ENSRNOG00000039969 (Dsc2)

rattus norvegicus

desmocollin 2

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Rattus norvegicus
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Created with Highcharts 6.2.0adult CCAP neuronalpha’/beta’ middle Kenyon cellcentrifugal neuron C3distal medullary amacrine neuron Dm10distal medullary amacrine neuron Dm9dopaminergic PAM neuron 6gamma dorsal Kenyon celllamina monopolar neuron L2lobula columnar neuron LC10alobula columnar neuron LC6lobula-lobula plate columnar neuron LLPC1mushroom body output neuronproximal medullary amacrine neuron Pm3transmedullary neuron Tm1transmedullary neuron Tm4adult lamina marginal glial cellalpha/beta posterior Kenyon cellcolumnar neuron T1distal medullary amacrine neuron Dm3dopaminergic PAM neuron 3dopaminergic PAM neuron 9lamina intrinsic neuronlamina monopolar neuron L5lobula columnar neuron LC10dlobula plate tangential neuronmedullary intrinsic neuron Mi4photoreceptor cell R7T neurontransmedullary neuron Tm29
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Log2-fold changeSpeciesGene nameComparisonExperimental variablesExperiment name
Adjusted p-valueLog2-fold change
2.5855 × 10-76.1
Dsc2'indomethacin; 50 milligram per kilogram' vs 'none' in 'indomethacin; liver' at '3 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with F to I.
Adjusted p-valueLog2-fold change
1.8806 × 10-85.9
Dsc2'indomethacin; 15 milligram per kilogram' vs 'none' in 'indomethacin; liver' at '3 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with F to I.
Adjusted p-valueLog2-fold change
1.6405 × 10-125.8
Dsc2'allopurinol; 50 milligram per kilogram' vs 'none' in 'allopurinol; liver' at '24 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with A.
Adjusted p-valueLog2-fold change
3.1473 × 10-165.7
Dsc2'puromycin aminonucleoside; 120 milligram per kilogram' vs 'none' in 'puromycin aminonucleoside; liver' at '6 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with P to R.
Adjusted p-valueLog2-fold change
1.4383 × 10-14-5.5
Dsc2'gentamicin; 10 milligram per kilogram' vs 'none' in 'gentamicin; liver' at '3 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with F to I.
Adjusted p-valueLog2-fold change
8.5941 × 10-125.5
Dsc2'imipramine; 100 milligram per kilogram' vs 'none' in 'imipramine; liver' at '6 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with F to I.
Adjusted p-valueLog2-fold change
9.3242 × 10-175.4
Dsc2'imipramine; 30 milligram per kilogram' vs 'none' in 'imipramine; liver' at '6 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with F to I.
Adjusted p-valueLog2-fold change
8.7598 × 10-16-5.3
Dsc2'cisplatin; 3 milligram per kilogram' vs 'none' in 'cisplatin; liver' at '3 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with C.
Adjusted p-valueLog2-fold change
8.3327 × 10-145.3
Dsc2'acetazolamide; 60 milligram per kilogram' vs 'none' in 'acetazolamide; kidney' at '6 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with A.
Adjusted p-valueLog2-fold change
2.4106 × 10-11-5.3
Dsc2'imipramine; 30 milligram per kilogram' vs 'none' in 'imipramine; liver' at '3 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with F to I.
Adjusted p-valueLog2-fold change
6.1582 × 10-205.2
Dsc2'allopurinol; 15 milligram per kilogram' vs 'none' in 'allopurinol; liver' at '24 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with A.
Adjusted p-valueLog2-fold change
4.2759 × 10-14-5.2
Dsc2'cephalothin; 300 milligram per kilogram' vs 'none' in 'cephalothin; liver' at '3 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with C.
Adjusted p-valueLog2-fold change
7.6421 × 10-12-5.2
Dsc2'puromycin aminonucleoside; 120 milligram per kilogram' vs 'none' in 'puromycin aminonucleoside; liver' at '24 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with P to R.
Adjusted p-valueLog2-fold change
1.4882 × 10-165.1
Dsc2'erythromycin ethylsuccinate; 1000 milligram per kilogram' vs 'none' in 'erythromycin ethylsuccinate; kidney' at '24 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with D and E.
Adjusted p-valueLog2-fold change
2.404 × 10-16-5.1
Dsc2'captopril; 100 milligram per kilogram' vs 'none' in 'captopril; liver' at '9 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with C.
Adjusted p-valueLog2-fold change
4.9233 × 10-15-5.1
Dsc2'cyclosporine A; 300 milligram per kilogram' vs 'none' in 'cyclosporine A; liver' at '3 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with C.
Adjusted p-valueLog2-fold change
1.1256 × 10-145.1
Dsc2'cyclophosphamide; 150 milligram per kilogram' vs 'none' in 'cyclophosphamide; liver' at '24 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with C.
Adjusted p-valueLog2-fold change
1.2033 × 10-145.1
Dsc2'erythromycin ethylsuccinate; 100 milligram per kilogram' vs 'none' in 'erythromycin ethylsuccinate; liver' at '9 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with D and E.
Adjusted p-valueLog2-fold change
1.9663 × 10-8-5.1
Dsc2'bromoethylamine; 6 milligram per kilogram' vs 'none' in 'bromoethylamine; liver' at '3 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with B.
Adjusted p-valueLog2-fold change
1.8544 × 10-6-5.1
Dsc2'bromoethylamine; 60 milligram per kilogram' vs 'none' in 'bromoethylamine; liver' at '3 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with B.
Adjusted p-valueLog2-fold change
1.3471 × 10-275
Dsc2'nitrofurantoin; 600 milligram per kilogram' vs 'none' in 'nitrofurantoin; liver' at '3 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with N to O.
Adjusted p-valueLog2-fold change
1.7748 × 10-18-5
Dsc2'allopurinol; 15 milligram per kilogram' vs 'none' in 'allopurinol; liver' at '3 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with A.
Adjusted p-valueLog2-fold change
1.3723 × 10-165
Dsc2'ketoconazole; 10 milligram per kilogram' vs 'none' in 'ketoconazole; liver' at '6 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with J to M.
Adjusted p-valueLog2-fold change
3.2206 × 10-165
Dsc2'cyclophosphamide; 150 milligram per kilogram' vs 'none' in 'cyclophosphamide; liver' at '9 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with C.
Adjusted p-valueLog2-fold change
1.7392 × 10-15-5
Dsc2'nitrofurantoin; 10 milligram per kilogram' vs 'none' in 'nitrofurantoin; liver' at '6 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with N to O.
Adjusted p-valueLog2-fold change
2.767 × 10-135
Dsc2'ethionine; 80 milligram per kilogram' vs 'none' in 'ethionine; liver' at '24 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with D and E.
Adjusted p-valueLog2-fold change
1.6102 × 10-12-5
Dsc2'caffeine; 10 milligram per kilogram' vs 'none' in 'caffeine; liver' at '9 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with C.
Adjusted p-valueLog2-fold change
7.0945 × 10-12-5
Dsc2'nitrofurantoin; 10 milligram per kilogram' vs 'none' in 'nitrofurantoin; liver' at '9 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with N to O.
Adjusted p-valueLog2-fold change
5.9368 × 10-23-4.8
Dsc2'cyclophosphamide; 5 milligram per kilogram' vs 'none' in 'cyclophosphamide; liver' at '6 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with C.
Adjusted p-valueLog2-fold change
7.3806 × 10-184.8
Dsc2'cyclophosphamide; 50 milligram per kilogram' vs 'none' in 'cyclophosphamide; liver' at '9 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with C.
Adjusted p-valueLog2-fold change
1.5988 × 10-16-4.8
Dsc2'captopril; 300 milligram per kilogram' vs 'none' in 'captopril; liver' at '3 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with C.
Adjusted p-valueLog2-fold change
2.399 × 10-15-4.8
Dsc2'acetazolamide; 60 milligram per kilogram' vs 'none' in 'acetazolamide; liver' at '24 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with A.
Adjusted p-valueLog2-fold change
2.0484 × 10-14-4.8
Dsc2'caffeine; 10 milligram per kilogram' vs 'none' in 'caffeine; liver' at '24 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with C.
Adjusted p-valueLog2-fold change
3.0636 × 10-9-4.8
Dsc2'caffeine; 100 milligram per kilogram' vs 'none' in 'caffeine; liver' at '24 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with C.
Adjusted p-valueLog2-fold change
8.1356 × 10-8-4.8
Dsc2'acetazolamide; 60 milligram per kilogram' vs 'none' in 'acetazolamide; liver' at '9 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with A.
Adjusted p-valueLog2-fold change
1.5897 × 10-194.7
Dsc2'omeprazole; 1000 milligram per kilogram' vs 'none' in 'omeprazole; kidney' at '9 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with N to O.
Adjusted p-valueLog2-fold change
9.8227 × 10-18-4.6
Dsc2'omeprazole; 100 milligram per kilogram' vs 'none' in 'omeprazole; liver' at '6 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with N to O.
Adjusted p-valueLog2-fold change
4.2856 × 10-134.6
Dsc2'omeprazole; 100 milligram per kilogram' vs 'none' in 'omeprazole; kidney' at '9 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with N to O.
Adjusted p-valueLog2-fold change
9.8915 × 10-11-4.6
Dsc2'carboplatin; 30 milligram per kilogram' vs 'none' in 'carboplatin; liver' at '6 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with C.
Adjusted p-valueLog2-fold change
3.6744 × 10-124.5
Dsc2'ciprofloxacin; 300 milligram per kilogram' vs 'none' in 'ciprofloxacin; liver' at '3 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with C.
Adjusted p-valueLog2-fold change
3.6913 × 10-6-3.9
Dsc2'bromobenzene; 30 milligram per kilogram' vs 'none' in 'bromobenzene; liver' at '3 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with B.
Adjusted p-valueLog2-fold change
1.6684 × 10-23.9
Dsc2'phenylbutazone; 200 milligram per kilogram' vs 'none' in 'phenylbutazone; liver' at '6 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with P to R.
Adjusted p-valueLog2-fold change
2.6829 × 10-33.8
Dsc2'bromobenzene; 100 milligram per kilogram' vs 'none' in 'bromobenzene; liver' at '6 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with B.
Adjusted p-valueLog2-fold change
2.4502 × 10-63.6
Dsc2'bromoethylamine; 20 milligram per kilogram' vs 'none' in 'bromoethylamine; liver' at '24 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with B.
Adjusted p-valueLog2-fold change
3.1502 × 10-4-3.6
Dsc2'skin expansion' at '20 hour' vs 'none' at '0 hour'stimulus, timeMicroarray data of rat expanded skin tissue
Adjusted p-valueLog2-fold change
1.0124 × 10-23.4
Dsc2'lomustine; 0.6 milligram per kilogram' vs 'none' in 'lomustine; liver' at '3 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with J to M.
Adjusted p-valueLog2-fold change
1.2095 × 10-2-3.4
Dsc2'rifampicin; 60 milligram per kilogram' vs 'none' in 'rifampicin; liver' at '3 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with P to R.
Adjusted p-valueLog2-fold change
6.4803 × 10-33.3
Dsc2'monocrotaline; 30 milligram per kilogram' vs 'none' in 'monocrotaline; liver' at '9 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with J to M.
Adjusted p-valueLog2-fold change
2.3897 × 10-23.3
Dsc2'thioacetamide; 15 milligram per kilogram' vs 'none' in 'thioacetamide; liver' at '6 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with S to T.
Adjusted p-valueLog2-fold change
1.2441 × 10-23.2
Dsc2'phenylbutazone; 60 milligram per kilogram' vs 'none' in 'phenylbutazone; liver' at '3 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with P to R.
Adjusted p-valueLog2-fold change
2.1581 × 10-2-3.2
Dsc2'lomustine; 6 milligram per kilogram' vs 'none' in 'lomustine; liver' at '24 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with J to M.
Adjusted p-valueLog2-fold change
8.5844 × 10-33.1
Dsc2'doxorubicin; 10 milligram per kilogram' vs 'none' in 'doxorubicin; liver' at '9 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with D and E.
Adjusted p-valueLog2-fold change
1.5773 × 10-2-3.1
Dsc2'puromycin aminonucleoside; 12 milligram per kilogram' vs 'none' in 'puromycin aminonucleoside; liver' at '9 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with P to R.
Adjusted p-valueLog2-fold change
7.3626 × 10-3-3
Dsc2'phenylbutazone; 20 milligram per kilogram' vs 'none' in 'phenylbutazone; liver' at '9 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with P to R.
Adjusted p-valueLog2-fold change
2.8772 × 10-2-3
Dsc2'nitrofurantoin; 100 milligram per kilogram' vs 'none' in 'nitrofurantoin; liver' at '9 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with N to O.
Adjusted p-valueLog2-fold change
4.8595 × 10-23
Dsc2'ethionine; 250 milligram per kilogram' vs 'none' in 'ethionine; liver' at '24 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with D and E.
Adjusted p-valueLog2-fold change
3.2458 × 10-52.9
Dsc2'naproxen; 60 milligram per kilogram' vs 'none' in 'naproxen; liver' at '4 day'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from repeat dosing studies: compounds starting with N to O.
Adjusted p-valueLog2-fold change
3.9051 × 10-42.9
Dsc2'allyl alcohol; 10 milligram per kilogram' vs 'none' in 'allyl alcohol; liver' at '9 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with A.
Adjusted p-valueLog2-fold change
2.0736 × 10-2-2.9
Dsc2'thioacetamide; 15 milligram per kilogram' vs 'none' in 'thioacetamide; liver' at '3 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with S to T.
Adjusted p-valueLog2-fold change
4.2062 × 10-22.9
Dsc2'triamterene; 50 milligram per kilogram' vs 'none' in 'triamterene; liver' at '3 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with S to T.
Adjusted p-valueLog2-fold change
1.0055 × 10-2-2.8
Dsc2'bromobenzene; 100 milligram per kilogram' vs 'none' in 'bromobenzene; liver' at '3 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with B.
Adjusted p-valueLog2-fold change
2.0482 × 10-22.8
Dsc2'cyclosporine A; 100 milligram per kilogram' vs 'none' in 'cyclosporine A; liver' at '6 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with C.
Adjusted p-valueLog2-fold change
3.4917 × 10-2-2.8
Dsc2'ciprofloxacin; 100 milligram per kilogram' vs 'none' in 'ciprofloxacin; liver' at '9 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with C.
Adjusted p-valueLog2-fold change
2.2643 × 10-7-2.7
Dsc2'allyl alcohol; 10 milligram per kilogram' vs 'none' in 'allyl alcohol; liver' at '6 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with A.
Adjusted p-valueLog2-fold change
2.0735 × 10-2-2.7
Dsc2'phenylbutazone; 200 milligram per kilogram' vs 'none' in 'phenylbutazone; liver' at '9 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with P to R.
Adjusted p-valueLog2-fold change
2.177 × 10-22.7
Dsc2'methyltestosterone; 300 milligram per kilogram' vs 'none' in 'methyltestosterone; liver' at '6 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with J to M.
Adjusted p-valueLog2-fold change
3.3871 × 10-22.7
Dsc2'14 day after denervation' vs 'innervated'treatmentGene regulation in denervated hairy skin of the adult rat
Adjusted p-valueLog2-fold change
4.7246 × 10-2-2.7
Dsc2'enalapril; 200 milligram per kilogram' vs 'none' in 'enalapril; liver' at '24 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with D and E.
Adjusted p-valueLog2-fold change
4.7637 × 10-2-2.7
Dsc2'ciprofloxacin; 300 milligram per kilogram' vs 'none' in 'ciprofloxacin; liver' at '9 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with C.
Adjusted p-valueLog2-fold change
1.4217 × 10-22.6
Dsc2'clofibrate; 30 milligram per kilogram' vs 'none' in 'clofibrate; liver' at '6 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with C.
Adjusted p-valueLog2-fold change
4.6461 × 10-22.6
Dsc2'cyclosporine A; 300 milligram per kilogram' vs 'none' in 'cyclosporine A; liver' at '6 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with C.
Adjusted p-valueLog2-fold change
1.0515 × 10-22.5
Dsc2'bucetin; 300 milligram per kilogram' vs 'none' in 'bucetin; liver' at '24 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with B.
Adjusted p-valueLog2-fold change
4.2793 × 10-6-2.4
Dsc2'acetazolamide; 600 milligram per kilogram' vs 'none' in 'acetazolamide; liver' at '24 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with A.
Adjusted p-valueLog2-fold change
8.0812 × 10-3-2.3
Dsc2'bucetin; 300 milligram per kilogram' vs 'none' in 'bucetin; liver' at '9 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with B.
Adjusted p-valueLog2-fold change
2.7502 × 10-22.2
Dsc2'squamous cell carcinoma' vs 'normal' in 'fibroblast'cell type, diseaseTranscription profiling by array of rat tongue epithelia and submucosal fibroblasts during oral carcinogenesis
Adjusted p-valueLog2-fold change
4.4805 × 10-22.2
Dsc2'carboplatin; 100 milligram per kilogram' vs 'none' in 'carboplatin; liver' at '24 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with C.
Adjusted p-valueLog2-fold change
2.3506 × 10-32.1
Dsc2'lornoxicam; 3 milligram per kilogram' vs 'none' in 'lornoxicam; liver' at '4 day'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from repeat dosing studies: compounds starting with J to M.
Adjusted p-valueLog2-fold change
8.8131 × 10-32.1
Dsc2'sciatic nerve transection for neuropathic pain' vs 'sham surgery'treatmentTranscription profiling of dorsal root ganglia from rats with and without traumatic neuropathic pain from sciatic nerve transection to identify genes responsible for mechanical hypersensitivity
Adjusted p-valueLog2-fold change
7.9695 × 10-27-2
Dsc2'24 hour culture at sarcomere length = 2.2 microns' vs 'control'stimulusRNA-Seq of rat myocardial slices cultured with biomimetic electromechanical stimulation
Adjusted p-valueLog2-fold change
4.6022 × 10-21-2
Dsc2'24 hour culture at sarcomere length = 1.8 microns' vs 'control'stimulusRNA-Seq of rat myocardial slices cultured with biomimetic electromechanical stimulation
Adjusted p-valueLog2-fold change
2.9929 × 10-32
Dsc2'meloxicam; 30 milligram per kilogram' vs 'none' in 'meloxicam; liver' at '8 day'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from repeat dosing studies: compounds starting with J to M.
Adjusted p-valueLog2-fold change
4.9415 × 10-22
Dsc2'valproic acid; 150 milligram per kilogram' vs 'none' in 'valproic acid; liver' at '6 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with U to Z.
Adjusted p-valueLog2-fold change
4.275 × 10-81.8
Dsc2'2 weeks after L5 spinal nerve ligation' vs 'control'growth condition, timeRNA-seq of rat dorsal root ganglia after ligation to investigate central nervous system transcriptomics in chronic pain using agnostic splice site discovery methods
Adjusted p-valueLog2-fold change
7.973 × 10-51.8
Dsc2'allopurinol; 150 milligram per kilogram' vs 'none' in 'allopurinol; kidney' at '29 day'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from repeat dosing studies: compounds starting with A.
Adjusted p-valueLog2-fold change
2.0707 × 10-21.8
Dsc2'lornoxicam; 3 milligram per kilogram' vs 'none' in 'lornoxicam; liver' at '8 day'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from repeat dosing studies: compounds starting with J to M.
Adjusted p-valueLog2-fold change
5.3001 × 10-51.7
Dsc2'puromycin aminonucleoside; 12 milligram per kilogram' vs 'none' in 'puromycin aminonucleoside; kidney' at '29 day'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from repeat dosing studies: compounds starting with P to R.
Adjusted p-valueLog2-fold change
3.5725 × 10-21.7
Dsc2'17beta-estradiol; 1 microgram per kilogram per day; male' vs '17beta-estradiol; 0 microgram per kilogram per day; male'compound, sexTranscription profiling by array of rat male and female mammary glands following exposure to exogenous estradiol
Adjusted p-valueLog2-fold change
2.0703 × 10-41.6
Dsc2'induced hypertension and diabetes' vs 'control'phenotypeTranscription profiling by array of kidney of Cyp1a1mRen2 rats during and following reversal of hyperglycaemia and hypertension
Adjusted p-valueLog2-fold change
1.7108 × 10-21.6
Dsc2'meloxicam; 30 milligram per kilogram' vs 'none' in 'meloxicam; liver' at '4 day'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from repeat dosing studies: compounds starting with J to M.
Adjusted p-valueLog2-fold change
2.051 × 10-21.6
Dsc2'vitamin A; 100 milligram per kilogram' vs 'none' in 'vitamin A; liver' at '29 day'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from repeat dosing studies: compounds starting with U to Z.
Adjusted p-valueLog2-fold change
3.6831 × 10-6-1.5
Dsc2'polysomal RNA' vs 'total RNA' in 'none'compound, fractionRegulation of total and polysomal RNA expression in rat neonatal cardiac myocytes by H2O2
Adjusted p-valueLog2-fold change
1.8567 × 10-31.5
Dsc2'naproxen; 60 milligram per kilogram' vs 'none' in 'naproxen; liver' at '8 day'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from repeat dosing studies: compounds starting with N to O.
Adjusted p-valueLog2-fold change
3.2903 × 10-21.5
Dsc2'17beta-estradiol; 10 microgram per kilogram per day; male' vs '17beta-estradiol; 0 microgram per kilogram per day; male'compound, sexTranscription profiling by array of rat male and female mammary glands following exposure to exogenous estradiol
Adjusted p-valueLog2-fold change
3.6066 × 10-21.5
Dsc2'allopurinol; 150 milligram per kilogram' vs 'none' in 'allopurinol; kidney' at '15 day'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from repeat dosing studies: compounds starting with A.
Adjusted p-valueLog2-fold change
2.0627 × 10-31.4
Dsc2'vitamin A; 100 milligram per kilogram' vs 'none' in 'vitamin A; liver' at '15 day'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from repeat dosing studies: compounds starting with U to Z.
Adjusted p-valueLog2-fold change
2.9967 × 10-3-1.4
Dsc2'bisphenol A; 10^-9 molar' at '7 day' vs 'control; 10^-9 molar' at '7 day'compound, timeAssessment of low-dose bisphenol A (BPA) toxicity in rat thyroid follicular cells by gene expression microarray
Adjusted p-valueLog2-fold change
4.2928 × 10-31.4
Dsc2'allopurinol; 150 milligram per kilogram' vs 'none' in 'allopurinol; kidney' at '8 day'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from repeat dosing studies: compounds starting with A.
Adjusted p-valueLog2-fold change
1.2119 × 10-21.4
Dsc2'naproxen; 200 milligram per kilogram' vs 'none' in 'naproxen; liver' at '24 hour'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from single dose studies: compounds starting with N to O.
Adjusted p-valueLog2-fold change
1.481 × 10-21.4
Dsc2'induced hypertension and diabetes then reversal' vs 'control'phenotypeTranscription profiling by array of kidney of Cyp1a1mRen2 rats during and following reversal of hyperglycaemia and hypertension
Adjusted p-valueLog2-fold change
2.6817 × 10-2-1.4
Dsc2'1-napthylisothiocyanate; bile duct' at '2 hour' vs 'vehicle; bile duct' at '2 hour'compound, organism part, timeGene expression in hepatocytes and bile ducts from ANIT-treated rats
Adjusted p-valueLog2-fold change
2.7923 × 10-21.4
Dsc2'1-napthylisothiocyanate; bile duct' at '6 hour' vs 'vehicle; bile duct' at '6 hour'compound, organism part, timeGene expression in hepatocytes and bile ducts from ANIT-treated rats
Adjusted p-valueLog2-fold change
2.0779 × 10-31.3
Dsc2'TNFa and IL1b' vs 'none'stimulusPro-inflammatory cytokines drive functional deregulation of potassium channels in primary synovial fibroblasts
Adjusted p-valueLog2-fold change
3.3368 × 10-31.3
Dsc2'naproxen; 60 milligram per kilogram' vs 'none' in 'naproxen; liver' at '15 day'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from repeat dosing studies: compounds starting with N to O.
Adjusted p-valueLog2-fold change
5.4274 × 10-31.3
Dsc2'lornoxicam; 3 milligram per kilogram' vs 'none' in 'lornoxicam; liver' at '15 day'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from repeat dosing studies: compounds starting with J to M.
Adjusted p-valueLog2-fold change
1.1061 × 10-21.3
Dsc2'puromycin aminonucleoside; 12 milligram per kilogram' vs 'none' in 'puromycin aminonucleoside; kidney' at '15 day'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from repeat dosing studies: compounds starting with P to R.
Adjusted p-valueLog2-fold change
7.4346 × 10-71.2
Dsc2'indomethacin; 5 milligram per kilogram' vs 'none' in 'indomethacin; liver' at '8 day'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from repeat dosing studies: compounds starting with F to I.
Adjusted p-valueLog2-fold change
1.3075 × 10-5-1.2
Dsc2'polysomal RNA' vs 'total RNA' in 'hydrogen peroxide; 0.2 millimolar'compound, fractionRegulation of total and polysomal RNA expression in rat neonatal cardiac myocytes by H2O2
Adjusted p-valueLog2-fold change
2.2971 × 10-41.2
Dsc2'ethambutol; 1000 milligram per kilogram' vs 'none' in 'ethambutol; liver' at '15 day'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from repeat dosing studies: compounds starting with D to E.
Adjusted p-valueLog2-fold change
2.3057 × 10-31.2
Dsc2'allopurinol; 150 milligram per kilogram' vs 'none' in 'allopurinol; kidney' at '4 day'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from repeat dosing studies: compounds starting with A.
Adjusted p-valueLog2-fold change
2.4965 × 10-31.2
Dsc2'ethambutol; 1000 milligram per kilogram' vs 'none' in 'ethambutol; liver' at '29 day'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from repeat dosing studies: compounds starting with D to E.
Adjusted p-valueLog2-fold change
8.7331 × 10-31.2
Dsc2'monocrotaline; 30 milligram per kilogram' vs 'none' in 'monocrotaline; liver' at '15 day'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from repeat dosing studies: compounds starting with J to M.
Adjusted p-valueLog2-fold change
1.7669 × 10-21.2
Dsc2'phenylanthranilic acid; 1000 milligram per kilogram' vs 'none' in 'phenylanthranilic acid; liver' at '15 day'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from repeat dosing studies: compounds starting with P to R.
Adjusted p-valueLog2-fold change
9.6365 × 10-61.1
Dsc2'indomethacin; 5 milligram per kilogram' vs 'none' in 'indomethacin; liver' at '15 day'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from repeat dosing studies: compounds starting with F to I.
Adjusted p-valueLog2-fold change
6.6548 × 10-31.1
Dsc2'squamous cell carcinoma' vs 'normal' in 'epithelial cell'cell type, diseaseTranscription profiling by array of rat tongue epithelia and submucosal fibroblasts during oral carcinogenesis
Adjusted p-valueLog2-fold change
7.0034 × 10-31.1
Dsc2'puromycin aminonucleoside; 40 milligram per kilogram' vs 'none' in 'puromycin aminonucleoside; liver' at '8 day'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from repeat dosing studies: compounds starting with P to R.
Adjusted p-valueLog2-fold change
9.5905 × 10-31.1
Dsc2'phenylanthranilic acid; 1000 milligram per kilogram' vs 'none' in 'phenylanthranilic acid; liver' at '4 day'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from repeat dosing studies: compounds starting with P to R.
Adjusted p-valueLog2-fold change
1.261 × 10-21.1
Dsc2'ethionamide; 300 milligram per kilogram' vs 'none' in 'ethionamide; liver' at '15 day'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from repeat dosing studies: compounds starting with D to E.
Adjusted p-valueLog2-fold change
4.7153 × 10-21.1
Dsc2'sulindac; 50 milligram per kilogram' vs 'none' in 'sulindac; liver' at '29 day'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from repeat dosing studies: compounds starting with S to T.
Adjusted p-valueLog2-fold change
1.0249 × 10-41
Dsc2'ibuprofen; 200 milligram per kilogram' vs 'none' in 'ibuprofen; liver' at '29 day'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from repeat dosing studies: compounds starting with F to I.
Adjusted p-valueLog2-fold change
1.8266 × 10-41
Dsc2'indomethacin; 5 milligram per kilogram' vs 'none' in 'indomethacin; liver' at '4 day'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from repeat dosing studies: compounds starting with F to I.
Adjusted p-valueLog2-fold change
4.0588 × 10-41
Dsc2'methapyrilene; 100 milligram per kilogram' vs 'none' in 'methapyrilene; liver' at '8 day'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from repeat dosing studies: compounds starting with J to M.
Adjusted p-valueLog2-fold change
2.454 × 10-31
Dsc2'methimazole; 100 milligram per kilogram' vs 'none' in 'methimazole; liver' at '15 day'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from repeat dosing studies: compounds starting with J to M.
Adjusted p-valueLog2-fold change
2.6559 × 10-31
Dsc2'gestational day 19; ORL' vs 'gestational day 19; Long Evans'developmental stage, strainCryptorchidism in the orl rat is associated with muscle patterning defects in the fetal gubernaculum and altered hormonal signaling
Adjusted p-valueLog2-fold change
4.5249 × 10-31
Dsc2'thioacetamide; 45 milligram per kilogram' vs 'none' in 'thioacetamide; liver' at '29 day'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from repeat dosing studies: compounds starting with S to T.
Adjusted p-valueLog2-fold change
1.3111 × 10-21
Dsc2'lomustine; 6 milligram per kilogram' vs 'none' in 'lomustine; kidney' at '29 day'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from repeat dosing studies: compounds starting with J to M.
Adjusted p-valueLog2-fold change
3.288 × 10-21
Dsc2'phenylanthranilic acid; 1000 milligram per kilogram' vs 'none' in 'phenylanthranilic acid; kidney' at '15 day'cohort, compound, organism part, timeTranscription profiling by array of rat liver and kidney after exposure to approximately 130 chemicals collected from repeat dosing studies: compounds starting with P to R.
Synonym
LOC291760, MGC124744
Ortholog
Gene ontology
InterPro
Ensembl gene
Ensembl transcript
Ensembl protein
Entrez
UniProt
Gene biotype
Design element
5932799, 6623042, 6500546, 6464249, 6202678, 6222603, 5830523, 6119511, 5836287, 10803359, 6206483, 6394534, 6363156, rc_AA851963_at, 5914585, 6531387, A_44_P555539, 6469951, 5883284, 5755552, 5900820, 5666926, 1375936_at
Reactome pathway ID