ENSMUSG00000044468 (Tent5c)

mus musculus

terminal nucleotidyltransferase 5C

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Mus musculus
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Showing 56 experiments:
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49 FANTOM5 project - adult
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49 FANTOM5 project - neonate
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49 FANTOM5 project - juvenile
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49 FANTOM5 project - embryonic day 18
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49 FANTOM5 project - embryonic day 17
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49 FANTOM5 project - embryonic day 16
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49 FANTOM5 project - embryonic day 15
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49 FANTOM5 project - embryonic day 14
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49 FANTOM5 project - embryonic day 12
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9 in 3 strains - DBA/2J
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9 in 3 strains - CD1
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14 - embryonic day 10.5
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9 in 3 strains - C57BL/6
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49 FANTOM5 project - embryonic day 13
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Mammalian Kaessmann
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GENCODE
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Vertebrates
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14 - embryonic day 9.5
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14 - embryonic day 8.5
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4 Bonthuis et al - CastEiJ
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Developing gut
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49 FANTOM5 project - embryonic day 11
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Gregg et al - CAST/EiJ
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Gregg et al - C57BL/6J
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Gregg et al - (CAST/EiJ X C57BL/6J)F1
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Gregg et al - (C57BL/6J X CAST/EiJ)F1
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4 Bonthuis et al - (CastEiJ X …
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4 Bonthuis et al - (C57BL/6J X …
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Mernberger et al 2019 - Organism Part
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49 FANTOM5 project - pregnant adult day …
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49 FANTOM5 project - pregnant adult day …
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3 Soumillon et al
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Sun et al., 2020 - Organism part
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4 Bonthuis et al - C57BL/6J
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Fat and muscle
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49 FANTOM5 project - pregnant adult day …
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49 FANTOM5 project - embryonic day 17.5
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49 FANTOM5 project - embryonic day 14.5
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49 FANTOM5 project - embryo
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4 Bonthuis et al - Idaho derived wild …
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Huttlin et al., 2010 - tissues - brain, …
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Linscheid et al., 2021 - tissue - heart …
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Duda et al., 2018 - organism part - …
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Duda et al., 2018 - organism part - …
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Linscheid et al. 2019 - organism part
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Deshmukh et al., 2015 - organism part
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Zhao et al., 2019 - tissue - lens
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Meierhofer et al., 2016 - organism part
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Proteomics
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Experimental variables
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Log2-fold changeSpeciesGene nameComparisonExperimental variablesExperiment name
Adjusted p-valueLog2-fold change
4.2904 × 10-26.8
Tent5c'CD81 positive' vs 'CD81 negative' in 'subcutaneous adipose tissue'organism part, phenotypeRNA-seq comparison of CD81 positive and negative cells in subcutaneous and visceral white fat and brown fat tissues in mouse
Adjusted p-valueLog2-fold change
8.621 × 10-96.3
Tent5c'erythroblast' vs 'hematopoietic stem cell'cell typeTranscription profiling by array of primary megakaryocytes (MEG) and erythroblasts (ERY) developed from murine fetal liver hematopoietic stem cells
Adjusted p-valueLog2-fold change
1.1118 × 10-1675.3
Tent5c'Influenza A virus' vs 'none'infectRNA-seq of mouse alveolar macrophages from control and Influenza A virus infected animals
Adjusted p-valueLog2-fold change
1.0733 × 10-12-5
Tent5c'Plasmodium berghei' vs 'none' in 'none'compound, infectTranscription profiling by array of mouse blood infected with Plasmodium berghei after treatment with activated charcoal
Adjusted p-valueLog2-fold change
6.9634 × 10-34.5
Tent5c'Vgamma6+, IL-17+' at '21 month' vs '3 month'age, phenotypeRNA sequencing of gamma-delta T cell subsets from young and old mice
Adjusted p-valueLog2-fold change
2.8239 × 10-44.4
Tent5c'120 day; Sod1 G93A' vs '120 day; wild type genotype'age, genotypeTranscription profiling of astrocytes from the symptomatic and late-stage time points of the SOD1(G93A) mouse model of amyotrophic lateral sclerosis (ALS)
Adjusted p-valueLog2-fold change
6.2807 × 10-94.3
Tent5c'transgenic' vs 'wild type' in '160 day; C57BL/6'age, genotype, strainWhole genome transcriptome analysis identifies indices of fast and slow disease progression in two ALS mouse models
Adjusted p-valueLog2-fold change
4.9998 × 10-94.2
Tent5c'transgenic' vs 'wild type' in '121 day; 129Sv'age, genotype, strainWhole genome transcriptome analysis identifies indices of fast and slow disease progression in two ALS mouse models
Adjusted p-valueLog2-fold change
7.1085 × 10-7-4.1
Tent5c'neural progenitor cell' vs 'niche cell'cell typeTranscription profiling by high throughput sequencing of three populations of primary dentate gyrus cells
Adjusted p-valueLog2-fold change
1.5229 × 10-18-4
Tent5c'PTEN null, P53-/-' vs 'wild type genotype'genotypeRNA seq of prostate gland from WT, PTEN pc -/- and PTEN pc-/-;P53 -/- mice
Adjusted p-valueLog2-fold change
2.4341 × 10-233.9
Tent5c'proliferating progenitor' vs 'differentiating progenitor'cell typeTranscription profiling by high throughput sequencing of proliferating neural stem cells, differentiating neurogenic progenitors and newborn neurons using a dual-reporter mouse line
Adjusted p-valueLog2-fold change
4.7946 × 10-63.9
Tent5c'megakaryocyte' vs 'hematopoietic stem cell'cell typeTranscription profiling by array of primary megakaryocytes (MEG) and erythroblasts (ERY) developed from murine fetal liver hematopoietic stem cells
Adjusted p-valueLog2-fold change
2.1291 × 10-2103.8
Tent5c'doxorubicin; 17.5 milligram per kilogram body weight' vs 'vehicle' in 'scramble; podocyte'cell type, compound, genotypeTranscription profiling to identify the role of MOF in primary MEFs and differentiated podocytes in response to Adriamycin
Adjusted p-valueLog2-fold change
2.9466 × 10-3-3.7
Tent5c'doxorubicin; 15 milligram per kilogram; wild type' vs 'none; ; wild type'compound, genotypeExpression data from DOX(doxorubicin) -treated wild type or CHIP knockout C57BL/6J mice at day 5
Adjusted p-valueLog2-fold change
2.0175 × 10-33.6
Tent5c'Lin- CD44- CD25+ thymocyte progenitor cell; embryonic day 14.5' vs 'Lin- CD44- CD25+ thymocyte progenitor cell; adult'cell type, developmental stageTranscription profiling of mouse adult and fetal T cell progenitors
Adjusted p-valueLog2-fold change
4.7061 × 10-343.5
Tent5c'extraembryonic endoderm stem cell; grown in ES cell medium' vs 'mouse embryonic fibroblast; control'cell type, growth conditionOSKM induce extraembryonic endoderm stem (iXEN) cells in parallel to iPS cells
Adjusted p-valueLog2-fold change
4.3786 × 10-43.5
Tent5c'transgenic' vs 'wild type' in '152 day; C57BL/6'age, genotype, strainWhole genome transcriptome analysis identifies indices of fast and slow disease progression in two ALS mouse models
Adjusted p-valueLog2-fold change
5.1352 × 10-8-3.4
Tent5c'anti-CD3/CSA' vs 'anti-CD3' in 'cyclosporine-sensitive'phenotype, treatmentActivating CD8 T cell clones via the T cell receptor complex in the absence and presence of cyclosporine A
Adjusted p-valueLog2-fold change
4.3066 × 10-43.4
Tent5c'transgenic' vs 'wild type' in '133 day; C57BL/6'age, genotype, strainWhole genome transcriptome analysis identifies indices of fast and slow disease progression in two ALS mouse models
Adjusted p-valueLog2-fold change
4.0861 × 10-163.3
Tent5c'clear cell sarcoma; TATCre' vs 'control'disease, genotypeMouse Model of Clear Cell Sarcoma
Adjusted p-valueLog2-fold change
4.793 × 10-5-3.3
Tent5c'cetrorelix; 3 milligram per kilogram' vs 'none' in 'inh-alpha/Tag transgenic'compound, genotypeNovel genes involved in the pathophysiology of gonadotropin-dependent adrenocortical tumorigenesis in mice.
Adjusted p-valueLog2-fold change
1.4279 × 10-23.3
Tent5c'heterozygous dn-p21ras' vs 'wild type'genotypeTranscription profiling of heart ventricles from 10 week old mice heterozygous for dn-p21ras and 3 month old wild type FVB mice to study severe dilated cardiomyopathy.
Adjusted p-valueLog2-fold change
1.9105 × 10-213.2
Tent5c'carotid body' vs 'adrenal medulla'organism partExpression profile of mouse carotid body and adrenal medulla [RNA-Seq]
Adjusted p-valueLog2-fold change
1.3555 × 10-173.2
Tent5c'induced extraembryonic endoderm stem cell; grown in ES cell medium' vs 'mouse embryonic fibroblast; control'cell type, growth conditionOSKM induce extraembryonic endoderm stem (iXEN) cells in parallel to iPS cells
Adjusted p-valueLog2-fold change
8.4387 × 10-53.2
Tent5c'inh-alpha/Tag transgenic' vs 'wild type' in 'none'compound, genotypeNovel genes involved in the pathophysiology of gonadotropin-dependent adrenocortical tumorigenesis in mice.
Adjusted p-valueLog2-fold change
9.1736 × 10-913.1
Tent5c'SMRT shRNA; CpG; 6 hour' vs 'none; none; 0 hour'RNA interference, stimulus, timeRNA-seq of Control and SMRT KD CD8α+ DCs at 0hr and 6hr CpG stimulation
Adjusted p-valueLog2-fold change
6.6435 × 10-153.1
Tent5c'PF-04691502–resistant cell; 1 micromolar; PF-04691502 removed for 48 hours' vs 'parental AKP cell; dimethyl sulfoxide'compound, phenotypeResistance to PI3K/mTOR inhibitor PF-04691502 in KRAS mutant colorectal cancer models reveals a sensitivity to combination with EGFR inhibition
Adjusted p-valueLog2-fold change
3.2982 × 10-53.1
Tent5c'untreated; Csf2rb-/-' vs 'untreated; wild type'clinical history, genotypeMouse GM-CSF-related alveolar macrophage genome-wide expression data
Adjusted p-valueLog2-fold change
1.2822 × 10-43.1
Tent5c'undifferentiated' vs 'differentiated; rosiglitazone' in 'AKR/J'phenotype, stimulus, strainRNA-seq of mouse subcutaneous SVF cells before and after differentiation with a brown fat differentiation cocktail
Adjusted p-valueLog2-fold change
4.8259 × 10-43.1
Tent5c'Alb-Cre;HIF1dPA/HIF2dPA' vs 'Alb-Cre'genotypeTranscription profiling by array of mice with liver-specific expression of hypoxia inducible factor, or inactivated von Hippel-Lindau tumor suppressor
Adjusted p-valueLog2-fold change
2.4136 × 10-953
Tent5c'Helicobacter hepaticus' vs 'none' in 'Alpk1 homozygous knockout'infect, phenotypeWhole transcriptome profiling of the steady state and Hh-treated (8 hrs) Alpk1+/- (heterozygous) and Alpk1-/- (knockout) BMDMs using RNA-Sequencing approach
Adjusted p-valueLog2-fold change
7.1634 × 10-173
Tent5c'SR-BI-/- apoE-/-' vs 'control' in '43 day; Chow diet'age, diet, genotypeExpression data from the hearts of a mouse model of spontaneous myocardial infarction
Adjusted p-valueLog2-fold change
3.5907 × 10-10-3
Tent5c'180 day' vs '1 day'ageTranscriptional profilling of female mice liver as a function of age
Adjusted p-valueLog2-fold change
8.9689 × 10-142.9
Tent5c'wormy, worm separated; Trichuris muris' vs 'control; non wormy' in 'caecum'environmental stress, infect, organism partRNA-seq of mouse intestinal mucosa to investigate infection by the parasitic nematode Trichuris muris
Adjusted p-valueLog2-fold change
3.5226 × 10-122.9
Tent5c'wormy, worm left; Trichuris muris' vs 'control; non wormy' in 'caecum'environmental stress, infect, organism partRNA-seq of mouse intestinal mucosa to investigate infection by the parasitic nematode Trichuris muris
Adjusted p-valueLog2-fold change
2.1667 × 10-9-2.9
Tent5c'365 day' vs '1 day'ageTranscriptional profilling of female mice liver as a function of age
Adjusted p-valueLog2-fold change
4.6103 × 10-72.9
Tent5c'TMEV infected' at '98 day' vs 'mock control' at '98 day'disease, timeTranscription profiling of mouse spinal cord from mock-infected and Theilers murine encephalomyelitis (TME)-virus infected animals - time series
Adjusted p-valueLog2-fold change
5.319 × 10-742.8
Tent5c'CpG; 6 hour' vs 'none; 0 hour' in 'none'RNA interference, stimulus, timeRNA-seq of Control and SMRT KD CD8α+ DCs at 0hr and 6hr CpG stimulation
Adjusted p-valueLog2-fold change
8.1512 × 10-62.8
Tent5c'Plasmodium chabaudi infection' vs 'no infection' in 'adjuvant only'infect, treatmentProtective vaccination against blood-stage malaria of Plasmodium chabaudi: differential gene expression in the liver of Balb/c mice towards the end of crisis phase
Adjusted p-valueLog2-fold change
6.1806 × 10-52.8
Tent5c'trichostatin A and LIF' at '12 hour' vs 'none' at '0 hour'compound, timeTranscription profiling of mouse embryonic stem cell line CGR8 grown in presence of Leukemia Inhibitory Factor and treated with trichostatin A
Adjusted p-valueLog2-fold change
2.3142 × 10-42.8
Tent5c'MOG35-55' vs 'none' at '20 day'compound, timeTranscriptomic profiling in the animal model of multiple sclerosis
Adjusted p-valueLog2-fold change
3.0148 × 10-9-2.7
Tent5c'90 day' vs '1 day'ageTranscriptional profilling of female mice liver as a function of age
Adjusted p-valueLog2-fold change
5.5382 × 10-9-2.7
Tent5c'60 day' vs '1 day'ageTranscriptional profilling of female mice liver as a function of age
Adjusted p-valueLog2-fold change
1.3928 × 10-3-2.7
Tent5c'19BL; differentiated 3factor-reprogrammed induced pluripotent stem cell' vs 'R1; differentiated embryonic stem cell' at '11 day'cell line, growth condition, timeNatural cardiogenesis-based template predicts cardiogenic potential of induced pluripotent stem cell lines
Adjusted p-valueLog2-fold change
5.6828 × 10-32.7
Tent5c'90 day; Sod1 G93A' vs '90 day; wild type genotype'age, genotypeTranscription profiling of astrocytes from the symptomatic and late-stage time points of the SOD1(G93A) mouse model of amyotrophic lateral sclerosis (ALS)
Adjusted p-valueLog2-fold change
1.5534 × 10-14-2.6
Tent5c'neuron' vs 'differentiating progenitor'cell typeTranscription profiling by high throughput sequencing of proliferating neural stem cells, differentiating neurogenic progenitors and newborn neurons using a dual-reporter mouse line
Adjusted p-valueLog2-fold change
5.9682 × 10-8-2.6
Tent5c'H-Ras expression; c-Myc activation' vs 'wild type'phenotypeRNA-seq of heart tissue from 15 day old mice 4 hours post MycER activation compared to wild type controls. RNA-seq of heart tissues from adult mice that have expressed oncogenic H-Ras for 4 weeks followed by MycER activation for 4 hours compared to MycER negative controls.
Adjusted p-valueLog2-fold change
9.0375 × 10-612.5
Tent5c'CpG; 6 hour' vs 'none; 0 hour' in 'SMRT shRNA'RNA interference, stimulus, timeRNA-seq of Control and SMRT KD CD8α+ DCs at 0hr and 6hr CpG stimulation
Adjusted p-valueLog2-fold change
2.4556 × 10-72.5
Tent5c'TMEV infected' at '196 day' vs 'mock control' at '196 day'disease, timeTranscription profiling of mouse spinal cord from mock-infected and Theilers murine encephalomyelitis (TME)-virus infected animals - time series
Adjusted p-valueLog2-fold change
1.542 × 10-52.5
Tent5c'MOG35-55' vs 'none' at '40 day'compound, timeTranscriptomic profiling in the animal model of multiple sclerosis
Adjusted p-valueLog2-fold change
2.0959 × 10-42.5
Tent5c'transgenic' vs 'wild type' in '111 day; 129Sv'age, genotype, strainWhole genome transcriptome analysis identifies indices of fast and slow disease progression in two ALS mouse models
Adjusted p-valueLog2-fold change
1.5668 × 10-32.5
Tent5c'Plasmodium chabaudi infection' vs 'no infection' in 'vaccination'infect, treatmentProtective vaccination against blood-stage malaria of Plasmodium chabaudi: differential gene expression in the liver of Balb/c mice towards the end of crisis phase
Adjusted p-valueLog2-fold change
9.3829 × 10-3-2.5
Tent5c'RAW264.7 macrophage cell line; control' vs 'bone marrow macrophage; control'cell type, growth conditionTranscription profiling of mouse bone marrow macrophages (BMM) compared to BMM co-cultured with 4T1.2 breast cancer cells, treated with tumour cell supernatant, or RAW macrophage cell line
Adjusted p-valueLog2-fold change
4.2552 × 10-2-2.5
Tent5c'induction of polymicrobial sepsis' vs 'control' at '72 hour' in '20 to 24 month mice'age, time, treatmentAged Mice are Unable to Mount an Effective Myeloid Response to Sepsis
Adjusted p-valueLog2-fold change
1.1394 × 10-232.4
Tent5c'Helicobacter hepaticus' vs 'none' in 'wild type phenotype'infect, phenotypeWhole transcriptome profiling of the steady state and Hh-treated (8 hrs) Alpk1+/- (heterozygous) and Alpk1-/- (knockout) BMDMs using RNA-Sequencing approach
Adjusted p-valueLog2-fold change
4.1991 × 10-72.4
Tent5c'Trichuris muris' vs 'control' in 'non wormy; caecum'environmental stress, infect, organism partRNA-seq of mouse intestinal mucosa to investigate infection by the parasitic nematode Trichuris muris
Adjusted p-valueLog2-fold change
6.4277 × 10-7-2.4
Tent5c'730 day' vs '1 day'ageTranscriptional profilling of female mice liver as a function of age
Adjusted p-valueLog2-fold change
2.8908 × 10-22.4
Tent5c'Runx3 knockout' vs 'wild type genotype' in 'IL-2'compound, genotypeRunx3 function in splenic NK cells (IL-2 or IL-15)
Adjusted p-valueLog2-fold change
3.6422 × 10-102.3
Tent5c'dexamethasome' vs 'methyl beta-clodextrin' in 'Nr1d1 homozygous knockout; 1 milligram per kilogram; ZT6'compound, genotype, timeRNASeq data analysis of wild type and reverb alpha knockout cells from mouse liver, at different time points, with or without DEX treatment
Adjusted p-valueLog2-fold change
1.9242 × 10-4-2.3
Tent5c'one year after pulmonary macrophage transplantation; Csf2rb-/-' vs 'untreated; Csf2rb-/-'clinical history, genotypeMouse GM-CSF-related alveolar macrophage genome-wide expression data
Adjusted p-valueLog2-fold change
1.3311 × 10-32.3
Tent5c'transgenic' vs 'wild type' in '101 day; 129Sv'age, genotype, strainWhole genome transcriptome analysis identifies indices of fast and slow disease progression in two ALS mouse models
Adjusted p-valueLog2-fold change
1.274 × 10-22.3
Tent5c'miR-155 overexpression' vs 'wild type genotype'genotypeExpression analysis of eu-miR-155 transgenic mice B-cells.
Adjusted p-valueLog2-fold change
2.5553 × 10-22.3
Tent5c'uterine-specific Tsc2-null' vs 'wild type' in '17beta-estradiol'genotype, treatmentTranscription profiling by high throughput sequencing of uterine-specific Tsc2-null mice
Adjusted p-valueLog2-fold change
7.125 × 10-202.2
Tent5c'Lymphocytic choriomeningitis mammarenavirus' vs 'none' in 'wild type genotype'genotype, infectComparison of Trail+/+ versus Trail-/- splenic NK cells from naïve and LCMV-infected mice
Adjusted p-valueLog2-fold change
7.1768 × 10-102.2
Tent5c'SR-BI-/- apoE-/-' vs 'control' in '31 day; Chow diet'age, diet, genotypeExpression data from the hearts of a mouse model of spontaneous myocardial infarction
Adjusted p-valueLog2-fold change
1.8362 × 10-92.2
Tent5c'14 days P. chabaudi infected' vs 'uninfected' in 'gonadectomized female'clinical information, disease, sex, timeTranscription profiling by array of mice infected with Plasmodium chabaudi after gonadectomization to investigate involvement of gonadal steroids
Adjusted p-valueLog2-fold change
1.4372 × 10-6-2.2
Tent5c'21 day' vs '1 day'ageTranscriptional profilling of female mice liver as a function of age
Adjusted p-valueLog2-fold change
3.6206 × 10-5-2.2
Tent5c'30 day' vs '1 day'ageTranscriptional profilling of female mice liver as a function of age
Adjusted p-valueLog2-fold change
3.9253 × 10-52.2
Tent5c'Lymphocytic choriomeningitis mammarenavirus' vs 'none' in 'TRAIL homozygous knock out'genotype, infectComparison of Trail+/+ versus Trail-/- splenic NK cells from naïve and LCMV-infected mice
Adjusted p-valueLog2-fold change
1.2647 × 10-32.2
Tent5c'extraembryonic endoderm stem cell; grown in XEN cell medium' vs 'mouse embryonic fibroblast; control'cell type, growth conditionOSKM induce extraembryonic endoderm stem (iXEN) cells in parallel to iPS cells
Adjusted p-valueLog2-fold change
5.9158 × 10-3-2.2
Tent5c'conditional UPF2 knockout; 36 hour after partial hepatechtomy' vs 'conditional UPF2 knockout; before partial hepatechtomy'genotype, sampling timeTranscription profiling of livers of adult UPF2 null mice in response to partial hepatechtomy
Adjusted p-valueLog2-fold change
7.0738 × 10-82.1
Tent5c'estradiol' at '30 hour' vs 'none' at '0 hour'compound, timeTranscription profiling by array of G1E cells during time course treatment with estradiol.
Adjusted p-valueLog2-fold change
6.5032 × 10-72.1
Tent5c'TMEV infected' at '42 day' vs 'mock control' at '42 day'disease, timeTranscription profiling of mouse spinal cord from mock-infected and Theilers murine encephalomyelitis (TME)-virus infected animals - time series
Adjusted p-valueLog2-fold change
1.1001 × 10-6-2.1
Tent5c'14 day' vs '1 day'ageTranscriptional profilling of female mice liver as a function of age
Adjusted p-valueLog2-fold change
2.805 × 10-52.1
Tent5c'trichostatin A and LIF' at '6 hour' vs 'none' at '0 hour'compound, timeTranscription profiling of mouse embryonic stem cell line CGR8 grown in presence of Leukemia Inhibitory Factor and treated with trichostatin A
Adjusted p-valueLog2-fold change
4.399 × 10-4-2.1
Tent5c'spontaneous lung tumor' vs 'normal'disease state, diseaseTranscription profiling by array of spontaneous lung tumors in mice to compare to human non-small cell lung cancer
Adjusted p-valueLog2-fold change
9.163 × 10-3-2.1
Tent5c'metaphase II oocyte' vs 'germinal vesicle oocyte'cell typeTranscription profiling of mouse in vivo matured MII oocytes and fully in vivo grown germinal vesicle oocytes to identify gene transcripts linked to epigenetic reprogramming
Adjusted p-valueLog2-fold change
1.3248 × 10-22.1
Tent5c'10 nanogram per milliliter; TGF-beta1' vs 'none' in 'common dendritic progenitor' at '2 hour'cell type, compound, timeDynamic Gene Expression Response to TGF-b Stimulation in Multipotent Progenitors and Common Dendritic Cell Progenitors
Adjusted p-valueLog2-fold change
3.879 × 10-22.1
Tent5c'Alb-Cre;HIF2dPA' vs 'Alb-Cre'genotypeTranscription profiling by array of mice with liver-specific expression of hypoxia inducible factor, or inactivated von Hippel-Lindau tumor suppressor
Adjusted p-valueLog2-fold change
9.026 × 10-292
Tent5c'germ free C57BL/6' vs 'specific pathogen free C57BL/6' in 'wild type genotype'genotype, strainRNA sequencing of primary isolated unstimulated murine splenic cDC from specific pathogen free (SPF), Germ Free (GF) and Interferon alpha/beta receptor 1 (Ifnar) knock out mice.
Adjusted p-valueLog2-fold change
1.3505 × 10-22-2
Tent5c'KrasG12D' vs 'wild type'genotypeAn oncogenic Kras expression signature identified by cross-species
Adjusted p-valueLog2-fold change
5.5763 × 10-11-2
Tent5c'Zbtb10 knockdown' vs 'control' at '6 hour'genotype, timeRNA-seq of Zbtb10 Knockdown and Control cDC1 dendritic cells (Cd8+)
Adjusted p-valueLog2-fold change
3.6887 × 10-5-2
Tent5c'wild type; mature luminal' vs 'wild type; MaSC/basal'cell type, genotypeExpression data from sorted control and Pygo2-null mouse mammary stem/basal cells
Adjusted p-valueLog2-fold change
5.3172 × 10-42
Tent5c'10 nanogram per milliliter; TGF-beta1' vs 'none' in 'common dendritic progenitor' at '4 hour'cell type, compound, timeDynamic Gene Expression Response to TGF-b Stimulation in Multipotent Progenitors and Common Dendritic Cell Progenitors
Adjusted p-valueLog2-fold change
1.0677 × 10-3-2
Tent5c'pkd1 knockout' vs 'wild type' in 'presence of fluid flow'genotype, stimulusTranscription profiling by array of mouse kidney epithelial cells from pkd1 knockout and wild type in response to fluid flow
Adjusted p-valueLog2-fold change
1.9186 × 10-2-2
Tent5c'doxorubicin; 15 milligram per kilogram; CHIP knockout' vs 'none; ; CHIP knockout'compound, genotypeExpression data from DOX(doxorubicin) -treated wild type or CHIP knockout C57BL/6J mice at day 5
Adjusted p-valueLog2-fold change
2.7345 × 10-481.9
Tent5c'lipopolysaccharide; 10 nanogram per milliliter' vs 'none' in 'primary cell line; MEF2C/D knockout'cell line, compound, genotypeBulk RNA-seq of wild type and MEF2A or MEF2C/D knockout mouse bone marrow macrophages under different stimulation conditions
Adjusted p-valueLog2-fold change
2.3349 × 10-8-1.9
Tent5c'Kit ligand' vs 'none' in 'wasp knockout'compound, genotypeTranscription profiling of bone marrow–derived mast cells from WASP-deficient mice after stimulation with kit ligand
Adjusted p-valueLog2-fold change
4.7595 × 10-81.9
Tent5c'3 day; osteogenesis differentiation' vs ' 0 day; control' in '2C12-pMirn378'cell line, growth condition, timeEffect of Mirn378 overexpression on gene expression during C2C12 myogenic and BMP2-induced osteogenic differentiation
Adjusted p-valueLog2-fold change
1.483 × 10-51.9
Tent5c'14 days P. chabaudi infected' vs 'uninfected' in 'intact female'clinical information, disease, sex, timeTranscription profiling by array of mice infected with Plasmodium chabaudi after gonadectomization to investigate involvement of gonadal steroids
Adjusted p-valueLog2-fold change
3.7374 × 10-5-1.9
Tent5c'SARS coronavirus MA15' vs 'none' in 'STAT1 -/-' at '5 day'genotype, infect, timeTranscriptomic analysis of host response to mouse-adapted SARS virus in wild type, STAT1 -/-, and IFNAR1 -/- mouse genetic backgrounds
Adjusted p-valueLog2-fold change
1.5275 × 10-41.9
Tent5c'estradiol' at '21 hour' vs 'none' at '0 hour'compound, timeTranscription profiling by array of G1E cells during time course treatment with estradiol.
Adjusted p-valueLog2-fold change
6.7831 × 10-4-1.9
Tent5c'azoxymethane and dextran sodium sulfate' vs 'control' in 'Myd88 knockout'compound, genotypeGene expression profiling of total colon in AOM/DSS-treated Myd88 knockout and wild type
Adjusted p-valueLog2-fold change
7.2685 × 10-3-1.9
Tent5c'V6.5; embryonic stem cell’ vs 'wild type; endothelial'cell line, cell type, genotypeCD47 Inhibits Self-renewal and Reprogramming by Regulating c-Myc and Other Stem Cell Transcription Factors
Adjusted p-valueLog2-fold change
4.0793 × 10-21.9
Tent5c'20 day; Ad-VEGF-A164' vs '0 day; control'time, treatmentTranscription profiling by array of stromal-based signatures for the classification of gastric cance
Adjusted p-valueLog2-fold change
4.7792 × 10-391.8
Tent5c'Ifnar1 knockout' vs 'wild type genotype' in 'specific pathogen free C57BL/6'genotype, strainRNA sequencing of primary isolated unstimulated murine splenic cDC from specific pathogen free (SPF), Germ Free (GF) and Interferon alpha/beta receptor 1 (Ifnar) knock out mice.
Adjusted p-valueLog2-fold change
1.2771 × 10-351.8
Tent5c'Aire knockout' vs 'wild type' in 'mTEClo'genotype, phenotypeTranscription profiling by high throughput sequencing of primary cTEC, mTEClo, and mTEChi harvested from wild type and Aire-deficient mice
Adjusted p-valueLog2-fold change
2.4836 × 10-191.8
Tent5c'nmf205, Gcn2 double mutant' vs 'wild type'genotypeTranscription profiling by high throughput sequencing in cerebellum of mouse Gcn2 -/-, nmf205-/- and nmf205-/-;Gcn2-/-
Adjusted p-valueLog2-fold change
1.6351 × 10-12-1.8
Tent5c'SARS coronavirus MA15; 4 day' vs 'mock' in '129S1/SvImJ'infect, strain, timeGenomic profiling of collaborative cross founder mouse strains infected with respiratory viruses to discover novel transcripts and infection-related strain-specific gene and isoform expression
Adjusted p-valueLog2-fold change
1.5682 × 10-61.8
Tent5c'ATF3 -/-' vs 'wild type' in '10 nanogram per milliliter; lipopolysaccharide' at '2 hour'compound, genotype, timeTranscription profiling by array of mouse bone marrow macrophages mutant for ATF3 after treatment with lipopolysaccharide
Adjusted p-valueLog2-fold change
9.9374 × 10-51.8
Tent5c'PF-04691502–resistant cell; 1 micromolar; PF-04691502' vs 'parental AKP cell; dimethyl sulfoxide'compound, phenotypeResistance to PI3K/mTOR inhibitor PF-04691502 in KRAS mutant colorectal cancer models reveals a sensitivity to combination with EGFR inhibition
Adjusted p-valueLog2-fold change
2.1238 × 10-31.8
Tent5c'10 nanogram per milliliter; TGF-beta1' vs 'none' in 'common dendritic progenitor' at '24 hour'cell type, compound, timeDynamic Gene Expression Response to TGF-b Stimulation in Multipotent Progenitors and Common Dendritic Cell Progenitors
Adjusted p-valueLog2-fold change
4.9139 × 10-21.8
Tent5c'eNOS knockout' vs 'wild type'genotypeTranscription profiling by array of left ventricles from eNOS knock-out mice
Adjusted p-valueLog2-fold change
2.123 × 10-22-1.7
Tent5c'5 week' vs '1 week' in 'Jak2+/V617F; CRISPR/Cas9 mediated knockout of Dnmt3a'genotype, timeRNA-seq of Jak2VF LSK cells transduced with Dnmt3a-Cas9-GFP lentivirus vs. emp-Cas9-GFP controls one week and five weeks post methylcellulose plating
Adjusted p-valueLog2-fold change
4.2992 × 10-20-1.7
Tent5c'intestinal smooth muscle culture supernatant' vs 'none' in 'organoid culture (ENR medium)'growth condition, stimulusRNA-seq of small intestinal organoids treated with the control medium ENR (EGF, Noggin, R-spondin1) in the presence or absence of muscle supernatant
Adjusted p-valueLog2-fold change
2.3753 × 10-191.7
Tent5c'dexamethasone; 100 nanomolar' vs 'none'compound, stimulusRNA-Seq of murine lung endothelial cells stimulated with IFN-gamma and dexamethasone
Adjusted p-valueLog2-fold change
2.864 × 10-15-1.7
Tent5c'interferon gamma' vs 'dexamethasone; 100 nanomolar'compound, stimulusRNA-Seq of murine lung endothelial cells stimulated with IFN-gamma and dexamethasone
Adjusted p-valueLog2-fold change
1.2515 × 10-111.7
Tent5c'Triple knockout (Zfp36-/-, TNFR1-/-, TNFR2-/-)' vs 'wild type'genotypeTranscription profiling by high throughput sequencing of douple (TNFR1-/-/TNFR2-/-) and triple (Zfp36-/-/TNFR1-/-/TNFR2-/-) knockout mouse spleens
Adjusted p-valueLog2-fold change
3.8076 × 10-71.7
Tent5c'Lactobacillus acidophilus NCFM and Bifidobacterium bifidum Z9' vs 'control'infectTranscription profiling by array of mouse dendritic cells after infection with Bifidobacterium bifidum and Lactobacillus acidophilus
Adjusted p-valueLog2-fold change
8.0802 × 10-71.7
Tent5c'dexamethasome' vs 'methyl beta-clodextrin' in 'wild type genotype; 1 milligram per kilogram; ZT6'compound, genotype, timeRNASeq data analysis of wild type and reverb alpha knockout cells from mouse liver, at different time points, with or without DEX treatment
Adjusted p-valueLog2-fold change
1.0073 × 10-5-1.7
Tent5c'acute myeloid leukemia' vs 'myeloproliferative disorder'diseaseTranscription profiling by high throughput sequencing of c-KIT+ splenocytes from murine acute myeloid leukemia and myeloproliferative neoplasm
Adjusted p-valueLog2-fold change
1.0134 × 10-51.7
Tent5c'ATF3 -/-' vs 'wild type' in 'none' at '0 hour'compound, genotype, timeTranscription profiling by array of mouse bone marrow macrophages mutant for ATF3 after treatment with lipopolysaccharide
Adjusted p-valueLog2-fold change
1.0907 × 10-41.7
Tent5c'Tg4510 genotype' vs 'wild type'genotype, phenotypeExpression data from Tg4510 and Wild-type mice after AAVTFEB injection
Adjusted p-valueLog2-fold change
6.8795 × 10-4-1.7
Tent5c'active gastritis with low grade metaplasia; Helicobacter pylori' vs 'normal; none' at '12 month'disease, infect, timeTranscription profiling of gastric tissues from mice infected with H. pylori strain SS1 for 6 or 12 months
Adjusted p-valueLog2-fold change
2.6669 × 10-31.7
Tent5c'AZD7507; 100 milligram per kilogram' vs 'none'compoundRNA-seq to investigate differentially expressed genes in KPC mouse PDAC treated with CSF-1R small molecule inhibitor AZD7507 and/or the CXCR2 small molecule inhibitor AZD5069
Adjusted p-valueLog2-fold change
3.3506 × 10-3-1.7
Tent5c'Macrophage of F4/80+, CD11b+, CD11c-+; obese leptin-deficient' vs 'Macrophage of F4/80+, CD11b+, CD11c-+; control'cell type, genotypeExpression data from mouse adipose tissue macrophage
Adjusted p-valueLog2-fold change
9.5945 × 10-31.7
Tent5c'swimming twice a day' at '3 week' vs 'control'time, treatmentTranscription profiling of heart ventricles from mice that have cardiac hypertrophy induced by swimming training
Adjusted p-valueLog2-fold change
2.0117 × 10-2-1.7
Tent5c'Staphylococcus aureus cutaneous infection' vs 'none' in 'wild type'disease, genotypeNeutrophil-derived IL-1β is sufficient for abscess formation in immunity against Staphylococcus aureus in mice
Adjusted p-valueLog2-fold change
2.4662 × 10-21.7
Tent5c'thermal injury' vs 'none'injuryMicroarray profiling of post-injury and uninjured mouse lung neutrophils from a thermal injury model
Adjusted p-valueLog2-fold change
3.269 × 10-21.7
Tent5c'130 milligram per kilogram; activated charcoal' vs 'none' in 'Plasmodium berghei'compound, infectTranscription profiling by array of mouse blood infected with Plasmodium berghei after treatment with activated charcoal
Adjusted p-valueLog2-fold change
4.8677 × 10-21.7
Tent5c'Alb-Cre;VHLf/f' vs 'Alb-Cre'genotypeTranscription profiling by array of mice with liver-specific expression of hypoxia inducible factor, or inactivated von Hippel-Lindau tumor suppressor
Adjusted p-valueLog2-fold change
1.2536 × 10-12-1.6
Tent5c'lipopolysaccharide; 10 nanogram per milliliter and prostaglandin E2; 1 micromolar' vs 'none' in 'primary cell line; wild type genotype'cell line, compound, genotypeBulk RNA-seq of wild type and MEF2A or MEF2C/D knockout mouse bone marrow macrophages under different stimulation conditions
Adjusted p-valueLog2-fold change
1.5924 × 10-12-1.6
Tent5c'Klf1-/-' vs 'wild type'genotypeNovel roles for Klf1 in regulating the erythroid transcriptome revealed by mRNA-seq
Adjusted p-valueLog2-fold change
6.7765 × 10-91.6
Tent5c'lipopolysaccharide; 10 nanogram per milliliter and PFI-1; 10 nanogram per milliliter' vs 'none' in 'primary cell line; wild type genotype'cell line, compound, genotypeBulk RNA-seq of wild type and MEF2A or MEF2C/D knockout mouse bone marrow macrophages under different stimulation conditions
Adjusted p-valueLog2-fold change
1.8617 × 10-61.6
Tent5c'lipopolysaccharide; 100 nanogram per milliliter and interferon gamma 20 nanogram per milliliter' vs 'none'stimulusTranscriptional profiling in macrophages in stimulated and unstimulated conditions.
Adjusted p-valueLog2-fold change
3.0567 × 10-6-1.6
Tent5c'none; XPF knockout' vs 'all-trans-retinoic acid; 10 micromolar; wild type genotype'compound, genotypeRNA-seq of mouse DNA repair endonuclease XPF knock out versus wild type and versus trans retinoic acid (tRA) treated wild type
Adjusted p-valueLog2-fold change
4.4056 × 10-61.6
Tent5c'ATF3 -/-' vs 'wild type' in '10 nanogram per milliliter; lipopolysaccharide' at '1 hour'compound, genotype, timeTranscription profiling by array of mouse bone marrow macrophages mutant for ATF3 after treatment with lipopolysaccharide
Adjusted p-valueLog2-fold change
7.8791 × 10-61.6
Tent5c'Apc and Msx1 knockout in Villin1 positive cells' vs 'wild type'phenotypeTranscription profiling by array of Apc-deficient proximal colonic epithelium upon Msx1 transcription factor depletion
Adjusted p-valueLog2-fold change
1.1473 × 10-51.6
Tent5c'14 days P. chabaudi infected' vs 'uninfected' in 'gonadectomized male'clinical information, disease, sex, timeTranscription profiling by array of mice infected with Plasmodium chabaudi after gonadectomization to investigate involvement of gonadal steroids
Adjusted p-valueLog2-fold change
3.1168 × 10-5-1.6
Tent5c'p48-Cre;KrasG12D;Ela-Tgfa' vs 'wild type'genotypeTranscription profiling by array of pancreas from KrasG12D, Ela-Tgfa and KrasG12D Ela-Tgfa mice
Adjusted p-valueLog2-fold change
3.6447 × 10-5-1.6
Tent5c'doxycicline-mediated expression of c-Jun' vs 'control'phenotypeTranscription profiling by array of mouse whole bone marrow after c-Jun induction
Adjusted p-valueLog2-fold change
3.9595 × 10-5-1.6
Tent5c'SARS coronavirus MA15; 10^5 PFU' vs 'none' at '4 day'stimulus, timeSM001: SARS CoV MA15 infection of C57Bl/6 mouse model – Data from 4 viral doses at 1, 2, 4 and 7 days post infection.
Adjusted p-valueLog2-fold change
1.1203 × 10-4-1.6
Tent5c'doxycycline; 200 nanogram per milliliter; neoplasm; 5 day' vs 'none; normal; 0 day'compound, phenotype, timeRNA-seq of doxycycline induced tumor and residual mouse primary mammary epithelial cells grown in 3D cell cultures against non-induced controls
Adjusted p-valueLog2-fold change
3.2662 × 10-41.6
Tent5c'alpha-amanitin; maternal Ring1-Rnf+' vs 'none; maternal Ring1-Rnf+'compound, genotypePolycomb function during oogenesis is required for mouse early embryonic development (2-cell embryos)
Adjusted p-valueLog2-fold change
3.9424 × 10-41.6
Tent5c'10 nanogram per milliliter; TGF-beta1' vs 'none' in 'common dendritic progenitor' at '8 hour'cell type, compound, timeDynamic Gene Expression Response to TGF-b Stimulation in Multipotent Progenitors and Common Dendritic Cell Progenitors
Adjusted p-valueLog2-fold change
4.7797 × 10-41.6
Tent5c'undifferentiated' vs 'differentiated; rosiglitazone' in 'F1.B6x129'phenotype, stimulus, strainRNA-seq of mouse subcutaneous SVF cells before and after differentiation with a brown fat differentiation cocktail
Adjusted p-valueLog2-fold change
1.0878 × 10-31.6
Tent5c'granulocyte' vs 'hemopoietic stem cell'cell typeGene expression data from mouse hemopoietic stem cells (LSKs), promyelocytes, myelocytes and granulocytes.
Adjusted p-valueLog2-fold change
4.2477 × 10-31.6
Tent5c'14 days P. chabaudi infected' vs 'uninfected' in 'intact male'clinical information, disease, sex, timeTranscription profiling by array of mice infected with Plasmodium chabaudi after gonadectomization to investigate involvement of gonadal steroids
Adjusted p-valueLog2-fold change
7.3327 × 10-3-1.6
Tent5c'conditional UPF2 knockout; 36 hour after partial hepatechtomy' vs 'control; 36 hour after partial hepatechtomy'genotype, sampling timeTranscription profiling of livers of adult UPF2 null mice in response to partial hepatechtomy
Adjusted p-valueLog2-fold change
1.8483 × 10-21.6
Tent5c'heat-shocked at 42 degreeC' vs 'grown at 33 degreeC' in 'wild type'genotype, growth conditionTranscription profiling by array of mouse wild type and Htt mutant striatal cells upon heat shock
Adjusted p-valueLog2-fold change
4.3047 × 10-21.6
Tent5c'Tyr mutant' vs 'wild type'genotypeMicroarray analysis of iris gene expression in mice with mutations relevant to glaucoma
Adjusted p-valueLog2-fold change
8.0296 × 10-341.5
Tent5c'embryo transfer' vs 'no embryo transfer'stimulusRNA-seq of whole mouse placentas at E10.5 comparing C57Bl/6 male conceptuses that had undergone blastocyst transfer to non-transferred C57Bl/6 male conceptuses
Adjusted p-valueLog2-fold change
4.7391 × 10-25-1.5
Tent5c'SARS coronavirus MA15; 4 day' vs 'mock' in 'PWK/PhJ'infect, strain, timeGenomic profiling of collaborative cross founder mouse strains infected with respiratory viruses to discover novel transcripts and infection-related strain-specific gene and isoform expression
Adjusted p-valueLog2-fold change
5.8237 × 10-101.5
Tent5c'AZD8835; 50 milligram per kilogram' vs 'none' at '14 day'compound, timeRNAseq of tumor samples from CT26 syngeneic mouse treated with a PI3Ka/d inhibitor (AZD8835)
Adjusted p-valueLog2-fold change
5.8637 × 10-81.5
Tent5c'follicle stimulating hormone and epidermal growth factor' vs '293H control medium'growth conditionTranscription profiling by array of mouse cumulus cells after culture with growth differentiation factor 9 or follicle stimulating hormone and epidermal growth factor
Adjusted p-valueLog2-fold change
6.988 × 10-71.5
Tent5c'Lactobacillus acidophilus NCFM' vs 'control'infectTranscription profiling by array of mouse dendritic cells after infection with Bifidobacterium bifidum and Lactobacillus acidophilus
Adjusted p-valueLog2-fold change
3.4059 × 10-6-1.5
Tent5c'21 percent oxygen, 37 degree Celsius, 10 percent serum' vs 'none'growth conditionRNA sequencing of native and ex vivo cultured murine tail tendon fascicles
Adjusted p-valueLog2-fold change
1.2457 × 10-51.5
Tent5c'curdlan' vs 'none' in 'wild type'compound, genotypeDendritic cell-derived IL-2 promotes apoptosis of terminally mature cells via a novel autocrine signaling pathway
Adjusted p-valueLog2-fold change
1.7751 × 10-51.5
Tent5c'adult definitive erythroid cell' vs 'primitive erythroid cell' in 'basophilic erythroblast'cell type, phenotypeTranscription profiling by array of differentiating primary primitive and definitive mouse red blood cells
Adjusted p-valueLog2-fold change
7.6768 × 10-51.5
Tent5c'pre-B acute lymphoblastic leukemia 8093; nilotinib; 3 day' vs 'pre-B acute lymphoblastic leukemia 8093; nilotinib; 0 day'cell type, compound, timeDrug tolerance development of mouse Bcr/Abl pre-B ALL cells on irradiated MEFs
Adjusted p-valueLog2-fold change
2.2747 × 10-41.5
Tent5c'10 nanogram per milliliter; TGF-beta1' vs 'none' in 'multipotent progenitor' at '2 hour'cell type, compound, timeDynamic Gene Expression Response to TGF-b Stimulation in Multipotent Progenitors and Common Dendritic Cell Progenitors
Adjusted p-valueLog2-fold change
2.9578 × 10-41.5
Tent5c'dexamethasome' vs 'methyl beta-clodextrin' in 'Nr1d1 homozygous knockout; 1 milligram per kilogram; ZT18'compound, genotype, timeRNASeq data analysis of wild type and reverb alpha knockout cells from mouse liver, at different time points, with or without DEX treatment
Adjusted p-valueLog2-fold change
5.5581 × 10-31.5
Tent5c'R-17-92 knockout' vs 'control'phenotypeFollicular B (FoB) cells purified from miR-17-92 tKO mice
Adjusted p-valueLog2-fold change
1.4946 × 10-21.5
Tent5c'swimming twice a day' at '2 week' vs 'control'time, treatmentTranscription profiling of heart ventricles from mice that have cardiac hypertrophy induced by swimming training
Adjusted p-valueLog2-fold change
1.5977 × 10-2-1.5
Tent5c"Evi1-GFP positive" vs "Evi1-GFP negative"phenotypeWhole genome expression profiling of Evi1-GFP positive and negative murine hematopoietic stem cell sub-populations.
Adjusted p-valueLog2-fold change
1.8457 × 10-2-1.5
Tent5c'MCKcre Pitx2 Flox/Flox' vs 'wild type' in '12 week'age, genotypeGene expression data of postnatal Pitx2 deficient heart
Adjusted p-valueLog2-fold change
1.8488 × 10-2-1.5
Tent5c'30 month' vs '5 month' in 'male'age, block, sexExpression data from tail skin in young (5 months) and old (30 months) CB6F1 mice
Adjusted p-valueLog2-fold change
2.7015 × 10-21.5
Tent5c'synovial sarcoma' vs 'normal'diseaseTranscription profiling by array of tumors excised from conditional mouse model of synovial sarcoma compared to skeletal muscle from wild type mice
Adjusted p-valueLog2-fold change
3.1778 × 10-2-1.5
Tent5c'MMTV-ras/p53-/-' vs 'MMTV-ras/p53+/+'genotypeExpression data from salivary tumor tissues derived from MMTV-ras transgenic mice with wild-type p53, no p53 or gain-of-function mutant p53
Adjusted p-valueLog2-fold change
4.6704 × 10-2-1.5
Tent5c'Hnf4a conditional knockout' vs 'wild type genotype'genotypeTranscription profiling of mouse conditional intestinal epithelial Hnf4Ialpha knockout to investigate the role of HNF4alpha in the adult colon
Adjusted p-valueLog2-fold change
4.7869 × 10-112-1.4
Tent5c'Egr2 and Egr3 knockout' vs 'Egr2-GFP knockin; Egr2-GFP high' in 'CD8-positive T cell'cell type, genotype, phenotypeRNAseq analysis of CD4 and CD8 T cells in response to vaccinia virus infection
Adjusted p-valueLog2-fold change
7.4095 × 10-105-1.4
Tent5c'Egr2 and Egr3 knockout' vs 'Egr2-GFP knockin; Egr2-GFP high' in 'CD4-positive T cell'cell type, genotype, phenotypeRNAseq analysis of CD4 and CD8 T cells in response to vaccinia virus infection
Adjusted p-valueLog2-fold change
5.5728 × 10-67-1.4
Tent5c'α-GalCer; 2 microgram' vs 'none' in 'Cd1d homozyous knockout'compound, genotypeCD1d-dependent immune suppression mediated by regulatory B cells through modulations of iNKT cells
Adjusted p-valueLog2-fold change
4.1421 × 10-63-1.4
Tent5c'tamoxifen induction at 2 months, wait 3 months' vs 'no tamoxifen induction' in 'luminal cell of prostate epithelium; Nkx3.1-CreERT2 targeted allele'cell type, genotype, growth conditionTranscription profiling by high throughput sequencing of PIN/tumor lesions from basal or luminal origins at time points at which mice displayed similar histopathological phenotypes
Adjusted p-valueLog2-fold change
5.5808 × 10-47-1.4
Tent5c'tamoxifen induction at 2 months, wait 3 months' vs 'no tamoxifen induction' in 'basal cell of prostate epithelium; CK5-CreERT2 transgenic line'cell type, genotype, growth conditionTranscription profiling by high throughput sequencing of PIN/tumor lesions from basal or luminal origins at time points at which mice displayed similar histopathological phenotypes
Adjusted p-valueLog2-fold change
2.2094 × 10-31-1.4
Tent5c'tamoxifen induction at 2 months, wait 1 months' vs 'no tamoxifen induction' in 'luminal cell of prostate epithelium; Nkx3.1-CreERT2 targeted allele'cell type, genotype, growth conditionTranscription profiling by high throughput sequencing of PIN/tumor lesions from basal or luminal origins at time points at which mice displayed similar histopathological phenotypes
Adjusted p-valueLog2-fold change
1.195 × 10-261.4
Tent5c'Follicular B cell' vs 'Pre-B cell' in 'wild type genotype; MHC II-positive'cell type, genotype, phenotypeEffect of MHC II expression in pro-B cells: Pre-B cells and follicular B cells from wild-type and MHC II conditional mice
Adjusted p-valueLog2-fold change
9.3722 × 10-13-1.4
Tent5c'Pcbp2 knockout' vs 'wild type genotype'genotypeTranscription profiling by RNA-seq of fetal liver from poly(C) binding protein 2 (Pcbp2) knockout mice
Adjusted p-valueLog2-fold change
4.7688 × 10-121.4
Tent5c'Tumor Necrosis Factor' vs 'none'stimulusTranscription profiling by high throughput sequencing of CD8 single positive thymocytes from F5 Rag1KO TCR transgenic mice stimulated with tumor necrosis factor
Adjusted p-valueLog2-fold change
2.6172 × 10-61.4
Tent5c'Bifidobacterium bifidum Z9' vs 'control'infectTranscription profiling by array of mouse dendritic cells after infection with Bifidobacterium bifidum and Lactobacillus acidophilus
Adjusted p-valueLog2-fold change
1.5207 × 10-51.4
Tent5c'recombinant growth differentiation factor 11; 100 nanogram per milliliter' vs 'vehicle'compoundTranscription profiling by array of mouse bone marrow-derived macrophages treated with recombinant growth differentiation factor 11 (rGDF11)
Adjusted p-valueLog2-fold change
1.972 × 10-5-1.4
Tent5c'TUT4 deficiency; TUT7 knockout' vs 'wild type'phenotypeMicroarray profiling of mouse pachytene cells deficient for UPF2 or both TUT4 and TUT7
Adjusted p-valueLog2-fold change
2.9127 × 10-5-1.4
Tent5c'SARS coronavirus MA15' vs 'none' at '4 day'infect, timeSM014 - SARS MA15 wild type, and SARS nsp16 mutant virus infections of C57BL6 mice - A time course
Adjusted p-valueLog2-fold change
3.3854 × 10-51.4
Tent5c'Apc knockout in Villin1 positive cells' vs 'wild type'phenotypeTranscription profiling by array of Apc-deficient proximal colonic epithelium upon Msx1 transcription factor depletion
Adjusted p-valueLog2-fold change
4.2861 × 10-51.4
Tent5c'beta(3)-adrenergic agonist Cl316,243' vs 'none' at '10 week'age, stimulusRNA-seq of age-associated transcriptome changes in brown adipose tissue
Adjusted p-valueLog2-fold change
5.601 × 10-5-1.4
Tent5c'dexamethasone (1 μM) and GW7647 (0.5 μM)' vs 'none'compoundRNA-seq of primary hepatocytes treated with GR and PPARalpha agonists in the presence of LPS
Adjusted p-valueLog2-fold change
6.7678 × 10-5-1.4
Tent5c'West Nile virus; early stage encephalitis' vs 'mock infection'infect, timeTranscriptomic profiling of the brains of WNV and CHIKV infection-induced encephalitis in young mice after 2, 3 or 5 days post infection
Adjusted p-valueLog2-fold change
2.4682 × 10-3-1.4
Tent5c'MyD88 homozygous knockout' vs 'wild type genotype' in 'TLR9 ligand CpG ODN (1826)'genotype, stimulusTranscription profiling by sequencing of murine MyD88 -/- and MyD88 +/+ mTECs stimulated with a TLR9 ligand
Adjusted p-valueLog2-fold change
7.077 × 10-31.4
Tent5c'K-ras mutant/Wt1-null' vs 'wild type'genotypeTranscription profiling by array of wild type, K-ras mutant, Wt1-null, and double K-ras mutant/Wt1-null mouse embryonic fibroblasts
Adjusted p-valueLog2-fold change
8.8482 × 10-3-1.4
Tent5c'intravenous injection of 10-100 thousand B-ALL cells' vs 'none' in 'lentiviral expression of mTie2-IFN-mirT and Tie2-driven overexpression of IFNalpha'genotype, stimulusRNA-seq of mouse macrophages to investigate how interferon gene therapy reprograms the leukemia microenvironment
Adjusted p-valueLog2-fold change
1.1541 × 10-21.4
Tent5c'expanded on HUVEC and m5GF in the presence of mD1R for 7 days' vs 'control'treatmentExpression data from cultured c-Kit+Sca-1+Lin- (KSL)cells
Adjusted p-valueLog2-fold change
2.5074 × 10-21.4
Tent5c'paracetamol; 529 milligram per kilogram' vs 'vehicle' at '4 hour'compound, timeTranscription profiling by array of CD1 mice after nontoxic and nonlethal hepatotoxic paracetamol administration
Adjusted p-valueLog2-fold change
3.6444 × 10-2-1.4
Tent5c'mdm2 knock out' vs 'wild type'genotypeTranscription profiling by array of Mdm2 knock out mice
Adjusted p-valueLog2-fold change
3.6481 × 10-2-1.4
Tent5c'MEF2A knockout' vs 'wild type genotype' in 'Hoxb8-FL; none'cell line, compound, genotypeBulk RNA-seq of wild type and MEF2A or MEF2C/D knockout mouse bone marrow macrophages under different stimulation conditions
Adjusted p-valueLog2-fold change
9.4879 × 10-50-1.3
Tent5c'upf3 knockout' vs 'wild type' in 'testis'cell type, genotypeUPF2 establishes testis-specific transcriptome enriched in transcripts with shorter 3’UTRs
Adjusted p-valueLog2-fold change
2.1596 × 10-11-1.3
Tent5c'TRIM28(flox/flox):Mx1Cre' vs 'TRIM28(flox/flox)' in 'CD71(hi)TER119-'genotype, phenotypeTranscription profiling by high throughput sequencing of bone marrow immature erythroid cells from Trim28flox/flox:TgMx1Cre congenic mice
Adjusted p-valueLog2-fold change
1.2285 × 10-8-1.3
Tent5c'organoid culture without Noggin (ER medium)' vs 'organoid culture (ENR medium)' in 'none'growth condition, stimulusRNA-seq of small intestinal organoids treated with the control medium ENR (EGF, Noggin, R-spondin1) in the presence or absence of muscle supernatant
Adjusted p-valueLog2-fold change
1.6878 × 10-8-1.3
Tent5c'tamoxifen induction at 2 months, wait 6 months' vs 'no tamoxifen induction' in 'basal cell of prostate epithelium; CK5-CreERT2 transgenic line'cell type, genotype, growth conditionTranscription profiling by high throughput sequencing of PIN/tumor lesions from basal or luminal origins at time points at which mice displayed similar histopathological phenotypes
Adjusted p-valueLog2-fold change
4.3983 × 10-8-1.3
Tent5c'Er1F/-' vs 'wild type genotype'genotypeRNA-Seq profiling of ERCC1-XPF DNA repair defect (Er1F/-) versus wild type (Er1F/+) macrophages
Adjusted p-valueLog2-fold change
9.4059 × 10-6-1.3
Tent5c'Tgfbeta inhibitor 20 micromolar' vs 'none'compoundExpression data from intestinal organoids altered for Tgfbeta signaling
Adjusted p-valueLog2-fold change
1.9182 × 10-51.3
Tent5c'Bcl6 +/+ BCR-ABL1-transformed B cell precursors; STI571 treated' vs 'Bcl6 +/+ BCR-ABL1-transformed B cell precursors; untreated'cell type, treatmentGene expression data of BCR-ABL1 transformed B cell precursors from BCL6 wild-type and BCL6 knockout mice
Adjusted p-valueLog2-fold change
4.3559 × 10-51.3
Tent5c'BL6; RML infected' at '16 week' vs 'BL6; uninfected' at '16 week'strain, time, treatmentTranscription profiling of mouse brain infected with prions in eight mouse-prion strain combinations in a systems approach to the study of prion disease
Adjusted p-valueLog2-fold change
9.3301 × 10-5-1.3
Tent5c'lipopolysaccharide; 10 nanogram per milliliter and prostaglandin E2; 1 micromolar and interferon beta; 100 units per milliliter' vs 'none' in 'primary cell line; wild type genotype'cell line, compound, genotypeBulk RNA-seq of wild type and MEF2A or MEF2C/D knockout mouse bone marrow macrophages under different stimulation conditions
Adjusted p-valueLog2-fold change
1.3167 × 10-41.3
Tent5c'10 nanogram per milliliter; TGF-beta1' vs 'none' in 'multipotent progenitor' at '8 hour'cell type, compound, timeDynamic Gene Expression Response to TGF-b Stimulation in Multipotent Progenitors and Common Dendritic Cell Progenitors
Adjusted p-valueLog2-fold change
2.7748 × 10-4-1.3
Tent5c'co-cultured with hematopoietic stem cell for 9 days' vs 'non co-cultured for 9 days' in 'stromal cell; expressing AKT1'cell type, growth condition, phenotypeTranscription profiling by high throughput sequencing of murine bone marrow endothelial cells and bone marrow stroma, in vitro and in vivo, with and without hematopoietic stem cells co-culture
Adjusted p-valueLog2-fold change
4.3276 × 10-41.3
Tent5c'10 nanogram per milliliter; TGF-beta1' vs 'none' in 'common dendritic progenitor' at '12 hour'cell type, compound, timeDynamic Gene Expression Response to TGF-b Stimulation in Multipotent Progenitors and Common Dendritic Cell Progenitors
Adjusted p-valueLog2-fold change
5.9443 × 10-4-1.3
Tent5c'dexamethasone; 1 micromolar' vs 'none'compoundRNA-seq of primary hepatocytes treated with GR and PPARalpha agonists in the presence of LPS
Adjusted p-valueLog2-fold change
6.173 × 10-4-1.3
Tent5c'Alb-Cre-ERT2 / Cnot1 flox/flox' vs 'Cnot1 flox/flox' in 'none'compound, genotype, timeRNA-seq of livers in control and Cnot1 tamoxifen-inducible liver-specific knockout mice
Adjusted p-valueLog2-fold change
7.8202 × 10-41.3
Tent5c'diet restriction' vs 'control'dietLiver mRNA microarray study for mice treated with various diets
Adjusted p-valueLog2-fold change
8.6471 × 10-4-1.3
Tent5c'resiquimod; 100 microgram' vs 'none' in 'ovalbumin; C57BL/6'compound, stimulus, strainTranscription profiling of mouse model of asthma reveals the effects of resiquimod treatment on the asthma transcriptome
Adjusted p-valueLog2-fold change
1.2927 × 10-31.3
Tent5c'curdlan' vs 'none' in 'IL2 knockout'compound, genotypeDendritic cell-derived IL-2 promotes apoptosis of terminally mature cells via a novel autocrine signaling pathway
Adjusted p-valueLog2-fold change
2.855 × 10-31.3
Tent5c'overexpression of CA-NFATc3' vs 'control'phenotypeExpression data from embryonic stem cells differentiation
Adjusted p-valueLog2-fold change
7.0208 × 10-31.3
Tent5c'scrapie ME7 inoculated' at '150 day' vs 'none' at '0 day'infect, timeTranscription profiling by array of brains from mice infected with scrapie ME7
Adjusted p-valueLog2-fold change
7.6376 × 10-31.3
Tent5c'left ventricle' vs 'right ventricle' in 'embryonic day 18.5'developmental stage, organism partTranscriptional Atlas of Cardiogenesis Maps Congenital Heart Disease Interactome
Adjusted p-valueLog2-fold change
8.3624 × 10-31.3
Tent5c'epithelial cell; E2' vs 'epithelial cell; vehicle'cell type, treatmentAffymetrix gene chip analysis for the whole mouse genome transcripts of epithelial and stromal cells from mouse uterine primary co-culture treated with either vehicle or E2
Adjusted p-valueLog2-fold change
1.3088 × 10-2-1.3
Tent5c'SARS coronavirus MA15' vs 'none' at '4 day'infect, timeSM012 - SARS MA15 wild type, and SARS deltaORF6 mutant virus infections of C57BL6 mice - A time course
Adjusted p-valueLog2-fold change
1.5576 × 10-21.3
Tent5c'Timp3-/-' vs 'wild type genotype'genotypeTranscription profiling by array of kidneys from diabetic wild type and T3-/- mice
Adjusted p-valueLog2-fold change
1.9076 × 10-21.3
Tent5c'undifferentiated' vs 'differentiated; rosiglitazone' in 'C57BL/6J'phenotype, stimulus, strainRNA-seq of mouse subcutaneous SVF cells before and after differentiation with a brown fat differentiation cocktail
Adjusted p-valueLog2-fold change
9.2472 × 10-16-1.2
Tent5c'neurogenin-3-expressing endocrine progenitor cell' vs 'neurogenin-3-lacking pancreatic progenitor cell' at 'embryonic day 15.5'cell type, developmental stageTranscription profiling by high throughput sequencing of murine beta cells at key stages of maturation
Adjusted p-valueLog2-fold change
3.0257 × 10-11-1.2
Tent5c'interferon gamma' vs 'none' in 'dexamethasone; 100 nanomolar'compound, stimulusRNA-Seq of murine lung endothelial cells stimulated with IFN-gamma and dexamethasone
Adjusted p-valueLog2-fold change
8.6074 × 10-10-1.2
Tent5c'Mettl6 knockout clone D1' vs 'wild type genotype'genotypeMETTL6 is a tRNA m3C methyltransferase that regulates translation and tumor cell proliferation
Adjusted p-valueLog2-fold change
2.5409 × 10-8-1.2
Tent5c'Kit ligand' vs 'none' in 'wild type'compound, genotypeTranscription profiling of bone marrow–derived mast cells from WASP-deficient mice after stimulation with kit ligand
Adjusted p-valueLog2-fold change
1.956 × 10-7-1.2
Tent5c'Kit ligand; wasp knockout' vs 'Kit ligand; wild type'compound, genotypeTranscription profiling of bone marrow–derived mast cells from WASP-deficient mice after stimulation with kit ligand
Adjusted p-valueLog2-fold change
8.8291 × 10-71.2
Tent5c'nmf205 mutant' vs 'wild type'genotypeTranscription profiling by high throughput sequencing in cerebellum of mouse Gcn2 -/-, nmf205-/- and nmf205-/-;Gcn2-/-
Adjusted p-valueLog2-fold change
1.3953 × 10-61.2
Tent5c'colitis' at '19 day' vs 'normal' at '0 day'disease, timeTemporal transcriptomic changes during DSS colitis development and resolution.
Adjusted p-valueLog2-fold change
3.2586 × 10-61.2
Tent5c'7 day' vs '0 day'ageTranscription profiling of mouse embyronic stem cell line CGR8 during the first 10 days of differentiation into embryoid bodies
Adjusted p-valueLog2-fold change
8.746 × 10-6-1.2
Tent5c'Porphyromonas gingivalis; hyperlipidemia' vs 'normal'infect, phenotypehyperlipidemia impaired innate response
Adjusted p-valueLog2-fold change
1.7978 × 10-51.2
Tent5c'10 nanogram per milliliter; TGF-beta1' vs 'none' in 'multipotent progenitor' at '24 hour'cell type, compound, timeDynamic Gene Expression Response to TGF-b Stimulation in Multipotent Progenitors and Common Dendritic Cell Progenitors
Adjusted p-valueLog2-fold change
1.8507 × 10-5-1.2
Tent5c'gamma radiation; 8 Gray' vs 'none' in 'Lgr5-Cre-ERT2; Il22-/-'genotype, irradiateRNA Seq of colonic Lgr5+ epithelial stem cells in Il22+/+ and Il22-/- mice during homeostasis and 24h after irradiation with 8 Gy
Adjusted p-valueLog2-fold change
3.6614 × 10-51.2
Tent5c'lipopolysaccharide; 10 nanogram per milliliter and SGC-CBP30; 10 nanogram per milliliter' vs 'none' in 'primary cell line; wild type genotype'cell line, compound, genotypeBulk RNA-seq of wild type and MEF2A or MEF2C/D knockout mouse bone marrow macrophages under different stimulation conditions
Adjusted p-valueLog2-fold change
6.8353 × 10-51.2
Tent5c'fetal definitive erythroid cell' vs 'primitive erythroid cell' in 'basophilic erythroblast'cell type, phenotypeTranscription profiling by array of differentiating primary primitive and definitive mouse red blood cells
Adjusted p-valueLog2-fold change
8.1144 × 10-5-1.2
Tent5c'Zbtb10 knockdown' vs 'control' at '2 hour'genotype, timeRNA-seq of Zbtb10 Knockdown and Control cDC1 dendritic cells (Cd8+)
Adjusted p-valueLog2-fold change
1.3072 × 10-41.2
Tent5c'postnatal >1 year; hindlimb' vs 'embryonic day 17.5; whole forelimb and hindlimb'age, organism partExpression data from skeletal muscle satellite cells at different development stages
Adjusted p-valueLog2-fold change
1.9933 × 10-41.2
Tent5c'adenoviral vector expressing human ACE2' vs 'empty adenoviral vector'genotypeRNA-seq of SARS-CoV-2 infected lungs from mice sensitized for SARS-CoV-2 infection by Ad5-hACE2 transduction compared to non-sensitized mice
Adjusted p-valueLog2-fold change
2.6645 × 10-41.2
Tent5c'10 nanogram per milliliter; TGF-beta1' vs 'none' in 'multipotent progenitor' at '4 hour'cell type, compound, timeDynamic Gene Expression Response to TGF-b Stimulation in Multipotent Progenitors and Common Dendritic Cell Progenitors
Adjusted p-valueLog2-fold change
3.3155 × 10-41.2
Tent5c'10 nanogram per milliliter; TGF-beta1' vs 'none' in 'multipotent progenitor' at '12 hour'cell type, compound, timeDynamic Gene Expression Response to TGF-b Stimulation in Multipotent Progenitors and Common Dendritic Cell Progenitors
Adjusted p-valueLog2-fold change
1.7976 × 10-31.2
Tent5c'Bcl6 -/- BCR-ABL1-transformed B cell precursors; STI571 treated' vs 'Bcl6 -/- BCR-ABL1-transformed B cell precursors; untreated'cell type, treatmentGene expression data of BCR-ABL1 transformed B cell precursors from BCL6 wild-type and BCL6 knockout mice
Adjusted p-valueLog2-fold change
1.8323 × 10-31.2
Tent5c'FVBNCr; RML infected' at '20 week' vs 'FVBNCr; uninfected' at '20 week'strain, time, treatmentTranscription profiling of mouse brain infected with prions in eight mouse-prion strain combinations in a systems approach to the study of prion disease
Adjusted p-valueLog2-fold change
1.9722 × 10-31.2
Tent5c'all-trans-retinoic acid; 10 micromolar' vs 'none' in 'wild type genotype'compound, genotypeRNA-seq of mouse DNA repair endonuclease XPF knock out versus wild type and versus trans retinoic acid (tRA) treated wild type
Adjusted p-valueLog2-fold change
2.4159 × 10-3-1.2
Tent5c'azoxymethane and dextran sodium sulfate' vs 'control' in 'wild type'compound, genotypeGene expression profiling of total colon in AOM/DSS-treated Myd88 knockout and wild type
Adjusted p-valueLog2-fold change
3.7027 × 10-3-1.2
Tent5c'ABIN1[D485N] knock-in' vs 'wild type genotype' in 'non-classical monocyte'cell type, genotypeRNA-seq of inflammatory monocytes, patrolling monocytes and neutrophils in wild type and ABIN1[D485N] mice
Adjusted p-valueLog2-fold change
5.324 × 10-31.2
Tent5c'scrapie ME7 inoculated' at '120 day' vs 'none' at '0 day'infect, timeTranscription profiling by array of brains from mice infected with scrapie ME7
Adjusted p-valueLog2-fold change
1.2259 × 10-2-1.2
Tent5c'Wnt1Cre Ezh2lox/lox' vs 'control'genotypeExpression data from E11.5 mouse branchial arch 1 (BA1) - comparison between Ezh2lox/lox and Wnt1Cre Ezh2lox/lox embryos
Adjusted p-valueLog2-fold change
1.4925 × 10-2-1.2
Tent5c'germanium(2+)' vs 'normal chow'dietTranscription profiling by array of mouse treated with normal chow or that containing 0.15% germanium dioxide for four months
Adjusted p-valueLog2-fold change
2.0408 × 10-21.2
Tent5c'AZD7507; AZD5069 (at same dosage); 100 milligram per kilogram' vs 'none'compoundRNA-seq to investigate differentially expressed genes in KPC mouse PDAC treated with CSF-1R small molecule inhibitor AZD7507 and/or the CXCR2 small molecule inhibitor AZD5069
Adjusted p-valueLog2-fold change
2.1011 × 10-21.2
Tent5c'12 day' vs '5 day' in 'doxycycline; 200 nanogram per milliliter; neoplasm'compound, phenotype, timeRNA-seq of doxycycline induced tumor and residual mouse primary mammary epithelial cells grown in 3D cell cultures against non-induced controls
Adjusted p-valueLog2-fold change
2.1106 × 10-21.2
Tent5c'110 week' vs '8 week'ageTranscription profiling by array of CD11C+ splenic dendritic cells from young (8 weeks) and old (110 weeks) mice treated with Poly I:C for 4 hours
Adjusted p-valueLog2-fold change
2.1683 × 10-2-1.2
Tent5c'control; 36 hour after partial hepatechtomy' vs 'control; before partial hepatechtomy'genotype, sampling timeTranscription profiling of livers of adult UPF2 null mice in response to partial hepatechtomy
Adjusted p-valueLog2-fold change
2.4042 × 10-2-1.2
Tent5c'SARS coronavirus MA15' vs 'none' in 'IFNAR1 -/-' at '5 day'genotype, infect, timeTranscriptomic analysis of host response to mouse-adapted SARS virus in wild type, STAT1 -/-, and IFNAR1 -/- mouse genetic backgrounds
Adjusted p-valueLog2-fold change
3.9239 × 10-2-1.2
Tent5c'Macrophage of F4/80+, CD11b+, CD11c-; obese leptin-deficient' vs 'Macrophage of F4/80+, CD11b+, CD11c-; control'cell type, genotypeExpression data from mouse adipose tissue macrophage
Adjusted p-valueLog2-fold change
5.1677 × 10-1231.1
Tent5c'Debaryomyces hansenii' at '2 hour' vs 'none' at '0 hour'stimulus, timeRNA seq of mouse bone marrow derived macrophages treated with Debaryomyces hansenii against untreated controls
Adjusted p-valueLog2-fold change
1.208 × 10-36-1.1
Tent5c'interferon gamma; 10 nanogram per milliliter and interleukin-22; 10 nanogram per milliliter' vs 'none'compoundRNAseq of small intestinal organoids from mice treated with the cytokines IFNG, IL-13 and IL-22 for 24 hours
Adjusted p-valueLog2-fold change
1.3214 × 10-12-1.1
Tent5c'stem cell of gastric corpus gland' vs 'epithelial cell of stomach'cell typeBulk RNA-seq of proliferating cells in the mouse stomach corpus epithelium from FUCCI mouse.
Adjusted p-valueLog2-fold change
1.3945 × 10-111.1
Tent5c'oxidized low density lipoprotein; 25 microgram per milliliter' vs 'none' in 'CD36 knockout'compound, genotypeQuantitative analysis of wild type and cd36-/- murine peritoneal macrophage transcriptomes
Adjusted p-valueLog2-fold change
1.1535 × 10-9-1.1
Tent5c'LDB1 knock-down' vs 'control shRNA'RNA interferenceRole of LDB1 in the transition from chromatin looping to transcription activation
Adjusted p-valueLog2-fold change
1.4097 × 10-7-1.1
Tent5c'Mettl6 knockout clone G6' vs 'wild type genotype'genotypeMETTL6 is a tRNA m3C methyltransferase that regulates translation and tumor cell proliferation
Adjusted p-valueLog2-fold change
1.7394 × 10-5-1.1
Tent5c'Porphyromonas gingivalis; normal' vs 'normal'infect, phenotypehyperlipidemia impaired innate response
Adjusted p-valueLog2-fold change
2.2576 × 10-51.1
Tent5c'West Nile virus; late stage encephalitis' vs 'early stage encephalitis'infect, timeTranscriptomic profiling of the brains of WNV and CHIKV infection-induced encephalitis in young mice after 2, 3 or 5 days post infection
Adjusted p-valueLog2-fold change
4.771 × 10-5-1.1
Tent5c'SARS coronavirus MA15' vs 'mock' in 'TLR3 knockout' at '4 day'genotype, infect, timeMouse lung tissue transcriptome response to a mouse-adapted strain of SARS-CoV in wild type C57BL6/NJ mice and TLR3-/- mice
Adjusted p-valueLog2-fold change
5.1323 × 10-51.1
Tent5c'Id2_Id3_double knockout' vs 'wild type' in 'CD4+TCRb+CD8– cell; thymus'cell type, genotype, organism partTranscription profiling by high throughput sequencing of Id-proteins (Id2 and Id3) gene knockout cells
Adjusted p-valueLog2-fold change
1.4322 × 10-4-1.1
Tent5c'IRAK1BP1 KO' vs 'wild type' in 'TNFα'genotype, treatmentIdentification of TNFα-induced genes that are IRAK1BP1 dependent
Adjusted p-valueLog2-fold change
2.4823 × 10-41.1
Tent5c'estradiol' at '14 hour' vs 'none' at '0 hour'compound, timeTranscription profiling by array of G1E cells during time course treatment with estradiol.
Adjusted p-valueLog2-fold change
2.6684 × 10-4-1.1
Tent5c'PAI1 knockout; SARS MA15; 4 day' vs 'PAI1 knockout; mock'genotype, infect, timeSARS infection of C57BL6, TIMP1 and Serpine1 knock-out mice
Adjusted p-valueLog2-fold change
3.3153 × 10-4-1.1
Tent5c'TRIM28(flox/flox):Mx1Cre' vs 'TRIM28(flox/flox)' in 'CD71(hi)TER119+'genotype, phenotypeTranscription profiling by high throughput sequencing of bone marrow immature erythroid cells from Trim28flox/flox:TgMx1Cre congenic mice
Adjusted p-valueLog2-fold change
3.6308 × 10-4-1.1
Tent5c'control mice [Gp130f/f]; cecal ligation and puncture' vs 'control mice [Gp130f/f]; control'genotype, treatmentHepatic acute phase proteins control innate immune responses during infection by promoting myeloid derived suppressor cell function
Adjusted p-valueLog2-fold change
6.1832 × 10-4-1.1
Tent5c'SARS coronavirus MA15 dORF6' vs 'none' at '4 day'infect, timeSM012 - SARS MA15 wild type, and SARS deltaORF6 mutant virus infections of C57BL6 mice - A time course
Adjusted p-valueLog2-fold change
8.0174 × 10-41.1
Tent5c'etoposide; 2.5 micromolar' vs 'none' in 'H2afj-∆7-KO'compound, genotypeRNA-seq of H2afj-ko and isogenic WT C57/Bl6-N mouse embryonic fibroblasts in proliferation and after etoposide-induced senescence.
Adjusted p-valueLog2-fold change
9.1619 × 10-41.1
Tent5c'old neuronal stem cells' vs 'young neuronal stem cells'ageA mechanism for the segregation of age in mammalian neural stem cells
Adjusted p-valueLog2-fold change
9.2006 × 10-41.1
Tent5c'lipid nanoparticle complexed with ribonucleic acid expressing respiratory synctial virus F protein' vs 'phosphate buffered saline'stimulusMicroarray analysis of mouse whole genome using self-amplifying messenger (SAM) RNA delivered with different formulations compared to controls
Adjusted p-valueLog2-fold change
1.0433 × 10-31.1
Tent5c'SR-BI-/- apoE-/-' vs 'control' in '21 day; Chow diet'age, diet, genotypeExpression data from the hearts of a mouse model of spontaneous myocardial infarction
Adjusted p-valueLog2-fold change
1.2147 × 10-3-1.1
Tent5c'21 percent oxygen, 37 degree Celsius, no serum' vs 'none'growth conditionRNA sequencing of native and ex vivo cultured murine tail tendon fascicles
Adjusted p-valueLog2-fold change
1.9715 × 10-3-1.1
Tent5c'actinomycin D; 8 hour' vs 'none' in 'Cnot1 flox/flox'compound, genotype, timeRNA-seq of livers in control and Cnot1 tamoxifen-inducible liver-specific knockout mice
Adjusted p-valueLog2-fold change
2.1941 × 10-31.1
Tent5c'Meis1; Meis2 conditional knockout' vs 'wild type phenotype'phenotypeMeis homeobox genes control cell competence within the eye-specified neuroepithelium (RNA-seq)
Adjusted p-valueLog2-fold change
3.6562 × 10-3-1.1
Tent5c'dextran sodium sulfate' vs 'none' in 'wild type genotype'compound, genotypeRNA-seq analysis of colonic intestinal epithelial cells (IECs) isolated from naive wild-type C57BL/6 mice, DSS-treated wild-type C57BL/6 mice, Il10-/- C57BL/6 mice and Il10-/- C57BL/6 mice with IEC-specific Rabgef1 deletion
Adjusted p-valueLog2-fold change
4.2236 × 10-31.1
Tent5c'human-Mfn2 T111A/S442A-overexpressing (Mfn2AA)' vs 'wild type' in '5 week; left ventricle'age, genotype, organism partTranscription profiling by high throughput sequencing of a mitofusin 2 (Mfn2) mutant in mouse
Adjusted p-valueLog2-fold change
4.7827 × 10-31.1
Tent5c'Fancc-/-' vs 'wild type'genotypeTranscription profiling by array of bone marrow cells from wild type, Fancc-deficient, Fancg-deficient, and doubly deficient (Fancc/Fancg) mice
Adjusted p-valueLog2-fold change
4.9816 × 10-3-1.1
Tent5c'SARS coronavirus MA15; 10^4 PFU' vs 'none' at '4 day'stimulus, timeSM001: SARS CoV MA15 infection of C57Bl/6 mouse model – Data from 4 viral doses at 1, 2, 4 and 7 days post infection.
Adjusted p-valueLog2-fold change
5.1046 × 10-3-1.1
Tent5c'SARS coronavirus MA15 nsp16 -/-' vs 'none' at '4 day'infect, timeSM014 - SARS MA15 wild type, and SARS nsp16 mutant virus infections of C57BL6 mice - A time course
Adjusted p-valueLog2-fold change
7.3477 × 10-3-1.1
Tent5c'homozygous Igf1 mutant' vs 'wild type'genotypeExpression data from E18.5 Igf1 -/- (homozygous mutant) and Igf1+/+ (normal wild type control) mouse lungs
Adjusted p-valueLog2-fold change
1.169 × 10-2-1.1
Tent5c'Irx3 knockout' vs 'control' at '1 day'genetic modification, timeRNA-Seq of mouse Irx3-KO and Control ME3 cells on days 1 and 7 of adipogenic differentiation
Adjusted p-valueLog2-fold change
1.4863 × 10-21.1
Tent5c'PolgD257A knockout' vs 'control'genotypeGene expression profile of gastrocnemius muscle from D257A mice
Adjusted p-valueLog2-fold change
2.2117 × 10-21.1
Tent5c'aire knock out' vs 'wild type'genotypeTranscription profiling by array of mice mutant for aire
Adjusted p-valueLog2-fold change
2.6485 × 10-21.1
Tent5c'14 month; QH2; liver' vs '14 month; control; liver'age, compound, organism partCoenzyme Q10-dependent gene expression in SAMP1 mice tissues
Adjusted p-valueLog2-fold change
4.6015 × 10-2-1.1
Tent5c'floxed HIF2alpha' vs 'wild type HIF2alpha'genotypeTranscription profiling by array of non-small cell lunch tumors from mice with floxed HIF2alpha
Adjusted p-valueLog2-fold change
4.4644 × 10-32-1
Tent5c'interferon gamma; 10 nanogram per milliliter' vs 'none'compoundRNAseq of small intestinal organoids from mice treated with the cytokines IFNG, IL-13 and IL-22 for 24 hours
Adjusted p-valueLog2-fold change
1.5041 × 10-111
Tent5c'artesunate and chloroquine (at same dosage); 30 milligram per kilogram; Plasmodium berghei ANKA; 10 day' vs 'none; none; 0 day'compound, infect, sampling time pointRNA-seq analysis of anti-malarial drug chemotherapy of murine experimental Cerebral Malaria (ECM)
Adjusted p-valueLog2-fold change
1.5223 × 10-7-1
Tent5c"Tgfbr2 knockout in CD11c positive cells" vs "wild type phenotype"phenotypeRNA-seq of mouse alveolar macrophages sorted from CD11cCre/+ Tgfbr2fl/fl and control Tgfbr2fl/fl neonatal mice
Adjusted p-valueLog2-fold change
1.0805 × 10-61
Tent5c'Salmonella enterica serovar Typhimurium' vs 'control' in 'bone marrow macrophage from 129P2 mouse strain'clinical information, infectGene expression profiles of mouse embryonic stem cell derived macrophages infected with Salmonella typhimurium
Adjusted p-valueLog2-fold change
4.6937 × 10-6-1
Tent5c'lung carcinoma' vs 'normal' in 'CD11b+Ly6G+ neutrophil'cell type, diseaseTranscriptome analysis of isolated stormal cells and tumor epithelial cells in mouse lung cancer by RNA-Seq
Adjusted p-valueLog2-fold change
1.3638 × 10-5-1
Tent5c'wild type genotype; SARS MA15; 4 day' vs 'wild type genotype; mock'genotype, infect, timeSARS infection of C57BL6, TIMP1 and Serpine1 knock-out mice
Adjusted p-valueLog2-fold change
3.7548 × 10-5-1
Tent5c'SARS coronavirus MA15; 4 day' vs 'mock' in 'WSB/EiJ'infect, strain, timeGenomic profiling of collaborative cross founder mouse strains infected with respiratory viruses to discover novel transcripts and infection-related strain-specific gene and isoform expression
Adjusted p-valueLog2-fold change
5.5151 × 10-5-1
Tent5c'TIMP1 knockout; SARS MA15; 4 day' vs 'TIMP1 knockout; mock'genotype, infect, timeSARS infection of C57BL6, TIMP1 and Serpine1 knock-out mice
Adjusted p-valueLog2-fold change
1.2862 × 10-41
Tent5c'interferon gamma' vs 'none'compoundType I and II Interferon-Stimulated Genes in Murine Primary Bone Marrow Macrophages
Adjusted p-valueLog2-fold change
1.8852 × 10-41
Tent5c'lipopolysaccharide' vs 'none' in 'bone marrow; wild type'cell type, compound, genotypeTranscription profiling by high throughput sequencing of spleens of GPR34 knockout and wild type mice
Adjusted p-valueLog2-fold change
4.1949 × 10-4-1
Tent5c'swimming twice a day, followed by 1 week of rest' at '4 week' vs 'control, followed by 1 week of rest'time, treatmentTranscription profiling of heart ventricles from mice that have cardiac hypertrophy induced by swimming training
Adjusted p-valueLog2-fold change
5.0169 × 10-4-1
Tent5c'SARS coronavirus MA15' vs 'none' in 'Tnfrsf1a/1b -/-' at '4 day'genotype, infect, timeSM019 - Infection with SARS MA15 of C57BL/6J mice and Tnfrsf1b knockout mice
Adjusted p-valueLog2-fold change
5.8923 × 10-41
Tent5c'smoke; 2250 microgram' vs 'control; 0 microgram' in 'wild type' at 'after 2 month exposure'compound, genotype, sampling time pointTranscription profiling by array of Nrf2 knockout mice exposed to cigarette smoke
Adjusted p-valueLog2-fold change
6.6661 × 10-4-1
Tent5c'SARS coronavirus MA15' vs 'none' in 'wild type genotype' at '4 day'genotype, infect, timeSM019 - Infection with SARS MA15 of C57BL/6J mice and Tnfrsf1b knockout mice
Adjusted p-valueLog2-fold change
7.8184 × 10-4-1
Tent5c'18 week; Str/ort' vs '18 week; CBA'age, strainExpression data of cartiliage from CBA and STR/ORT mice
Adjusted p-valueLog2-fold change
1.4558 × 10-31
Tent5c'Adjuvant System 03' vs 'PBS' in 'hindlimb muscle' at '4 hour'organism part, stimulus, timeExpression data from draining lymph node and muscle of mice immunised with AS03 or PBS
Adjusted p-valueLog2-fold change
3.8453 × 10-31
Tent5c'Aire knockout' vs 'wild type' in 'cTEC'genotype, phenotypeTranscription profiling by high throughput sequencing of primary cTEC, mTEClo, and mTEChi harvested from wild type and Aire-deficient mice
Adjusted p-valueLog2-fold change
4.2099 × 10-3-1
Tent5c'hepatocyte-specific deletion of JAK2' vs 'wild type genotype' in '12 week'age, genotypeHepatic Deletion of Janus Kinase 2 Counteracts Inflammation, Oxidative Stress and Liver Cancer Formation in Growth Hormone Transgenic Mice
Adjusted p-valueLog2-fold change
4.9384 × 10-31
Tent5c'estradiol' at '7 hour' vs 'none' at '0 hour'compound, timeTranscription profiling by array of G1E cells during time course treatment with estradiol.
Adjusted p-valueLog2-fold change
1.0093 × 10-2-1
Tent5c'co-cultured with hematopoietic stem cell for 9 days' vs 'non co-cultured for 9 days' in 'endothelial cell; expressing AKT1'cell type, growth condition, phenotypeTranscription profiling by high throughput sequencing of murine bone marrow endothelial cells and bone marrow stroma, in vitro and in vivo, with and without hematopoietic stem cells co-culture
Adjusted p-valueLog2-fold change
1.1474 × 10-21
Tent5c'Irx3 knockout' vs 'control' at '7 day'genetic modification, timeRNA-Seq of mouse Irx3-KO and Control ME3 cells on days 1 and 7 of adipogenic differentiation
Adjusted p-valueLog2-fold change
1.2429 × 10-2-1
Tent5c'SARS coronavirus MA15; 10^5 PFU' vs 'none' at '7 day'stimulus, timeSM001: SARS CoV MA15 infection of C57Bl/6 mouse model – Data from 4 viral doses at 1, 2, 4 and 7 days post infection.
Adjusted p-valueLog2-fold change
1.5293 × 10-2-1
Tent5c'non-alcoholic fatty liver disease' vs 'normal' in 'SGLT5 knockout'disease, genotypeTranscription profiling by array of SGLT5 knockout mice under conditions of long-term fructose consumption
Adjusted p-valueLog2-fold change
1.901 × 10-2-1
Tent5c'Chikungunya virus; early stage encephalitis' vs 'mock infection'infect, timeTranscriptomic profiling of the brains of WNV and CHIKV infection-induced encephalitis in young mice after 2, 3 or 5 days post infection
Adjusted p-valueLog2-fold change
2.0143 × 10-21
Tent5c'Col1a1-tetO-MLL/ENL' vs 'wild type' in 'hematopoietic stem cell'cell type, genotypeTranscription profiling by high throughput sequencing of hematopoietic stem cells from a conditional-inducible mouse model of the MLL-ENL fusion oncogene
Adjusted p-valueLog2-fold change
2.7276 × 10-21
Tent5c'DAPT' vs 'dimethyl sulfoxide' in 'Ngn3tTA/tTA'compound, genotypeNeurog3-independant role of Notch signaling in pancreas explants. Microarray of pancreata of Wildtype or Neurog3tTA/tTA (Neurog3-Null) background at E12.5, explanted for 3d + treatment 24h with DAPT/vehicle.
Adjusted p-valueLog2-fold change
2.8608 × 10-2-1
Tent5c'azoxymethane and dextran sodium sulfate; Myd88 knockout' vs 'azoxymethane and dextran sodium sulfate; wild type'compound, genotypeGene expression profiling of total colon in AOM/DSS-treated Myd88 knockout and wild type
Synonym
Fam46c, 4930431B09Rik
Ortholog
T23F11.6 (Caenorhabditis elegans), TENT5C (Homo sapiens), ENSCING00000014994 (Ciona savignyi), TENT5C (Monodelphis domestica), TENT5C (Bos taurus), ENSOANG00000003065 (Sus scrofa), C42D4.3 (Caenorhabditis elegans), F26G1.5 (Caenorhabditis elegans), TENT5C (Chlorocebus sabaeus), ENSCSAVG00000007111 (Ciona savignyi), TENT5C (Sus scrofa), tent5c (Xenopus tropicalis), TENT5C (Pan troglodytes), FAM46C (Gallus gallus), tent5c (Danio rerio), TENT5C (Macaca mulatta), F17C11.22 (Caenorhabditis elegans), pqn-44 (Caenorhabditis elegans), TENT5C (Equus caballus), ENSPANG00000005228 (Papio anubis), TENT5C (Gorilla gorilla), TENT5C (Pongo abelii), Tent5c (Rattus norvegicus), F26G1.9 (Caenorhabditis elegans), TENT5C (Anas platyrhynchos), CG46385 (Drosophila melanogaster), TENT5C (Dasypus novemcinctus), ENSOARG00020001120 (Sus scrofa)
Gene ontology
InterPro
Ensembl gene
Ensembl transcript
Ensembl protein
Entrez
UniProt
MGI ID (Mouse)
MGI description
Gene biotype
Design element
104477_at, 5247465, 5607002, ILMN_2684205, 4532839, 5037474, 5090524, 5201384, 1429682_at, 17408414, aa289002_s_at, 5015100, 4857517, 4571789, 10500610, 4834184, 4762605, A_51_P447976, 134703_at, 1448021_at, 5028530, 5164608