ENSMUSG00000045539 (Sprr3)

mus musculus

small proline-rich protein 3

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Mus musculus
Organism part
Showing 56 experiments:
image/svg+xml aorta circulatory system blood vessel brown adipose tissue white adipose tissue skin stomach duodenum pancreas spleen adrenal gland kidney colon small intestine caecum jejunum ileum esophagus gall bladder parotid gland submandibular gland lymph node parathyroid gland tongue Peyer’s patch prostate gland vas deferens epididymis testis seminal vesicle penis urinary bladder thymus femur bone marrow cartilage quadriceps femoris spinal cord lung diaphragm peripheral nervous system trachea hindlimb trigeminal nerve eye sciatic nerve intestinal mucosa liver heart brain skeletal muscle
Created with Highcharts 6.2.0adrenal glandcentral neural epitheliumepidermal ectodermhippocampuslungolfactory bulbskeletal muscle organtracheaaxillary lymph nodebronchuscorpora quadrigeminadiencephalonfloor plateheartintestinal mucosalateral prominence neural epitheliummedial nasal prominencemuscle (biceps femoris)oviductpreoptic areaspleensubventricular zonevesicular glandwhole organism
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49 FANTOM5 project - adult
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49 FANTOM5 project - neonate
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49 FANTOM5 project - juvenile
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49 FANTOM5 project - embryonic day 18
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49 FANTOM5 project - embryonic day 17
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49 FANTOM5 project - embryonic day 16
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49 FANTOM5 project - embryonic day 15
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49 FANTOM5 project - embryonic day 14
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49 FANTOM5 project - embryonic day 12
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9 in 3 strains - DBA/2J
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9 in 3 strains - CD1
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14 - embryonic day 10.5
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9 in 3 strains - C57BL/6
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49 FANTOM5 project - embryonic day 13
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Mammalian Kaessmann
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GENCODE
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Vertebrates
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14 - embryonic day 9.5
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14 - embryonic day 8.5
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4 Bonthuis et al - CastEiJ
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Developing gut
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49 FANTOM5 project - embryonic day 11
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3
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Gregg et al - CAST/EiJ
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Gregg et al - C57BL/6J
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Gregg et al - (CAST/EiJ X C57BL/6J)F1
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Gregg et al - (C57BL/6J X CAST/EiJ)F1
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4 Bonthuis et al - (CastEiJ X …
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4 Bonthuis et al - (C57BL/6J X …
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Mernberger et al 2019 - Organism Part
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49 FANTOM5 project - pregnant adult day …
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49 FANTOM5 project - pregnant adult day …
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3 Soumillon et al
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Sun et al., 2020 - Organism part
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4 Bonthuis et al - C57BL/6J
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Fat and muscle
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49 FANTOM5 project - pregnant adult day …
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49 FANTOM5 project - pregnant adult day …
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49 FANTOM5 project - embryonic day 17.5
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49 FANTOM5 project - embryonic day 14.5
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49 FANTOM5 project - embryo
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4 Bonthuis et al - Idaho derived wild …
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Huttlin et al., 2010 - tissues - brain, …
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Linscheid et al., 2021 - tissue - heart …
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Duda et al., 2018 - organism part - …
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Duda et al., 2018 - organism part - …
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Linscheid et al. 2019 - organism part
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Deshmukh et al., 2015 - organism part
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Zhao et al., 2019 - tissue - lens
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Meierhofer et al., 2016 - organism part
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Proteomics
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Transcriptomics
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Kingdom
Species
Experiment type
Experimental variables
Regulation
Log2-fold changeSpeciesGene nameComparisonExperimental variablesExperiment name
Adjusted p-valueLog2-fold change
3.7102 × 10-97.6
Sprr3'oral hard palate epithelium' vs 'tail skin epithelium'organism partTranscriptional profiling of mouse oral and skin epithelium to study their intrinsic difference in global gene expression
Adjusted p-valueLog2-fold change
5.1883 × 10-86.1
Sprr3'Lkb1 -/- Pten-/-' vs 'wild type'genotypeLoss of Lkb1 and Pten Leads to Lung Squamous Cell Carcinoma with Elevated Pdl1 Expression: Epithelial Cells
Adjusted p-valueLog2-fold change
3.3499 × 10-10-4.8
Sprr3'Mycobacterium tuberculosis; C57BL/6J; 30 day' vs 'control; C57BL/6J; 0 day'infect, strain, timeTranscription profiling of mouse lung from C57BL6 and DBA2 parental strains and D2.B6-Chr7 and D2.B6-Chr19 congenic mice following aerosol infection with Mycobacterium tuberculosis for 30 and 70 days
Adjusted p-valueLog2-fold change
4.4683 × 10-10-4.7
Sprr3'Mycobacterium tuberculosis; C57BL/6J; 70 day' vs 'control; C57BL/6J; 0 day'infect, strain, timeTranscription profiling of mouse lung from C57BL6 and DBA2 parental strains and D2.B6-Chr7 and D2.B6-Chr19 congenic mice following aerosol infection with Mycobacterium tuberculosis for 30 and 70 days
Adjusted p-valueLog2-fold change
8.4494 × 10-7-4.6
Sprr3'bronchoalveolar adenocarcinoma induced using doxycycline' vs 'normal'diseaseTranscription profiling by array of lung alveolar type II epithelial cells with bronchoalveolar adenocarcinoma
Adjusted p-valueLog2-fold change
1.5567 × 10-34.4
Sprr3'CFTR-; female; BALB' vs 'wild type; female; BALB'genotype, sex, strainTranscription profiling of lung from a mouse model of cystic fibrosis fromB6 and Balb strains vs wild type littermates to determine strain specific differences
Adjusted p-valueLog2-fold change
1.7528 × 10-604.2
Sprr3'etoposide; 2.5 micromolar' vs 'none' in 'wild type genotype'compound, genotypeRNA-seq of H2afj-ko and isogenic WT C57/Bl6-N mouse embryonic fibroblasts in proliferation and after etoposide-induced senescence.
Adjusted p-valueLog2-fold change
1.603 × 10-444
Sprr3'etoposide; 2.5 micromolar' vs 'none' in 'H2afj-∆7-KO'compound, genotypeRNA-seq of H2afj-ko and isogenic WT C57/Bl6-N mouse embryonic fibroblasts in proliferation and after etoposide-induced senescence.
Adjusted p-valueLog2-fold change
9.2695 × 10-4-3.8
Sprr3'Mycobacterium tuberculosis; D2.B6-Chr19 congenic; 70 day' vs 'control; D2.B6-Chr19 congenic; 0 day'infect, strain, timeTranscription profiling of mouse lung from C57BL6 and DBA2 parental strains and D2.B6-Chr7 and D2.B6-Chr19 congenic mice following aerosol infection with Mycobacterium tuberculosis for 30 and 70 days
Adjusted p-valueLog2-fold change
3.1316 × 10-2-3.8
Sprr3'cortical epithelial cell; Lin- Dapi-EpCAM+ CD31-UEA1-Ly51+ td-tomato+t vs 'medullary epithelial cell; Lin- Dapi-EpCAM+ CD31-UEA1+Ly51- td-tomato-'cell type, phenotypeThymic T-cell progenitor development is supported by membrane bound Kit ligand provided by a combined vascular endothelial and epithelial niche.
Adjusted p-valueLog2-fold change
9.3461 × 10-4-3.7
Sprr3'Mycobacterium tuberculosis; D2.B6-Chr19 congenic; 30 day' vs 'control; D2.B6-Chr19 congenic; 0 day'infect, strain, timeTranscription profiling of mouse lung from C57BL6 and DBA2 parental strains and D2.B6-Chr7 and D2.B6-Chr19 congenic mice following aerosol infection with Mycobacterium tuberculosis for 30 and 70 days
Adjusted p-valueLog2-fold change
3.308 × 10-2-3.6
Sprr3'30 days of tuberculosis' vs 'uninfected'disease, timeTranscription profiling by array of lungs from mice infected with tuberculosis
Adjusted p-valueLog2-fold change
2.6394 × 10-3-3.4
Sprr3'induced extraembryonic endoderm stem cell; grown in ES cell medium' vs 'mouse embryonic fibroblast; control'cell type, growth conditionOSKM induce extraembryonic endoderm stem (iXEN) cells in parallel to iPS cells
Adjusted p-valueLog2-fold change
2.4875 × 10-23.1
Sprr3'carcinoma' vs 'normal'diseaseGene expression profile between normal mouse skin and carcinomas arising in the skin of RbF/F;K14creERTM;p107-/- mouse
Adjusted p-valueLog2-fold change
1.9642 × 10-32.9
Sprr3'transplanted secondary tumors' vs 'normal' in 'kidney'clinical information, organism partPremature termination of in vivo reprogramming leads to cancer development through altered epigenetic regulation [array]
Adjusted p-valueLog2-fold change
1.6836 × 10-22.8
Sprr3'chronic DSS-induced colitis; 2x DSS, additional recovery' vs 'none; none'clinical treatment, diseaseTranscription profiling by array of colon tissues isolated from mice with acute and chronic dextran sodium sulphate (DSS)-induced colitis
Adjusted p-valueLog2-fold change
2.3012 × 10-5-2.1
Sprr3'Gprc5a knockout' vs 'control'genotypeGene expression profile of lung epithelial cells cultured from normal tracheas of Gprc5a knockout and wild-type mice
Adjusted p-valueLog2-fold change
1.0689 × 10-62
Sprr3'K14-Cre-ERT2; none; UVB irradiation; 7 day' vs 'K14-Cre-ERT2; none; none'genotype, irradiate, timeAblation of casein kinase 1 in keratinocytes induces p53-dependent hyperpigmentation of the skin
Adjusted p-valueLog2-fold change
4.3851 × 10-2-2
Sprr3'induced extraembryonic endoderm stem cell; grown in XEN cell medium' vs 'mouse embryonic fibroblast; control'cell type, growth conditionOSKM induce extraembryonic endoderm stem (iXEN) cells in parallel to iPS cells
Adjusted p-valueLog2-fold change
2.2112 × 10-5-1.9
Sprr3'3D culture' vs '2D culture'growth conditionmRNA-seq of mouse salivary gland cancer cells cultured in adherent or non-adherent culture
Adjusted p-valueLog2-fold change
4.0452 × 10-2-1.9
Sprr3'Trp53 knockout' vs 'wild type genotype' in 'Nutlin-3a; 10 micromolar'compound, phenotypeResidual tumor suppressor activities of tumorigenic p53 mutants enhance survival under chemotherapy
Adjusted p-valueLog2-fold change
4.8901 × 10-2-1.9
Sprr3'extraembryonic endoderm stem cell; grown in XEN cell medium' vs 'mouse embryonic fibroblast; control'cell type, growth conditionOSKM induce extraembryonic endoderm stem (iXEN) cells in parallel to iPS cells
Adjusted p-valueLog2-fold change
2.1293 × 10-4-1.8
Sprr3'acute oropharyngeal candidiasis wild type mice'; female' vs 'healthy wild type genotype mice'compound, disease, genotype, sexTranscription profiling by array of antibody blockade of IL-17-family cytokines in immunity to acute murine oral mucosal candidiasis
Adjusted p-valueLog2-fold change
1.1452 × 10-2-1.8
Sprr3'active gastritis with low grade metaplasia; Helicobacter pylori' vs 'normal; none' at '12 month'disease, infect, timeTranscription profiling of gastric tissues from mice infected with H. pylori strain SS1 for 6 or 12 months
Adjusted p-valueLog2-fold change
4.5659 × 10-5-1.6
Sprr3'Aire knock out' vs 'wild type'genotypeTranscription profiling by array of mouse thymic medullary epithelial cells mutant for Aire
Adjusted p-valueLog2-fold change
1.911 × 10-51.5
Sprr3'Men1-null' vs 'wild type'genotypeDifferentially regulated genes in adipocytes derived from Men1-null vs WT mouse embryonic stem cells
Adjusted p-valueLog2-fold change
2.7981 × 10-7-1.4
Sprr3'induced neural stem cell' vs 'mouse embryonic fibroblast cell'cell typeGene expression profile of mouse induced neural stem cells
Adjusted p-valueLog2-fold change
4.5733 × 10-61.4
Sprr3'N-acetylcysteine; 4 day differentiated; 1 millimolar' vs 'none; 4 day differentiated'compound, developmental stageRNA-seq of C17.2 neuronal progenitor cells exposed to cerium oxide nanoparticles during cell differentiation
Adjusted p-valueLog2-fold change
1.126 × 10-3-1.3
Sprr3'co-cultured with hematopoietic stem cell for 9 days' vs 'non co-cultured for 9 days' in 'endothelial cell; expressing AKT1'cell type, growth condition, phenotypeTranscription profiling by high throughput sequencing of murine bone marrow endothelial cells and bone marrow stroma, in vitro and in vivo, with and without hematopoietic stem cells co-culture
Adjusted p-valueLog2-fold change
7.672 × 10-3-1.3
Sprr3'missense mutation (T2996C) in Mucin 2 (Muc2)' vs 'wild type genotype'genotypeTranscription profiling of mouse intestine in ENU mutagenesis mouse strains with missense mutations in Muc2 mucin and ER stress
Adjusted p-valueLog2-fold change
1.9723 × 10-21
Sprr3'3 hour' vs '1 hour' in 'fetal bovine serum; 10 percent'growth condition, timeTranscriptomic changes in C3H10T1/2 cells exposed to lipid deprivation
Adjusted p-valueLog2-fold change
2.1301 × 10-21
Sprr3'all-trans-retinoic acid; 10 micromolar' vs 'none' in 'wild type genotype'compound, genotypeRNA-seq of mouse DNA repair endonuclease XPF knock out versus wild type and versus trans retinoic acid (tRA) treated wild type
Adjusted p-valueLog2-fold change
4.6578 × 10-21
Sprr3'NKCC1 knockout' vs 'wild type'genotypeIon Transporter NKCC1 - Modulator of Neurogenesis in Murine Olfactory Neurons