8 | | Miat | 'PF-04691502–resistant cell; 1 micromolar; PF-04691502' vs 'parental AKP cell; dimethyl sulfoxide' | compound, phenotype | Resistance to PI3K/mTOR inhibitor PF-04691502 in KRAS mutant colorectal cancer models reveals a sensitivity to combination with EGFR inhibition |
7.4 | | Miat | 'PF-04691502–resistant cell; 1 micromolar; PF-04691502 removed for 48 hours' vs 'parental AKP cell; dimethyl sulfoxide' | compound, phenotype | Resistance to PI3K/mTOR inhibitor PF-04691502 in KRAS mutant colorectal cancer models reveals a sensitivity to combination with EGFR inhibition |
6.8 | | Miat | 'neurogenin-3-expressing endocrine progenitor cell' vs 'neurogenin-3-lacking pancreatic progenitor cell' at 'embryonic day 15.5' | cell type, developmental stage | Transcription profiling by high throughput sequencing of murine beta cells at key stages of maturation |
-6.7 | | Miat | 'extraembryonic endoderm stem cell; grown in XEN cell medium' vs 'mouse embryonic fibroblast; control' | cell type, growth condition | OSKM induce extraembryonic endoderm stem (iXEN) cells in parallel to iPS cells |
5.4 | | Miat | 'neurosphere in differentiation medium; 12 day' vs 'neurosphere; 0 day' in 'wild type genotype' | genotype, growth condition, time | Transcriptome analysis of neurospheres derived from Cstb-KO mouse embryo brains during differentiation |
5.3 | | Miat | 'subventicular zone of the lateral ventricle' vs 'cerebellum' | organism part | Expression data from adult Shh-responding astroglia cells in mice |
5.2 | | Miat | 'neurosphere in differentiation medium; 5 day' vs 'neurosphere; 0 day' in 'wild type genotype' | genotype, growth condition, time | Transcriptome analysis of neurospheres derived from Cstb-KO mouse embryo brains during differentiation |
-5 | | Miat | 'P60; insulin-expressing mature beta cells' vs 'E16.5; insulin-expressing nascent beta cells' | age, cell type | Transcriptional profiling of nascent and mature pancreatic beta cells |
-5 | | Miat | 'induced extraembryonic endoderm stem cell; grown in ES cell medium' vs 'mouse embryonic fibroblast; control' | cell type, growth condition | OSKM induce extraembryonic endoderm stem (iXEN) cells in parallel to iPS cells |
-4.6 | | Miat | 'cortical epithelial cell; Lin- Dapi-EpCAM+ CD31-UEA1-Ly51+ td-tomato+t vs 'medullary epithelial cell; Lin- Dapi-EpCAM+ CD31-UEA1+Ly51- td-tomato-' | cell type, phenotype | Thymic T-cell progenitor development is supported by membrane bound Kit ligand provided by a combined vascular endothelial and epithelial niche. |
4.5 | | Miat | 'neurosphere in differentiation medium; 12 day' vs 'neurosphere; 0 day' in 'Cstb knockout' | genotype, growth condition, time | Transcriptome analysis of neurospheres derived from Cstb-KO mouse embryo brains during differentiation |
4.4 | | Miat | 'neurosphere in differentiation medium; 5 day' vs 'neurosphere; 0 day' in 'Cstb knockout' | genotype, growth condition, time | Transcriptome analysis of neurospheres derived from Cstb-KO mouse embryo brains during differentiation |
4.3 | | Miat | 'Ngn3-expressing cell' vs 'Ngn3-null cell' | cell type | Transcriptional profiling of Ngn3-dependent pancreatic endocrine differentiation at E15.5 |
4.1 | | Miat | 'extracellular vesicle; non-stimulated culture medium' vs 'none' | sampling site, stimulus | Cellular and extracellular vesicle RNA sequence for E-cadherin-RFP EMT reporter system expressing mouse breast cancer cell line Py2T during EMT/MET |
-3.9 | | Miat | '21 percent oxygen, 37 degree Celsius, 10 percent serum' vs 'none' | growth condition | RNA sequencing of native and ex vivo cultured murine tail tendon fascicles |
3.8 | | Miat | 'Stat5b (Stat5abnull/Stat5a-)' vs 'wild type' at 'pregnancy' | genotype, sampling time point | Transcription profiling by high throughput sequencing of mouse wild type and Stat5-mutant mammary tissues at parturition and early pregnancy |
3.7 | | Miat | 'SOD1-G93A transgenic' vs 'wild type' at 'day 65' in 'B6/SJL' | genotype, sampling time point, strain | Transcription profiling by high throughput sequencing of acutely isolated microglia from an amyotrophic lateral sclerosis mouse model |
3.7 | | Miat | 'neurosphere in differentiation medium; 1 day' vs 'neurosphere; 0 day' in 'wild type genotype' | genotype, growth condition, time | Transcriptome analysis of neurospheres derived from Cstb-KO mouse embryo brains during differentiation |
3.6 | | Miat | 'neurosphere in differentiation medium; 1 day' vs 'neurosphere; 0 day' in 'Cstb knockout' | genotype, growth condition, time | Transcriptome analysis of neurospheres derived from Cstb-KO mouse embryo brains during differentiation |
3.4 | | Miat | 'Stat5a (Stat5abnull/Stat5b-)' vs 'wild type' at 'pregnancy' | genotype, sampling time point | Transcription profiling by high throughput sequencing of mouse wild type and Stat5-mutant mammary tissues at parturition and early pregnancy |
2.8 | | Miat | 'carotid body' vs 'adrenal medulla' | organism part | Expression profile of mouse carotid body and adrenal medulla [RNA-Seq] |
2.8 | | Miat | 'HoxA11 HoxD11 null' vs 'wild type' in 'metanephric mesenchyme' | genotype, organism part | Transcription profiling by array of wild type and HoxA11 metenephric mesenchyme and ureteric bud from embryonic day 11.5 mice |
2.8 | | Miat | 'hippocampus' vs 'cerebellum' | organism part | Expression data from adult Shh-responding astroglia cells in mice |
2.8 | | Miat | 'neural progenitor cell' vs 'niche cell' | cell type | Transcription profiling by high throughput sequencing of three populations of primary dentate gyrus cells |
2.7 | | Miat | 'Mettl6 knockout clone D1' vs 'wild type genotype' | genotype | METTL6 is a tRNA m3C methyltransferase that regulates translation and tumor cell proliferation |
2.7 | | Miat | 'Triple knockout (Zfp36-/-, TNFR1-/-, TNFR2-/-)' vs 'wild type' | genotype | Transcription profiling by high throughput sequencing of douple (TNFR1-/-/TNFR2-/-) and triple (Zfp36-/-/TNFR1-/-/TNFR2-/-) knockout mouse spleens |
2.7 | | Miat | 'p150 subunit of CAF-1 siRNA knockdown' vs 'scrambled siRNA' | RNA interference | RNA-seq of control siRNA, p150 siRNA and p60 siRNA transfected mES cells |
2.7 | | Miat | 'Pdx1::Ngn3ER' vs 'Ngn3 knock out' | genotype | Transcriptome profiling of mouse pancreatic epithelium from Pdx1-Ngn3ER-IRES-GFP mice bred into a Neurog3-null background at embryonic day 11.25 |
2.6 | | Miat | 'Egr2 and Egr3 knockout' vs 'Egr2-GFP knockin; Egr2-GFP high' in 'CD4-positive T cell' | cell type, genotype, phenotype | RNAseq analysis of CD4 and CD8 T cells in response to vaccinia virus infection |
2.6 | | Miat | 'AZD5069; 100 milligram per kilogram' vs 'none' | compound | RNA-seq to investigate differentially expressed genes in KPC mouse PDAC treated with CSF-1R small molecule inhibitor AZD7507 and/or the CXCR2 small molecule inhibitor AZD5069 |
2.6 | | Miat | 'uterine-specific Tsc2-null' vs 'wild type' in '17beta-estradiol' | genotype, treatment | Transcription profiling by high throughput sequencing of uterine-specific Tsc2-null mice |
2.5 | | Miat | 'Dlx3Oc-c knockout' vs 'wild type' in 'femur metaphysis' | genotype, organism part | Transcription profiling by high throughput sequencing in diaphysis and metaphysis from femur of 5-week-old Dlx3Oc-cKO and wild type mice |
2.5 | | Miat | 'K14-Cre-ERT2 / CK1α fl/fl; 4-hydroxytamoxifen; none; 14 day' vs 'K14-Cre-ERT2; none; none' | genotype, irradiate, time | Ablation of casein kinase 1 in keratinocytes induces p53-dependent hyperpigmentation of the skin |
2.4 | | Miat | 'Mettl6 knockout clone G6' vs 'wild type genotype' | genotype | METTL6 is a tRNA m3C methyltransferase that regulates translation and tumor cell proliferation |
-2.4 | | Miat | 'Pkhd1Cre; Pkd2 F/F; miR-21null' vs 'wild type' | genotype | Next Generation Sequencing of PKD2 mutant mice kidneys |
2.3 | | Miat | 'synovial sarcoma' vs 'control' | disease, genotype | Mouse Model of Clear Cell Sarcoma |
-2.3 | | Miat | 'induced extraembryonic endoderm stem cell; grown in XEN cell medium' vs 'mouse embryonic fibroblast; control' | cell type, growth condition | OSKM induce extraembryonic endoderm stem (iXEN) cells in parallel to iPS cells |
-2.3 | | Miat | 'Bmi1-overexpressing lentiviral vector' vs 'empty vector control' | genotype | Control and Bmi1-overexpressing adult murine neural stem cells |
-2.1 | | Miat | 'Rfx2 knock out' vs 'wild type genotype' | genotype | Next Generation Sequencing Analysis of Wild Type and Rfx2-/- Testicular Transcriptomes at post natal day 30 [RNA-Seq P30] |
2.1 | | Miat | 'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector' | genotype | Transcription profiling by array of mouse primary neural stem cells mutant for p53 after infection with retrovirus expressing PLAGL2 |
2.1 | | Miat | 'p60 subunit of CAF-1 siRNA knockdown' vs 'scrambled siRNA' | RNA interference | RNA-seq of control siRNA, p150 siRNA and p60 siRNA transfected mES cells |
2.1 | | Miat | 'high fat diet; 30 degree celsius' vs 'chow; 23 degree celsius' in 'brown adipose tissue' | diet, organism part, temperature | RNA-seq of brown and white mouse adipose tissue at thermoneutrality and high-fat diet |
-2 | | Miat | 'Chikungunya virus; late stage encephalitis' vs 'mock infection' | infect, time | Transcriptomic profiling of the brains of WNV and CHIKV infection-induced encephalitis in young mice after 2, 3 or 5 days post infection |
-2 | | Miat | 'old neuronal stem cells' vs 'young neuronal stem cells' | age | A mechanism for the segregation of age in mammalian neural stem cells |
-2 | | Miat | 'Id3 knockout' vs 'wild type' in 'Tet+CD24-CD44+NK1.1- Invariant natural killer T' | cell type, genotype | Essential functions for ID proteins at multiple checkpoints in natural killer T cell development |
2 | | Miat | 'P19; transduced with NeuroD2 lentivirus' vs 'P19; control' | cell line, treatment | Genetic and epigenetic determinants of neurogenesis and myogenesis [expression profiling] |
-2 | | Miat | 'osteosarcoma' vs 'control' | disease, genotype | Mouse Model of Clear Cell Sarcoma |
2 | | Miat | 'neuronal stem cell; positive staining for GFP and prominin' vs 'astrocyte; positive staining for GFP' | cell type, phenotype | Transcription profiling by array of adult neural stem cells (hGFAP-GFP+/prominin1+ cells) compared to parenchymal astrocytes that are not neurogenic (hGFAP-GFP+ cells from the diencephalon) |
2 | | Miat | 'Crx knockout' vs 'control' at '6 zeitgeber' | genotype, time | Transcriptome in 129sv and Crx-/- pineal gland at ZT (Zeitgeber time) 6 and ZT20 |
-1.9 | | Miat | 'proliferating progenitor' vs 'differentiating progenitor' | cell type | Transcription profiling by high throughput sequencing of proliferating neural stem cells, differentiating neurogenic progenitors and newborn neurons using a dual-reporter mouse line |
-1.9 | | Miat | 'Insm1-expressing/Pdx1-high expressing endocrine progenitor cell' vs 'Insm1-expressing/Pdx1-low expressing endocrine progenitor cell' in 'embryonic day 18.5' | cell type, developmental stage | Transcriptional regulation of endocrine cell differentiation by Insm1 |
-1.9 | | Miat | 'Wnt1Cre Ezh2lox/lox' vs 'control' | genotype | Expression data from E11.5 mouse branchial arch 1 (BA1) - comparison between Ezh2lox/lox and Wnt1Cre Ezh2lox/lox embryos |
-1.9 | | Miat | 'Pkhd1Cre; Pkd2 F/F' vs 'wild type' | genotype | Next Generation Sequencing of PKD2 mutant mice kidneys |
-1.9 | | Miat | 'Ink4a/Arf-/-; EGFRvIII' vs 'wild type genotype' in 'co-culture' | genotype, growth condition | RNA-seq of wild-type and transformed Ink4a/Arf-/-; EGFRvIII neural stem cells in separate or co-culture conditions |
1.9 | | Miat | 'etoposide; 2.5 micromolar' vs 'none' in 'wild type genotype' | compound, genotype | RNA-seq of H2afj-ko and isogenic WT C57/Bl6-N mouse embryonic fibroblasts in proliferation and after etoposide-induced senescence. |
-1.8 | | Miat | 'Rfx2 knock out' vs 'wild type genotype' | genotype | Next Generation Sequencing Analysis of Wild Type and Rfx2-/- Testicular Transcriptomes at post natal day 21 [RNA-Seq P21] |
1.8 | | Miat | 'epithelium-specific Apc knockout' vs 'wild type' | phenotype | RNAseq of murine small intestinal tissue following epithelium-specific deletion of Bcl9/9l +/- Apc +/- mutant B-catenin |
-1.8 | | Miat | 'carcinoma' vs 'normal' | disease | Gene expression profile between normal mouse skin and carcinomas arising in the skin of RbF/F;K14creERTM;p107-/- mouse |
1.8 | | Miat | 'Men1-null' vs 'wild type' | genotype | Differentially regulated genes in adipocytes derived from Men1-null vs WT mouse embryonic stem cells |
-1.8 | | Miat | 'Insm1-expressing/Pdx1-high expressing endocrine progenitor cell' vs 'Insm1-expressing/Pdx1-low expressing endocrine progenitor cell' in 'embryonic day 15.5' | cell type, developmental stage | Transcriptional regulation of endocrine cell differentiation by Insm1 |
-1.8 | | Miat | 'lung carcinoma' vs 'normal' in 'CD11b+Ly6G+ neutrophil' | cell type, disease | Transcriptome analysis of isolated stormal cells and tumor epithelial cells in mouse lung cancer by RNA-Seq |
-1.7 | | Miat | 'fear conditioning' vs 'none' | stimulus | Gene-expression changes in neurons active during contextual fear conditioning compared to controls left in the homecage |
1.7 | | Miat | 'Mycobacterium tuberculosis H37Rv' vs 'none' in 'TNF-alpha knockout' | compound, genotype, infect | 4-week mouse comparative study on effect of neutralizing IL-17A, IL-17F and TNFa antibodies |
1.7 | | Miat | 'doxorubicin; 17.5 milligram per kilogram body weight' vs 'vehicle' in 'scramble; podocyte' | cell type, compound, genotype | Transcription profiling to identify the role of MOF in primary MEFs and differentiated podocytes in response to Adriamycin |
-1.6 | | Miat | '21 percent oxygen, 37 degree Celsius, no serum' vs 'none' | growth condition | RNA sequencing of native and ex vivo cultured murine tail tendon fascicles |
-1.6 | | Miat | 'seizure-preconditioning followed by intra-amygdala kainic acid' vs 'sham-preconditioning followed by intra-amygdala vehicle' | clinical treatment | Transcription profiling by array of mice with epileptic tolerance |
-1.6 | | Miat | 'bisphenol AF; 10 micromolar' vs 'vehicle' | compound | Transcriptomic analyses of 11.5 dpc female germ cell (mouse) exposed or not to Bisphenol A analogues (BPAF and BADGE) |
-1.6 | | Miat | 'Influenza A virus (A/Puerto Rico/8/1934(H1N1)); 2 day' vs 'mock' in 'CAST/EiJ' | infect, strain, time | Genomic profiling of collaborative cross founder mouse strains infected with respiratory viruses to discover novel transcripts and infection-related strain-specific gene and isoform expression |
1.5 | | Miat | 'Egr2 and Egr3 knockout' vs 'Egr2-GFP knockin; Egr2-GFP high' in 'CD8-positive T cell' | cell type, genotype, phenotype | RNAseq analysis of CD4 and CD8 T cells in response to vaccinia virus infection |
-1.5 | | Miat | 'oral hard palate epithelium' vs 'tail skin epithelium' | organism part | Transcriptional profiling of mouse oral and skin epithelium to study their intrinsic difference in global gene expression |
1.5 | | Miat | 'beta cell specific Pax6 knockout' vs 'wild type' | phenotype | RNA-Seq of pancreatic islets from beta cell-specific Pax6 knockout mice |
-1.5 | | Miat | 'Drosha -/-' vs 'wild type genotype' | genotype | RNA-seq of mouse ES cells with conditional Drosha knockout against wild type controls to identify pri-miRNAs |
1.5 | | Miat | 'prostaglandin E2; 1 micromolar' vs 'none' in 'primary cell line; wild type genotype' | cell line, compound, genotype | Bulk RNA-seq of wild type and MEF2A or MEF2C/D knockout mouse bone marrow macrophages under different stimulation conditions |
-1.5 | | Miat | 'Influenza A virus (A/Puerto Rico/8/1934(H1N1)); 2 day' vs 'mock' in 'NOD/ShiLtJ' | infect, strain, time | Genomic profiling of collaborative cross founder mouse strains infected with respiratory viruses to discover novel transcripts and infection-related strain-specific gene and isoform expression |
-1.4 | | Miat | 'cut nerve; 7 day' vs 'none' | injury, protocol, time | Changes in the coding/non-coding transcriptome and DNA methylome that define the Schwann cell repair phenotype after nerve injury |
-1.4 | | Miat | 'sham-preconditioning followed by intra-amygdala kainic acid' vs 'sham-preconditioning followed by intra-amygdala vehicle' | clinical treatment | Transcription profiling by array of mice with epileptic tolerance |
-1.4 | | Miat | 'clear cell sarcoma; Rosa26CreER' vs 'control' | disease, genotype | Mouse Model of Clear Cell Sarcoma |
1.4 | | Miat | 'Crx knockout' vs 'control' at '20 zeitgeber' | genotype, time | Transcriptome in 129sv and Crx-/- pineal gland at ZT (Zeitgeber time) 6 and ZT20 |
-1.4 | | Miat | 'uterine-specific Tsc2-null' vs 'wild type' in 'oopherectomized' | genotype, treatment | Transcription profiling by high throughput sequencing of uterine-specific Tsc2-null mice |
-1.4 | | Miat | 'Nippostrongylus brasiliensis' vs 'none' | infect | RNAseq of small intestinal epithelium extracted from mice infected with Nippostrongylus brasiliensis |
-1.3 | | Miat | 'Pbx1 -/-; Pbx2 -/-' vs 'wild type genotype' at '12 hour' | genotype, time | RNA-seq of wild-type, Pbx1/Pbx2 double-knockout and pMsgn1-mut EpiSCs differentiated in vitro to pre-somitic mesoderm in the first 24 hours of differentiation. |
1.3 | | Miat | '2 day' vs '0 day' | age | Transcription profiling of mouse embyronic stem cell line CGR8 during the first 10 days of differentiation into embryoid bodies |
-1.3 | | Miat | 'Cln3Δex7/8' vs 'wild type genotype' in 'vehicle; male' | compound, genotype, sex | Gene expression analyses in male and female Cln3Δex7/8 mouse brains following oral administration of flupirtine for 14 weeks |
-1.3 | | Miat | 'high fat diet' vs 'normal chow' in '28 week; ReverbαFlox2-6AdipoCre+' | age, diet, genotype | Tissue-autonomous regulation of adipose expansion by core clock protein REVERBα |
-1.3 | | Miat | 'Chikungunya virus; late stage encephalitis' vs 'early stage encephalitis' | infect, time | Transcriptomic profiling of the brains of WNV and CHIKV infection-induced encephalitis in young mice after 2, 3 or 5 days post infection |
1.2 | | Miat | 'FusΔNLS/+' vs 'wild type genotype' at '12 hour' | genotype, time | Mutant FUS triggers age-dependent synaptic impairment in presymptomatic ALS-FUS mice (RNA-seq part2) |
1.2 | | Miat | 'E2f1, E2f2, E2f3 triple knockout' vs 'control' at 'neonate' | developmental stage, genotype | Expression data from lenses triply deficient for E2F1, E2F2, and E2F3 transcription factors |
1.2 | | Miat | 'epithelium-specific Apc; Bcl9; Bcl9l knockout' vs 'wild type' | phenotype | RNAseq of murine small intestinal tissue following epithelium-specific deletion of Bcl9/9l +/- Apc +/- mutant B-catenin |
1.2 | | Miat | 'Get-1 null mutant' vs 'wild type' | genotype | Transcription profiling of mouse skins of embryos lacking Grainyhead-like epithelial transactivator (Get-1) |
-1.1 | | Miat | 'chronic pancreatitis' vs 'control' | disease | Pancreatic gene expression associated with cerulein induced chronic pancreatitis in mice |
1.1 | | Miat | 'HDAC1 deletion' vs 'wild type' | phenotype | Whole transcriptome sequencing of mouse regulatory T cells with and without Mef2d, Mef2c, HDAC1, HDAC2 or Dyrk1 deletion |
1.1 | | Miat | 'Scara3 overexpression' vs 'wild type phenotype' | phenotype | RNA sequencing of Mus musculus T helper cell type 2 with retroviral overexpression of different genes |
-1.1 | | Miat | 'Cln3Δex7/8' vs 'wild type genotype' in 'vehicle; female' | compound, genotype, sex | Gene expression analyses in male and female Cln3Δex7/8 mouse brains following oral administration of flupirtine for 14 weeks |
-1.1 | | Miat | 'adipose tissue specific Trim28 knockout' vs 'wild type genotype' in 'male' | genotype, sex | RNA-seq of gonadal adipose tissue from male and female Trim28-WT and Trim28 adipose specific KO mice |
-1.1 | | Miat | 'co-cultured with hematopoietic stem cell for 9 days' vs 'non co-cultured for 9 days' in 'endothelial cell; expressing AKT1' | cell type, growth condition, phenotype | Transcription profiling by high throughput sequencing of murine bone marrow endothelial cells and bone marrow stroma, in vitro and in vivo, with and without hematopoietic stem cells co-culture |
1.1 | | Miat | 'wormy, worm separated; Trichuris muris' vs 'control; non wormy' in 'caecum' | environmental stress, infect, organism part | RNA-seq of mouse intestinal mucosa to investigate infection by the parasitic nematode Trichuris muris |
-1.1 | | Miat | 'organoid culture without Noggin (ER medium)' vs 'organoid culture (ENR medium)' in 'none' | growth condition, stimulus | RNA-seq of small intestinal organoids treated with the control medium ENR (EGF, Noggin, R-spondin1) in the presence or absence of muscle supernatant |
1 | | Miat | 'male' vs 'female' in 'A/J' | sex, strain | Transcription profiling by high throughput sequencing of hippocampus from adult males and females of six inbred strains of mice |
1 | | Miat | '1 day' vs '0 day' | age | Transcription profiling of mouse embyronic stem cell line CGR8 during the first 10 days of differentiation into embryoid bodies |
-1 | | Miat | 'CD4-positive T cell' vs 'CD8-positive T cell' in 'Egr2-GFP knockin; Egr2-GFP high' | cell type, genotype, phenotype | RNAseq analysis of CD4 and CD8 T cells in response to vaccinia virus infection |
-1 | | Miat | 'West Nile virus; early stage encephalitis' vs 'mock infection' | infect, time | Transcriptomic profiling of the brains of WNV and CHIKV infection-induced encephalitis in young mice after 2, 3 or 5 days post infection |
-1 | | Miat | 'K14-Cre-ERT2; none; UVB irradiation; 7 day' vs 'K14-Cre-ERT2; none; none' | genotype, irradiate, time | Ablation of casein kinase 1 in keratinocytes induces p53-dependent hyperpigmentation of the skin |
1 | | Miat | 'epithelium-specific mutant beta-catenin expression' vs 'wild type' | phenotype | RNAseq of murine small intestinal tissue following epithelium-specific deletion of Bcl9/9l +/- Apc +/- mutant B-catenin |