ensg00000088970 (KIZ)

homo sapiens

kizuna centrosomal protein

Filter your results

Homo sapiens
Organism part
Showing 33 experiments:
image/svg+xml human body features 2009-05-27 Sjef text : Kevin (tsaitgaist) REDON http://commons.wikimedia.org/wiki/File:Human_body_features.svg cerebral cortex pleura brain heart breast thyroid gland adrenal gland lymph node bone marrow adipose tissue skeletal muscle leukocyte frontal cortex temporal lobe prefrontal cortex pituitary gland atrial appendage aorta coronary artery gastroesophageal junction left ventricle hippocampus hippocampus caecum ileum rectum nose tongue left atrium pulmonary valve mitral valve penis vas deferens seminal vesicle testis epididymis eye nasal septum oral cavity tonsil nasal pharynx lung spinal cord amygdala trachea throat bronchus tricuspid valve diaphragm liver stomach spleen duodenum gall bladder pancreas colon small intestine appendix smooth muscle urinary bladder prostate gland nerve cerebellum cerebellar hemisphere kidney renal cortex bone cartilage esophagus salivary gland parotid gland submandibular gland skin
Created with Highcharts 6.2.0adiposecerebellar hemispherefallopian tubeleft cardiac atriumnucleus accumbensrectumsubmandibular glandvermiform appendixanimal ovaryatrium auricular regionbraincolondorsal thalamusendometriumfrontal lobeheart left ventriclehippocampuslivermammary glandminor salivary glandovarypineal bodyprefrontal cortexsaliva-secreting glandskeletal muscle of trunksmooth muscle tissuetestistibial nerveurinary bladder
P
Proteomics
T
Transcriptomics
High
Medium
Low
Below cutoff
No data available

Filter your results

Kingdom
Species
Experiment type
Experimental variables
Regulation
Log2-fold changeSpeciesGene nameComparisonExperimental variablesExperiment name
Adjusted p-valueLog2-fold change
7.584 × 10-43.9
KIZ'wild type; BREFELDIN A' vs 'wild type; control'genotype, treatmentInduction of ER stress in HCT116 colon cancer cells
Adjusted p-valueLog2-fold change
7.8528 × 10-5-3.1
KIZ'Staphylococcus aureus strain 10254' at '6 hour' vs 'none' at '0 hour'time, treatmentTranscription profiling by array of human peripheral blood mononuclear cells after treatment with community-associated Staphylococcus aureus and incubation for different lengths of time
Adjusted p-valueLog2-fold change
3.8939 × 10-10-3
KIZ'blood alcohol content 0.04%rising' vs 'control' in 'time point 2'sampling time point, treatmentMicroarray characterization of gene expression changes in blood during acute ethanol exposure
Adjusted p-valueLog2-fold change
9.3655 × 10-8-3
KIZ'Staphylococcus aureus strain Col' at '6 hour' vs 'none' at '0 hour'time, treatmentTranscription profiling by array of human peripheral blood mononuclear cells after treatment with community-associated Staphylococcus aureus and incubation for different lengths of time
Adjusted p-valueLog2-fold change
9.3305 × 10-12-2.9
KIZ'blood alcohol content 0.02%declining' vs 'control' in 'time point 5'sampling time point, treatmentMicroarray characterization of gene expression changes in blood during acute ethanol exposure
Adjusted p-valueLog2-fold change
2.3306 × 10-5-2.9
KIZ'Staphylococcus aureus strain 9897' at '6 hour' vs 'none' at '0 hour'time, treatmentTranscription profiling by array of human peripheral blood mononuclear cells after treatment with community-associated Staphylococcus aureus and incubation for different lengths of time
Adjusted p-valueLog2-fold change
6.8238 × 10-5-2.9
KIZ'Staphylococcus aureus strain 11490' at '6 hour' vs 'none' at '0 hour'time, treatmentTranscription profiling by array of human peripheral blood mononuclear cells after treatment with community-associated Staphylococcus aureus and incubation for different lengths of time
Adjusted p-valueLog2-fold change
1.6863 × 10-53-2.8
KIZ'lipopolysaccharide' vs 'none' in 'systemic-onset juvenile idiopathic arthritis'disease, stimulusA multidimensional blood stimulation assay reveals immune alterations underlying systemic juvenile idiopathic arthritis [RNA-Seq]
Adjusted p-valueLog2-fold change
4.2413 × 10-11-2.8
KIZ'blood alcohol content 0.08%' vs 'control' in 'time point 3'sampling time point, treatmentMicroarray characterization of gene expression changes in blood during acute ethanol exposure
Adjusted p-valueLog2-fold change
2.4637 × 10-5-2.8
KIZ'ChiPS4; hepatocyte-like cell' vs 'ChiPS4; induced pluripotent stem cell'block, cell line, cell type, fractionGene expression profile of human embryonic stem cell-derived hepatocyte-like cells
Adjusted p-valueLog2-fold change
7.9046 × 10-4-2.8
KIZ'SW-620; adenocarcinoma of colon; P10' vs 'SW-620; adenocarcinoma of colon; P0'cell line, disease, passageMicroarray analysis of xenograft models in use at the Developmental Therapeutics Program of the National Cancer Institute (DTP-NCI)
Adjusted p-valueLog2-fold change
1.1636 × 10-22.8
KIZ'wild type; tunicamycin' vs 'wild type; control'genotype, treatmentInduction of ER stress in HCT116 colon cancer cells
Adjusted p-valueLog2-fold change
5.057 × 10-6-2.7
KIZ'SA181; hepatocyte-like cell' vs 'SA181; embryonic stem cell'block, cell line, cell type, fractionGene expression profile of human embryonic stem cell-derived hepatocyte-like cells
Adjusted p-valueLog2-fold change
1.7622 × 10-22.7
KIZ'p53KO; tunicamycin' vs 'p53KO; control'genotype, treatmentInduction of ER stress in HCT116 colon cancer cells
Adjusted p-valueLog2-fold change
1.5384 × 10-33-2.6
KIZ'lipopolysaccharide' vs 'none' in 'normal'disease, stimulusA multidimensional blood stimulation assay reveals immune alterations underlying systemic juvenile idiopathic arthritis [RNA-Seq]
Adjusted p-valueLog2-fold change
6.2537 × 10-11-2.6
KIZ'blood alcohol content 0.04%declining' vs 'control' in 'time point 4'sampling time point, treatmentMicroarray characterization of gene expression changes in blood during acute ethanol exposure
Adjusted p-valueLog2-fold change
6.697 × 10-5-2.6
KIZ'transduced with HOXA1' vs 'control'treatmentGene expression profiling of enforced HOXA1 expression in melanoma cell line
Adjusted p-valueLog2-fold change
9.9725 × 10-52.6
KIZ'25 milligram; Asoprisnil' vs 'placebo' in 'endometrium'compound, organism partRegulation of endometrial bleeding by uNK cells
Adjusted p-valueLog2-fold change
1.8694 × 10-4-2.6
KIZ'myeloid-related protein 8' vs 'control' on 'Affymetrix GeneChip Human Genome U133 Plus 2.0 [HG-U133_Plus_2]'stimulusTranscription profiling by array of human blood monocyte stimulated with various stimuli (control, MRP8, LPS, TNF, IL1) to study signalling pathways in phagocytic activation
Adjusted p-valueLog2-fold change
3.1849 × 10-39-2.5
KIZ'12 hour' vs '0 hour' in 'MCF-10A-H1047R'cell line, timeKnock-in of PIK3CA-H1047R into MCF-10A
Adjusted p-valueLog2-fold change
1.4062 × 10-9-2.5
KIZ'blood alcohol content 0%' vs 'control' in 'time point 1'sampling time point, treatmentMicroarray characterization of gene expression changes in blood during acute ethanol exposure
Adjusted p-valueLog2-fold change
2.0318 × 10-15-2.4
KIZ'24 hour' vs '0 hour' in 'MCF-10A'cell line, timeKnock-in of PIK3CA-H1047R into MCF-10A
Adjusted p-valueLog2-fold change
2.4715 × 10-32.4
KIZ'metastatic recurrence; tumor' vs 'metastatic recurrence; normal adjacent tissue'clinical information, sampling siteGene expression profile of primary colorectal tumors with and without distant metastasis
Adjusted p-valueLog2-fold change
7.5246 × 10-6-2.3
KIZ'SW-620; adenocarcinoma of colon; P04' vs 'SW-620; adenocarcinoma of colon; P0'cell line, disease, passageMicroarray analysis of xenograft models in use at the Developmental Therapeutics Program of the National Cancer Institute (DTP-NCI)
Adjusted p-valueLog2-fold change
8.3047 × 10-4-2.3
KIZ'Francisella tularensis novicida' vs 'uninfected'infectTranscription profiling by array of human peripheral blood mononuclear cells infected with Francisella tularensis
Adjusted p-valueLog2-fold change
9.9833 × 10-42.3
KIZ'DICERER5/EX5; tunicamycin' vs 'DICERER5/EX5; control'genotype, treatmentInduction of ER stress in HCT116 colon cancer cells
Adjusted p-valueLog2-fold change
5.0274 × 10-131-2.2
KIZ'injected in NSG mouse' vs 'none' in 'none'stimulus, xenograftRNA-Seq of T cells sorted from human PBMCs, or from T cells stimulated with CD3/CD28 beads for 4 days, or from the spleen of NSG or NSG-HLA-A2/HHD mice, 7 days after transplantation with human PBMCs
Adjusted p-valueLog2-fold change
5.5169 × 10-28-2.2
KIZ'12 hour' vs '0 hour' in 'MCF-10A'cell line, timeKnock-in of PIK3CA-H1047R into MCF-10A
Adjusted p-valueLog2-fold change
1.7814 × 10-6-2.2
KIZ'Staphylococcus aureus strain 252' at '6 hour' vs 'none' at '0 hour'time, treatmentTranscription profiling by array of human peripheral blood mononuclear cells after treatment with community-associated Staphylococcus aureus and incubation for different lengths of time
Adjusted p-valueLog2-fold change
5.5746 × 10-125-2.1
KIZ'injected in NSG-HLA-A2/HHD mouse' vs 'none' in 'none'stimulus, xenograftRNA-Seq of T cells sorted from human PBMCs, or from T cells stimulated with CD3/CD28 beads for 4 days, or from the spleen of NSG or NSG-HLA-A2/HHD mice, 7 days after transplantation with human PBMCs
Adjusted p-valueLog2-fold change
1.8014 × 10-32.1
KIZ'cells p16-transfected' vs 'control'treatmentInduction of apoptotic processes in Capan-1 pancreatic carcinoma cells by restoration of p16INK4a expression
Adjusted p-valueLog2-fold change
1.2612 × 10-8-2
KIZ'human intestinal organoids derived from H9 stem cells' vs 'Undifferentiated H9 Stem Cells'cell typeTranscriptional Profiling of human pluripotent stem cells and and derived tissues
Adjusted p-valueLog2-fold change
4.9609 × 10-8-2
KIZ'deferoxamine; 100 nanomolar echinomycin' vs 'deferoxamine; none'growth condition, treatmentTranscription profiling by array of human glioblastoma cells after stimulation with deferoxamine and treatment with polyamide 1, echinomycin, or HIF-1a siRNA
Adjusted p-valueLog2-fold change
7.2785 × 10-82
KIZ'BEZ235; max' vs 'DMSO; 'compoundComparison of gene expression alterations induced by distinct PI3K inhibitors
Adjusted p-valueLog2-fold change
7.043 × 10-5-2
KIZ'SW-620; adenocarcinoma of colon; P01' vs 'SW-620; adenocarcinoma of colon; P0'cell line, disease, passageMicroarray analysis of xenograft models in use at the Developmental Therapeutics Program of the National Cancer Institute (DTP-NCI)
Adjusted p-valueLog2-fold change
7.1335 × 10-4-2
KIZ'tumor necrosis factor alpha' vs 'control' on 'Affymetrix GeneChip Human Genome U133 Plus 2.0 [HG-U133_Plus_2]'stimulusTranscription profiling by array of human blood monocyte stimulated with various stimuli (control, MRP8, LPS, TNF, IL1) to study signalling pathways in phagocytic activation
Adjusted p-valueLog2-fold change
2.352 × 10-22-1.9
KIZ'24 hour' vs '0 hour' in 'MCF-10A-H1047R'cell line, timeKnock-in of PIK3CA-H1047R into MCF-10A
Adjusted p-valueLog2-fold change
3.4578 × 10-8-1.9
KIZ'stimulation' vs 'control'growth conditionEffect of human breast tumor supernatant on normal CD4+ T cells (Confirmation Set SN)
Adjusted p-valueLog2-fold change
3.7709 × 10-81.9
KIZ'plateau transepithelial electrical resistance' vs 'monolayer control'phenotypeGene Expression in MCF10A cells through Differentiation on Transwells
Adjusted p-valueLog2-fold change
4.1125 × 10-8-1.9
KIZ'ovarian cancer' vs 'normal' in 'epithelial cell'cell type, diseaseA cancer associated fibroblasts (CAFs) specific gene signature in high grade serous ovarian cancer
Adjusted p-valueLog2-fold change
8.6973 × 10-81.9
KIZ'BEZ235; 90 per cent inhibitory concentration' vs 'DMSO; 'compoundComparison of gene expression alterations induced by distinct PI3K inhibitors
Adjusted p-valueLog2-fold change
4.3749 × 10-6-1.9
KIZ'PKA RII-beta over expression' vs 'wild type'genotypeTranscription profiling by array of human ovarian cancer cells over-expressing PKA regulatory subunits
Adjusted p-valueLog2-fold change
1.1637 × 10-5-1.9
KIZ'DMSO' in 'stimulated with interferon gamma and lipopolysaccharide' vs 'none' at '6 hour'compound, time, treatmentGPBAR1 agonism has a broad impact on blocking macrophage activation
Adjusted p-valueLog2-fold change
3.5145 × 10-4-1.9
KIZ'teratozoospermia' vs 'normospermic'diseaseTranscription profiling by array of human sperm from normospermic and teratozoospermic individuals
Adjusted p-valueLog2-fold change
5.1593 × 10-4-1.9
KIZ'Newcastle disease virus' at '14 hour' vs 'none' at '0 hour'infect, timeTranscription profiling by array of human dendritic cells infected with Newcastle Disease Virus
Adjusted p-valueLog2-fold change
9.5145 × 10-431.8
KIZ'lapatinib; 500 nanomolar; 1 day' vs 'dimethyl sulfoxide; 1 day'compound, timeRNA-seq of human oesophageal adenocarcinoma OE19 cell line treated with lapatinib
Adjusted p-valueLog2-fold change
1.2851 × 10-201.8
KIZ'Barrett’s esophagus; low-grade dysplasia' vs 'normal'disease, disease stagingWhole transcriptome profiling of Esophageal adenocarcinoma and Barrett's
Adjusted p-valueLog2-fold change
1.236 × 10-9-1.8
KIZ'ejaculatory azoospermia; Johnsen score count 2' vs 'normal; Johnsen score count 10'disease, histologyTranscription profiling of human testis samples from men with highly defined and homogenous testicular pathologies reveals patterns that correlate with distinct stages of spermatogenesis
Adjusted p-valueLog2-fold change
1.7583 × 10-9-1.8
KIZ'non-small cell lung carcinoma' vs 'normal'block, diseaseRNA-seq of blood platelets from six tumor types and healthy donors
Adjusted p-valueLog2-fold change
1.5973 × 10-8-1.8
KIZ'ejaculatory azoospermia; Johnsen score count 3.2' vs 'normal; Johnsen score count 10'disease, histologyTranscription profiling of human testis samples from men with highly defined and homogenous testicular pathologies reveals patterns that correlate with distinct stages of spermatogenesis
Adjusted p-valueLog2-fold change
1.7872 × 10-4-1.8
KIZ'AsPC-1; pancreatic adenocarcinoma; P01' vs 'AsPC-1; pancreatic adenocarcinoma; P0'cell line, disease, passageMicroarray analysis of xenograft models in use at the Developmental Therapeutics Program of the National Cancer Institute (DTP-NCI)
Adjusted p-valueLog2-fold change
4.8133 × 10-3-1.8
KIZ'Newcastle disease virus' at '12 hour' vs 'none' at '0 hour'infect, timeTranscription profiling by array of human dendritic cells infected with Newcastle Disease Virus
Adjusted p-valueLog2-fold change
5.2427 × 10-3-1.8
KIZ'Newcastle disease virus' at '16 hour' vs 'none' at '0 hour'infect, timeTranscription profiling by array of human dendritic cells infected with Newcastle Disease Virus
Adjusted p-valueLog2-fold change
1.0358 × 10-2-1.8
KIZ'differention medium' vs 'proliferation medium' in 'interstitial cystitis'disease, growth conditionTranscription profiling by array of human female interstitial cystitis urothelial cells after inducing differentiation
Adjusted p-valueLog2-fold change
9.2504 × 10-48-1.7
KIZ'SNCA overexpression' vs 'wild type genotype'genotypeRNA-seq of human midbrain organoid models of Parkinson's Disease
Adjusted p-valueLog2-fold change
9.7397 × 10-37-1.7
KIZ'doxycycline; 0.5 microgram per milliliter; Day 4 post Neurogenin induction' vs 'control'compound, treatmentRapid neurogenesis through transcriptional activation in human stem cell (RNA-Seq)
Adjusted p-valueLog2-fold change
1.2869 × 10-7-1.7
KIZ'cycloheximide; control (ethanol vehicle)' vs 'DMSO control; control (ethanol vehicle)'compound, growth conditionTranscription profiling by array of human MCF7 breast cancer cells after growth with cyclohexamide followed by treatment with 17beta-estradiol
Adjusted p-valueLog2-fold change
4.4333 × 10-7-1.7
KIZ'Staphylococcus aureus strain 9897' at '3 hour' vs 'none' at '0 hour'time, treatmentTranscription profiling by array of human peripheral blood mononuclear cells after treatment with community-associated Staphylococcus aureus and incubation for different lengths of time
Adjusted p-valueLog2-fold change
1.1072 × 10-2-1.7
KIZ'Newcastle disease virus' at '10 hour' vs 'none' at '0 hour'infect, timeTranscription profiling by array of human dendritic cells infected with Newcastle Disease Virus
Adjusted p-valueLog2-fold change
1.1755 × 10-2-1.7
KIZ'TNF-treated' vs 'untreated'treatmentExpression data from primary human keratinocytes exposed to cytokines in vitro (IL-4, IL-13, IL-17A, IFN-alpha, IFN-gamma, TNF)
Adjusted p-valueLog2-fold change
4.319 × 10-2-1.7
KIZ'differention medium' vs 'proliferation medium' in 'normal'disease, growth conditionTranscription profiling by array of human female interstitial cystitis urothelial cells after inducing differentiation
Adjusted p-valueLog2-fold change
4.0123 × 10-13-1.6
KIZ'cisplatin; 100 micromolar' vs 'none' in 'TMEM45A knockdown by siRNA'RNA interference, compoundRNA-seq of human head and neck cancer cell line SQD9 knock-out for TMEM45A exposed to cisplatin
Adjusted p-valueLog2-fold change
7.9969 × 10-11-1.6
KIZ'EX00000246; stimulated with interferon gamma and lipopolysaccharide' vs 'none' at '24 hour'compound, time, treatmentGPBAR1 agonism has a broad impact on blocking macrophage activation
Adjusted p-valueLog2-fold change
9.2652 × 10-11-1.6
KIZ'heat-killed Escherichia coli' vs 'none' in 'ulcerative colitis'disease, stimulusTranscription profiling by array of primary human macrophages cultured from patients with ulcerative colitis or healthy individuals with or without stimulation by heat-killed E. coli
Adjusted p-valueLog2-fold change
2.3496 × 10-71.6
KIZ'mid transepithelial electrical resistance' vs 'monolayer control'phenotypeGene Expression in MCF10A cells through Differentiation on Transwells
Adjusted p-valueLog2-fold change
8.8666 × 10-61.6
KIZ'AQM' vs 'normal' on 'Affymetrix HG-U133B'diseaseTranscription profiling by array of 12 human muscle diseases
Adjusted p-valueLog2-fold change
1.0637 × 10-5-1.6
KIZ'Staphylococcus aureus strain Col' at '3 hour' vs 'none' at '0 hour'time, treatmentTranscription profiling by array of human peripheral blood mononuclear cells after treatment with community-associated Staphylococcus aureus and incubation for different lengths of time
Adjusted p-valueLog2-fold change
3.4752 × 10-5-1.6
KIZ'heat-killed Escherichia coli' vs 'none' in 'normal'disease, stimulusTranscription profiling by array of primary human macrophages cultured from patients with ulcerative colitis or healthy individuals with or without stimulation by heat-killed E. coli
Adjusted p-valueLog2-fold change
4.236 × 10-5-1.6
KIZ'Staphylococcus aureus strain 11490' at '3 hour' vs 'none' at '0 hour'time, treatmentTranscription profiling by array of human peripheral blood mononuclear cells after treatment with community-associated Staphylococcus aureus and incubation for different lengths of time
Adjusted p-valueLog2-fold change
1.4224 × 10-91-1.5
KIZ'CD3/CD28 beads' vs 'none' in 'none'stimulus, xenograftRNA-Seq of T cells sorted from human PBMCs, or from T cells stimulated with CD3/CD28 beads for 4 days, or from the spleen of NSG or NSG-HLA-A2/HHD mice, 7 days after transplantation with human PBMCs
Adjusted p-valueLog2-fold change
2.1064 × 10-27-1.5
KIZ'doxycycline; 0.5 microgram per milliliter; Day 3 post Neurogenin induction' vs 'control'compound, treatmentRapid neurogenesis through transcriptional activation in human stem cell (RNA-Seq)
Adjusted p-valueLog2-fold change
8.2 × 10-141.5
KIZ'gefitinib; 24 hour' vs 'none; 2 hour'compound, timeRNA-seq of A431 cell line after gefitinib treatment
Adjusted p-valueLog2-fold change
2.4392 × 10-10-1.5
KIZ'DMSO' in 'stimulated with interferon gamma and lipopolysaccharide' vs 'none' at '24 hour'compound, time, treatmentGPBAR1 agonism has a broad impact on blocking macrophage activation
Adjusted p-valueLog2-fold change
9.0037 × 10-81.5
KIZ'HPAF_II; CI-1040; 2 millimolar' vs 'HPAF_II; vehicle; 'cell line, compoundExpression Data from 22 human pancreatic cancer cell lines grown in triplicates +/- MEK inhibitor CI-1040
Adjusted p-valueLog2-fold change
3.7458 × 10-7-1.5
KIZ'200 nanomolar retinoic acid' vs 'none'compoundTranscription profiling by array of human embryonic stem cells response to retinoic acid exposure
Adjusted p-valueLog2-fold change
1.1827 × 10-6-1.5
KIZ'breast carcinoma' vs 'normal'block, diseaseRNA-seq of blood platelets from six tumor types and healthy donors
Adjusted p-valueLog2-fold change
2.0823 × 10-61.5
KIZ'low transepithelial electrical resistance' vs 'monolayer control'phenotypeGene Expression in MCF10A cells through Differentiation on Transwells
Adjusted p-valueLog2-fold change
2.1531 × 10-6-1.5
KIZ'CLS1; 6 passages' vs 'CLS1; co-culture with CAF to generate sphere'cell line, growth condition, passageCancer-Associated Fibroblasts Support Lung Cancer Stemness through Paracrine IGF-II/IGF1R/Nanog Signaling
Adjusted p-valueLog2-fold change
4.7029 × 10-5-1.5
KIZ'10 day' vs '0 day'timeGlobal expression profiling time series of early human embryonic stem cell differentiation towards the mesoderm lineage
Adjusted p-valueLog2-fold change
6.7851 × 10-5-1.5
KIZ'AsPC-1; pancreatic adenocarcinoma; P04' vs 'AsPC-1; pancreatic adenocarcinoma; P0'cell line, disease, passageMicroarray analysis of xenograft models in use at the Developmental Therapeutics Program of the National Cancer Institute (DTP-NCI)
Adjusted p-valueLog2-fold change
3.2104 × 10-41.5
KIZ'ETP-45658' vs 'DMSO'compoundGene expression profiling upon PI3K inhibition using different inhibitors
Adjusted p-valueLog2-fold change
3.8836 × 10-4-1.5
KIZ'T-helper 2 polarising' at '1 day' vs 'no stimulus'cell type, sampling time point, stimulusTranscription profiling by array of human CD4+T-cells, Th1/Th2 polarized time-series and primary memory subsets
Adjusted p-valueLog2-fold change
4.2184 × 10-4-1.5
KIZ'T-helper 1 polarising' at '1 day' vs 'no stimulus'cell type, sampling time point, stimulusTranscription profiling by array of human CD4+T-cells, Th1/Th2 polarized time-series and primary memory subsets
Adjusted p-valueLog2-fold change
5.203 × 10-4-1.5
KIZ'T-helper 2 polarising' at '5 days' vs 'no stimulus'cell type, sampling time point, stimulusTranscription profiling by array of human CD4+T-cells, Th1/Th2 polarized time-series and primary memory subsets
Adjusted p-valueLog2-fold change
8.6045 × 10-4-1.5
KIZ'T-helper 1 polarising' at '5 days' vs 'no stimulus'cell type, sampling time point, stimulusTranscription profiling by array of human CD4+T-cells, Th1/Th2 polarized time-series and primary memory subsets
Adjusted p-valueLog2-fold change
1.5116 × 10-3-1.5
KIZ'Newcastle disease virus' at '8 hour' vs 'none' at '0 hour'infect, timeTranscription profiling by array of human dendritic cells infected with Newcastle Disease Virus
Adjusted p-valueLog2-fold change
1.5773 × 10-31.5
KIZ'astrocyte overexpressing 7 genes' vs 'glioblastoma cell line'phenotypeTranscription profiling by array of human primary astrocytes, cancer stem cells derived from astrocytes overexpressing various oncogenic and iPSC-inducing factors, glioma stem cells and gliblastomat cell line to compare their expression profiles and tumor-initiating capabilities
Adjusted p-valueLog2-fold change
8.679 × 10-31.5
KIZ'BEZ235; 50 per cent inhibitory concentration' vs 'DMSO; 'compoundComparison of gene expression alterations induced by distinct PI3K inhibitors
Adjusted p-valueLog2-fold change
8.9275 × 10-31.5
KIZ'type I diabetes mellitus' vs 'normal'disease stagingTranscription profiling human whole blood from children with pre-type1diabetes
Adjusted p-valueLog2-fold change
4.8935 × 10-2-1.5
KIZ'metastatic prostate cancer' vs 'benign prostate tumor'diseaseTranscription profiling by array of human benign prostate, primary and metastatic prostate cancer samples to reveal signatures of metastatic progression
Adjusted p-valueLog2-fold change
8.5345 × 10-41-1.4
KIZ' neural stem cell' vs 'induced pluripotent stem cell' in 'normal'cell type, diseaseHuman iPSC-Derived Cerebellar Neurons from a Patient with Ataxia-Telangiectasia Reveal Disrupted Gene Regulatory Networks
Adjusted p-valueLog2-fold change
3.1839 × 10-281.4
KIZ'lapatinib; 500 nanomolar; 7 day' vs 'dimethyl sulfoxide; 1 day'compound, timeRNA-seq of human oesophageal adenocarcinoma OE19 cell line treated with lapatinib
Adjusted p-valueLog2-fold change
5.9296 × 10-25-1.4
KIZ'doxycycline; 0.5 microgram per milliliter; Day 1 post Neurogenin induction' vs 'control'compound, treatmentRapid neurogenesis through transcriptional activation in human stem cell (RNA-Seq)
Adjusted p-valueLog2-fold change
1.452 × 10-181.4
KIZ'18 day' vs '0 day'timeRNA-Seq characterization of human H1-derived NPC differentiation timecourse
Adjusted p-valueLog2-fold change
8.2287 × 10-16-1.4
KIZ'Growth Medium' vs 'none' in 'systemic-onset juvenile idiopathic arthritis'disease, stimulusA multidimensional blood stimulation assay reveals immune alterations underlying systemic juvenile idiopathic arthritis [RNA-Seq]
Adjusted p-valueLog2-fold change
5.7706 × 10-121.4
KIZ'JDM' vs 'normal' on 'Affymetrix HG-U133B'diseaseTranscription profiling by array of 12 human muscle diseases
Adjusted p-valueLog2-fold change
6.4736 × 10-9-1.4
KIZ'papillary thyroid carcinoma' vs 'normal'diseaseRNA-Sequencing of human papillary thyroid carcinomas
Adjusted p-valueLog2-fold change
1.994 × 10-71.4
KIZ'esophageal adenocarcinoma' vs 'normal'disease, disease stagingWhole transcriptome profiling of Esophageal adenocarcinoma and Barrett's
Adjusted p-valueLog2-fold change
4.8121 × 10-7-1.4
KIZ'SUMO knockout' vs 'control'genotypeGene expression profile of SUMO knockout in human mammary epithelial cells
Adjusted p-valueLog2-fold change
7.9182 × 10-7-1.4
KIZ'200 nanomolar; retinoic acid' vs '1 micromolar DMSO'compoundTranscription profiling by array of human embryonic stem cells response to retinoic acid exposure
Adjusted p-valueLog2-fold change
1.3579 × 10-6-1.4
KIZ'stimulated' vs 'unstimulated' in 'none'compound, treatmentTranscription profiling by array of stimulated or unstimulated human CD4+ T cells incubated with edelfosine
Adjusted p-valueLog2-fold change
4.836 × 10-61.4
KIZ'PLX4032; 500 nanomolar' vs 'DMSO'compoundParent vs. Induced drug tolerant cells Microarray Analysis
Adjusted p-valueLog2-fold change
5.2103 × 10-6-1.4
KIZ'APE1 RNAi' vs 'scrambled control'RNA interferenceRNAi knock down of the DNA-repair enzyme and transcriptional co-activator APE1 in human HeLa cells
Adjusted p-valueLog2-fold change
6.8161 × 10-61.4
KIZ'valproic acid; 15 millimolar' vs 'control' at '1 day'compound, sampling time pointRNA-seq of Primary Human Hepatocytes (PHH) exposed to Valproic Acid (VPA) for 3 days daily and 3 days daily exposure followed by 3 days washout.
Adjusted p-valueLog2-fold change
1.7372 × 10-5-1.4
KIZ'mesendoderm/endoderm progenitor cell' vs 'embryonic stem cell'cell typeTranscription profiling of human embryonic stem cells and their differentiated progeny grown in chemically defined conditions
Adjusted p-valueLog2-fold change
2.9996 × 10-5-1.4
KIZ'8 day' vs '0 day'timeGlobal expression profiling time series of early human embryonic stem cell differentiation towards the mesoderm lineage
Adjusted p-valueLog2-fold change
3.9859 × 10-5-1.4
KIZ'786-0; renal adenocarcinoma; P01' vs '786-0; renal adenocarcinoma; P0'cell line, disease, passageMicroarray analysis of xenograft models in use at the Developmental Therapeutics Program of the National Cancer Institute (DTP-NCI)
Adjusted p-valueLog2-fold change
8.2579 × 10-5-1.4
KIZ'AsPC-1; pancreatic adenocarcinoma; P10' vs 'AsPC-1; pancreatic adenocarcinoma; P0'cell line, disease, passageMicroarray analysis of xenograft models in use at the Developmental Therapeutics Program of the National Cancer Institute (DTP-NCI)
Adjusted p-valueLog2-fold change
2.7439 × 10-4-1.4
KIZ'stimulated with interferon gamma and lipopolysaccharide' vs 'unstimulated' in 'EX00000246' at '6 hour'compound, time, treatmentGPBAR1 agonism has a broad impact on blocking macrophage activation
Adjusted p-valueLog2-fold change
4.7246 × 10-41.4
KIZ'hypoxia' vs 'normoxia' in 'SW982'cell line, growth conditionHypoxia and Intrinsic Transcriptomic Subtyping of Soft Tissue Sarcoma
Adjusted p-valueLog2-fold change
5.4962 × 10-4-1.4
KIZ'astrocyte overexpressing 4 genes' vs 'astrocyte'phenotypeTranscription profiling by array of human primary astrocytes, cancer stem cells derived from astrocytes overexpressing various oncogenic and iPSC-inducing factors, glioma stem cells and gliblastomat cell line to compare their expression profiles and tumor-initiating capabilities
Adjusted p-valueLog2-fold change
6.147 × 10-4-1.4
KIZ'insulin-like growth factor' at '24 hour' vs 'control' at '24 hour'compound, timeExpression data from MCF-7 cells stimulated by Estrogen or IGF-I
Adjusted p-valueLog2-fold change
1.0765 × 10-31.4
KIZ'PI-103' vs 'DMSO'compoundGene expression profiling upon PI3K inhibition using different inhibitors
Adjusted p-valueLog2-fold change
1.2611 × 10-3-1.4
KIZ'6BIO' vs 'DMSO' in 'EPT1'cell line, compound, timeTranscription profiling of effected genes by compound BIO,3G4 and knockdown of MED23
Adjusted p-valueLog2-fold change
2.5967 × 10-2-1.4
KIZ'Newcastle disease virus' at '10 hour' vs 'none' at '10 hour'infect, timeTranscription profiling by array of human dendritic cells infected with Newcastle Disease Virus
Adjusted p-valueLog2-fold change
3.0943 × 10-131.3
KIZ'4 day' vs '0 day'timeRNA-Seq characterization of human H1-derived NPC differentiation timecourse
Adjusted p-valueLog2-fold change
2.5367 × 10-11-1.3
KIZ'Human gammaherpesvirus 4' at '4 day' vs 'none' at '0 day'infect, timeInfection of naïve primary human B-lymphocytes with Epstein-Barr virus (EBV) – time course transcriptomic analysis in the pre-latent phase of viral infection
Adjusted p-valueLog2-fold change
1.1839 × 10-10-1.3
KIZ'adult; burn; middle stage' vs 'adult; control'developmental stage, injury, sampling time pointGene expression of blood samples from pediatric and adult patients with severe burns collected at an early and middle stage after injury.
Adjusted p-valueLog2-fold change
2.6738 × 10-10-1.3
KIZ'cisplatin; 100 micromolar' vs 'none' in 'scrambled siRNA'RNA interference, compoundRNA-seq of human head and neck cancer cell line SQD9 knock-out for TMEM45A exposed to cisplatin
Adjusted p-valueLog2-fold change
9.3947 × 10-71.3
KIZ'small activating RNA; 50 nanomolar' vs 'none; 'RNA interferenceCharacterization of gene expression profiles induced by HIC-1 reactivation on breast cancer
Adjusted p-valueLog2-fold change
1.9814 × 10-61.3
KIZ'autoantibodies against islet cells' vs 'normal'disease stagingTranscription profiling human whole blood from children with pre-type1diabetes
Adjusted p-valueLog2-fold change
3.0014 × 10-6-1.3
KIZ'smoke' vs 'air control' at '6 hour'growth condition, timeTranscription profiling by array of human bronchial epithelial cells after exposure to cigarette smoke
Adjusted p-valueLog2-fold change
4.436 × 10-6-1.3
KIZ'Myc overexpression and SUMO knockout' vs 'control'genotypeGene expression profile of SUMO knockout in human mammary epithelial cells
Adjusted p-valueLog2-fold change
9.9904 × 10-6-1.3
KIZ'2 micromolar retinoic acid' vs 'none'compoundTranscription profiling by array of human embryonic stem cells response to retinoic acid exposure
Adjusted p-valueLog2-fold change
4.0593 × 10-51.3
KIZ'colon adenocarcinoma' vs 'normal'diseaseRNA-seq of 21 sessile serrated colon adenoma/polyps, 10 hyperplastic polyps, 10 adenomas, 21 uninvolved colon and 20 control colon specimens
Adjusted p-valueLog2-fold change
4.6987 × 10-41.3
KIZ'paediatric' vs 'foetal' in 'epithelial cell of small intestine'cell type, developmental stageTranscriptional profiling by array of intestinal epithelial cells from foetal and paediatric gut
Adjusted p-valueLog2-fold change
5.9155 × 10-4-1.3
KIZ'let-7 overexpression in HPAT5 knockout' vs 'let-7 overexpression in HPAT5 wild type'genotypeTranscription profiling by array after let-7 overexpression in human embryonic stem cells with HPAT5 knockout
Adjusted p-valueLog2-fold change
6.1918 × 10-4-1.3
KIZ'S1 stimulation (French trial conditions)' at '48 hour' vs 'control' at '0 hour'growth condition, timeTranscription profilin by array of human CD34+ hematopoietic progenitor cells grown under different conditions
Adjusted p-valueLog2-fold change
9.0223 × 10-4-1.3
KIZ'IGA glomerulonephritis' vs 'normal'diseaseTranscriptomic and proteomic profiling reveal insights of mesangial cell function in patients with IgA Nephropathy
Adjusted p-valueLog2-fold change
1.0496 × 10-31.3
KIZ'20 percent oxygen; old' vs '20 percent oxygen; young'growth condition, phenotypeTranscription profiling of human lung fibroblasts at young and senescent stage grown at different oxygen levels
Adjusted p-valueLog2-fold change
1.7601 × 10-3-1.3
KIZ'9 day' vs '0 day'timeGlobal expression profiling time series of early human embryonic stem cell differentiation towards the mesoderm lineage
Adjusted p-valueLog2-fold change
2.6099 × 10-31.3
KIZ'lethal factor (anthrax toxin)' vs 'lacZ'genotypeMKK2 is sufficient but not necessary for proliferation and anchorage-independent growth of SK-MEL-28 cells.
Adjusted p-valueLog2-fold change
3.8391 × 10-3-1.3
KIZ'lurbinectedin; 10 nanomolar' vs 'none'compoundWhole transcriptome profiling by microarray of monocytes stimulated with LPS and treated with trabectedin, lurbinectedin or doxorubicin
Adjusted p-valueLog2-fold change
8.9355 × 10-3-1.3
KIZ'Interleulin 1 beta' vs 'control' on 'Affymetrix GeneChip Human Genome U133 Plus 2.0 [HG-U133_Plus_2]'stimulusTranscription profiling by array of human blood monocyte stimulated with various stimuli (control, MRP8, LPS, TNF, IL1) to study signalling pathways in phagocytic activation
Adjusted p-valueLog2-fold change
1.0636 × 10-21.3
KIZ'chronic kidney disease' vs 'normal' in 'validation set'cohort, diseaseDevelopment of gene expression profiles in human chronic kidney disease
Adjusted p-valueLog2-fold change
1.066 × 10-2-1.3
KIZ'CD3 and CD28' vs 'none'compound, diseaseTranscription profiling by array of human CD3-positive T cells from patients with systemic lupus erythematosus
Adjusted p-valueLog2-fold change
2.6791 × 10-2-1.3
KIZ'cooked broccoli' at '1 minute' vs 'water'growth condition, timeTranscription profiling of human colon Caco2 cells treated with extracts from broccoli that had been cooked for different lengths of time
Adjusted p-valueLog2-fold change
1.4378 × 10-471.2
KIZ'tunicamycin; 4 microgram per milliliter' at '8 hour' vs 'none; ' at '8 hour'compound, timeTranscription profiling by array of human immortalized B cells from unrelated individuals or twins after treatment with tunicamycin or thapsigargin
Adjusted p-valueLog2-fold change
3.8671 × 10-261.2
KIZ'doxycycline-mediated expression of dominant-negative FOS' vs 'wild type'phenotypeTranscription profiling of oesophageal adenocarcinoma by RNA-seq
Adjusted p-valueLog2-fold change
2.2596 × 10-24-1.2
KIZ' neural stem cell' vs 'induced pluripotent stem cell' in 'Ataxia-telangiectasia'cell type, diseaseHuman iPSC-Derived Cerebellar Neurons from a Patient with Ataxia-Telangiectasia Reveal Disrupted Gene Regulatory Networks
Adjusted p-valueLog2-fold change
8.2182 × 10-201.2
KIZ'ERBB2 siRNA' vs 'scrambled siRNA'RNA interferenceRNA-seq of OE19 cells treated with siNT or siERBB2 for 72 hours
Adjusted p-valueLog2-fold change
1.1829 × 10-16-1.2
KIZ'GATA6 R456C/+; Patient A' vs 'wild type genotype; H9' in 'definitive endoderm cell'cell line, cell type, genotype, individualRNA-seq of definitive endoderm and pancreatic progenitor cells derived in vitro from human pluripotent stem cells in order to study the role of transcription factor GATA6 in human pancreas development
Adjusted p-valueLog2-fold change
2.276 × 10-10-1.2
KIZ'Human gammaherpesvirus 4' at '3 day' vs 'none' at '0 day'infect, timeInfection of naïve primary human B-lymphocytes with Epstein-Barr virus (EBV) – time course transcriptomic analysis in the pre-latent phase of viral infection
Adjusted p-valueLog2-fold change
2.2842 × 10-10-1.2
KIZ'adult; burn; early stage' vs 'adult; control'developmental stage, injury, sampling time pointGene expression of blood samples from pediatric and adult patients with severe burns collected at an early and middle stage after injury.
Adjusted p-valueLog2-fold change
6.1158 × 10-10-1.2
KIZ'EIF2AK3 homozygous knockout' vs 'wild type'phenotypeRNA-seq of human near-haploid cell line HAP1 with CRISPR-edited frameshift mutations
Adjusted p-valueLog2-fold change
1.7987 × 10-91.2
KIZ'Barrett’s esophagus; non-dysplastic' vs 'normal'disease, disease stagingWhole transcriptome profiling of Esophageal adenocarcinoma and Barrett's
Adjusted p-valueLog2-fold change
2.5207 × 10-8-1.2
KIZ'RNH1 knockout' vs 'wild type genotype'genotypeExpression data from Ribonuclease Inhibitor (RI/Rnh1) deficient Human K562 cells
Adjusted p-valueLog2-fold change
2.0827 × 10-6-1.2
KIZ'Growth Medium' vs 'none' in 'normal'disease, stimulusA multidimensional blood stimulation assay reveals immune alterations underlying systemic juvenile idiopathic arthritis [RNA-Seq]
Adjusted p-valueLog2-fold change
3.8588 × 10-6-1.2
KIZ'HCC-2998; colon carcinoma; P10' vs 'HCC-2998; colon carcinoma; P0'cell line, disease, passageMicroarray analysis of xenograft models in use at the Developmental Therapeutics Program of the National Cancer Institute (DTP-NCI)
Adjusted p-valueLog2-fold change
5.205 × 10-6-1.2
KIZ'Staphylococcus aureus strain 10254' at '3 hour' vs 'none' at '0 hour'time, treatmentTranscription profiling by array of human peripheral blood mononuclear cells after treatment with community-associated Staphylococcus aureus and incubation for different lengths of time
Adjusted p-valueLog2-fold change
5.2661 × 10-6-1.2
KIZ'ejaculatory azoospermia; Johnsen score count 5' vs 'normal; Johnsen score count 10'disease, histologyTranscription profiling of human testis samples from men with highly defined and homogenous testicular pathologies reveals patterns that correlate with distinct stages of spermatogenesis
Adjusted p-valueLog2-fold change
1.6125 × 10-5-1.2
KIZ'inflammatory breast cancer' vs 'normal'diseaseExpression Analysis of Microdissected Inflammatory Breast Cancer
Adjusted p-valueLog2-fold change
1.6564 × 10-5-1.2
KIZ'SKR6LR cells resistant to lapanitib' vs 'SKR6 cells with elevated HER2 expression'phenotypeNuclear factor kappa B activation-induced anti-apoptosis renders HER2 positive cells drug resistant and accelerates tumor growth
Adjusted p-valueLog2-fold change
2.5863 × 10-5-1.2
KIZ'CRISPR-Cas9 induced GNRH1 reporter; 27 day' vs 'wild type genotype; 20 day'genotype, stimulus, timeRNA-Seq of GNRH1 neurons differentiated from human pluripotent stem cells
Adjusted p-valueLog2-fold change
3.179 × 10-5-1.2
KIZ'ACO2-V5 overexpression #UD' vs 'empty vector'genotypeTranscription profiling by array of HT29 colon carcinoma cells overexpressing mitochondrial aconitase ACO2
Adjusted p-valueLog2-fold change
5.6561 × 10-5-1.2
KIZ'2 micromolar; retinoic acid' vs '1 micromolar DMSO'compoundTranscription profiling by array of human embryonic stem cells response to retinoic acid exposure
Adjusted p-valueLog2-fold change
1.036 × 10-4-1.2
KIZ'Staphylococcus aureus strain 252' at '3 hour' vs 'none' at '0 hour'time, treatmentTranscription profiling by array of human peripheral blood mononuclear cells after treatment with community-associated Staphylococcus aureus and incubation for different lengths of time
Adjusted p-valueLog2-fold change
1.1713 × 10-4-1.2
KIZ'long term estrogen deprived' vs 'control' in 'ZR75-1'cell line, growth conditionTranscription profiling by array of human estrogen receptor positive breast cancer cell lines after long-term estrogen deprivation
Adjusted p-valueLog2-fold change
1.2289 × 10-4-1.2
KIZ'ACO2-V5 overexpression #C' vs 'empty vector'genotypeTranscription profiling by array of HT29 colon carcinoma cells overexpressing mitochondrial aconitase ACO2
Adjusted p-valueLog2-fold change
1.9915 × 10-41.2
KIZ'P-bodies (cytosolic RNP granules)' vs 'pre-sorted fraction'fractionRNA-Seq of purified P-bodies from HEK293 cells
Adjusted p-valueLog2-fold change
2.8338 × 10-4-1.2
KIZ'docosahexaenoic acid; lipopolysaccharide' vs 'docosahexaenoic acid; vehicle'clinical history, stimulusTranscription profiling by array of human peripheral blood mononuclear cells from patients with hypertriglyceridemia after treatment with docosahexaenoic acid and/or lipopolysaccharide
Adjusted p-valueLog2-fold change
3.8553 × 10-4-1.2
KIZ'ejaculatory azoospermia; Johnsen score count 2' vs 'ejaculatory azoospermia; Johnsen score count 8'disease, histologyTranscription profiling of human testis samples from men with highly defined and homogenous testicular pathologies reveals patterns that correlate with distinct stages of spermatogenesis
Adjusted p-valueLog2-fold change
3.9415 × 10-4-1.2
KIZ'hyperglycemic condition' vs 'non-diabetic condition'clinical informationTranscription profiling by array of human pancreatic beta cells transplanted into mice
Adjusted p-valueLog2-fold change
4.224 × 10-4-1.2
KIZ'phorbol 13-acetate 12-myristate; 100 nanomolar; interleukin-4 and interleukin-13; 2 day' vs 'none; none; 0 day'compound, stimulus, timeTranscriptional profiling of THP1-derived human macrophages with different stimuli
Adjusted p-valueLog2-fold change
4.9671 × 10-4-1.2
KIZ'Francisella tularensis Schu S4' vs 'uninfected'infectTranscription profiling by array of human peripheral blood mononuclear cells infected with Francisella tularensis
Adjusted p-valueLog2-fold change
8.7859 × 10-4-1.2
KIZ'S2 stimulation (British trial conditions)' at '48 hour' vs 'control' at '0 hour'growth condition, timeTranscription profilin by array of human CD34+ hematopoietic progenitor cells grown under different conditions
Adjusted p-valueLog2-fold change
9.779 × 10-41.2
KIZ'rotenone; 50 nanomolar' at '4 week' vs 'vehicle; ' at '4 week'compound, timeTranscriptome analysis of a chronic in vitro model of Parkinsonism
Adjusted p-valueLog2-fold change
1.0213 × 10-3-1.2
KIZ'EX00000246; stimulated with interferon gamma and lipopolysaccharide' vs 'none' at '6 hour'compound, time, treatmentGPBAR1 agonism has a broad impact on blocking macrophage activation
Adjusted p-valueLog2-fold change
1.0235 × 10-3-1.2
KIZ'ejaculatory azoospermia; Johnsen score count 2' vs 'ejaculatory azoospermia; Johnsen score count 7'disease, histologyTranscription profiling of human testis samples from men with highly defined and homogenous testicular pathologies reveals patterns that correlate with distinct stages of spermatogenesis
Adjusted p-valueLog2-fold change
1.0573 × 10-3-1.2
KIZ'pancreatic adenocarcinoma' vs 'normal'block, diseaseRNA-seq of blood platelets from six tumor types and healthy donors
Adjusted p-valueLog2-fold change
2.8552 × 10-3-1.2
KIZ'tumor' vs 'adjacent normal tissue'sampling siteTranscription profiling of human papillary thyroid carcinoma and paired normal tissues
Adjusted p-valueLog2-fold change
3.1443 × 10-3-1.2
KIZ'7 day' vs '0 day'timeGlobal expression profiling time series of early human embryonic stem cell differentiation towards the mesoderm lineage
Adjusted p-valueLog2-fold change
1.3351 × 10-2-1.2
KIZ'Salmonella typhimurium' vs 'mock'infectTranscriptomic profiling of HeLa cells infected with Salmonella Typhimurium
Adjusted p-valueLog2-fold change
2.2185 × 10-2-1.2
KIZ'IFNg-treated' vs 'untreated'treatmentExpression data from primary human keratinocytes exposed to cytokines in vitro (IL-4, IL-13, IL-17A, IFN-alpha, IFN-gamma, TNF)
Adjusted p-valueLog2-fold change
2.3961 × 10-21.2
KIZ'mutated IDH1' vs 'wild type'genotypeComparison of gene expression profiles of anaplastic glioma with or without the mutated IDH1/2 gene
Adjusted p-valueLog2-fold change
3.5675 × 10-21.2
KIZ'P0 cells' vs 'untreated P4 cells'passage, treatmentTranscription profiling by high throughput sequencing of human fetal differentiated P0 retinal pigment epithelial cells, mesenchymal P4 cells, and A-83-01 rescued P4 cells
Adjusted p-valueLog2-fold change
4.8756 × 10-2-1.2
KIZ'cocultured with activated T cells' vs 'control' in 'none'compound, growth conditionGene signature of CLL cells cultured with activated T cells or CD40L-expressing cells
Adjusted p-valueLog2-fold change
1.9084 × 10-13-1.1
KIZ'GATA6 R456C/+; Patient A' vs 'wild type genotype; H9' in 'progenitor cell of endocrine pancreas'cell line, cell type, genotype, individualRNA-seq of definitive endoderm and pancreatic progenitor cells derived in vitro from human pluripotent stem cells in order to study the role of transcription factor GATA6 in human pancreas development
Adjusted p-valueLog2-fold change
2.1335 × 10-9-1.1
KIZ'cycloheximide; 17beta-estradiol' vs 'DMSO control; 17beta-estradiol'compound, growth conditionTranscription profiling by array of human MCF7 breast cancer cells after growth with cyclohexamide followed by treatment with 17beta-estradiol
Adjusted p-valueLog2-fold change
1.8859 × 10-8-1.1
KIZ'PI4KB homozygous knockout' vs 'wild type'phenotypeRNA-seq of human near-haploid cell line HAP1 with CRISPR-edited frameshift mutations
Adjusted p-valueLog2-fold change
3.1699 × 10-81.1
KIZ'miR-221/222' vs 'control'RNA interferenceGene expression profiling of MCF10A (miR-221/222 vs control)
Adjusted p-valueLog2-fold change
1.2605 × 10-6-1.1
KIZ'medium with BMP4 and inhibitors' vs 'medium'treatmentTranscription profiling of human embryonic stem cells treated with BMP4 in chemically-defined medium, with and without inhibitors of Activin and FGF signalling to investigate the induction of extra-embryonic tissue differentiation by BMP signalling
Adjusted p-valueLog2-fold change
1.597 × 10-61.1
KIZ'EPZ6438; 10x lowest cytotoxic concentration' vs 'DMSO' in 'KARPAS_422' at '6 day'cell line, compound, timeExpression data from EZH2 inhibitor treated Non-Hodgkins Lymphoma cell lines
Adjusted p-valueLog2-fold change
4.4876 × 10-6-1.1
KIZ'p63 knockdown by siRNA' vs 'scrambled siRNA' in 'BxPC-3'RNA interference, cell lineRNA-seq of human pancreatic cell lines, L3.6pl and BxPC-3, upon knockdown of p63 for 48 hours compared to siControl
Adjusted p-valueLog2-fold change
7.369 × 10-61.1
KIZ'beta-catenin knockdown' vs 'control'genotypeTranscription profiling of human multiple myeloma cells ( MM1.S) cells with control or beta-catenin knockdown.
Adjusted p-valueLog2-fold change
2.5332 × 10-5-1.1
KIZ'HCT-116; colon carcinoma; P10' vs 'HCT-116; colon carcinoma; P0'cell line, disease, passageMicroarray analysis of xenograft models in use at the Developmental Therapeutics Program of the National Cancer Institute (DTP-NCI)
Adjusted p-valueLog2-fold change
4.8736 × 10-5-1.1
KIZ'786-0; renal adenocarcinoma; P10' vs '786-0; renal adenocarcinoma; P0'cell line, disease, passageMicroarray analysis of xenograft models in use at the Developmental Therapeutics Program of the National Cancer Institute (DTP-NCI)
Adjusted p-valueLog2-fold change
6.3655 × 10-51.1
KIZ'epithelial cell of small intestine' vs 'epithelial cell of large intestine' in 'paediatric'cell type, developmental stageTranscriptional profiling by array of intestinal epithelial cells from foetal and paediatric gut
Adjusted p-valueLog2-fold change
6.4146 × 10-5-1.1
KIZ'incubated with 10 ng/ml lipopolysaccharide' vs 'incubated in control medium'growth conditionTranscription profiling of normal human monocytes in response to Aspergillus fumigatus
Adjusted p-valueLog2-fold change
8.3837 × 10-51.1
KIZ'kidney transplant; tolerance' vs 'none; none'clinical history, clinical informationIntragraft molecular pathways associated with tolerance induction in renal transplantation
Adjusted p-valueLog2-fold change
2.0813 × 10-4-1.1
KIZ'miR15a/miR16-1' vs 'empty vector'genotypeTranscription profiling by array of MEG-01 cells transfected with miR-15a and miR-16-1
Adjusted p-valueLog2-fold change
5.3731 × 10-4-1.1
KIZ'6 day' vs '0 day'timeGlobal expression profiling time series of early human embryonic stem cell differentiation towards the mesoderm lineage
Adjusted p-valueLog2-fold change
1.1383 × 10-31.1
KIZ'gamma tocotrienol; 40 micromolar' vs 'DMSO'compoundExpression data of MCF-7 cells treated with gamma tocotrienol (g-T3)
Adjusted p-valueLog2-fold change
1.5726 × 10-3-1.1
KIZ'S2 stimulation (British trial conditions)' at '72 hour' vs 'control' at '0 hour'growth condition, timeTranscription profilin by array of human CD34+ hematopoietic progenitor cells grown under different conditions
Adjusted p-valueLog2-fold change
1.9185 × 10-3-1.1
KIZ'colorectal carcinoma' vs 'normal'block, diseaseRNA-seq of blood platelets from six tumor types and healthy donors
Adjusted p-valueLog2-fold change
1.9347 × 10-3-1.1
KIZ'Alzheimers disease' vs 'normal' in 'entorhinal cortex'disease, organism partMicroarray analysis of six brain areas from Alzheimers disease patients and normal individuals
Adjusted p-valueLog2-fold change
3.1958 × 10-3-1.1
KIZ'Ataxia-telangiectasia' vs 'normal'diseaseAtaxia-telangiectasia cerebellar cortex expression
Adjusted p-valueLog2-fold change
7.0206 × 10-31.1
KIZ'Panc-2.12; PD032590; 15 milligram per kilogram' vs 'Panc-2.12; vehicle; 'cell line, compoundExpression Data from 24 orthotopic tumors grown in the pancreas of mice +/- MEK inhibitor PD0325901
Adjusted p-valueLog2-fold change
7.4228 × 10-3-1.1
KIZ'cocultured with CD40L- cells' vs 'control' in 'none'compound, growth conditionGene signature of CLL cells cultured with activated T cells or CD40L-expressing cells
Adjusted p-valueLog2-fold change
1.2515 × 10-2-1.1
KIZ'S1 stimulation (French trial conditions)' at '72 hour' vs 'control' at '0 hour'growth condition, timeTranscription profilin by array of human CD34+ hematopoietic progenitor cells grown under different conditions
Adjusted p-valueLog2-fold change
1.5349 × 10-2-1.1
KIZ'TIA-1 and TIAR siRNA' vs 'control siRNA'rna interference, RNA interferenceTranscription profiling by array of HeLa cells with RNAi knockdown of T-cell intracellular antigen proteins
Adjusted p-valueLog2-fold change
4.1891 × 10-2-1.1
KIZ'trabectedin; 10 nanomolar' vs 'none'compoundWhole transcriptome profiling by microarray of monocytes stimulated with LPS and treated with trabectedin, lurbinectedin or doxorubicin
Adjusted p-valueLog2-fold change
9.5912 × 10-16-1
KIZ'6 hour' vs '0 hour' in 'MCF-10A-H1047R'cell line, timeKnock-in of PIK3CA-H1047R into MCF-10A
Adjusted p-valueLog2-fold change
1.6817 × 10-10-1
KIZ'child; burn; middle stage' vs 'child; control'developmental stage, injury, sampling time pointGene expression of blood samples from pediatric and adult patients with severe burns collected at an early and middle stage after injury.
Adjusted p-valueLog2-fold change
3.9231 × 10-8-1
KIZ'breast cancer' vs 'normal'diseaseGene expression profiling of LCM captured breast cancer cells
Adjusted p-valueLog2-fold change
2.3911 × 10-7-1
KIZ'HDAC1 homozygous knockout' vs 'wild type'phenotypeRNA-seq of human near-haploid cell line HAP1 with CRISPR-edited frameshift mutations
Adjusted p-valueLog2-fold change
9.4314 × 10-71
KIZ'serum deprivation' vs 'asynchronous growth'growth conditionTranscription profiling by array of human T98G cells under growth arrest
Adjusted p-valueLog2-fold change
1.6088 × 10-61
KIZ'2 day' vs '0 day'timeRNA-Seq characterization of human H1-derived NPC differentiation timecourse
Adjusted p-valueLog2-fold change
1.7588 × 10-61
KIZ'EPZ6438; 10x lowest cytotoxic concentration' vs 'DMSO' in 'SUDHL6' at '6 day'cell line, compound, timeExpression data from EZH2 inhibitor treated Non-Hodgkins Lymphoma cell lines
Adjusted p-valueLog2-fold change
2.7517 × 10-61
KIZ'resistant to methotrexate' vs 'sensitive to methotrexate'phenotypeNetworking of differentially expressed genes in human MIA PaCa2 pancreatic cancer cells resistant to methotrexate
Adjusted p-valueLog2-fold change
3.6265 × 10-61
KIZ'vemurafenib' vs 'DMSO'compoundExpression data from BRAFV600E A375 melanoma cells treated with vehicle or vemurafenib
Adjusted p-valueLog2-fold change
5.1608 × 10-61
KIZ'BKM120; 90 per cent inhibitory concentration (max)' vs 'DMSO; 'compoundComparison of gene expression alterations induced by distinct PI3K inhibitors
Adjusted p-valueLog2-fold change
7.2337 × 10-6-1
KIZ'Numb4 overexpression' vs 'control' in 'MDAMB231'cell line, genotypeExpression profile of MDA-MB-231 and MCF7 cells stably transfected with GFP-Numb4, GFP-Numb5, GFP-Numb6
Adjusted p-valueLog2-fold change
7.7034 × 10-61
KIZ'WZ4002 resistant' vs 'control'phenotypeAberrant ERK signaling causes resistance to EGFR kinase inhibitors
Adjusted p-valueLog2-fold change
7.8807 × 10-61
KIZ'C1013G/CXCR4 variant' vs 'control'genotypeGene expression profile of C1013G/CXCR4 mutated WM cells
Adjusted p-valueLog2-fold change
8.2705 × 10-6-1
KIZ'medium with BMP4' vs 'medium'treatmentTranscription profiling of human embryonic stem cells treated with BMP4 in chemically-defined medium, with and without inhibitors of Activin and FGF signalling to investigate the induction of extra-embryonic tissue differentiation by BMP signalling
Adjusted p-valueLog2-fold change
1.2975 × 10-51
KIZ'BRD4 inhibitor JQ1' vs 'none' in 'Mel202'cell line, compoundTranscription profiling by array of uveal melanoma cell lines with wild type and mutant G-proteins (GNAQ or GNA11) in response to treatment with BRAD4 inhibitor JQ1
Adjusted p-valueLog2-fold change
1.4101 × 10-5-1
KIZ'ochratoxin A; 130 nanomolar' vs 'none' at '1 day'compound, timeMicroarray mRNA data of RPTEC/TERT1 cells exposed to nephrotoxic chemicals ochratoxin A and potassium bromate
Adjusted p-valueLog2-fold change
1.9209 × 10-5-1
KIZ'KLF17 overexpression' at '24 day' vs 'wild type' at '0 day'phenotype, timeRNA-seq of hESCs undergoing primed to naive-like resetting via exogenous KLF17 overexpression
Adjusted p-valueLog2-fold change
1.9735 × 10-5-1
KIZ'tuberculin' vs 'saline'stimulusTranscriptional profiling of the tuberculin skin test in individuals cured of active tuberculosis disease (RNA-Seq)
Adjusted p-valueLog2-fold change
2.043 × 10-5-1
KIZ'lipopolysaccharide; 100 nanogram per milliliter' vs 'none' in 'wild type'compound, genotypeTranscription profiling by array of human THP-1 cells overexpressing or silenced for GAM after treatment with lipopolysaccharide
Adjusted p-valueLog2-fold change
2.9779 × 10-51
KIZ'UV' vs 'none' in '(no brct expression) GFP control'phenotype, stimulusTranscriptional profiling by array of U2OS cells overexpressing the BRCT domain of PARP1 after UV radiation
Adjusted p-valueLog2-fold change
3.0086 × 10-5-1
KIZ'154; 0.4 micromolar' vs 'DMSO'compoundDevelopment of a small molecule for treatment of castration resistant prostate cancer via androgen receptor and IL6/STAT3 pathways
Adjusted p-valueLog2-fold change
3.8214 × 10-51
KIZ'ICG-001; 10 micromolar' vs 'DMSO' at '24 hour'compound, timeExpression data from AsPC1 cells treated with ICG-001
Adjusted p-valueLog2-fold change
4.3197 × 10-51
KIZ'doxycycline' vs 'none' in 'Caki1'cell line, compoundRNA-seq upon PAX8 knockdown in Renal Cell Carcinoma cell lines
Adjusted p-valueLog2-fold change
5.8688 × 10-51
KIZ'CB-5083; 5 micromolar' vs 'dimethyl sulfoxide' in 'resistant to CB-5083'compound, phenotypeRNA-seq of human ovarian cancer cell line OVSAHO parental and CB-5083-resistant cells
Adjusted p-valueLog2-fold change
8.0338 × 10-5-1
KIZ'PRPF8' vs 'control'RNA interferenceRegulation of constitutive and alternative messenger RNA splicing across the human transcriptome by PRPF8 is determined by 5' splice site strength
Adjusted p-valueLog2-fold change
8.7221 × 10-51
KIZ'Panc-2.13; CI-1040; 2 millimolar' vs 'Panc-2.13; vehicle; 'cell line, compoundExpression Data from 22 human pancreatic cancer cell lines grown in triplicates +/- MEK inhibitor CI-1040
Adjusted p-valueLog2-fold change
1.3372 × 10-4-1
KIZ'MAGEA3 shRNA' vs 'scrambled shRNA'RNA interferenceRNA-seq of the human HCC cell line PLC5 after 72 hours treatment with either MAGEA3 shRNA or Scramble control
Adjusted p-valueLog2-fold change
1.3744 × 10-4-1
KIZ'SARS coronavirus Urbani ΔORF6 mutant' vs 'mock' at '72 hour'infect, timeTime course analysis of icSARS CoV Urbani or icSARS deltaORF6 infected Calu-3 2B4 bronchial epithelial cells
Adjusted p-valueLog2-fold change
1.5348 × 10-41
KIZ'AQM' vs 'normal' on 'Affymetrix HG-U133A'diseaseTranscription profiling by array of 12 human muscle diseases
Adjusted p-valueLog2-fold change
1.9118 × 10-41
KIZ'hypoxia' vs 'normoxia' at '7 day'environmental stress, timeTranscription profiling by array of the effect of hypoxia in tumour-initiating cells derived from a colorectal cancer patient
Adjusted p-valueLog2-fold change
2.8276 × 10-41
KIZ'Snail overexpression' vs 'control'treatmentExpression data from breast cancer cell line MCF-7 with ectopic expression of the transcription factor Snail
Adjusted p-valueLog2-fold change
3.4306 × 10-4-1
KIZ'MOF siRNA' vs 'control siRNA' in 'doxycycline-mediated repression of FOXP3'RNA interference, phenotypeTranscription profiling by array of human MCF-7 breast cancer cells with FOXP3 target gene expression with and without MOF knockdown
Adjusted p-valueLog2-fold change
4.0562 × 10-4-1
KIZ'stimulated with interferon gamma and lipopolysaccharide' vs 'unstimulated' in 'EX00000246' at '24 hour'compound, time, treatmentGPBAR1 agonism has a broad impact on blocking macrophage activation
Adjusted p-valueLog2-fold change
5.4037 × 10-4-1
KIZ'Staphylococcus aureus strain Col' at '2 hour' vs 'none' at '0 hour'time, treatmentTranscription profiling by array of human peripheral blood mononuclear cells after treatment with community-associated Staphylococcus aureus and incubation for different lengths of time
Adjusted p-valueLog2-fold change
6.4591 × 10-4-1
KIZ'SARS coronavirus Urbani' vs 'mock' at '54 hour'infect, timeTime course analysis of icSARS CoV Urbani or icSARS deltaORF6 infected Calu-3 2B4 bronchial epithelial cells
Adjusted p-valueLog2-fold change
1.1388 × 10-3-1
KIZ'replicatively senescent; grown until growth arrest' vs 'spontaneously immortal cells; control'phenotype, treatmentPathway Profiling of Replicative and Induced Senescence
Adjusted p-valueLog2-fold change
1.1561 × 10-3-1
KIZ'vehicle; lipopolysaccharide' vs 'vehicle; vehicle'clinical history, stimulusTranscription profiling by array of human peripheral blood mononuclear cells from patients with hypertriglyceridemia after treatment with docosahexaenoic acid and/or lipopolysaccharide
Adjusted p-valueLog2-fold change
1.3702 × 10-3-1
KIZ'phorbol 13-acetate 12-myristate; 100 nanomolar; interleukin-4; 2 day' vs 'none; 3 day' in 'none; none; 0 day'compound, stimulus, timeTranscriptional profiling of THP1-derived human macrophages with different stimuli
Adjusted p-valueLog2-fold change
1.4205 × 10-3-1
KIZ'cultured skin substitute; 28 day' vs 'skin; 0 day'organism part, timeTranscription profiling by array of human grafted engineered skin substitutes
Adjusted p-valueLog2-fold change
1.5918 × 10-31
KIZ'erythroleukemia; ZRSR2 shRNA' vs 'normal'disease, genotypeRNA-seq of bone marrow from patients with myelodysplastic syndrome
Adjusted p-valueLog2-fold change
2.4685 × 10-3-1
KIZ'Mycobacterium tuberculosis' vs 'none' in 'adult'developmental stage, infectMultifaceted dysfunction of infant airway macrophages in response to Mycobacterium tuberculosis
Adjusted p-valueLog2-fold change
2.5426 × 10-31
KIZ'induced pluripotent stem cell' vs 'cardiac muscle cell'cell typeGene expression profiling by RNA-seq of human iPSC and iPSC-derived cardiomyocytes from an Yoruban individual (NA19101)
Adjusted p-valueLog2-fold change
3.1241 × 10-31
KIZ'100 microgram per milliliter trovafloxacin' vs 'none'compoundTranscription profiling by array of human primary hepatocytes treated with trovafloxacin
Adjusted p-valueLog2-fold change
3.4527 × 10-3-1
KIZ'glioblastoma' vs 'normal'block, diseaseRNA-seq of blood platelets from six tumor types and healthy donors
Adjusted p-valueLog2-fold change
3.5293 × 10-3-1
KIZ'non-inflammatory breast cancer' vs 'normal'diseaseExpression Analysis of Microdissected Inflammatory Breast Cancer
Adjusted p-valueLog2-fold change
4.1826 × 10-3-1
KIZ'7 hour after induction of differentiation' vs '0 hour'timeTranscription profiling time series of human mesenchymal stem cells after induction of differentiation
Adjusted p-valueLog2-fold change
8.7669 × 10-3-1
KIZ'rotenone; 50 nanomolar' at '1 week' vs 'vehicle; ' at '1 week'compound, timeTranscriptome analysis of a chronic in vitro model of Parkinsonism
Adjusted p-valueLog2-fold change
1.2678 × 10-21
KIZ'non metastasis; tumor' vs 'non metastasis; normal adjacent tissue'clinical information, sampling siteGene expression profile of primary colorectal tumors with and without distant metastasis
Adjusted p-valueLog2-fold change
1.3098 × 10-2-1
KIZ'S1 stimulation (French trial conditions)' at '96 hour' vs 'control' at '0 hour'growth condition, timeTranscription profilin by array of human CD34+ hematopoietic progenitor cells grown under different conditions
Adjusted p-valueLog2-fold change
3.8513 × 10-2-1
KIZ'zebularine; 1000 micromolar' vs 'none'compoundTreatment of renal cell carcinoma cell line A-498 with zebularine
Adjusted p-valueLog2-fold change
4.035 × 10-2-1
KIZ'3 h DRB 8 min 4sU' vs 'untreated'treatment4sUDRB-seq: measuring transcription elongation and initiation genomewide
Synonym
PLK1S1, NCRNA00153, C20orf19, HT013
Ortholog
Gene ontology
InterPro
Ensembl gene
Ensembl transcript
Ensembl protein
Entrez
UniProt
Gene biotype
Design element
3879423, 65723_g_at, 55857_at, 3879420, 3879384, 3879385, 3879440, 11760183_at, 3879380, 228291_s_at, ILMN_1779536, 69074_g_at, 16911923, 78682_at, 3879409, 11756416_a_at, 3879408, 3879425, 3879426, 69072_at, 3879379, 11756417_x_at, 3879435, 3879377, 228290_at, 3879378, 3879397, A_23_P154740, 3879395, 3879373, 65722_at, 3879374, 3879396, 3879393, 11760184_at, Hs.173515.1.A1_3p_at, 3879394, 69076_at, 8061305, 219961_s_at, 3879418, g8923814_3p_a_at, 3879419, 3879438, 3879417, 3879439, 3879436, 3879437