ENSMUSG00000095863 (Ighv1-67)

mus musculus

immunoglobulin heavy variable V1-67

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Mus musculus
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Showing 2 experiments:
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Log2-fold changeSpeciesGene nameComparisonExperimental variablesExperiment name
Adjusted p-valueLog2-fold change
2.3579 × 10-33.4
Ighv1-67'Cbs knockout' vs 'wild type'genotypeGene expression profile of CD4-positive T cells from mouse Cbs knockout
Adjusted p-valueLog2-fold change
2.5369 × 10-103.3
Ighv1-67'Triple knockout (Zfp36-/-, TNFR1-/-, TNFR2-/-)' vs 'wild type'genotypeTranscription profiling by high throughput sequencing of douple (TNFR1-/-/TNFR2-/-) and triple (Zfp36-/-/TNFR1-/-/TNFR2-/-) knockout mouse spleens
Adjusted p-valueLog2-fold change
2.5054 × 10-5-2.9
Ighv1-67'Rb;E2f8 knock-out' vs 'wild type'genotypeExpression data from WT, E2f8 KO, Rb KO and Rb;E2f8 DKO spleen Ter19+CD71high sorted cells
Adjusted p-valueLog2-fold change
8.9902 × 10-3-2.5
Ighv1-67'intravenous injection of 10-100 thousand B-ALL cells' vs 'none' in 'lentiviral expression of mTie2-IFN-mirT and Tie2-driven overexpression of IFNalpha'genotype, stimulusRNA-seq of mouse macrophages to investigate how interferon gene therapy reprograms the leukemia microenvironment
Adjusted p-valueLog2-fold change
1.6943 × 10-2-2.5
Ighv1-67'α-GalCer; 2 microgram' vs 'none' in 'Cd1d homozyous knockout'compound, genotypeCD1d-dependent immune suppression mediated by regulatory B cells through modulations of iNKT cells
Adjusted p-valueLog2-fold change
1.077 × 10-2-2.4
Ighv1-67'Vldlr knockout' vs 'wild type genotype' in 'house dust mite'genotype, treatmentTranscription profiling by array of lungs of Vldlr-/- mice and wild type (WT) B6129SF2/J mice that had received intranasal house dust mite (HDM) challenges to induce experimental asthma or saline
Adjusted p-valueLog2-fold change
2.8966 × 10-22.4
Ighv1-67'wormy, worm separated; Trichuris muris' vs 'control; non wormy' in 'caecum'environmental stress, infect, organism partRNA-seq of mouse intestinal mucosa to investigate infection by the parasitic nematode Trichuris muris
Adjusted p-valueLog2-fold change
8.0627 × 10-5-2.2
Ighv1-67'E2f8 knock-out' vs 'wild type'genotypeExpression data from WT, E2f8 KO, Rb KO and Rb;E2f8 DKO spleen Ter19+CD71high sorted cells
Adjusted p-valueLog2-fold change
3.1623 × 10-3-2.2
Ighv1-67'α-GalCer; 2 microgram' vs 'none' in 'wild type genotype'compound, genotypeCD1d-dependent immune suppression mediated by regulatory B cells through modulations of iNKT cells
Adjusted p-valueLog2-fold change
3.0629 × 10-22.2
Ighv1-67'wormy, worm left; Trichuris muris' vs 'control; non wormy' in 'caecum'environmental stress, infect, organism partRNA-seq of mouse intestinal mucosa to investigate infection by the parasitic nematode Trichuris muris
Adjusted p-valueLog2-fold change
1.6353 × 10-32.1
Ighv1-67'Plasmodium chabaudi infection' vs 'no infection' in 'adjuvant only'infect, treatmentProtective vaccination against blood-stage malaria of Plasmodium chabaudi: differential gene expression in the liver of Balb/c mice towards the end of crisis phase
Adjusted p-valueLog2-fold change
3.4389 × 10-3-2.1
Ighv1-67'neoplasm' vs 'normal tissue adjacent to neoplasm'sampling siteTranscription profiling by array of Apc+/Delta716 mouse intestinal polyps vs normal intestinal mucosa
Adjusted p-valueLog2-fold change
2.84 × 10-22
Ighv1-67'Plasmodium chabaudi infection' vs 'no infection' in 'vaccination'infect, treatmentProtective vaccination against blood-stage malaria of Plasmodium chabaudi: differential gene expression in the liver of Balb/c mice towards the end of crisis phase
Adjusted p-valueLog2-fold change
4.1009 × 10-2-1.8
Ighv1-67'Vldlr knockout' vs 'wild type genotype' in 'saline'genotype, treatmentTranscription profiling by array of lungs of Vldlr-/- mice and wild type (WT) B6129SF2/J mice that had received intranasal house dust mite (HDM) challenges to induce experimental asthma or saline
Adjusted p-valueLog2-fold change
3.7942 × 10-121.6
Ighv1-67'Double knockout (TNFR1-/-, TNFR2-/-)' vs 'wild type'genotypeTranscription profiling by high throughput sequencing of douple (TNFR1-/-/TNFR2-/-) and triple (Zfp36-/-/TNFR1-/-/TNFR2-/-) knockout mouse spleens
Adjusted p-valueLog2-fold change
2.944 × 10-21.5
Ighv1-67'epithelium-specific mutant beta-catenin expression' vs 'wild type'phenotypeRNAseq of murine small intestinal tissue following epithelium-specific deletion of Bcl9/9l +/- Apc +/- mutant B-catenin
Adjusted p-valueLog2-fold change
7.2566 × 10-61.4
Ighv1-67'transplanted with bone marrow from Tfr2 knockout mouse' vs 'transplanted with bone marrow from Tfr2 wild type mouse'stimulusRNAseq of the spleen of Hbb(th3/+) mice transplanted with bone marrow from Tfr2-ko or Tfr2 wt mice
Adjusted p-valueLog2-fold change
1.9547 × 10-31.4
Ighv1-67'chronic DSS-induced colitis; 2x DSS, recovery' vs 'none; none'clinical treatment, diseaseTranscription profiling by array of colon tissues isolated from mice with acute and chronic dextran sodium sulphate (DSS)-induced colitis
Adjusted p-valueLog2-fold change
5.7637 × 10-6-1.3
Ighv1-67'WT (VH81x transgenic Rag1-/-)' vs 'control'genotypePre-BCR Signaling induce IgK Locus Accessibility by functional redistribution of Enhancer-mediated chromatin Interactions
Adjusted p-valueLog2-fold change
3.8401 × 10-91.2
Ighv1-67'LGK974; 5 milligram per kilogram body weight' vs 'vehicle'compoundRNA-seq analysis of mouse (C57/B6) small intestinal tissue after Porcupine Inhibitor treatment or vehicle control.
Adjusted p-valueLog2-fold change
1.5731 × 10-31.2
Ighv1-67'chronic DSS-induced colitis; 1x DSS, recovery' vs 'none; none'clinical treatment, diseaseTranscription profiling by array of colon tissues isolated from mice with acute and chronic dextran sodium sulphate (DSS)-induced colitis
Adjusted p-valueLog2-fold change
6.3055 × 10-31.2
Ighv1-67'chronic DSS-induced colitis; 2x DSS, additional recovery' vs 'none; none'clinical treatment, diseaseTranscription profiling by array of colon tissues isolated from mice with acute and chronic dextran sodium sulphate (DSS)-induced colitis
Adjusted p-valueLog2-fold change
8.8369 × 10-3-1.2
Ighv1-67'Btk KO (VH81x transgenic Rag1-/-)' vs 'control'genotypePre-BCR Signaling induce IgK Locus Accessibility by functional redistribution of Enhancer-mediated chromatin Interactions
Adjusted p-valueLog2-fold change
4.0932 × 10-21.2
Ighv1-67'bone marrow macrophage; co-cultured with breast cancer cell line 4T1.2' vs 'bone marrow macrophage; control'cell type, growth conditionTranscription profiling of mouse bone marrow macrophages (BMM) compared to BMM co-cultured with 4T1.2 breast cancer cells, treated with tumour cell supernatant, or RAW macrophage cell line
Adjusted p-valueLog2-fold change
6.0881 × 10-3-1
Ighv1-67'Slp KO (VH81x transgenic Rag1-/-)' vs 'control'genotypePre-BCR Signaling induce IgK Locus Accessibility by functional redistribution of Enhancer-mediated chromatin Interactions
Ortholog
Gene ontology
Ensembl gene
Ensembl transcript
Ensembl protein
UniProt
MGI ID (Mouse)
MGI description
Gene biotype
Design element
5180546, 17284626, 10403057, 5598200, A_55_P2130497
Reactome pathway ID
Initial triggering of complement, Regulation of actin dynamics for phagocytic cup formation, Cell surface interactions at the vascular wall, Role of phospholipids in phagocytosis, Complement cascade, Innate Immune System, Vesicle-mediated transport, FCGR activation, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, Classical antibody-mediated complement activation, Role of LAT2/NTAL/LAB on calcium mobilization, FCERI mediated Ca+2 mobilization, Signaling by the B Cell Receptor (BCR), Regulation of Complement cascade, FCERI mediated MAPK activation, CD22 mediated BCR regulation, Creation of C4 and C2 activators, Immune System, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers, Fcgamma receptor (FCGR) dependent phagocytosis, Scavenging of heme from plasma, Hemostasis, Fc epsilon receptor (FCERI) signaling, Adaptive Immune System, FCERI mediated NF-kB activation, Binding and Uptake of Ligands by Scavenger Receptors