPC mouse PDAC treated with CSF-1R small molecule inhibitor AZD7507 and/or the CXCR2 small molecule inhibitor AZD5069 |
2.5 | | Lhx6 | 'fed 0.5 percent cholate for 30 days; wild type' vs 'wild type' | diet, genotype, pregnancy | Transcription profiling by array of mouse liver from control, pregnant, cholate fed mice and Frx null mice |
-2.5 | | Lhx6 | 'doxycycline; 200 nanogram per milliliter; neoplasm; 5 day' vs 'none; normal; 0 day' | compound, phenotype, time | RNA-seq of doxycycline induced tumor and residual mouse primary mammary epithelial cells grown in 3D cell cultures against non-induced controls |
-2.2 | | Lhx6 | 'co-cultured with hematopoietic stem cell for 9 days' vs 'non co-cultured for 9 days' in 'stromal cell; expressing AKT1' | cell type, growth condition, phenotype | Transcription profiling by high throughput sequencing of murine bone marrow endothelial cells and bone marrow stroma, in vitro and in vivo, with and without hematopoietic stem cells co-culture |
2.1 | | Lhx6 | 'cut nerve; 7 day' vs 'none' | injury, protocol, time | Changes in the coding/non-coding transcriptome and DNA methylome that define the Schwann cell repair phenotype after nerve injury |
2.1 | | Lhx6 | 'undifferentiated' vs 'differentiated; rosiglitazone' in 'C57BL/6J' | phenotype, stimulus, strain | RNA-seq of mouse subcutaneous SVF cells before and after differentiation with a brown fat differentiation cocktail |
2.1 | | Lhx6 | 'PTEN null, P53-/-' vs 'wild type genotype' | genotype | RNA seq of prostate gland from WT, PTEN pc -/- and PTEN pc-/-;P53 -/- mice |
-1.9 | | Lhx6 | 'Irx3 knockout' vs 'control' at '1 day' | genetic modification, time | RNA-Seq of mouse Irx3-KO and Control ME3 cells on days 1 and 7 of adipogenic differentiation |
-1.9 | | Lhx6 | 'Influenza A virus' vs 'mock' in 'IgG1' | infect, stimulus | Transcription profiling by array of pulmonary gene expression in response to interleukin-22 during severe influenza |
-1.9 | | Lhx6 | 'liver specific SMARCB1 knockout' vs 'wild type' | phenotype | TP53 is a master regulator of proteostasis in SMARCB1-deficient malignant rhabdoid tumors |
1.9 | | Lhx6 | 'Salmonella enterica serovar Typhimurium' vs 'control' in 'derived macrophage from E14 cell line' | clinical information, infect | Gene expression profiles of mouse embryonic stem cell derived macrophages infected with Salmonella typhimurium |
1.9 | | Lhx6 | 'Ink4a/Arf-/-; EGFRvIII' vs 'wild type genotype' in 'co-culture' | genotype, growth condition | RNA-seq of wild-type and transformed Ink4a/Arf-/-; EGFRvIII neural stem cells in separate or co-culture conditions |
-1.9 | | Lhx6 | 'lung carcinoma' vs 'normal' in 'CD11b+Ly6G+ neutrophil' | cell type, disease | Transcriptome analysis of isolated stormal cells and tumor epithelial cells in mouse lung cancer by RNA-Seq |
1.8 | | Lhx6 | 'Reverbα -/-' vs 'wild type genotype' | genotype | Antibody-independent ChIP-sequencing and liver-targeted deletion redefine REVERBα repressor function - RNA-seq |
-1.7 | | Lhx6 | 'Abcc8 knockout' vs 'wild type' | genotype | Transcription profiling by high throughput sequencing of pancreatic beta cells from wild type and Abcc8 knockout mice |
1.7 | | Lhx6 | 'mutant (Pdgfc-/-; Pdgfra GFP/+)' vs 'control' | genotype | Cerebral gene expression changes in Pdgfc and Pdgfra mutant |
1.7 | | Lhx6 | 'CHOP-/-' vs 'wild type' in 'DMSO' | compound, genotype | Microarray to find CHOP dependent genes in response to proteasome inhibition |
-1.7 | | Lhx6 | 'Alk5 fl/fl; Wnt1-Cre' vs 'control' | genotype | Gene expression profiling of the mandibular arch from Alk5 mutant mouse models |
1.7 | | Lhx6 | 'carotid body' vs 'adrenal medulla' | organism part | Expression profile of mouse carotid body and adrenal medulla [RNA-Seq] |
-1.7 | | Lhx6 | 'neoplasm' vs 'normal tissue adjacent to neoplasm' | sampling site | Transcription profiling by array of Apc+/Delta716 mouse intestinal polyps vs normal intestinal mucosa |
1.7 | | Lhx6 | 'Nr1d1 homozygous knockout' vs 'wild type genotype' in 'methyl beta-clodextrin; 1 milligram per kilogram; ZT6' | compound, genotype, time | RNASeq data analysis of wild type and reverb alpha knockout cells from mouse liver, at different time points, with or without DEX treatment |
1.7 | | Lhx6 | 'undifferentiated' vs 'differentiated; rosiglitazone' in 'A/J' | phenotype, stimulus, strain | RNA-seq of mouse subcutaneous SVF cells before and after differentiation with a brown fat differentiation cocktail |
1.6 | | Lhx6 | 'Irx3 knockout' vs 'control' at '7 day' | genetic modification, time | RNA-Seq of mouse Irx3-KO and Control ME3 cells on days 1 and 7 of adipogenic differentiation |
-1.6 | | Lhx6 | '3 day; myogenesis differentiation' vs ' 0 day; control' in '2C12-pMirn0' | cell line, growth condition, time | Effect of Mirn378 overexpression on gene expression during C2C12 myogenic and BMP2-induced osteogenic differentiation |
1.6 | | Lhx6 | 'subconfluent monolayer on collagen' at '5 day' vs 'freshly isolated' at '0 day' | growth condition, time | Transcription profiling of primary mouse hepatocytes under different culture conditions |
-1.6 | | Lhx6 | 'H-Ras expression' vs 'wild type' | phenotype | RNA-seq of heart tissue from 15 day old mice 4 hours post MycER activation compared to wild type controls. RNA-seq of heart tissues from adult mice that have expressed oncogenic H-Ras for 4 weeks followed by MycER activation for 4 hours compared to MycER negative controls. |
-1.6 | | Lhx6 | 'uterine-specific Tsc2-null' vs 'wild type' in 'oopherectomized' | genotype, treatment | Transcription profiling by high throughput sequencing of uterine-specific Tsc2-null mice |
-1.5 | | Lhx6 | 'control mice [Gp130f/f]; cecal ligation and puncture' vs 'control mice [Gp130f/f]; control' | genotype, treatment | Hepatic acute phase proteins control innate immune responses during infection by promoting myeloid derived suppressor cell function |
-1.5 | | Lhx6 | 'SARS coronavirus MA15' vs 'mock' | infect | Host responses contributing to the attenuation of severe acute respiratory syndrome coronaviruses missing E protein domains |
1.4 | | Lhx6 | 'extracellular vesicle; MET cell culture medium' vs 'none' | sampling site, stimulus | Cellular and extracellular vesicle RNA sequence for E-cadherin-RFP EMT reporter system expressing mouse breast cancer cell line Py2T during EMT/MET |
-1.4 | | Lhx6 | '3 day; myogenesis differentiation' vs ' 0 day; control' in '2C12-pMirn378' | cell line, growth condition, time | Effect of Mirn378 overexpression on gene expression during C2C12 myogenic and BMP2-induced osteogenic differentiation |
1.4 | | Lhx6 | 'adipose tissue specific Cnot1 knockout' vs 'wild type phenotype' in 'brown adipose tissue' | organism part, phenotype | RNA-seq to identify the role of mRNA decay in mouse adipose tissues |
1.4 | | Lhx6 | 'subconfluent monolayer on collagen' at '3 day' vs 'freshly isolated' at '0 day' | growth condition, time | Transcription profiling of primary mouse hepatocytes under different culture conditions |
1.4 | | Lhx6 | 'tamoxifen induction at 2 months, wait 6 months' vs 'no tamoxifen induction' in 'basal cell of prostate epithelium; CK5-CreERT2 transgenic line' | cell type, genotype, growth condition | Transcription profiling by high throughput sequencing of PIN/tumor lesions from basal or luminal origins at time points at which mice displayed similar histopathological phenotypes |
-1.4 | | Lhx6 | 'H-Ras expression; c-Myc activation' vs 'wild type' | phenotype | RNA-seq of heart tissue from 15 day old mice 4 hours post MycER activation compared to wild type controls. RNA-seq of heart tissues from adult mice that have expressed oncogenic H-Ras for 4 weeks followed by MycER activation for 4 hours compared to MycER negative controls. |
1.4 | | Lhx6 | 'Albumin Cre+/-;Hnf4a fl/fl' vs 'wild type genotype' | genotype | Transcription profiling by array of liver-specific Hnf4alpha knock-out mice |
1.3 | | Lhx6 | 'interferon gamma' vs 'dexamethasone; 100 nanomolar' | compound, stimulus | RNA-Seq of murine lung endothelial cells stimulated with IFN-gamma and dexamethasone |
1.3 | | Lhx6 | '6 day' vs '0 day' | age | Transcription profiling of mouse embyronic stem cell line CGR8 during the first 10 days of differentiation into embryoid bodies |
1.3 | | Lhx6 | 'Influenza A virus (A/Puerto Rico/8/1934(H1N1)); 4 day' vs 'mock' in '129S1/SvImJ' | infect, strain, time | Genomic profiling of collaborative cross founder mouse strains infected with respiratory viruses to discover novel transcripts and infection-related strain-specific gene and isoform expression |
1.3 | | Lhx6 | 'FusΔNLS/+' vs 'wild type genotype' at '12 hour' | genotype, time | Mutant FUS triggers age-dependent synaptic impairment in presymptomatic ALS-FUS mice (RNA-seq part2) |
1.3 | | Lhx6 | 'SARS coronavirus MA15; 2 day' vs 'mock' in '129S1/SvImJ' | infect, strain, time | Genomic profiling of collaborative cross founder mouse strains infected with respiratory viruses to discover novel transcripts and infection-related strain-specific gene and isoform expression |
-1.3 | | Lhx6 | 'cycloheximide and 100 unit per milliliter interferon gamma' vs 'DMSO' | compound | Dissecting primary (translation independent) from secondary (translation dependent) IFN-mediated differential gene expression |
1.3 | | Lhx6 | 'PGC-1 beta knock in' vs 'wild type' | genotype | Transcription profiling by array of skeletal muscle from PGC-1 beta transgenic mice |
1.3 | | Lhx6 | 'atherogenic rodent' vs 'control' | diet | Liver mRNA microarray study for mice treated with various diets |
-1.3 | | Lhx6 | '3D culture' vs '2D culture' | growth condition | mRNA-seq of mouse salivary gland cancer cells cultured in adherent or non-adherent culture |
-1.3 | | Lhx6 | 'SARS coronavirus MA15 E protein mutant Δ3' vs 'mock' | infect | Host responses contributing to the attenuation of severe acute respiratory syndrome coronaviruses missing E protein domains |
1.2 | | Lhx6 | 'LDB1 knock-down' vs 'control shRNA' | RNA interference | Role of LDB1 in the transition from chromatin looping to transcription activation |
-1.2 | | Lhx6 | '6 day; myogenesis differentiation' vs ' 0 day; control' in '2C12-pMirn378' | cell line, growth condition, time | Effect of Mirn378 overexpression on gene expression during C2C12 myogenic and BMP2-induced osteogenic differentiation |
1.2 | | Lhx6 | '7 day' vs '0 day' | age | Transcription profiling of mouse embyronic stem cell line CGR8 during the first 10 days of differentiation into embryoid bodies |
-1.2 | | Lhx6 | '6 day; osteogenesis differentiation' vs ' 0 day; control' in '2C12-pMirn0' | cell line, growth condition, time | Effect of Mirn378 overexpression on gene expression during C2C12 myogenic and BMP2-induced osteogenic differentiation |
1.2 | | Lhx6 | 'Mif knockout' vs 'wild type genotype' | genotype | Role of Macrophage migration inhibitory factor (MIF) in pancreatic stellate cells (PSCs) |
1.2 | | Lhx6 | 'Adjuvant System 03' vs 'PBS' in 'lymph node' at '6 hour' | organism part, stimulus, time | Expression data from draining lymph node and muscle of mice immunised with AS03 or PBS |
1.2 | | Lhx6 | 'tamoxifen induction at 2 months, wait 3 months' vs 'no tamoxifen induction' in 'basal cell of prostate epithelium; CK5-CreERT2 transgenic line' | cell type, genotype, growth condition | Transcription profiling by high throughput sequencing of PIN/tumor lesions from basal or luminal origins at time points at which mice displayed similar histopathological phenotypes |
1.2 | | Lhx6 | 'Trichuris muris' vs 'control' in 'non wormy; caecum' | environmental stress, infect, organism part | RNA-seq of mouse intestinal mucosa to investigate infection by the parasitic nematode Trichuris muris |
-1.2 | | Lhx6 | 'beta(3)-adrenergic agonist Cl316,243' vs 'none' at '10 week' | age, stimulus | RNA-seq of age-associated transcriptome changes in brown adipose tissue |
1.1 | | Lhx6 | 'LDB1 knock-down with Ldb1 delta 4/5 construct' vs 'control shRNA' | RNA interference | Role of LDB1 in the transition from chromatin looping to transcription activation |
-1.1 | | Lhx6 | '6 day; osteogenesis differentiation' vs ' 0 day; control' in '2C12-pMirn378' | cell line, growth condition, time | Effect of Mirn378 overexpression on gene expression during C2C12 myogenic and BMP2-induced osteogenic differentiation |
-1.1 | | Lhx6 | '6 day; myogenesis differentiation' vs ' 0 day; control' in '2C12-pMirn0' | cell line, growth condition, time | Effect of Mirn378 overexpression on gene expression during C2C12 myogenic and BMP2-induced osteogenic differentiation |
1.1 | | Lhx6 | 'subconfluent monolayer on collagen' at '2 day' vs 'freshly isolated' at '0 day' | growth condition, time | Transcription profiling of primary mouse hepatocytes under different culture conditions |
1.1 | | Lhx6 | 'SARS coronavirus MA15; 10^5 PFU' vs 'none' at '4 day' | stimulus, time | SM001: SARS CoV MA15 infection of C57Bl/6 mouse model – Data from 4 viral doses at 1, 2, 4 and 7 days post infection. |
1.1 | | Lhx6 | 'SARS coronavirus MA15; 4 day' vs 'mock' in 'PWK/PhJ' | infect, strain, time | Genomic profiling of collaborative cross founder mouse strains infected with respiratory viruses to discover novel transcripts and infection-related strain-specific gene and isoform expression |
1.1 | | Lhx6 | 'SARS coronavirus MA15' vs 'none' at '1 day' | infect, time | SM012 - SARS MA15 wild type, and SARS deltaORF6 mutant virus infections of C57BL6 mice - A time course |
-1.1 | | Lhx6 | 'Abcc8-/-' vs 'wild type genotype' in 'normal; male' | diet, genotype, sex | Effects of increased intracellular calcium and overnutrition on pancreatic beta cell transcriptome |
1.1 | | Lhx6 | 'stabilization-competent' vs 'stabilization-incompetent' in '23 day; secondary reprogramming cell' | age, cell type, phenotype | Transcription profiling by high throughput sequencing in gene expresion profile of 4 SC clones and 4 SI clones at different time points defined a stabilization competency signiture |
1 | | Lhx6 | 'confluent monolayer on collagen' at '3 day' vs 'freshly isolated' at '0 day' | growth condition, time | Transcription profiling of primary mouse hepatocytes under different culture conditions |
-1 | | Lhx6 | 'L-Pex5 knock-out' vs 'wild type' | genotype | Transcription profiling by array of liver from L-Pex5 knock-out mice |
1 | | Lhx6 | 'confluent monolayer on collagen' at '5 day' vs 'freshly isolated' at '0 day' | growth condition, time | Transcription profiling of primary mouse hepatocytes under different culture conditions |
1 | | Lhx6 | 'SARS coronavirus MA15; 10^5 PFU' vs 'none' at '2 day' | stimulus, time | SM001: SARS CoV MA15 infection of C57Bl/6 mouse model – Data from 4 viral doses at 1, 2, 4 and 7 days post infection. |
-1 | | Lhx6 | 'trypsinized and mock FACS sorted' vs 'untreated' | treatment | Expression data from mammary epithelial cells harvested from 8-9 week old C3H female mice - various isolation conditions |
1 | | Lhx6 | 'extracellular vesicle; EMT cell culture medium' vs 'none' | sampling site, stimulus | Cellular and extracellular vesicle RNA sequence for E-cadherin-RFP EMT reporter system expressing mouse breast cancer cell line Py2T during EMT/MET |
1 | | Lhx6 | 'Influenza A virus (A/Puerto Rico/8/1934(H1N1)); 2 day' vs 'mock' in '129S1/SvImJ' | infect, strain, time | Genomic profiling of collaborative cross founder mouse strains infected with respiratory viruses to discover novel transcripts and infection-related strain-specific gene and isoform expression |
-1 | | Lhx6 | 'liver-specific Gp130 knockout mice [Gp130delta(hepa)]; cecal ligation and puncture' vs 'liver-specific Gp130 knockout mice [Gp130delta(hepa)]; control' | genotype, treatment | Hepatic acute phase proteins control innate immune responses during infection by promoting myeloid derived suppressor cell function |
-1 | | Lhx6 | 'transgenic C3(1)-SV40Tag; 20 week' vs 'wild type; 8 week' | age, genotype | Prevention of mammary tumor progression by silencing HoxA1 via intraductal injection of nanoparticle-formulated siRNA |
1 | | Lhx6 | 'SARS coronavirus MA15' vs 'none' at '4 day' | infect, time | SM012 - SARS MA15 wild type, and SARS deltaORF6 mutant virus infections of C57BL6 mice - A time course |
-1 | | Lhx6 | 'natural ingredient' vs 'control' | diet | Liver mRNA microarray study for mice treated with various diets |
-1 | | Lhx6 | 'heat-shocked at 42 degreeC' vs 'grown at 33 degreeC' in 'HdhQ111 knock-in' | genotype, growth condition | Transcription profiling by array of mouse wild type and Htt mutant striatal cells upon heat shock |
-1 | | Lhx6 | 'diet restriction' vs 'control' | diet | Liver mRNA microarray study for mice treated with various diets |