ENSMUSG00000076612 (Ighg2c)

mus musculus

immunoglobulin heavy constant gamma 2C

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Mus musculus
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Showing 2 experiments:
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Log2-fold changeSpeciesGene nameComparisonExperimental variablesExperiment name
Adjusted p-valueLog2-fold change
8.9918 × 10-149
Ighg2c'70 week' vs '6 week' in 'none; none;age, irradiatePericyte induced reprogramming of the bone marrow microenvironment drives stem and cancer cell quiescence
Adjusted p-valueLog2-fold change
3.7182 × 10-118.6
Ighg2c'TMEV infected' at '196 day' vs 'mock control' at '196 day'disease, timeTranscription profiling of mouse spinal cord from mock-infected and Theilers murine encephalomyelitis (TME)-virus infected animals - time series
Adjusted p-valueLog2-fold change
1.2819 × 10-118.5
Ighg2c'TMEV infected' at '98 day' vs 'mock control' at '98 day'disease, timeTranscription profiling of mouse spinal cord from mock-infected and Theilers murine encephalomyelitis (TME)-virus infected animals - time series
Adjusted p-valueLog2-fold change
3.2686 × 10-158.2
Ighg2c'TMEV infected' at '42 day' vs 'mock control' at '42 day'disease, timeTranscription profiling of mouse spinal cord from mock-infected and Theilers murine encephalomyelitis (TME)-virus infected animals - time series
Adjusted p-valueLog2-fold change
6.8745 × 10-57.7
Ighg2c'B6.Sle1a.1' vs 'wild type'genotypeTranscription profiling by array of mouse CD4+ T cells mutant for Sle1a.1
Adjusted p-valueLog2-fold change
1.022 × 10-57.3
Ighg2c'70 days of tuberculosis' vs 'uninfected'disease, timeTranscription profiling by array of lungs from mice infected with tuberculosis
Adjusted p-valueLog2-fold change
1.9212 × 10-1217.2
Ighg2c'wormy, worm left; Trichuris muris' vs 'control; non wormy' in 'caecum'environmental stress, infect, organism partRNA-seq of mouse intestinal mucosa to investigate infection by the parasitic nematode Trichuris muris
Adjusted p-valueLog2-fold change
9.8914 × 10-2286.6
Ighg2c'Mycobacterium tuberculosis H37Rv' vs 'none'infectThe global transcriptome of whole lungs extracted from M. tuberculosis infected C57BL6 mice
Adjusted p-valueLog2-fold change
9.3837 × 10-96.5
Ighg2c'Mycobacterium tuberculosis H37Rv' vs 'none' in 'TNF-alpha knockout'compound, genotype, infect4-week mouse comparative study on effect of neutralizing IL-17A, IL-17F and TNFa antibodies
Adjusted p-valueLog2-fold change
8.9581 × 10-66.3
Ighg2c'Plasmodium chabaudi infection' vs 'no infection' in 'adjuvant only'infect, treatmentProtective vaccination against blood-stage malaria of Plasmodium chabaudi: differential gene expression in the liver of Balb/c mice towards the end of crisis phase
Adjusted p-valueLog2-fold change
6.4423 × 10-126.2
Ighg2c'Mycobacterium tuberculosis H37Rv' vs 'none' in 'wild type'compound, genotype, infect4-week mouse comparative study on effect of neutralizing IL-17A, IL-17F and TNFa antibodies
Adjusted p-valueLog2-fold change
5.0188 × 10-10-6
Ighg2c'brown adipose tissue' vs 'white adipose tissue' in 'chow; 23 degree celsius'diet, organism part, temperatureRNA-seq of brown and white mouse adipose tissue at thermoneutrality and high-fat diet
Adjusted p-valueLog2-fold change
9.1406 × 10-235.9
Ighg2c'PTEN null' vs 'wild type genotype'genotypeRNA seq of prostate gland from WT, PTEN pc -/- and PTEN pc-/-;P53 -/- mice
Adjusted p-valueLog2-fold change
3.0004 × 10-185-5.8
Ighg2c'CD4-positive T cell' vs 'CD8-positive T cell' in 'Egr2 and Egr3 knockout'cell type, genotype, phenotypeRNAseq analysis of CD4 and CD8 T cells in response to vaccinia virus infection
Adjusted p-valueLog2-fold change
1.7264 × 10-255.8
Ighg2c'Trichuris muris' vs 'control' in 'non wormy; caecum'environmental stress, infect, organism partRNA-seq of mouse intestinal mucosa to investigate infection by the parasitic nematode Trichuris muris
Adjusted p-valueLog2-fold change
1.1548 × 10-255.7
Ighg2c'colitis' at '19 day' vs 'normal' at '0 day'disease, timeTemporal transcriptomic changes during DSS colitis development and resolution.
Adjusted p-valueLog2-fold change
3.731 × 10-13-5.7
Ighg2c"muscularis externa layer of small intestine" vs "lamina propria of small intestine" in "YFP negative"organism part, phenotypeBulk RNA-sequencing of self-maintaining versus monocyte-replaced gut macrophages
Adjusted p-valueLog2-fold change
1.5859 × 10-11-5.7
Ighg2c'clear cell sarcoma; TATCre' vs 'control'disease, genotypeMouse Model of Clear Cell Sarcoma
Adjusted p-valueLog2-fold change
7.6996 × 10-95.7
Ighg2c'Salmonella enterica serovar Typhimurium' vs 'control' in 'bone marrow macrophage from 129P2 mouse strain'clinical information, infectGene expression profiles of mouse embryonic stem cell derived macrophages infected with Salmonella typhimurium
Adjusted p-valueLog2-fold change
1.3493 × 10-2695.5
Ighg2c'CpG; 6 hour' vs 'none; 0 hour' in 'SMRT shRNA'RNA interference, stimulus, timeRNA-seq of Control and SMRT KD CD8α+ DCs at 0hr and 6hr CpG stimulation
Adjusted p-valueLog2-fold change
7.1233 × 10-65.5
Ighg2c'30 days of tuberculosis' vs 'uninfected'disease, timeTranscription profiling by array of lungs from mice infected with tuberculosis
Adjusted p-valueLog2-fold change
6.3092 × 10-35.5
Ighg2c'Plasmodium chabaudi infection' vs 'no infection' in 'vaccination'infect, treatmentProtective vaccination against blood-stage malaria of Plasmodium chabaudi: differential gene expression in the liver of Balb/c mice towards the end of crisis phase
Adjusted p-valueLog2-fold change
2.0983 × 10-45.4
Ighg2c'active Sendai virus' vs 'UV-inactivated Sendai virus' at '49 day' on 'Affymetrix Mouse430_2 Array'infect, timeTranscription profiling by array of lungs from C57BL/6J mice infected with Sendai virus
Adjusted p-valueLog2-fold change
1.1522 × 10-125.3
Ighg2c'14 days P. chabaudi infected' vs 'uninfected' in 'gonadectomized male'clinical information, disease, sex, timeTranscription profiling by array of mice infected with Plasmodium chabaudi after gonadectomization to investigate involvement of gonadal steroids
Adjusted p-valueLog2-fold change
8.7354 × 10-9-5.3
Ighg2c"muscularis externa layer of small intestine" vs "lamina propria of small intestine" in "YFP positive"organism part, phenotypeBulk RNA-sequencing of self-maintaining versus monocyte-replaced gut macrophages
Adjusted p-valueLog2-fold change
1.0472 × 10-140-5.2
Ighg2c'Egr2 and Egr3 knockout' vs 'Egr2-GFP knockin; Egr2-GFP high' in 'CD4-positive T cell'cell type, genotype, phenotypeRNAseq analysis of CD4 and CD8 T cells in response to vaccinia virus infection
Adjusted p-valueLog2-fold change
4.4674 × 10-55.2
Ighg2c'SARS coronavirus MA15' vs 'none' in 'wild type genotype' at '7 day'genotype, infect, timeSM015 - Infection with SARS MA15 of C57BL/6J mice and Tnfrsf1a/1b knockouts
Adjusted p-valueLog2-fold change
2.8978 × 10-1765
Ighg2c'Follicular B cell' vs 'Pre-B cell' in 'wild type genotype; MHC II-positive'cell type, genotype, phenotypeEffect of MHC II expression in pro-B cells: Pre-B cells and follicular B cells from wild-type and MHC II conditional mice
Adjusted p-valueLog2-fold change
1.6487 × 10-55
Ighg2c'SARS coronavirus MA15' vs 'none' in 'wild type genotype' at '7 day'genotype, infect, timeSM019 - Infection with SARS MA15 of C57BL/6J mice and Tnfrsf1b knockout mice
Adjusted p-valueLog2-fold change
7.2613 × 10-64.9
Ighg2c'14 days P. chabaudi infected' vs 'uninfected' in 'intact female'clinical information, disease, sex, timeTranscription profiling by array of mice infected with Plasmodium chabaudi after gonadectomization to investigate involvement of gonadal steroids
Adjusted p-valueLog2-fold change
4.9276 × 10-394.8
Ighg2c'Trichuris muris' vs 'control' in 'mesenteric lymph node'environmental stress, infect, organism partRNA-seq of mouse intestinal mucosa to investigate infection by the parasitic nematode Trichuris muris
Adjusted p-valueLog2-fold change
7.7905 × 10-54.7
Ighg2c'Mycobacterium tuberculosis; C57BL/6J; 70 day' vs 'control; C57BL/6J; 0 day'infect, strain, timeTranscription profiling of mouse lung from C57BL6 and DBA2 parental strains and D2.B6-Chr7 and D2.B6-Chr19 congenic mice following aerosol infection with Mycobacterium tuberculosis for 30 and 70 days
Adjusted p-valueLog2-fold change
6.3364 × 10-34.7
Ighg2c'Hnf4a-pKO;Hnf1aHET double mutant' vs 'wild type genotype'genotypeTranscription profiling by array of pancreatic islets from pancreas-specific Hnf4alpha knockout, heterozygous Hnf1alpha, and double mutant mice
Adjusted p-valueLog2-fold change
7.5739 × 10-2164.6
Ighg2c'SMRT shRNA; CpG; 6 hour' vs 'none; none; 0 hour'RNA interference, stimulus, timeRNA-seq of Control and SMRT KD CD8α+ DCs at 0hr and 6hr CpG stimulation
Adjusted p-valueLog2-fold change
1.6175 × 10-194.5
Ighg2c'ABIN1[D485N] knock-in' vs 'wild type genotype' in 'non-classical monocyte'cell type, genotypeRNA-seq of inflammatory monocytes, patrolling monocytes and neutrophils in wild type and ABIN1[D485N] mice
Adjusted p-valueLog2-fold change
1.6562 × 10-44.5
Ighg2c'SARS coronavirus MA15' vs 'mock' in 'wild type genotype' at '7 day'genotype, infect, timeMouse lung tissue transcriptome response to a mouse-adapted strain of SARS-CoV in wild type C57BL6/NJ mice and TLR3-/- mice
Adjusted p-valueLog2-fold change
2.7858 × 10-24.5
Ighg2c'ulcer' vs 'distant normal tissue' in 'wild type genotype'genotype, sampling site, timeIntestinal ulcers from biopsy-wounded wild-type and Bmp4-overexpressing mice
Adjusted p-valueLog2-fold change
1.1296 × 10-54.4
Ighg2c'ABIN1[D485N] knock-in' vs 'wild type genotype' in 'neutrophil'cell type, genotypeRNA-seq of inflammatory monocytes, patrolling monocytes and neutrophils in wild type and ABIN1[D485N] mice
Adjusted p-valueLog2-fold change
6.973 × 10-104.3
Ighg2c'14 days P. chabaudi infected' vs 'uninfected' in 'gonadectomized female'clinical information, disease, sex, timeTranscription profiling by array of mice infected with Plasmodium chabaudi after gonadectomization to investigate involvement of gonadal steroids
Adjusted p-valueLog2-fold change
2.3824 × 10-3-4.3
Ighg2c'smoke; 3000 microgram' vs 'control; 0 microgram' in 'wild type' at 'after 5 month exposure and 1 day post-exposure'compound, genotype, sampling time pointTranscription profiling by array of Nrf2 knockout mice exposed to cigarette smoke
Adjusted p-valueLog2-fold change
4.527 × 10-2-4.3
Ighg2c'high fat' vs 'control'dietTranscription profiling by array of lung tissue from mice exposed to high fat or control diet
Adjusted p-valueLog2-fold change
2.6071 × 10-74.2
Ighg2c'14 days P. chabaudi infected' vs 'uninfected' in 'intact male'clinical information, disease, sex, timeTranscription profiling by array of mice infected with Plasmodium chabaudi after gonadectomization to investigate involvement of gonadal steroids
Adjusted p-valueLog2-fold change
4.8166 × 10-44.2
Ighg2c'active Sendai virus' vs 'UV-inactivated Sendai virus' at '21 day' on 'Affymetrix MOE430A Array'infect, timeTranscription profiling by array of lungs from C57BL/6J mice infected with Sendai virus
Adjusted p-valueLog2-fold change
1.506 × 10-18-4.1
Ighg2c'10 Gy Gray; x-ray' vs 'none' in 'tumor and stromal cell'cell type, irradiateRNA-seq of effector (CD43+) CD8+ T cells, CD45+ hematopoietic cells and CD45- tumor/stromal cells from mice bearing bilateral AT-3 tumors following radio-immunotherapy of which one tumor was irradiated
Adjusted p-valueLog2-fold change
6.5665 × 10-74
Ighg2c'7 days P. chabaudi infected' vs 'uninfected' in 'intact male'clinical information, disease, sex, timeTranscription profiling by array of mice infected with Plasmodium chabaudi after gonadectomization to investigate involvement of gonadal steroids
Adjusted p-valueLog2-fold change
2.1382 × 10-54
Ighg2c'SARS coronavirus MA15' vs 'none' in 'wild type genotype' at '7 day'genotype, infect, timeSM020 - Infection with SARS MA15 of C57BL/6J mice and KEPI (ppp1r14c) knockouts
Adjusted p-valueLog2-fold change
6.1153 × 10-3-4
Ighg2c'smoke; 2250 microgram' vs 'control; 0 microgram' in 'wild type' at 'after 5 month exposure and 1 day post-exposure'compound, genotype, sampling time pointTranscription profiling by array of Nrf2 knockout mice exposed to cigarette smoke
Adjusted p-valueLog2-fold change
1.2382 × 10-24
Ighg2c'18 month' vs '2 month' in 'C57BL/6J'age, strainTranscription profiling by array of ageing mouse lung
Adjusted p-valueLog2-fold change
1.765 × 10-83.9
Ighg2c'Influenza A virus' vs 'none'infectRNA-seq of mouse alveolar macrophages from control and Influenza A virus infected animals
Adjusted p-valueLog2-fold change
2.3881 × 10-4-3.9
Ighg2c'tamoxifen induction at 2 months, wait 3 months' vs 'no tamoxifen induction' in 'basal cell of prostate epithelium; CK5-CreERT2 transgenic line'cell type, genotype, growth conditionTranscription profiling by high throughput sequencing of PIN/tumor lesions from basal or luminal origins at time points at which mice displayed similar histopathological phenotypes
Adjusted p-valueLog2-fold change
7.3513 × 10-17-3.8
Ighg2c'brown adipose tissue' vs 'white adipose tissue' in 'high fat diet; 30 degree celsius'diet, organism part, temperatureRNA-seq of brown and white mouse adipose tissue at thermoneutrality and high-fat diet
Adjusted p-valueLog2-fold change
7.6351 × 10-33.8
Ighg2c'Ptenf/f x CCSPiCre' vs 'wild type' at '7 month'age, genotypeErbB2 Pathway Activation upon Smad4 Loss Promotes Lung Tumor Growth and Metastasis [expression]
Adjusted p-valueLog2-fold change
1.6576 × 10-23.8
Ighg2c'colitis' at '8 day' vs 'normal' at '0 day'disease, timeTemporal transcriptomic changes during DSS colitis development and resolution.
Adjusted p-valueLog2-fold change
1.261 × 10-23.7
Ighg2c'110 week' vs '8 week'ageTranscription profiling by array of CD11C+ splenic dendritic cells from young (8 weeks) and old (110 weeks) mice treated with Poly I:C for 4 hours
Adjusted p-valueLog2-fold change
1.5108 × 10-53.6
Ighg2c'Mycobacterium tuberculosis; C57BL/6J; 30 day' vs 'control; C57BL/6J; 0 day'infect, strain, timeTranscription profiling of mouse lung from C57BL6 and DBA2 parental strains and D2.B6-Chr7 and D2.B6-Chr19 congenic mice following aerosol infection with Mycobacterium tuberculosis for 30 and 70 days
Adjusted p-valueLog2-fold change
1.1952 × 10-83.5
Ighg2c'7 days P. chabaudi infected' vs 'uninfected' in 'gonadectomized female'clinical information, disease, sex, timeTranscription profiling by array of mice infected with Plasmodium chabaudi after gonadectomization to investigate involvement of gonadal steroids
Adjusted p-valueLog2-fold change
3.3186 × 10-4-3.5
Ighg2c'clear cell sarcoma; Rosa26CreER' vs 'control'disease, genotypeMouse Model of Clear Cell Sarcoma
Adjusted p-valueLog2-fold change
1.3578 × 10-33.5
Ighg2c'PLAT knockout; SARS MA15; 7 day' vs 'PLAT knockout; mock'genotype, infect, timeSARS infection of C57BL6, and PLAT knock-out mice
Adjusted p-valueLog2-fold change
5.8784 × 10-6-3.4
Ighg2c'reduced expression of miR-25' vs 'wild type'phenotypeTranscription profiling by high throughput sequencing of wild type and miR-25 agomir or antagomir treated mice
Adjusted p-valueLog2-fold change
1.1411 × 10-23.4
Ighg2c'130 week' vs '13 week' in 'lung'age, organism partTranscription profiling by array of liver, lung, spleen and kidney from young and old mice.
Adjusted p-valueLog2-fold change
2.3589 × 10-11-3.1
Ighg2c'Ifnar1 knockout' vs 'wild type genotype' in 'specific pathogen free C57BL/6'genotype, strainRNA sequencing of primary isolated unstimulated murine splenic cDC from specific pathogen free (SPF), Germ Free (GF) and Interferon alpha/beta receptor 1 (Ifnar) knock out mice.
Adjusted p-valueLog2-fold change
3.8498 × 10-43.1
Ighg2c'7 days P. chabaudi infected' vs 'uninfected' in 'intact female'clinical information, disease, sex, timeTranscription profiling by array of mice infected with Plasmodium chabaudi after gonadectomization to investigate involvement of gonadal steroids
Adjusted p-valueLog2-fold change
2.3834 × 10-23.1
Ighg2c'SARS coronavirus MA15' vs 'none' at '7 day'infect, timeSM014 - SARS MA15 wild type, and SARS nsp16 mutant virus infections of C57BL6 mice - A time course
Adjusted p-valueLog2-fold change
3.0029 × 10-2-3.1
Ighg2c'SARS coronavirus MA15 nsp16 -/-' vs 'none' at '2 day'infect, timeSM014 - SARS MA15 wild type, and SARS nsp16 mutant virus infections of C57BL6 mice - A time course
Adjusted p-valueLog2-fold change
1.0744 × 10-4-3
Ighg2c'renin-expression' vs 'control'phenotypeExpression data from mouse bone marrow cells expressing renin driven expression of green fluorescent protein.
Adjusted p-valueLog2-fold change
7.3407 × 10-33
Ighg2c'IkL/L mutant' vs 'wild type genotype'genotypeGene expression in WT and Ikaros-deficient LSK cells
Adjusted p-valueLog2-fold change
3.3183 × 10-42.9
Ighg2c'Influenza A virus' vs 'mock' in 'interleukin-22'infect, stimulusTranscription profiling by array of pulmonary gene expression in response to interleukin-22 during severe influenza
Adjusted p-valueLog2-fold change
1.9584 × 10-3-2.9
Ighg2c'tamoxifen induction at 2 months, wait 1 months' vs 'no tamoxifen induction' in 'luminal cell of prostate epithelium; Nkx3.1-CreERT2 targeted allele'cell type, genotype, growth conditionTranscription profiling by high throughput sequencing of PIN/tumor lesions from basal or luminal origins at time points at which mice displayed similar histopathological phenotypes
Adjusted p-valueLog2-fold change
6.6255 × 10-82.8
Ighg2c'24 hour' vs '0 hour' in 'WT1-KTS'genotype, timeEWS-WT1 Oncogene Activates a Neuronal Reprogramming Factor ASCL1 and Mediates Partial Neural Differentiation
Adjusted p-valueLog2-fold change
9.974 × 10-32.8
Ighg2c'high fat diet; 30 degree celsius' vs 'chow; 23 degree celsius' in 'brown adipose tissue'diet, organism part, temperatureRNA-seq of brown and white mouse adipose tissue at thermoneutrality and high-fat diet
Adjusted p-valueLog2-fold change
1.3686 × 10-22.8
Ighg2c'Klhl6 knock out' vs 'wild type genotype' at '0 hour'genotype, sampling time pointKlhl6 deficiency impairs transitional B cell survival and differentiation
Adjusted p-valueLog2-fold change
8.1705 × 10-42.7
Ighg2c'double Fancc-/- Fancg-/-' vs 'wild type'genotypeTranscription profiling by array of bone marrow cells from wild type, Fancc-deficient, Fancg-deficient, and doubly deficient (Fancc/Fancg) mice
Adjusted p-valueLog2-fold change
4.4816 × 10-32.7
Ighg2c'SARS coronavirus MA15' vs 'none' in 'Tnfrsf1a/1b -/-' at '7 day'genotype, infect, timeSM015 - Infection with SARS MA15 of C57BL/6J mice and Tnfrsf1a/1b knockouts
Adjusted p-valueLog2-fold change
1.1916 × 10-702.6
Ighg2c'CpG; 6 hour' vs 'none; 0 hour' in 'none'RNA interference, stimulus, timeRNA-seq of Control and SMRT KD CD8α+ DCs at 0hr and 6hr CpG stimulation
Adjusted p-valueLog2-fold change
1.8771 × 10-4-2.6
Ighg2c'Yersinia pestis' vs 'control' in 'neutrophil'cell type, infect, sampling siteSpatially distinct neutrophil responses within the inflammatory lesions of pneumonic plague
Adjusted p-valueLog2-fold change
7.2331 × 10-3-2.6
Ighg2c'liver specific SMARCB1 knockout' vs 'wild type'phenotypeTP53 is a master regulator of proteostasis in SMARCB1-deficient malignant rhabdoid tumors
00
Log2-fold change
-2.4
Ighg2c'CD4-positive T cell' vs 'CD8-positive T cell' in 'Egr2-GFP knockin; Egr2-GFP high'cell type, genotype, phenotypeRNAseq analysis of CD4 and CD8 T cells in response to vaccinia virus infection
Adjusted p-valueLog2-fold change
1.0211 × 10-4-2.4
Ighg2c'doxycicline-mediated expression of c-Jun' vs 'control'phenotypeTranscription profiling by array of mouse whole bone marrow after c-Jun induction
Adjusted p-valueLog2-fold change
1.5859 × 10-32.4
Ighg2c'PD1-/-' vs 'wild type genotype'genotypeTranscription profiling by array of mouse CD8 central memory T-cells derived from spleens of 7-month old PD-1 knockout or wild-type mice
Adjusted p-valueLog2-fold change
2.0623 × 10-22.4
Ighg2c'Mesenchymal cell-specific homozygous deletion of Sbds' vs 'wild type genotype'genotypeTranscription profiling of mouse osteoblasts with mesenchymal-specific homozygous deletion of Sbds against wild type counterparts in a model studying human leukemia predisposition syndromes
Adjusted p-valueLog2-fold change
3.0051 × 10-4-2.3
Ighg2c'Zbtb10 knockdown' vs 'control' at '6 hour'genotype, timeRNA-seq of Zbtb10 Knockdown and Control cDC1 dendritic cells (Cd8+)
Adjusted p-valueLog2-fold change
7.0655 × 10-3-2.3
Ighg2c'neoplasm' vs 'normal tissue adjacent to neoplasm'sampling siteTranscription profiling by array of Apc+/Delta716 mouse intestinal polyps vs normal intestinal mucosa
Adjusted p-valueLog2-fold change
3.0673 × 10-22.3
Ighg2c'Klhl6 knock out' vs 'wild type genotype' at '24 hour'genotype, sampling time pointKlhl6 deficiency impairs transitional B cell survival and differentiation
Adjusted p-valueLog2-fold change
3.474 × 10-42.2
Ighg2c'CD36 knockout' vs 'wild type genotype' in 'oxidized low density lipoprotein; 25 microgram per milliliter'compound, genotypeQuantitative analysis of wild type and cd36-/- murine peritoneal macrophage transcriptomes
Adjusted p-valueLog2-fold change
1.9041 × 10-32.2
Ighg2c'NOD' vs 'C57BL/6' in 'steady state' at '0 hour'strain, time, treatmentExpression data from NOD and C57BL/6 mouse pancreas CD8α- Dendritic Cells (DCs) under steady-state and after in-vitro LPS stimulation
Adjusted p-valueLog2-fold change
8.2431 × 10-32.2
Ighg2c'SARS coronavirus MA15; 2 day' vs 'mock' in 'C57BL/6J'infect, strain, timeGenomic profiling of collaborative cross founder mouse strains infected with respiratory viruses to discover novel transcripts and infection-related strain-specific gene and isoform expression
Adjusted p-valueLog2-fold change
9.1795 × 10-32.2
Ighg2c'130 week' vs '13 week' in 'kidney'age, organism partTranscription profiling by array of liver, lung, spleen and kidney from young and old mice.
Adjusted p-valueLog2-fold change
1.0165 × 10-22.2
Ighg2c'fl-p300/Foxp3cre' vs 'wild type'genotypeTwo Histone/Protein Acetyltransferases, CBP and p300, Are Indispensable for Foxp3+ T-regulatory Cell Development and Function
Adjusted p-valueLog2-fold change
1.7379 × 10-22.2
Ighg2c'lung carcinoma' vs 'normal' in 'CD11b+Ly6G+ neutrophil'cell type, diseaseTranscriptome analysis of isolated stormal cells and tumor epithelial cells in mouse lung cancer by RNA-Seq
Adjusted p-valueLog2-fold change
4.2116 × 10-4-2.1
Ighg2c'irf4-/-' vs 'wild type genotype'genotypeTranscription profiling by array of mouse irf4 knockout mature splenic B cells against wild type controls from littermates
Adjusted p-valueLog2-fold change
7.5154 × 10-4-2.1
Ighg2c'germ free C57BL/6' vs 'specific pathogen free C57BL/6' in 'wild type genotype'genotype, strainRNA sequencing of primary isolated unstimulated murine splenic cDC from specific pathogen free (SPF), Germ Free (GF) and Interferon alpha/beta receptor 1 (Ifnar) knock out mice.
Adjusted p-valueLog2-fold change
2.7239 × 10-2-2.1
Ighg2c'Tnfrsf1a/1b -/-' vs 'wild type genotype' in 'SARS coronavirus MA15' at '7 day'genotype, infect, timeSM015 - Infection with SARS MA15 of C57BL/6J mice and Tnfrsf1a/1b knockouts
Adjusted p-valueLog2-fold change
7.0536 × 10-28-2
Ighg2c'extracellular vesicles from wild type BV16 cells; 20 microgram' vs 'none'stimulusTranscription profiling of mouse lung upon exposure to BAG6KO or wild type exosomes derived from BV16 cells
Adjusted p-valueLog2-fold change
4.799 × 10-32
Ighg2c'TIMP1 knockout; SARS MA15; 7 day' vs 'TIMP1 knockout; mock'genotype, infect, timeSARS infection of C57BL6, TIMP1 and Serpine1 knock-out mice
Adjusted p-valueLog2-fold change
2.7092 × 10-2-2
Ighg2c'Lymphocytic choriomeningitis mammarenavirus' vs 'none' in 'wild type genotype'genotype, infectComparison of Trail+/+ versus Trail-/- splenic NK cells from naïve and LCMV-infected mice
Adjusted p-valueLog2-fold change
8.3831 × 10-451.9
Ighg2c'SMRT shRNA' vs 'none' in 'CpG' at '6 hour'RNA interference, stimulus, timeRNA-seq of Control and SMRT KD CD8α+ DCs at 0hr and 6hr CpG stimulation
Adjusted p-valueLog2-fold change
1.2176 × 10-16-1.9
Ighg2c'Dlx3Oc-c knockout' vs 'wild type' in 'femur diaphysis'genotype, organism partTranscription profiling by high throughput sequencing in diaphysis and metaphysis from femur of 5-week-old Dlx3Oc-cKO and wild type mice
Adjusted p-valueLog2-fold change
4.4939 × 10-51.9
Ighg2c'wild type genoytpe; siRNA Keap1-1' vs 'wild type genotype; scrambled shRNA'RNA interference, compound, genotypeCharacterization of RA839, a non-covalent small-molecule binder to Keap1 and selective activator of Nrf2 signalling
Adjusted p-valueLog2-fold change
4.1536 × 10-3-1.9
Ighg2c'Zbtb10 knockdown' vs 'control' at '2 hour'genotype, timeRNA-seq of Zbtb10 Knockdown and Control cDC1 dendritic cells (Cd8+)
Adjusted p-valueLog2-fold change
5.1954 × 10-31.9
Ighg2c'Debaryomyces hansenii' at '12 hour' vs 'none' at '0 hour'stimulus, timeRNA seq of mouse bone marrow derived macrophages treated with Debaryomyces hansenii against untreated controls
Adjusted p-valueLog2-fold change
2.3555 × 10-21.9
Ighg2c'SARS coronavirus MA15; 4 day' vs 'mock' in 'A/J'infect, strain, timeGenomic profiling of collaborative cross founder mouse strains infected with respiratory viruses to discover novel transcripts and infection-related strain-specific gene and isoform expression
Adjusted p-valueLog2-fold change
3.3274 × 10-21.9
Ighg2c'CKIαΔgut/p53R172H' vs 'CKIαΔgut/p53Δgut' in 'jejunum'compound, genotype, organism partRNAseq of enterocytes of the jejunum and Ileum from transgene C57BL/6 mice harboring a CKIαΔgut knock-out
00
Log2-fold change
-1.8
Ighg2c'Egr2 and Egr3 knockout' vs 'Egr2-GFP knockin; Egr2-GFP high' in 'CD8-positive T cell'cell type, genotype, phenotypeRNAseq analysis of CD4 and CD8 T cells in response to vaccinia virus infection
Adjusted p-valueLog2-fold change
4.8319 × 10-31.8
Ighg2c'α-GalCer; 2 microgram' vs 'none' in 'wild type genotype'compound, genotypeCD1d-dependent immune suppression mediated by regulatory B cells through modulations of iNKT cells
Adjusted p-valueLog2-fold change
8.6276 × 10-31.8
Ighg2c'Influenza A virus (A/Puerto Rico/8/1934(H1N1)); 4 day' vs 'mock' in 'A/J'infect, strain, timeGenomic profiling of collaborative cross founder mouse strains infected with respiratory viruses to discover novel transcripts and infection-related strain-specific gene and isoform expression
Adjusted p-valueLog2-fold change
4.2572 × 10-6-1.7
Ighg2c'R6/2 transgenic' vs 'wild type' in '12 week; brain cortex'age, genotype, organism partTranscription profiling by high throughput sequencing in wild type and R6/2 mutant mouse cortex and striatum at 8 and 12 weeks.
Adjusted p-valueLog2-fold change
5.4741 × 10-41.7
Ighg2c'wild type genoytpe; siRNA Keap1-2' vs 'wild type genotype; scrambled shRNA'RNA interference, compound, genotypeCharacterization of RA839, a non-covalent small-molecule binder to Keap1 and selective activator of Nrf2 signalling
Adjusted p-valueLog2-fold change
5.9436 × 10-41.7
Ighg2c'IL-10 egfp/egfp' vs 'wild type genotype' in 'CD21hiCD24hi'genotype, phenotypeTranscription profiling by array to investigate how Aryl hydrocarbon receptor governs a transcriptional programme that determines regulatory B cell differentiation and function
Adjusted p-valueLog2-fold change
1.8052 × 10-31.7
Ighg2c'3110043O21Rik knockout; spleen' vs 'wild type genotype; spleen'genotype, organism part, sampling siteRNAseq of coding RNA in the liver, spleen, kidney, abdominal muscle and gonadal adipose tissue of knock out mice and wild type controls.
Adjusted p-valueLog2-fold change
3.3349 × 10-31.7
Ighg2c'Fancg-/-' vs 'wild type'genotypeTranscription profiling by array of bone marrow cells from wild type, Fancc-deficient, Fancg-deficient, and doubly deficient (Fancc/Fancg) mice
Adjusted p-valueLog2-fold change
8.7615 × 10-61.6
Ighg2c'high fat diet' vs 'normal chow' in '28 week; ReverbαFlox2-6AdipoCre+'age, diet, genotypeTissue-autonomous regulation of adipose expansion by core clock protein REVERBα
Adjusted p-valueLog2-fold change
2.6375 × 10-41.6
Ighg2c'Reverbα-/- global knockout' vs 'Reverbα wild type' in 'not applicable; 13 week'age, diet, genotypeTissue-autonomous regulation of adipose expansion by core clock protein REVERBα
Adjusted p-valueLog2-fold change
8.8599 × 10-4-1.6
Ighg2c'PolgD257A knockout' vs 'control'genotypeGene expression profile of gastrocnemius muscle from D257A mice
Adjusted p-valueLog2-fold change
9.0481 × 10-31.6
Ighg2c'Fancc-/-' vs 'wild type'genotypeTranscription profiling by array of bone marrow cells from wild type, Fancc-deficient, Fancg-deficient, and doubly deficient (Fancc/Fancg) mice
Adjusted p-valueLog2-fold change
4.2354 × 10-21.6
Ighg2c'SARS coronavirus MA15 dORF6' vs 'none' at '1 day'infect, timeSM012 - SARS MA15 wild type, and SARS deltaORF6 mutant virus infections of C57BL6 mice - A time course
Adjusted p-valueLog2-fold change
1.6875 × 10-21.5
Ighg2c'wild type genotype; SARS MA15; 7 day' vs 'wild type genotype; mock'genotype, infect, timeSARS infection of C57BL6, TIMP1 and Serpine1 knock-out mice
Adjusted p-valueLog2-fold change
1.772 × 10-21.5
Ighg2c'adipose tissue specific Cnot1 knockout' vs 'wild type phenotype' in 'inguinal fat pad'organism part, phenotypeRNA-seq to identify the role of mRNA decay in mouse adipose tissues
Adjusted p-valueLog2-fold change
2.2891 × 10-2-1.5
Ighg2c'5 milligram per kilogram LNA antimiR 122' vs 'saline control'compoundTranscription profiling by array of mice with diet-induced obesity treated with a locked-nucleic-acid-modified oligonucleotide (LNA-antimiR) which antagonises liver-expressed miR-122
Adjusted p-valueLog2-fold change
2.4889 × 10-21.4
Ighg2c'10 microgram; ovalbumin' vs 'none' in 'wild type'compound, genotypeTranscription profiling by array of lungs from mice mutant for RAG after challenge with ovalbumin
Adjusted p-valueLog2-fold change
3.5478 × 10-21.4
Ighg2c'female hypothalamus' vs 'male hypothalamus'organism part, sexTranscription profiling of mouse hypothalamus, liver, kidney, ovary, and testes from male and female mice to assess sex specific differences in transcription
Adjusted p-valueLog2-fold change
5.9485 × 10-61.3
Ighg2c'9V/null' vs 'wild type' in 'saline; spleen'compound, genotype, organism partGaucher Disease: Transcriptome Analyses Using Microarray or mRNA Sequencing in a Mouse Model Treated with velaglucerase alfa or imiglucerase [RNA-Seq]
Adjusted p-valueLog2-fold change
2.3386 × 10-5-1.3
Ighg2c'overexpression of miR-25' vs 'wild type'phenotypeTranscription profiling by high throughput sequencing of wild type and miR-25 agomir or antagomir treated mice
Adjusted p-valueLog2-fold change
9.582 × 10-41.3
Ighg2c'STAT5 double knocked in' vs 'wild type' in 'interleukin-2' at '17 hour'compound, genotype, timeGene expression profile of splenic T cells from STAT5 double knocked in mice treated with IL-2
Adjusted p-valueLog2-fold change
4.9318 × 10-31.3
Ighg2c'Pax7 driven Mef2a overexpression' vs 'wild type'phenotypeMetabolic maturation during muscle stem cell differentiation is achieved by miR-1/133a-mediated inhibition of the Dlk-Dio3 mega gene cluster.
Adjusted p-valueLog2-fold change
2.1829 × 10-21.3
Ighg2c'db/db' vs 'wild type genotype' in 'control miRNA; re-fed'RNA interference, diet, genotypeGene expression profiling of liver from C57BLKS/J and db/db 8 mice with an AAV harboring a control or GAbpa-specific miRNA under the LP1 promoter
Adjusted p-valueLog2-fold change
3.8834 × 10-2-1.3
Ighg2c"YFP positive" vs "YFP negative" in "lamina propria of small intestine"organism part, phenotypeBulk RNA-sequencing of self-maintaining versus monocyte-replaced gut macrophages
Adjusted p-valueLog2-fold change
6.9313 × 10-4-1.2
Ighg2c'3 days P. chabaudi infected' vs 'uninfected' in 'gonadectomized female'clinical information, disease, sex, timeTranscription profiling by array of mice infected with Plasmodium chabaudi after gonadectomization to investigate involvement of gonadal steroids
Adjusted p-valueLog2-fold change
2.9396 × 10-31.2
Ighg2c'24 month' vs '6 month'ageRNA-seq of coding RNA of gastrocnemius muscle from 6-month and 24-month old mice to study the effect of aging on skeletal muscles
Adjusted p-valueLog2-fold change
2.2777 × 10-21.2
Ighg2c'1,2-Dibromoethane; 62 milligram per kilogram; corn oil' vs 'none; ; corn oil'compound, treatmentTranscription profiling by array of Mus musculus liver tissue after exposure to various carcinogenic chemicals
Adjusted p-valueLog2-fold change
2.5335 × 10-21.2
Ighg2c'high fat diet; 30 degree celsius' vs 'chow; 23 degree celsius' in 'white adipose tissue'diet, organism part, temperatureRNA-seq of brown and white mouse adipose tissue at thermoneutrality and high-fat diet
Adjusted p-valueLog2-fold change
1.223 × 10-6-1.1
Ighg2c'butyrate' vs 'none'compoundHDAC inhibition by TSA and Butyrate In Flt3L-elicited DC
Adjusted p-valueLog2-fold change
1.394 × 10-6-1.1
Ighg2c'chronic pancreatitis' vs 'control'diseasePancreatic gene expression associated with cerulein induced chronic pancreatitis in mice
Adjusted p-valueLog2-fold change
7.5805 × 10-7-1
Ighg2c'trichostatin A' vs 'none'compoundHDAC inhibition by TSA and Butyrate In Flt3L-elicited DC
Adjusted p-valueLog2-fold change
6.7903 × 10-31
Ighg2c'dorsolateral nucleus motor neuron' vs 'lumbar motor neurons'cell typeComparison of gene expression in motor pools with differential vulnerability in ALS
Adjusted p-valueLog2-fold change
9.4766 × 10-31
Ighg2c'transgenic humanSODG93A' vs 'wild type' in 'gastrocnemius'clinical treatment, genotype, organism partGene expression profiling of muscles from transgenic humanSODG93A mice at symptomatic stage
Adjusted p-valueLog2-fold change
1.0268 × 10-21
Ighg2c'PTIP knockout' vs 'control'genotypeTranscription profiling by array of mouse cardiac tissue mutant for PTIP
Adjusted p-valueLog2-fold change
1.8662 × 10-21
Ighg2c'SARS coronavirus MA15; 10^5 PFU' vs 'none' at '2 day'stimulus, timeSM001: SARS CoV MA15 infection of C57Bl/6 mouse model – Data from 4 viral doses at 1, 2, 4 and 7 days post infection.
Adjusted p-valueLog2-fold change
2.6509 × 10-2-1
Ighg2c'epithelium-specific Bcl9; Bcl9l knockout and mutant beta-catenin expression' vs 'wild type'phenotypeRNAseq of murine small intestinal tissue following epithelium-specific deletion of Bcl9/9l +/- Apc +/- mutant B-catenin
Adjusted p-valueLog2-fold change
4.0109 × 10-21
Ighg2c'doxorubicin; 15 milligram per kilogram; CHIP knockout' vs 'doxorubicin; 15 milligram per kilogram; wild type'compound, genotypeExpression data from DOX(doxorubicin) -treated wild type or CHIP knockout C57BL/6J mice at day 5