ENSMUSG00000044594 (Serpinb3a)

mus musculus

serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3A

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Mus musculus
Organism part
Showing 56 experiments:
image/svg+xml aorta circulatory system blood vessel brown adipose tissue white adipose tissue skin stomach duodenum pancreas spleen adrenal gland kidney colon small intestine caecum jejunum ileum esophagus gall bladder parotid gland submandibular gland lymph node parathyroid gland tongue Peyer’s patch prostate gland vas deferens epididymis testis seminal vesicle penis urinary bladder thymus femur bone marrow cartilage quadriceps femoris spinal cord lung diaphragm peripheral nervous system trachea hindlimb trigeminal nerve eye sciatic nerve intestinal mucosa liver heart brain skeletal muscle
Created with Highcharts 6.2.0adrenal glandcentral neural epitheliumepidermal ectodermhippocampuslungolfactory bulbskeletal muscle organtracheaaxillary lymph nodebronchuscorpora quadrigeminadiencephalonfloor plateheartintestinal mucosalateral prominence neural epitheliummedial nasal prominencemuscle (biceps femoris)oviductpreoptic areaspleensubventricular zonevesicular glandwhole organism
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49 FANTOM5 project - adult
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49 FANTOM5 project - neonate
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49 FANTOM5 project - juvenile
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49 FANTOM5 project - embryonic day 18
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49 FANTOM5 project - embryonic day 17
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49 FANTOM5 project - embryonic day 16
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49 FANTOM5 project - embryonic day 15
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49 FANTOM5 project - embryonic day 14
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49 FANTOM5 project - embryonic day 12
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9 in 3 strains - DBA/2J
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9 in 3 strains - CD1
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14 - embryonic day 10.5
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9 in 3 strains - C57BL/6
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49 FANTOM5 project - embryonic day 13
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Mammalian Kaessmann
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GENCODE
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Vertebrates
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14 - embryonic day 9.5
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4 Bonthuis et al - CastEiJ
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Developing gut
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49 FANTOM5 project - embryonic day 11
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Gregg et al - CAST/EiJ
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Gregg et al - C57BL/6J
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Gregg et al - (CAST/EiJ X C57BL/6J)F1
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Gregg et al - (C57BL/6J X CAST/EiJ)F1
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4 Bonthuis et al - (CastEiJ X …
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4 Bonthuis et al - (C57BL/6J X …
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Mernberger et al 2019 - Organism Part
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49 FANTOM5 project - pregnant adult day …
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3 Soumillon et al
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Sun et al., 2020 - Organism part
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4 Bonthuis et al - C57BL/6J
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Fat and muscle
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49 FANTOM5 project - embryonic day 17.5
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49 FANTOM5 project - embryonic day 14.5
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49 FANTOM5 project - embryo
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4 Bonthuis et al - Idaho derived wild …
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Huttlin et al., 2010 - tissues - brain, …
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Linscheid et al., 2021 - tissue - heart …
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Duda et al., 2018 - organism part - …
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Linscheid et al. 2019 - organism part
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Deshmukh et al., 2015 - organism part
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Zhao et al., 2019 - tissue - lens
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Meierhofer et al., 2016 - organism part
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Proteomics
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Transcriptomics
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Kingdom
Species
Experiment type
Experimental variables
Regulation
Log2-fold changeSpeciesGene nameComparisonExperimental variablesExperiment name
Adjusted p-valueLog2-fold change
8.7211 × 10-97.3
Serpinb3a'cortical epithelial cell; Lin- Dapi-EpCAM+ CD31-UEA1-Ly51+ td-tomato+t vs 'medullary epithelial cell; Lin- Dapi-EpCAM+ CD31-UEA1+Ly51- td-tomato-'cell type, phenotypeThymic T-cell progenitor development is supported by membrane bound Kit ligand provided by a combined vascular endothelial and epithelial niche.
Adjusted p-valueLog2-fold change
3.3984 × 10-94.8
Serpinb3a'carcinoma' vs 'normal'diseaseGene expression profile between normal mouse skin and carcinomas arising in the skin of RbF/F;K14creERTM;p107-/- mouse
Adjusted p-valueLog2-fold change
2.8272 × 10-24.1
Serpinb3a'CpG ODN' vs 'PBS' at '4 hour'compound, timeTranscription profiling by array of mouse vaginal samples following adjuvant treatment
Adjusted p-valueLog2-fold change
3.3839 × 10-8-4
Serpinb3a'bronchoalveolar adenocarcinoma induced using doxycycline' vs 'normal'diseaseTranscription profiling by array of lung alveolar type II epithelial cells with bronchoalveolar adenocarcinoma
Adjusted p-valueLog2-fold change
2.451 × 10-9-3.3
Serpinb3a'Gprc5a knockout' vs 'control'genotypeGene expression profile of lung epithelial cells cultured from normal tracheas of Gprc5a knockout and wild-type mice
Adjusted p-valueLog2-fold change
5.1682 × 10-9-3.3
Serpinb3a'Mycobacterium tuberculosis; C57BL/6J; 70 day' vs 'control; C57BL/6J; 0 day'infect, strain, timeTranscription profiling of mouse lung from C57BL6 and DBA2 parental strains and D2.B6-Chr7 and D2.B6-Chr19 congenic mice following aerosol infection with Mycobacterium tuberculosis for 30 and 70 days
Adjusted p-valueLog2-fold change
7.8127 × 10-9-3.3
Serpinb3a'Mycobacterium tuberculosis; C57BL/6J; 30 day' vs 'control; C57BL/6J; 0 day'infect, strain, timeTranscription profiling of mouse lung from C57BL6 and DBA2 parental strains and D2.B6-Chr7 and D2.B6-Chr19 congenic mice following aerosol infection with Mycobacterium tuberculosis for 30 and 70 days
Adjusted p-valueLog2-fold change
3.3581 × 10-3-3.2
Serpinb3a'Mycobacterium tuberculosis; D2.B6-Chr19 congenic; 70 day' vs 'control; D2.B6-Chr19 congenic; 0 day'infect, strain, timeTranscription profiling of mouse lung from C57BL6 and DBA2 parental strains and D2.B6-Chr7 and D2.B6-Chr19 congenic mice following aerosol infection with Mycobacterium tuberculosis for 30 and 70 days
Adjusted p-valueLog2-fold change
3.4667 × 10-3-3.1
Serpinb3a'Mycobacterium tuberculosis; D2.B6-Chr19 congenic; 30 day' vs 'control; D2.B6-Chr19 congenic; 0 day'infect, strain, timeTranscription profiling of mouse lung from C57BL6 and DBA2 parental strains and D2.B6-Chr7 and D2.B6-Chr19 congenic mice following aerosol infection with Mycobacterium tuberculosis for 30 and 70 days
Adjusted p-valueLog2-fold change
2.2842 × 10-42.8
Serpinb3a'transplanted secondary tumors' vs 'normal' in 'kidney'clinical information, organism partPremature termination of in vivo reprogramming leads to cancer development through altered epigenetic regulation [array]
Adjusted p-valueLog2-fold change
4.9247 × 10-22.5
Serpinb3a'30 month' vs '5 month' in 'male'age, block, sexExpression data from tail skin in young (5 months) and old (30 months) CB6F1 mice
Adjusted p-valueLog2-fold change
3.8642 × 10-22.4
Serpinb3a'chronic DSS-induced colitis; 2x DSS, additional recovery' vs 'none; none'clinical treatment, diseaseTranscription profiling by array of colon tissues isolated from mice with acute and chronic dextran sodium sulphate (DSS)-induced colitis
Adjusted p-valueLog2-fold change
2.5885 × 10-2-2.3
Serpinb3a'neural stem cell' vs 'niche cell'cell typeTranscription profiling by high throughput sequencing of three populations of primary dentate gyrus cells
Adjusted p-valueLog2-fold change
3.5485 × 10-2-2.3
Serpinb3a'neural progenitor cell' vs 'niche cell'cell typeTranscription profiling by high throughput sequencing of three populations of primary dentate gyrus cells
Adjusted p-valueLog2-fold change
2.0036 × 10-22.2
Serpinb3a'CFTR-; female; BALB' vs 'wild type; female; BALB'genotype, sex, strainTranscription profiling of lung from a mouse model of cystic fibrosis fromB6 and Balb strains vs wild type littermates to determine strain specific differences
Adjusted p-valueLog2-fold change
7.0302 × 10-62
Serpinb3a'dinitrofluorobenzene' vs 'control' in 'wild type'compound, genotypeTranscription profiling of mouse Cannabinoid receptor double knockouts (Cnr1 -/- /Cnr2 -/-) in CHS model to investigate cutaneous contact hypersensitivity
Adjusted p-valueLog2-fold change
3.3133 × 10-2-2
Serpinb3a'30 days of tuberculosis' vs 'uninfected'disease, timeTranscription profiling by array of lungs from mice infected with tuberculosis
Adjusted p-valueLog2-fold change
4.3883 × 10-2-2
Serpinb3a'70 days of tuberculosis' vs 'uninfected'disease, timeTranscription profiling by array of lungs from mice infected with tuberculosis
Adjusted p-valueLog2-fold change
4.5325 × 10-21.9
Serpinb3a'P60; insulin-expressing mature beta cells' vs 'E16.5; insulin-expressing nascent beta cells'age, cell typeTranscriptional profiling of nascent and mature pancreatic beta cells
Adjusted p-valueLog2-fold change
1.4776 × 10-51.7
Serpinb3a'oral hard palate epithelium' vs 'tail skin epithelium'organism partTranscriptional profiling of mouse oral and skin epithelium to study their intrinsic difference in global gene expression
Adjusted p-valueLog2-fold change
1.1938 × 10-41.7
Serpinb3a'dinitrofluorobenzene' vs 'control' in 'Cnr1 -/- /Cnr2 -/-'compound, genotypeTranscription profiling of mouse Cannabinoid receptor double knockouts (Cnr1 -/- /Cnr2 -/-) in CHS model to investigate cutaneous contact hypersensitivity
Adjusted p-valueLog2-fold change
7.0236 × 10-3-1.7
Serpinb3a'primary hair placode keratinocyte' vs 'interfollicular epidermal keratinocyte'cell typeTranscription profiling of mouse primary hair placode keratinocytes compared to interfollicular epidermal keratinocytes
Adjusted p-valueLog2-fold change
2.2257 × 10-41.6
Serpinb3a'6 day' vs '0 day'timeTranscription profiling by array of mouse colon tissues under dextran sodium sulphate induction for 2, 4 and 6 days against uninduced controls at day 0
Adjusted p-valueLog2-fold change
5.8425 × 10-3-1.6
Serpinb3a'blocked NF-kB pathway' vs 'wild type genotype'genotypeTranscription profiling of total epidermis of embryonic day 14.5 mouse embryos with blocked NF-kB pathway
Adjusted p-valueLog2-fold change
4.1034 × 10-21.5
Serpinb3a"98 to 119 week; reproductively old" vs "6 to 12 week; reproductively young"age, phenotypeRNAseq of whole ovarian follicles from young and old mice.
Adjusted p-valueLog2-fold change
4.6075 × 10-31.1
Serpinb3a'K14-Cre-ERT2 / CK1α fl/fl; 4-hydroxytamoxifen; none; 14 day' vs 'K14-Cre-ERT2; none; none'genotype, irradiate, timeAblation of casein kinase 1 in keratinocytes induces p53-dependent hyperpigmentation of the skin
Adjusted p-valueLog2-fold change
6.9453 × 10-51
Serpinb3a'Dicer knock out' vs 'wild type'genotypeTranscription profiling by array of mouse Dicer-deficient ooctyes
Adjusted p-valueLog2-fold change
8.5601 × 10-4-1
Serpinb3a'calorie restricted diet' vs 'normal diet' at '15 month'age, dietTranscription profiling by array of cochleae from mice fed a calorie-restricted diet
Adjusted p-valueLog2-fold change
2.5607 × 10-3-1
Serpinb3a'Aire knock out' vs 'wild type'genotypeTranscription profiling by array of mouse thymic medullary epithelial cells mutant for Aire
Synonym
Sqn5
Ortholog
SERPINB4 (Homo sapiens), OVALX (Gallus gallus), ENSPANG00000003493 (Papio anubis), Serpinb3a (Rattus norvegicus), serpinb4 (Xenopus tropicalis), ENSMMUG00000042415 (Macaca mulatta), Serpinb3 (Rattus norvegicus), ENSPPYG00000009219 (Pongo abelii), ENSPPYG00000009218 (Pongo abelii), ENSOANG00000045217 (Ornithorhynchus anatinus), ENSBTAG00000048720 (Bos taurus), ENSMMUG00000058384 (Macaca mulatta), ENSBTAG00000052012 (Bos taurus), SERPINB3 (Pan troglodytes), SERPINB4 (Bos taurus), ENSPTRG00000049226 (Bos taurus), ENSCSAG00000018203 (Chlorocebus sabaeus), ENSMODG00000005407 (Monodelphis domestica), ENSECAG00000035510 (Equus caballus), OVALY (Gallus gallus), ENSAPLG00000008266 (Anas platyrhynchos), ENSMODG00000005323 (Monodelphis domestica), ENSBTAG00000052162 (Bos taurus), ENSDNOG00000013567 (Dasypus novemcinctus), ENSSSCG00000033560 (Sus scrofa), ENSBTAG00000048835 (Bos taurus), ENSOARG00020014134 (Pan troglodytes), ENSAPLG00000027763 (Anas platyrhynchos), ENSACAG00000000878 (Anolis carolinensis), ENSPANG00000002793 (Papio anubis), ENSBTAG00000049569 (Bos taurus), ENSPTRG00000051194 (Pan troglodytes), SERPINB3 (Homo sapiens), ENSOARG00020025894 (Pongo abelii), ENSBTAG00000051132 (Bos taurus), ENSOCUG00000010529 (Oryctolagus cuniculus), ENSBTAG00000054882 (Bos taurus), SERPINB4 (Gorilla gorilla), OVA (Gallus gallus)
Gene ontology
InterPro
Ensembl gene
Ensembl transcript
Ensembl protein
Entrez
UniProt
MGI ID (Mouse)
MGI description
Gene biotype
Design element
1437517_x_at, 4675193, 17226080, 10357072, 5423712, ILMN_2687408, 5111962, ILMN_2837969, A_52_P277455, 5398803, 5462919, A_51_P230599, 4964174, A_55_P2003746, 101816_at
Reactome pathway ID