ensmusg00000024190 (Dusp1)

mus musculus

dual specificity phosphatase 1

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Mus musculus
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Showing 32 experiments:
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Log2-fold changeSpeciesGene nameComparisonExperimental variablesExperiment name
Adjusted p-valueLog2-fold change
3.6074 × 10-1046
Dusp1'lipopolysaccharide; 10 nanogram per milliliter' vs 'none' in 'Hoxb8-FL; wild type genotype'cell line, compound, genotypeBulk RNA-seq of wild type and MEF2A or MEF2C/D knockout mouse bone marrow macrophages under different stimulation conditions
Adjusted p-valueLog2-fold change
9.8719 × 10-204.7
Dusp1'lipopolysaccharide; 10 nanogram per milliliter' vs 'none' in 'Hoxb8-FL; MEF2A knockout'cell line, compound, genotypeBulk RNA-seq of wild type and MEF2A or MEF2C/D knockout mouse bone marrow macrophages under different stimulation conditions
Adjusted p-valueLog2-fold change
1.2967 × 10-29-4.5
Dusp1'SMRT shRNA' vs 'none' in 'CpG' at '6 hour'RNA interference, stimulus, timeRNA-seq of Control and SMRT KD CD8α+ DCs at 0hr and 6hr CpG stimulation
Adjusted p-valueLog2-fold change
7.803 × 10-4-4.5
Dusp1'fetal definitive erythroid cell' vs 'primitive erythroid cell' in 'reticulocyte'cell type, phenotypeTranscription profiling by array of differentiating primary primitive and definitive mouse red blood cells
00
Log2-fold change
4.2
Dusp1'lipopolysaccharide; 10 nanogram per milliliter and prostaglandin E2; 1 micromolar' vs 'none' in 'primary cell line; MEF2C/D knockout'cell line, compound, genotypeBulk RNA-seq of wild type and MEF2A or MEF2C/D knockout mouse bone marrow macrophages under different stimulation conditions
Adjusted p-valueLog2-fold change
7.7568 × 10-354.2
Dusp1'lipopolysaccharide; 10 nanogram per milliliter and prostaglandin E2; 1 micromolar' vs 'none' in 'primary cell line; wild type genotype'cell line, compound, genotypeBulk RNA-seq of wild type and MEF2A or MEF2C/D knockout mouse bone marrow macrophages under different stimulation conditions
Adjusted p-valueLog2-fold change
7.5981 × 10-2364.1
Dusp1'Helicobacter hepaticus' vs 'none' in 'Alpk1 homozygous knockout'infect, phenotypeWhole transcriptome profiling of the steady state and Hh-treated (8 hrs) Alpk1+/- (heterozygous) and Alpk1-/- (knockout) BMDMs using RNA-Sequencing approach
Adjusted p-valueLog2-fold change
2.8814 × 10-1134.1
Dusp1'P60; insulin-expressing mature beta cells' vs 'E16.5; insulin-expressing nascent beta cells'age, cell typeTranscriptional profiling of nascent and mature pancreatic beta cells
Adjusted p-valueLog2-fold change
3.0885 × 10-1374
Dusp1'reduced expression of miR-25' vs 'wild type'phenotypeTranscription profiling by high throughput sequencing of wild type and miR-25 agomir or antagomir treated mice
Adjusted p-valueLog2-fold change
4.0482 × 10-63.8
Dusp1'tristetrapolin knockout' vs 'wild type' in 'actinomycin D' at '30 minute'compound, genotype, timeTranscription profiling by array of fibroblasts from TTP knock out mice
Adjusted p-valueLog2-fold change
7.3189 × 10-1403.7
Dusp1'Salmonella enterica serovar Typhimurium' vs 'control' in 'derived macrophage from E14 cell line'clinical information, infectGene expression profiles of mouse embryonic stem cell derived macrophages infected with Salmonella typhimurium
Adjusted p-valueLog2-fold change
8.742 × 10-1373.7
Dusp1'Helicobacter hepaticus' vs 'none' in 'wild type phenotype'infect, phenotypeWhole transcriptome profiling of the steady state and Hh-treated (8 hrs) Alpk1+/- (heterozygous) and Alpk1-/- (knockout) BMDMs using RNA-Sequencing approach
Adjusted p-valueLog2-fold change
1.3787 × 10-923.7
Dusp1'Salmonella enterica serovar Typhimurium' vs 'control' in 'bone marrow macrophage from 129P2 mouse strain'clinical information, infectGene expression profiles of mouse embryonic stem cell derived macrophages infected with Salmonella typhimurium
Adjusted p-valueLog2-fold change
4.0013 × 10-27-3.6
Dusp1'Zbtb10 knockdown' vs 'control' at '6 hour'genotype, timeRNA-seq of Zbtb10 Knockdown and Control cDC1 dendritic cells (Cd8+)
Adjusted p-valueLog2-fold change
1.2904 × 10-26-3.6
Dusp1'Zbtb10 knockdown' vs 'control' at '2 hour'genotype, timeRNA-seq of Zbtb10 Knockdown and Control cDC1 dendritic cells (Cd8+)
Adjusted p-valueLog2-fold change
3.5775 × 10-233.6
Dusp1'Salmonella enterica serovar Typhimurium' vs 'control' in 'derived macrophage from E14 Traf2 mutant cell line'clinical information, infectGene expression profiles of mouse embryonic stem cell derived macrophages infected with Salmonella typhimurium
Adjusted p-valueLog2-fold change
1.2953 × 10-113.6
Dusp1"muscularis externa layer of small intestine" vs "lamina propria of small intestine" in "YFP positive"organism part, phenotypeBulk RNA-sequencing of self-maintaining versus monocyte-replaced gut macrophages
Adjusted p-valueLog2-fold change
6.4212 × 10-43.6
Dusp1'Staphylococcus aureus Sanger476; 2 hour' vs 'none; 0 hour' in 'BALB/cByJ'infect, strain, timeGene Expression-Based Classifiers Identify Staphylococcus aureus Infection in Mice and Humans
Adjusted p-valueLog2-fold change
1.0688 × 10-33.6
Dusp1'human chorionic gonadotropin; 5 International Unit' vs 'none' in 'bER knockout'compound, genotypeLaser Capture Microdissection isolation of preovulatory granulosa cells from WT and bERKO ovaries
Adjusted p-valueLog2-fold change
3.3178 × 10-8-3.5
Dusp1'Kin-' vs 'wild type' in 'cAMP' at '2 hour'compound, genotype, timeTranscription profiling by array of mouse S49 cells mutant for Kin after treatment with cAMP
Adjusted p-valueLog2-fold change
2.0032 × 10-33.5
Dusp1'induction of polymicrobial sepsis' vs 'control' at '24 hour' in '1.5 to 3 month mice'age, time, treatmentAged Mice are Unable to Mount an Effective Myeloid Response to Sepsis
Adjusted p-valueLog2-fold change
3.9959 × 10-26-3.4
Dusp1'ABIN1[D485N] knock-in' vs 'wild type genotype' in 'neutrophil'cell type, genotypeRNA-seq of inflammatory monocytes, patrolling monocytes and neutrophils in wild type and ABIN1[D485N] mice
Adjusted p-valueLog2-fold change
3.1595 × 10-7-3.4
Dusp1'myeloid progenitor cell; FoxO1/3/4 triple knockout' vs 'myeloid progenitor cell; wild type genotype'cell type, genotypeTranscription profiling of bone marrow hematopoietic stem cells and myeloid progenitors from mice with conditional deletion of Forkhead O (FoxO) family of transcription factors
Adjusted p-valueLog2-fold change
2.9873 × 10-33.4
Dusp1'induction of polymicrobial sepsis' vs 'control' at '2 hour' in '1.5 to 3 month mice'age, time, treatmentAged Mice are Unable to Mount an Effective Myeloid Response to Sepsis
Adjusted p-valueLog2-fold change
1.5942 × 10-9-3.3
Dusp1'5 week' vs '1 week' in 'Jak2+/V617F; CRISPR/Cas9 mediated knockout of Dnmt3a'genotype, timeRNA-seq of Jak2VF LSK cells transduced with Dnmt3a-Cas9-GFP lentivirus vs. emp-Cas9-GFP controls one week and five weeks post methylcellulose plating
Adjusted p-valueLog2-fold change
8.0715 × 10-1623.2
Dusp1'co-cultured with hematopoietic stem cell for 9 days' vs 'non co-cultured for 9 days' in 'stromal cell; expressing AKT1'cell type, growth condition, phenotypeTranscription profiling by high throughput sequencing of murine bone marrow endothelial cells and bone marrow stroma, in vitro and in vivo, with and without hematopoietic stem cells co-culture
Adjusted p-valueLog2-fold change
3.1576 × 10-26-3.2
Dusp1'Klf1-/-' vs 'wild type'genotypeNovel roles for Klf1 in regulating the erythroid transcriptome revealed by mRNA-seq
Adjusted p-valueLog2-fold change
1.6344 × 10-83.2
Dusp1"muscularis externa layer of small intestine" vs "lamina propria of small intestine" in "YFP negative"organism part, phenotypeBulk RNA-sequencing of self-maintaining versus monocyte-replaced gut macrophages
Adjusted p-valueLog2-fold change
7.0024 × 10-73.1
Dusp1'lipopolysaccharide; 10 nanogram per milliliter and prostaglandin E2; 1 micromolar and interferon beta; 100 units per milliliter' vs 'none' in 'primary cell line; wild type genotype'cell line, compound, genotypeBulk RNA-seq of wild type and MEF2A or MEF2C/D knockout mouse bone marrow macrophages under different stimulation conditions
Adjusted p-valueLog2-fold change
3.5618 × 10-33.1
Dusp1'paracetamol; 529 milligram per kilogram' vs 'vehicle' at '4 hour'compound, timeTranscription profiling by array of CD1 mice after nontoxic and nonlethal hepatotoxic paracetamol administration
Adjusted p-valueLog2-fold change
4.1161 × 10-1033
Dusp1'interleukin-22 (Mus Musculus); 10 nanogram per milliliter' vs 'none'compoundRNAseq of small intestinal organoids from mice treated with the cytokines IFNG, IL-13 and IL-22 for 24 hours
Adjusted p-valueLog2-fold change
5.279 × 10-11-3
Dusp1'induced neural stem cell' vs 'mouse embryonic fibroblast cell'cell typeGene expression profile of mouse induced neural stem cells
Adjusted p-valueLog2-fold change
9.2768 × 10-83
Dusp1'Lactobacillus acidophilus NCFM and Bifidobacterium bifidum Z9' vs 'control'infectTranscription profiling by array of mouse dendritic cells after infection with Bifidobacterium bifidum and Lactobacillus acidophilus
Adjusted p-valueLog2-fold change
4.3835 × 10-73
Dusp1'polarized with E coli lipopolysacharide and INF-gamma' vs 'untreated'compound, treatmentExpression data from polarized macrophages: effect of p53
Adjusted p-valueLog2-fold change
4.5928 × 10-43
Dusp1'Staphylococcus aureus Sanger476; 2 hour' vs 'none; 0 hour' in 'AKR/J'infect, strain, timeGene Expression-Based Classifiers Identify Staphylococcus aureus Infection in Mice and Humans
Adjusted p-valueLog2-fold change
3.9695 × 10-72.9
Dusp1'hypoxia' vs 'control'treatmentTranscription profiling of mouse Jardine SIDS Model
Adjusted p-valueLog2-fold change
5.6498 × 10-92.8
Dusp1'Staphylococcus aureus Sanger476; 4 hour' vs 'none; 0 hour' in 'A/J'infect, strain, timeGene Expression-Based Classifiers Identify Staphylococcus aureus Infection in Mice and Humans
Adjusted p-valueLog2-fold change
3.1764 × 10-3-2.8
Dusp1'co-transplanted with NOD-scid IL2Rgamma null HSCs' vs 'co-transplanted with wild type HSCs'growth conditionRNA-seq of mouse wildtype HSCs purified from recipient mice co-transplanted with wildtype or different types of lymphoid cell deficient HSCs
Adjusted p-valueLog2-fold change
2.0773 × 10-22.8
Dusp1'bER knockout' vs 'wild type' in 'human chorionic gonadotropin; 5 International Unit'compound, genotypeLaser Capture Microdissection isolation of preovulatory granulosa cells from WT and bERKO ovaries
Adjusted p-valueLog2-fold change
1.1218 × 10-18-2.7
Dusp1'acute graft vs. host disease; T-cell depleted bone marrow + T cells transplant' vs 'normal; T-cell depleted bone marrow transplant'disease, stimulusRNA-Seq of lymph node fibroblastic reticular cells isolated from bone marrow transplant recipient mice with or without acute Graft-versus-host disease on day 7 or untransplanted control mice
Adjusted p-valueLog2-fold change
2.9846 × 10-112.7
Dusp1'CpG; 6 hour' vs 'none; 0 hour' in 'none'RNA interference, stimulus, timeRNA-seq of Control and SMRT KD CD8α+ DCs at 0hr and 6hr CpG stimulation
Adjusted p-valueLog2-fold change
8.4989 × 10-72.7
Dusp1'Bifidobacterium bifidum Z9' vs 'control'infectTranscription profiling by array of mouse dendritic cells after infection with Bifidobacterium bifidum and Lactobacillus acidophilus
Adjusted p-valueLog2-fold change
3.9923 × 10-62.7
Dusp1'doxycicline-mediated expression of c-Jun' vs 'control'phenotypeTranscription profiling by array of mouse whole bone marrow after c-Jun induction
Adjusted p-valueLog2-fold change
7.8144 × 10-62.7
Dusp1'recombinant human interleukin-2; 100 unit per milliliter; 0.5 hour' vs 'control; 0 hour'compound, timeTranscription profiling by array of mouse CTLL-2 cell line treated with recombinant human interleukin-2
Adjusted p-valueLog2-fold change
1.0267 × 10-52.7
Dusp1'recombinant human interleukin-2; 100 unit per milliliter; 1 hour' vs 'control; 0 hour'compound, timeTranscription profiling by array of mouse CTLL-2 cell line treated with recombinant human interleukin-2
Adjusted p-valueLog2-fold change
1.306 × 10-52.7
Dusp1'Lin- CD44- CD25+ thymocyte progenitor cell; embryonic day 14.5' vs 'Lin- CD44- CD25+ thymocyte progenitor cell; adult'cell type, developmental stageTranscription profiling of mouse adult and fetal T cell progenitors
Adjusted p-valueLog2-fold change
5.1873 × 10-5-2.7
Dusp1'Kin-' vs 'wild type' in 'cAMP' at '6 hour'compound, genotype, timeTranscription profiling by array of mouse S49 cells mutant for Kin after treatment with cAMP
Adjusted p-valueLog2-fold change
1.5093 × 10-42.7
Dusp1'colitis' at '8 day' vs 'normal' at '0 day'disease, timeTemporal transcriptomic changes during DSS colitis development and resolution.
Adjusted p-valueLog2-fold change
4.7188 × 10-42.7
Dusp1'Staphylococcus aureus Sanger476; 2 hour' vs 'none; 0 hour' in '129S1/SvImJ'infect, strain, timeGene Expression-Based Classifiers Identify Staphylococcus aureus Infection in Mice and Humans
Adjusted p-valueLog2-fold change
9.558 × 10-122.6
Dusp1'Staphylococcus aureus Sanger476; 12 hour' vs 'none; 0 hour' in 'C57BL/6J'infect, strain, timeGene Expression-Based Classifiers Identify Staphylococcus aureus Infection in Mice and Humans
Adjusted p-valueLog2-fold change
2.2782 × 10-72.6
Dusp1'Staphylococcus aureus MW2; 2 hour' vs 'none; 0 hour' in 'A/J'infect, strain, timeGene Expression-Based Classifiers Identify Staphylococcus aureus Infection in Mice and Humans
Adjusted p-valueLog2-fold change
2.1893 × 10-62.6
Dusp1'MYC inhibitor (10058F4); polarized with interleukin 4 and interleukin 13.' vs 'untreated'compound, treatmentExpression data from polarized macrophages: effect of p53
Adjusted p-valueLog2-fold change
1.2477 × 10-52.6
Dusp1'prednisolone; wild type' vs 'vehicle; wild type'compound, genotypePrednisolone-induced differential gene expression in liver of mice carrying the wild type or a dimerization-defective glucocorticoid receptor
Adjusted p-valueLog2-fold change
3.8819 × 10-692.5
Dusp1'interferon gamma; 10 nanogram per milliliter and interleukin-22; 10 nanogram per milliliter' vs 'none'compoundRNAseq of small intestinal organoids from mice treated with the cytokines IFNG, IL-13 and IL-22 for 24 hours
Adjusted p-valueLog2-fold change
5.2625 × 10-492.5
Dusp1'Adjuvant System 03' at '8 hour' vs 'none'compound, timeRNA-Seq of RAW 264.7 cells stimulated with the AS03 adjuvant after 4 and 8 hours
Adjusted p-valueLog2-fold change
1.0851 × 10-162.5
Dusp1'3D culture' vs '2D culture'growth conditionmRNA-seq of mouse salivary gland cancer cells cultured in adherent or non-adherent culture
Adjusted p-valueLog2-fold change
1.2435 × 10-62.5
Dusp1'Staphylococcus aureus Sanger476; 6 hour' vs 'none; 0 hour' in 'A/J'infect, strain, timeGene Expression-Based Classifiers Identify Staphylococcus aureus Infection in Mice and Humans
Adjusted p-valueLog2-fold change
2.9211 × 10-62.5
Dusp1'Adjuvant System 03' vs 'PBS' in 'lymph node' at '6 hour'organism part, stimulus, timeExpression data from draining lymph node and muscle of mice immunised with AS03 or PBS
Adjusted p-valueLog2-fold change
7.6702 × 10-5-2.5
Dusp1'prednisolone; dimerization-defective glucocorticoid receptor' vs 'prednisolone; wild type'compound, genotypePrednisolone-induced differential gene expression in liver of mice carrying the wild type or a dimerization-defective glucocorticoid receptor
Adjusted p-valueLog2-fold change
8.2579 × 10-32.5
Dusp1'ulcer' vs 'distant normal tissue' in 'Bmp4 overexpression'genotype, sampling site, timeIntestinal ulcers from biopsy-wounded wild-type and Bmp4-overexpressing mice
Adjusted p-valueLog2-fold change
3.2763 × 10-22.5
Dusp1'IFNR null' vs 'wild type' in 'influenza infected'compound, disease, genotypeTranscription profiling of mouse influenza virus infected in wild type and mutant animals revels induced gene expression changes of regional B cells are mediated in part through type I IFN
Adjusted p-valueLog2-fold change
2.051 × 10-112.4
Dusp1'Staphylococcus aureus Sanger476; 12 hour' vs 'none; 0 hour' in 'A/J'infect, strain, timeGene Expression-Based Classifiers Identify Staphylococcus aureus Infection in Mice and Humans
Adjusted p-valueLog2-fold change
4.2974 × 10-82.4
Dusp1'dexamethasome' vs 'methyl beta-clodextrin' in 'Nr1d1 homozygous knockout; 1 milligram per kilogram; ZT6'compound, genotype, timeRNASeq data analysis of wild type and reverb alpha knockout cells from mouse liver, at different time points, with or without DEX treatment
Adjusted p-valueLog2-fold change
9.8873 × 10-82.4
Dusp1'Staphylococcus aureus Sanger476; 6 hour' vs 'none; 0 hour' in 'C57BL/6J'infect, strain, timeGene Expression-Based Classifiers Identify Staphylococcus aureus Infection in Mice and Humans
Adjusted p-valueLog2-fold change
2.1788 × 10-72.4
Dusp1'Lactobacillus acidophilus NCFM' vs 'control'infectTranscription profiling by array of mouse dendritic cells after infection with Bifidobacterium bifidum and Lactobacillus acidophilus
Adjusted p-valueLog2-fold change
1.0565 × 10-6-2.4
Dusp1'Yersinia pestis' vs 'control' in 'neutrophil'cell type, infect, sampling siteSpatially distinct neutrophil responses within the inflammatory lesions of pneumonic plague
Adjusted p-valueLog2-fold change
3.8311 × 10-52.4
Dusp1'CCl4; 1.6 gram per kilogram' at '2 hour' vs 'none' at '0 hour'compound, timeTranscriptional responses in liver upon acute CCl4 intoxication
Adjusted p-valueLog2-fold change
4.1633 × 10-22.4
Dusp1'induction of polymicrobial sepsis' vs 'control' at '72 hour' in '1.5 to 3 month mice'age, time, treatmentAged Mice are Unable to Mount an Effective Myeloid Response to Sepsis
Adjusted p-valueLog2-fold change
1.8671 × 10-512.3
Dusp1'Adjuvant System 03' at '4 hour' vs 'none'compound, timeRNA-Seq of RAW 264.7 cells stimulated with the AS03 adjuvant after 4 and 8 hours
Adjusted p-valueLog2-fold change
7.7587 × 10-132.3
Dusp1'lipopolysaccharide; 10 nanogram per milliliter' vs 'none' in 'primary cell line; wild type genotype'cell line, compound, genotypeBulk RNA-seq of wild type and MEF2A or MEF2C/D knockout mouse bone marrow macrophages under different stimulation conditions
Adjusted p-valueLog2-fold change
2.2077 × 10-82.3
Dusp1'Staphylococcus aureus Sanger476; 4 hour' vs 'none; 0 hour' in 'C57BL/6J'infect, strain, timeGene Expression-Based Classifiers Identify Staphylococcus aureus Infection in Mice and Humans
Adjusted p-valueLog2-fold change
2.7526 × 10-62.3
Dusp1'extracellular vesicle; non-stimulated culture medium' vs 'none'sampling site, stimulusCellular and extracellular vesicle RNA sequence for E-cadherin-RFP EMT reporter system expressing mouse breast cancer cell line Py2T during EMT/MET
Adjusted p-valueLog2-fold change
3.3417 × 10-62.3
Dusp1'Staphylococcus aureus Sanger476; 2 hour' vs 'none; 0 hour' in 'CD1'infect, strain, timeGene Expression-Based Classifiers Identify Staphylococcus aureus Infection in Mice and Humans
Adjusted p-valueLog2-fold change
3.0475 × 10-5-2.3
Dusp1'Kin-' vs 'wild type' in 'cAMP' at '24 hour'compound, genotype, timeTranscription profiling by array of mouse S49 cells mutant for Kin after treatment with cAMP
Adjusted p-valueLog2-fold change
8.4531 × 10-42.3
Dusp1'Staphylococcus aureus cutaneous infection' vs 'none' in 'IL-1R knockout'disease, genotypeNeutrophil-derived IL-1β is sufficient for abscess formation in immunity against Staphylococcus aureus in mice
Adjusted p-valueLog2-fold change
1.1507 × 10-22.3
Dusp1'oxygen/glucose-deprivation followed by restoration of oxygen/glucose' vs 'none' in 'Ubc9 overexpression; differentiated'genotype, growth condition, stimulusSUMOylation promotes survival and integration of neural stem cell grafts in stroke
Adjusted p-valueLog2-fold change
1.5615 × 10-2-2.3
Dusp1'megakaryocyte' vs 'hematopoietic stem cell'cell typeTranscription profiling by array of primary megakaryocytes (MEG) and erythroblasts (ERY) developed from murine fetal liver hematopoietic stem cells
Adjusted p-valueLog2-fold change
2.1155 × 10-8-2.2
Dusp1'interleukin-3 and interleukin-33' vs 'interleukin-3'growth conditionStem cell factor programs the mast cell activation phenotype
Adjusted p-valueLog2-fold change
1.6407 × 10-7-2.2
Dusp1'SMRT shRNA' vs 'none' in 'none' at '0 hour'RNA interference, stimulus, timeRNA-seq of Control and SMRT KD CD8α+ DCs at 0hr and 6hr CpG stimulation
Adjusted p-valueLog2-fold change
1.1924 × 10-62.2
Dusp1'postnatal >1 year; hindlimb' vs 'embryonic day 17.5; whole forelimb and hindlimb'age, organism partExpression data from skeletal muscle satellite cells at different development stages
Adjusted p-valueLog2-fold change
2.9808 × 10-102.1
Dusp1'isotype-control; 150 micrograms' vs 'none' in 'methotrexate; first dose 120 milligram per kilogram; second dose 60 milligram per kilogram; wild type phenotype' at '1 day'compound, phenotype, stimulus, timeRNA-seq of mouse crypts to investigate Rorc gamma t-deficient mice tissue repair compared to wild type controls
Adjusted p-valueLog2-fold change
1.8684 × 10-82.1
Dusp1'Staphylococcus aureus USA300; 2 hour' vs 'none; 0 hour' in 'CD1'infect, strain, timeGene Expression-Based Classifiers Identify Staphylococcus aureus Infection in Mice and Humans
Adjusted p-valueLog2-fold change
1.0794 × 10-52.1
Dusp1'tristetrapolin knockout' vs 'wild type' in 'actinomycin D' at '60 minute'compound, genotype, timeTranscription profiling by array of fibroblasts from TTP knock out mice
Adjusted p-valueLog2-fold change
1.223 × 10-52.1
Dusp1'Adjuvant System 03' vs 'PBS' in 'lymph node' at '4 hour'organism part, stimulus, timeExpression data from draining lymph node and muscle of mice immunised with AS03 or PBS
Adjusted p-valueLog2-fold change
4.111 × 10-42.1
Dusp1'Staphylococcus aureus cutaneous infection' vs 'none' in 'wild type'disease, genotypeNeutrophil-derived IL-1β is sufficient for abscess formation in immunity against Staphylococcus aureus in mice
Adjusted p-valueLog2-fold change
3.9815 × 10-612
Dusp1'N-acetylcysteine; 1 day differentiated; 1 millimolar' vs 'none; 1 day differentiated'compound, developmental stageRNA-seq of C17.2 neuronal progenitor cells exposed to cerium oxide nanoparticles during cell differentiation
Adjusted p-valueLog2-fold change
5.1043 × 10-13-2
Dusp1'21 percent oxygen, 37 degree Celsius, no serum' vs 'none'growth conditionRNA sequencing of native and ex vivo cultured murine tail tendon fascicles
Adjusted p-valueLog2-fold change
7.6722 × 10-102
Dusp1'anti-IL-22; 150 micrograms' vs 'none' in 'methotrexate; first dose 120 milligram per kilogram; second dose 60 milligram per kilogram; wild type phenotype' at '1 day'compound, phenotype, stimulus, timeRNA-seq of mouse crypts to investigate Rorc gamma t-deficient mice tissue repair compared to wild type controls
Adjusted p-valueLog2-fold change
4.132 × 10-82
Dusp1'dexamethasome' vs 'methyl beta-clodextrin' in 'Nr1d1 homozygous knockout; 1 milligram per kilogram; ZT18'compound, genotype, timeRNASeq data analysis of wild type and reverb alpha knockout cells from mouse liver, at different time points, with or without DEX treatment
Adjusted p-valueLog2-fold change
3.2993 × 10-72
Dusp1'anti-CD3/CSA' vs 'anti-CD3' in 'cyclosporine-sensitive'phenotype, treatmentActivating CD8 T cell clones via the T cell receptor complex in the absence and presence of cyclosporine A
Adjusted p-valueLog2-fold change
9.0163 × 10-72
Dusp1'hepatocyte-derived proliferative ducts (hepPDs)' vs 'hepatocyte'cell typeTranscription profiling by high throughput sequencing of hepatocyte-derived progenitors cells in a mouse model of oval cell activation
Adjusted p-valueLog2-fold change
2.3664 × 10-62
Dusp1'hyperthermia' vs 'control'treatmentTranscription profiling of mouse Jardine SIDS Model
Adjusted p-valueLog2-fold change
2.8156 × 10-62
Dusp1'fasted' vs 're-fed' in 'wild type genotype; control miRNA'RNA interference, diet, genotypeGene expression profiling of liver from C57BLKS/J and db/db 8 mice with an AAV harboring a control or GAbpa-specific miRNA under the LP1 promoter
Adjusted p-valueLog2-fold change
6.2604 × 10-62
Dusp1'Staphylococcus aureus USA100; 2 hour' vs 'none; 0 hour' in 'A/J'infect, strain, timeGene Expression-Based Classifiers Identify Staphylococcus aureus Infection in Mice and Humans
Adjusted p-valueLog2-fold change
2.6571 × 10-52
Dusp1'db/db' vs 'wild type genotype' in 'Gabpa miRNA; re-fed'RNA interference, diet, genotypeGene expression profiling of liver from C57BLKS/J and db/db 8 mice with an AAV harboring a control or GAbpa-specific miRNA under the LP1 promoter
Adjusted p-valueLog2-fold change
3.2363 × 10-5-2
Dusp1'extraembryonic endoderm stem cell; grown in ES cell medium' vs 'mouse embryonic fibroblast; control'cell type, growth conditionOSKM induce extraembryonic endoderm stem (iXEN) cells in parallel to iPS cells
Adjusted p-valueLog2-fold change
6.7235 × 10-52
Dusp1'postnatal 2-3 month; hindlimb' vs 'embryonic day 17.5; whole forelimb and hindlimb'age, organism partExpression data from skeletal muscle satellite cells at different development stages
Adjusted p-valueLog2-fold change
2.3456 × 10-42
Dusp1'Runx3 knockout' vs 'wild type genotype' in 'CD27-high, CD11b-high natural killer cell'cell type, genotypeRunx3 function in splenic NK cells activated in vivo by IL-15.
Adjusted p-valueLog2-fold change
1.1267 × 10-3-2
Dusp1'synovial sarcoma' vs 'normal'diseaseTranscription profiling by array of tumors excised from conditional mouse model of synovial sarcoma compared to skeletal muscle from wild type mice
Adjusted p-valueLog2-fold change
4.938 × 10-123-1.9
Dusp1'Debaryomyces hansenii' at '24 hour' vs 'none' at '0 hour'stimulus, timeRNA seq of mouse bone marrow derived macrophages treated with Debaryomyces hansenii against untreated controls
Adjusted p-valueLog2-fold change
1.45 × 10-38-1.9
Dusp1'α-GalCer; 2 microgram' vs 'none' in 'Cd1d homozyous knockout'compound, genotypeCD1d-dependent immune suppression mediated by regulatory B cells through modulations of iNKT cells
Adjusted p-valueLog2-fold change
7.5859 × 10-241.9
Dusp1'N-acetylcysteine; 4 day differentiated; 1 millimolar' vs 'none; 4 day differentiated'compound, developmental stageRNA-seq of C17.2 neuronal progenitor cells exposed to cerium oxide nanoparticles during cell differentiation
Adjusted p-valueLog2-fold change
2.2455 × 10-91.9
Dusp1'Staphylococcus aureus Sanger476; 2 hour' vs 'none; 0 hour' in 'A/J'infect, strain, timeGene Expression-Based Classifiers Identify Staphylococcus aureus Infection in Mice and Humans
Adjusted p-valueLog2-fold change
5.4772 × 10-7-1.9
Dusp1'cholesterol' vs 'vehicle (cyclodextrin)'compound, timeArray results for differential gene expression in 661W, a mouse cone photoreceptor-derived cell line, comparing cells incubated with vehicle controls vs. those treated with either of two 7-dehdyrocholesterol-derived oxysterols or cholesterol
Adjusted p-valueLog2-fold change
2.7358 × 10-61.9
Dusp1'AZD5069; 100 milligram per kilogram' vs 'none'compoundRNA-seq to investigate differentially expressed genes in KPC mouse PDAC treated with CSF-1R small molecule inhibitor AZD7507 and/or the CXCR2 small molecule inhibitor AZD5069
Adjusted p-valueLog2-fold change
3.3821 × 10-51.9
Dusp1'Staphylococcus aureus USA300; 2 hour' vs 'none; 0 hour' in 'A/J'infect, strain, timeGene Expression-Based Classifiers Identify Staphylococcus aureus Infection in Mice and Humans
Adjusted p-valueLog2-fold change
3.9157 × 10-51.9
Dusp1'tristetrapolin knockout' vs 'wild type' in 'none' at '0 minute'compound, genotype, timeTranscription profiling by array of fibroblasts from TTP knock out mice
Adjusted p-valueLog2-fold change
2.7422 × 10-4-1.9
Dusp1'induced extraembryonic endoderm stem cell; grown in ES cell medium' vs 'mouse embryonic fibroblast; control'cell type, growth conditionOSKM induce extraembryonic endoderm stem (iXEN) cells in parallel to iPS cells
Adjusted p-valueLog2-fold change
6.5811 × 10-41.9
Dusp1'granulocyte' vs 'hemopoietic stem cell'cell typeGene expression data from mouse hemopoietic stem cells (LSKs), promyelocytes, myelocytes and granulocytes.
Adjusted p-valueLog2-fold change
1.8311 × 10-31.9
Dusp1'oxygen/glucose-deprivation followed by restoration of oxygen/glucose' vs 'none' in 'Ubc9 overexpression; undifferentiated'genotype, growth condition, stimulusSUMOylation promotes survival and integration of neural stem cell grafts in stroke
Adjusted p-valueLog2-fold change
2.9342 × 10-31.9
Dusp1'interferon gamma; 1 nanogram per milliliter' vs 'none'stimulusAnalysis of transcriptomes in intestinal stem cells in response to Interferon gamma
Adjusted p-valueLog2-fold change
7.8169 × 10-3-1.9
Dusp1'extraembryonic endoderm stem cell; grown in XEN cell medium' vs 'mouse embryonic fibroblast; control'cell type, growth conditionOSKM induce extraembryonic endoderm stem (iXEN) cells in parallel to iPS cells
Adjusted p-valueLog2-fold change
2.8001 × 10-52-1.8
Dusp1'Irx3 knockout' vs 'control' at '7 day'genetic modification, timeRNA-Seq of mouse Irx3-KO and Control ME3 cells on days 1 and 7 of adipogenic differentiation
Adjusted p-valueLog2-fold change
4.8677 × 10-511.8
Dusp1'KRas siRNA' vs 'non-targeting siRNA'RNA interferenceRNA-SEQ analysis of KMC murine pancreatic ductal adenocarcinoma (PDAC) cell line upon siRNA depletion of MYC, KRas or Miz1 (aka Zbtb17)
Adjusted p-valueLog2-fold change
9.9604 × 10-7-1.8
Dusp1'spontaneous lung tumor' vs 'normal'disease state, diseaseTranscription profiling by array of spontaneous lung tumors in mice to compare to human non-small cell lung cancer
Adjusted p-valueLog2-fold change
6.4061 × 10-6-1.8
Dusp1'interleukin-3 and stem cell factor' vs 'interleukin-3'growth conditionStem cell factor programs the mast cell activation phenotype
Adjusted p-valueLog2-fold change
7.0152 × 10-6-1.8
Dusp1'interferon gamma' vs 'none'compoundType I and II Interferon-Stimulated Genes in Murine Primary Bone Marrow Macrophages
Adjusted p-valueLog2-fold change
1.0241 × 10-5-1.8
Dusp1'SMRT shRNA; CpG; 6 hour' vs 'none; none; 0 hour'RNA interference, stimulus, timeRNA-seq of Control and SMRT KD CD8α+ DCs at 0hr and 6hr CpG stimulation
Adjusted p-valueLog2-fold change
1.5078 × 10-5-1.8
Dusp1'Elp3fl/fl vav-iCreT/+' vs 'Elp3fl/fl' in 'total RNA'fraction, genotypePolysome profiling analysis of myeloid progenitors of control mice or mice conditionally deficient for Elp3 in the hematopoietic system
Adjusted p-valueLog2-fold change
2.6738 × 10-41.8
Dusp1'dibenzazapine 10 micromoles per kilogram' vs 'none'compound, doseTranscription profiling by array of pancreatic cells from C57BL/6 mice following dibenzazepine treatment
Adjusted p-valueLog2-fold change
3.5077 × 10-41.8
Dusp1'recombinant human interleukin-2; 100 unit per milliliter; 4 hour' vs 'control; 0 hour'compound, timeTranscription profiling by array of mouse CTLL-2 cell line treated with recombinant human interleukin-2
Adjusted p-valueLog2-fold change
4.4294 × 10-31.8
Dusp1'Runx3 knockout' vs 'wild type genotype' in 'CD27-high, CD11b-low natural killer cell'cell type, genotypeRunx3 function in splenic NK cells activated in vivo by IL-15.
Adjusted p-valueLog2-fold change
5.358 × 10-3-1.8
Dusp1'SGC-CBP30; 10 nanogram per milliliter' vs 'none' in 'primary cell line; wild type genotype'cell line, compound, genotypeBulk RNA-seq of wild type and MEF2A or MEF2C/D knockout mouse bone marrow macrophages under different stimulation conditions
Adjusted p-valueLog2-fold change
8.1272 × 10-3-1.8
Dusp1'PFI-1; 10 nanogram per milliliter' vs 'none' in 'primary cell line; wild type genotype'cell line, compound, genotypeBulk RNA-seq of wild type and MEF2A or MEF2C/D knockout mouse bone marrow macrophages under different stimulation conditions
Adjusted p-valueLog2-fold change
3.4789 × 10-21.8
Dusp1'Taf10-/-' vs 'wild type'genotypeTranscription profiling by array of liver from Taf10 knock out mice
Adjusted p-valueLog2-fold change
8.0144 × 10-481.7
Dusp1'prostaglandin E2; 1 micromolar' vs 'none' in 'primary cell line; MEF2C/D knockout'cell line, compound, genotypeBulk RNA-seq of wild type and MEF2A or MEF2C/D knockout mouse bone marrow macrophages under different stimulation conditions
Adjusted p-valueLog2-fold change
1.4261 × 10-181.7
Dusp1'tamoxifen induction at 2 months, wait 3 months' vs 'no tamoxifen induction' in 'basal cell of prostate epithelium; CK5-CreERT2 transgenic line'cell type, genotype, growth conditionTranscription profiling by high throughput sequencing of PIN/tumor lesions from basal or luminal origins at time points at which mice displayed similar histopathological phenotypes
Adjusted p-valueLog2-fold change
8.8078 × 10-111.7
Dusp1'LDB1 knock-down' vs 'control shRNA'RNA interferenceRole of LDB1 in the transition from chromatin looping to transcription activation
Adjusted p-valueLog2-fold change
4.2897 × 10-91.7
Dusp1'16 day' vs '0 day'ageGene expression profile of mouse differentiating embryonic stem cells (day 0, 6, 16, and 26)
Adjusted p-valueLog2-fold change
1.413 × 10-8-1.7
Dusp1'mutant MyoD expression' at '24 hour' vs 'wild type MyoD expression' at '0 hour'phenotype, timeTranscription profiling of mouse embryoic fibroblasts expressing wild type MyoD or its non-acetylatable version MyoD RRR to investigate how MyoD acetylation may contribute to differential gene activation.
Adjusted p-valueLog2-fold change
3.9342 × 10-81.7
Dusp1'sham-preconditioning followed by intra-amygdala kainic acid' vs 'sham-preconditioning followed by intra-amygdala vehicle'clinical treatmentTranscription profiling by array of mice with epileptic tolerance
Adjusted p-valueLog2-fold change
2.1811 × 10-71.7
Dusp1'prostaglandin E2; 1 micromolar' vs 'none' in 'primary cell line; wild type genotype'cell line, compound, genotypeBulk RNA-seq of wild type and MEF2A or MEF2C/D knockout mouse bone marrow macrophages under different stimulation conditions
Adjusted p-valueLog2-fold change
1.8804 × 10-61.7
Dusp1'WT (VH81x transgenic Rag1-/-)' vs 'control'genotypePre-BCR Signaling induce IgK Locus Accessibility by functional redistribution of Enhancer-mediated chromatin Interactions
Adjusted p-valueLog2-fold change
4.2208 × 10-6-1.7
Dusp1'cancer' vs 'normal' in 'lymph node medullary sinus macrophage'cell type, diseaseRNA Sequencing of CD169+ lymph node macrophages isolated from naïve or tumor-bearing mice
Adjusted p-valueLog2-fold change
4.7513 × 10-61.7
Dusp1'inhibition of BRD4 with JQ1' vs 'DMSO'treatmentExpression Data For BRD4 Inhibition
Adjusted p-valueLog2-fold change
2.2164 × 10-51.7
Dusp1'dexamethasome' vs 'methyl beta-clodextrin' in 'wild type genotype; 1 milligram per kilogram; ZT6'compound, genotype, timeRNASeq data analysis of wild type and reverb alpha knockout cells from mouse liver, at different time points, with or without DEX treatment
Adjusted p-valueLog2-fold change
1.6472 × 10-4-1.7
Dusp1'myeloid lineage restricted progenitor cell' vs 'long term hematopoietic stem cell' in 'Elp3fl/fl'cell type, genotypeRNA-seq of long-term hematopoietic stem cells and myeloid progenitors of control mice or mice conditionally deficient for Trp53 or Elp3 or both genes in the hematopoietic system
Adjusted p-valueLog2-fold change
5.1861 × 10-4-1.7
Dusp1'induced extraembryonic endoderm stem cell; grown in XEN cell medium' vs 'mouse embryonic fibroblast; control'cell type, growth conditionOSKM induce extraembryonic endoderm stem (iXEN) cells in parallel to iPS cells
Adjusted p-valueLog2-fold change
6.1263 × 10-41.7
Dusp1'Btk KO (VH81x transgenic Rag1-/-)' vs 'control'genotypePre-BCR Signaling induce IgK Locus Accessibility by functional redistribution of Enhancer-mediated chromatin Interactions
Adjusted p-valueLog2-fold change
1.0871 × 10-3-1.7
Dusp1'normobaric hypoxia' vs 'control'growth conditionComparison of gene expression in whole blood of mice subjected to normobaric hypoxia in vivo.
Adjusted p-valueLog2-fold change
1.2273 × 10-3-1.7
Dusp1'FusΔNLS/+' vs 'wild type genotype' at '12 hour'genotype, timeMutant FUS triggers age-dependent synaptic impairment in presymptomatic ALS-FUS mice (RNA-seq part2)
Adjusted p-valueLog2-fold change
2.7937 × 10-31.7
Dusp1'Lin- CD44+ CD25+ thymocyte progenitor cell; embryonic day 14.5' vs 'Lin- CD44+ CD25+ thymocyte progenitor cell; adult'cell type, developmental stageTranscription profiling of mouse adult and fetal T cell progenitors
Adjusted p-valueLog2-fold change
4.1497 × 10-31.7
Dusp1'Btk Slp KO (VH81x transgenic Rag1-/-)' vs 'control'genotypePre-BCR Signaling induce IgK Locus Accessibility by functional redistribution of Enhancer-mediated chromatin Interactions
Adjusted p-valueLog2-fold change
5.322 × 10-31.7
Dusp1'Runx3 knockout' vs 'wild type genotype' in 'CD27-low, CD11b-high natural killer cell'cell type, genotypeRunx3 function in splenic NK cells activated in vivo by IL-15.
Adjusted p-valueLog2-fold change
2.8529 × 10-21.7
Dusp1'oxygen/glucose-deprivation followed by restoration of oxygen/glucose' vs 'none' in 'wild type genotype; differentiated'genotype, growth condition, stimulusSUMOylation promotes survival and integration of neural stem cell grafts in stroke
Adjusted p-valueLog2-fold change
4.0341 × 10-2-1.7
Dusp1'colitis' vs 'normal' in 'wild type'compound, disease, genotypeTranscription profiling by array of wild-type or Thrombospondin 1 (TSP-1) null mouse dextran sulphate sodium (DSS)-induced colitis treated with various forms of TSP-1, a protein with regulatory functions in inflammation and cancer
Adjusted p-valueLog2-fold change
3.1512 × 10-401.6
Dusp1'lipopolysaccharide; 10 nanogram per milliliter' vs 'none' in 'primary cell line; MEF2C/D knockout'cell line, compound, genotypeBulk RNA-seq of wild type and MEF2A or MEF2C/D knockout mouse bone marrow macrophages under different stimulation conditions
Adjusted p-valueLog2-fold change
5.8504 × 10-331.6
Dusp1'lipopolysaccharide' vs 'none' in 'bone marrow; wild type'cell type, compound, genotypeTranscription profiling by high throughput sequencing of spleens of GPR34 knockout and wild type mice
Adjusted p-valueLog2-fold change
9.1159 × 10-8-1.6
Dusp1'anti-CD3/anti-CD28' vs 'none' in 'empty vector'genotype, stimulusTranscription profiling by array of FOXP3 overexpression in resting and activated mouse CD4+ T cells
Adjusted p-valueLog2-fold change
7.2071 × 10-71.6
Dusp1'seizure-preconditioning followed by intra-amygdala kainic acid' vs 'sham-preconditioning followed by intra-amygdala vehicle'clinical treatmentTranscription profiling by array of mice with epileptic tolerance
Adjusted p-valueLog2-fold change
4.1897 × 10-6-1.6
Dusp1'intravenous injection of 10-100 thousand B-ALL cells' vs 'none' in 'lentiviral expression of mTie2-IFN-mirT and Tie2-driven overexpression of IFNalpha'genotype, stimulusRNA-seq of mouse macrophages to investigate how interferon gene therapy reprograms the leukemia microenvironment
Adjusted p-valueLog2-fold change
1.4105 × 10-51.6
Dusp1'confluent monolayer on collagen' at '7 day' vs 'freshly isolated' at '0 day'growth condition, timeTranscription profiling of primary mouse hepatocytes under different culture conditions
Adjusted p-valueLog2-fold change
2.5141 × 10-5-1.6
Dusp1'7 days P. chabaudi infected' vs 'uninfected' in 'intact male'clinical information, disease, sex, timeTranscription profiling by array of mice infected with Plasmodium chabaudi after gonadectomization to investigate involvement of gonadal steroids
Adjusted p-valueLog2-fold change
3.4476 × 10-51.6
Dusp1'Mkl1-RFP with a deletion of the SAP domain' vs 'full length Mkl1-RFP'genotypeTranscription profiling by array of HC11 mammary epithelial cell strains stably expressing different variants of the transcriptional regulator megakaryoblastic leukemia-1 (Mkl1)
Adjusted p-valueLog2-fold change
1.1851 × 10-41.6
Dusp1'adult definitive erythroid cell' vs 'primitive erythroid cell' in 'proerythroblast'cell type, phenotypeTranscription profiling by array of differentiating primary primitive and definitive mouse red blood cells
Adjusted p-valueLog2-fold change
4.6324 × 10-4-1.6
Dusp1'M-CSF' at '6 day' vs 'none' at '0 day'compound, timeMicroarray profiling of polyploid macrophage progeny
Adjusted p-valueLog2-fold change
5.7103 × 10-41.6
Dusp1'recombinant human interleukin-2; 100 unit per milliliter; 8 hour' vs 'control; 0 hour'compound, timeTranscription profiling by array of mouse CTLL-2 cell line treated with recombinant human interleukin-2
Adjusted p-valueLog2-fold change
6.9042 × 10-41.6
Dusp1'ABIN1[D485N] knock-in' vs 'wild type genotype' in 'non-classical monocyte'cell type, genotypeRNA-seq of inflammatory monocytes, patrolling monocytes and neutrophils in wild type and ABIN1[D485N] mice
Adjusted p-valueLog2-fold change
7.5451 × 10-4-1.6
Dusp1'homozygous Igf1 mutant' vs 'wild type'genotypeExpression data from E18.5 Igf1 -/- (homozygous mutant) and Igf1+/+ (normal wild type control) mouse lungs
Adjusted p-valueLog2-fold change
7.6858 × 10-4-1.6
Dusp1'CCl4 and diethylnitrosamine' vs 'none' in 'wild type genotype'genotype, treatmentGene expression accompanying the promotion of hepatocellular carcinoma by intestinal microbiota and Tlr4 in mice.
Adjusted p-valueLog2-fold change
8.267 × 10-41.6
Dusp1'paracetamol; 529 milligram per kilogram' vs 'vehicle' at '1 hour'compound, timeTranscription profiling by array of CD1 mice after nontoxic and nonlethal hepatotoxic paracetamol administration
Adjusted p-valueLog2-fold change
1.3822 × 10-31.6
Dusp1'recombinant human interleukin-2; 100 unit per milliliter; 2 hour' vs 'control; 0 hour'compound, timeTranscription profiling by array of mouse CTLL-2 cell line treated with recombinant human interleukin-2
Adjusted p-valueLog2-fold change
2.058 × 10-31.6
Dusp1'quisinostat; 1.5 milligram per kilogram' vs 'vehicle'compoundTranscriptional profiling of 5T33MM cells treated in vivo with quisinostat, decitabine or the combination.
Adjusted p-valueLog2-fold change
3.9748 × 10-3-1.6
Dusp1'high fat diet' vs 'regular chow diet' in 'liver-specific Pit1 knockout'diet, genotypeTranscription profiling by array of liver tissues from mice with liver-specific knockout of Pit1 and wild-type littermates fed with either a high-fat diet or chow control diet
Adjusted p-valueLog2-fold change
1.4201 × 10-26-1.5
Dusp1'α-GalCer; 2 microgram' vs 'none' in 'wild type genotype'compound, genotypeCD1d-dependent immune suppression mediated by regulatory B cells through modulations of iNKT cells
Adjusted p-valueLog2-fold change
1.593 × 10-61.5
Dusp1'phosgene - carbonyl chloride' at '0.5 hour' vs 'none' at '0 hour'compound, timeTranscription profiling of lung from mouse exposed to carbonyl chloride (phosgene) for different lengths of time to investigate the molecular mechanism of phosgene-induced lung injury
Adjusted p-valueLog2-fold change
4.1276 × 10-6-1.5
Dusp1'S3 control; TGF beta 1; 5 nanogram per milliliter' vs 'S3 control; vehicle; 5 nanogram per milliliter'RNA interference, compoundtranscription profiling by array mouse mammary epithelial cells treated with TGF-beta to induce epithelial-to-mesenchymal transition
Adjusted p-valueLog2-fold change
1.0758 × 10-51.5
Dusp1'Escherichia coli O18:K1:H7; 6 hour' vs 'none; 0 hour' in 'A/J'infect, strain, timeGene Expression-Based Classifiers Identify Staphylococcus aureus Infection in Mice and Humans
Adjusted p-valueLog2-fold change
2.9595 × 10-41.5
Dusp1'Adjuvant System 03' vs 'PBS' in 'lymph node' at '2 hour'organism part, stimulus, timeExpression data from draining lymph node and muscle of mice immunised with AS03 or PBS
Adjusted p-valueLog2-fold change
6.2497 × 10-4-1.5
Dusp1'infarct and border region of left ventricle 5 days post-myocardial infarction; C57BL/6J' vs 'left ventricle at baseline (no myocardial infarction) in the same region as the infarct in post-myocardial infarction hearts; C57BL/6J'clinical information, strainExpression data from C57BL/6J and MRL/MpJ hearts following acute myocardial infarction
Adjusted p-valueLog2-fold change
7.2779 × 10-41.5
Dusp1'CCl4; 1.6 gram per kilogram' at '8 hour' vs 'none' at '0 hour'compound, timeTranscriptional responses in liver upon acute CCl4 intoxication
Adjusted p-valueLog2-fold change
2.1054 × 10-3-1.5
Dusp1'total RNA; HRasV12 and c-Myc overexpression and Eif4e heterozygous knockout' vs 'total RNA; wild type'fraction, genotypeRedefining the role of eIF4E dose in development, cancer, and protein synthesis
Adjusted p-valueLog2-fold change
2.6202 × 10-31.5
Dusp1'Hnf4a-pKO;Hnf1aHET double mutant' vs 'wild type genotype'genotypeTranscription profiling by array of pancreatic islets from pancreas-specific Hnf4alpha knockout, heterozygous Hnf1alpha, and double mutant mice
Adjusted p-valueLog2-fold change
1.5525 × 10-2-1.5
Dusp1'FusΔNLS/+' vs 'wild type genotype' at '8 hour'genotype, timeMutant FUS triggers age-dependent synaptic impairment in presymptomatic ALS-FUS mice (RNA-seq part2)
Adjusted p-valueLog2-fold change
2.2853 × 10-2-1.5
Dusp1'MEF2A knockout' vs 'wild type genotype' in 'Hoxb8-FL; lipopolysaccharide; 10 nanogram per milliliter'cell line, compound, genotypeBulk RNA-seq of wild type and MEF2A or MEF2C/D knockout mouse bone marrow macrophages under different stimulation conditions
Adjusted p-valueLog2-fold change
3.3482 × 10-2-1.5
Dusp1'double Fancc-/- Fancg-/-' vs 'wild type'genotypeTranscription profiling by array of bone marrow cells from wild type, Fancc-deficient, Fancg-deficient, and doubly deficient (Fancc/Fancg) mice
Adjusted p-valueLog2-fold change
3.8049 × 10-2-1.5
Dusp1'total RNA; HRasV12 and c-Myc overexpression and Eif4e wild type' vs 'total RNA; wild type'fraction, genotypeRedefining the role of eIF4E dose in development, cancer, and protein synthesis
Adjusted p-valueLog2-fold change
6.9104 × 10-1681.4
Dusp1'CD4-positive T cell' vs 'CD8-positive T cell' in 'Egr2 and Egr3 knockout'cell type, genotype, phenotypeRNAseq analysis of CD4 and CD8 T cells in response to vaccinia virus infection
Adjusted p-valueLog2-fold change
2.6747 × 10-261.4
Dusp1'Miz1 siRNA' vs 'non-targeting siRNA'RNA interferenceRNA-SEQ analysis of KMC murine pancreatic ductal adenocarcinoma (PDAC) cell line upon siRNA depletion of MYC, KRas or Miz1 (aka Zbtb17)
Adjusted p-valueLog2-fold change
6.7093 × 10-81.4
Dusp1'phosgene - carbonyl chloride' at '0.5 hour' vs 'air' at '0.5 hour'compound, timeTranscription profiling of lung from mouse exposed to carbonyl chloride (phosgene) for different lengths of time to investigate the molecular mechanism of phosgene-induced lung injury
Adjusted p-valueLog2-fold change
5.2548 × 10-7-1.4
Dusp1'Gprc5a knockout' vs 'control'genotypeGene expression profile of lung epithelial cells cultured from normal tracheas of Gprc5a knockout and wild-type mice
Adjusted p-valueLog2-fold change
5.8355 × 10-7-1.4
Dusp1'4 day' vs '0 day'ageTranscription profiling of mouse embyronic stem cell line CGR8 during the first 10 days of differentiation into embryoid bodies
Adjusted p-valueLog2-fold change
6.7828 × 10-7-1.4
Dusp1'neurosphere in differentiation medium; 1 day' vs 'neurosphere; 0 day' in 'Cstb knockout'genotype, growth condition, timeTranscriptome analysis of neurospheres derived from Cstb-KO mouse embryo brains during differentiation
Adjusted p-valueLog2-fold change
1.1408 × 10-6-1.4
Dusp1'7 day' vs '0 day'ageTranscription profiling of mouse embyronic stem cell line CGR8 during the first 10 days of differentiation into embryoid bodies
Adjusted p-valueLog2-fold change
1.8112 × 10-6-1.4
Dusp1'interferon gamma' vs 'dexamethasone; 100 nanomolar'compound, stimulusRNA-Seq of murine lung endothelial cells stimulated with IFN-gamma and dexamethasone
Adjusted p-valueLog2-fold change
2.1198 × 10-61.4
Dusp1'SARS coronavirus MA15; 2 day' vs 'mock' in 'CAST/EiJ'infect, strain, timeGenomic profiling of collaborative cross founder mouse strains infected with respiratory viruses to discover novel transcripts and infection-related strain-specific gene and isoform expression
Adjusted p-valueLog2-fold change
6.1519 × 10-61.4
Dusp1'KrasG12D extinction' vs 'sustained KrasG12D expression' in 'parental culture'growth condition, phenotypeKras is required for pancreatic tumor maintenance through regulation of hexosamine biosynthesis and the non-oxidative pentose phosphate pathway
Adjusted p-valueLog2-fold change
3.2568 × 10-51.4
Dusp1'Escherichia coli O18:K1:H7; 2 hour' vs 'none; 0 hour' in 'A/J'infect, strain, timeGene Expression-Based Classifiers Identify Staphylococcus aureus Infection in Mice and Humans
Adjusted p-valueLog2-fold change
1.5454 × 10-41.4
Dusp1'Stella maternal / zygotic knockout' vs 'wild type genotype' in '2-cell embryo'developmental stage, genotypeTranscription profiling of wild type and Stella knockout oocytes, wild type and Stella maternal/zygotic knockout embryos to study to the role of Stella in early mouse development
Adjusted p-valueLog2-fold change
1.697 × 10-4-1.4
Dusp1'H-Ras expression; c-Myc activation' vs 'wild type'phenotypeRNA-seq of heart tissue from 15 day old mice 4 hours post MycER activation compared to wild type controls. RNA-seq of heart tissues from adult mice that have expressed oncogenic H-Ras for 4 weeks followed by MycER activation for 4 hours compared to MycER negative controls.
Adjusted p-valueLog2-fold change
2.6237 × 10-41.4
Dusp1'fasted' vs 're-fed' in 'wild type genotype; Gabpa miRNA'RNA interference, diet, genotypeGene expression profiling of liver from C57BLKS/J and db/db 8 mice with an AAV harboring a control or GAbpa-specific miRNA under the LP1 promoter
Adjusted p-valueLog2-fold change
4.0103 × 10-41.4
Dusp1'phosgene - carbonyl chloride' at '1 hour' vs 'air' at '1 hour'compound, timeTranscription profiling of lung from mouse exposed to carbonyl chloride (phosgene) for different lengths of time to investigate the molecular mechanism of phosgene-induced lung injury
Adjusted p-valueLog2-fold change
3.573 × 10-31.4
Dusp1'decitabine; 0.2 milligram per kilogram' vs 'vehicle'compoundTranscriptional profiling of 5T33MM cells treated in vivo with quisinostat, decitabine or the combination.
Adjusted p-valueLog2-fold change
3.6982 × 10-31.4
Dusp1'dexamethasome' vs 'methyl beta-clodextrin' in 'wild type genotype; 1 milligram per kilogram; ZT18'compound, genotype, timeRNASeq data analysis of wild type and reverb alpha knockout cells from mouse liver, at different time points, with or without DEX treatment
Adjusted p-valueLog2-fold change
3.7302 × 10-3-1.4
Dusp1'synovial sarcoma' vs 'control'disease, genotypeMouse Model of Clear Cell Sarcoma
Adjusted p-valueLog2-fold change
4.4109 × 10-3-1.4
Dusp1'10 microgram; ovalbumin' vs 'none' in 'wild type'compound, genotypeTranscription profiling by array of lungs from mice mutant for RAG after challenge with ovalbumin
Adjusted p-valueLog2-fold change
5.3631 × 10-31.4
Dusp1'decitabine and quisinostat; 0.2 and 1.5 milligram per kilogram' vs 'vehicle'compoundTranscriptional profiling of 5T33MM cells treated in vivo with quisinostat, decitabine or the combination.
Adjusted p-valueLog2-fold change
1.2674 × 10-21.4
Dusp1'Pten knockout' vs 'wild type' at '15 month'genotype, timeTranscription profiling by array of Pten knockout liver cells of mouse
Adjusted p-valueLog2-fold change
1.5458 × 10-21.4
Dusp1'thermal injury' vs 'none'injuryMicroarray profiling of post-injury and uninjured mouse lung neutrophils from a thermal injury model
Adjusted p-valueLog2-fold change
2.896 × 10-2-1.4
Dusp1'Tet2 knockout' vs 'wild type' in 'hematopoietic stem cell'cell type, genotypeTranscription profiling by high throughput sequencing of bone marrow stem and progenitor cells from Tet2 depleted mice
Adjusted p-valueLog2-fold change
1.841 × 10-1411.3
Dusp1'Debaryomyces hansenii' at '2 hour' vs 'none' at '0 hour'stimulus, timeRNA seq of mouse bone marrow derived macrophages treated with Debaryomyces hansenii against untreated controls
Adjusted p-valueLog2-fold change
2.1178 × 10-271.3
Dusp1'MYC siRNA' vs 'non-targeting siRNA'RNA interferenceRNA-SEQ analysis of KMC murine pancreatic ductal adenocarcinoma (PDAC) cell line upon siRNA depletion of MYC, KRas or Miz1 (aka Zbtb17)
Adjusted p-valueLog2-fold change
3.2802 × 10-171.3
Dusp1'interferon gamma; 10 nanogram per milliliter and interleukin-13; 10 nanogram per milliliter' vs 'none'compoundRNAseq of small intestinal organoids from mice treated with the cytokines IFNG, IL-13 and IL-22 for 24 hours
Adjusted p-valueLog2-fold change
6.2444 × 10-161.3
Dusp1'oxidized low density lipoprotein; 25 microgram per milliliter' vs 'none' in 'wild type genotype'compound, genotypeQuantitative analysis of wild type and cd36-/- murine peritoneal macrophage transcriptomes
Adjusted p-valueLog2-fold change
1.1231 × 10-12-1.3
Dusp1'KrasG12D' vs 'wild type'genotypeAn oncogenic Kras expression signature identified by cross-species
Adjusted p-valueLog2-fold change
4.2643 × 10-10-1.3
Dusp1'actinomycin D; 4 hour' vs 'none' in 'Alb-Cre-ERT2 / Cnot1 flox/flox'compound, genotype, timeRNA-seq of livers in control and Cnot1 tamoxifen-inducible liver-specific knockout mice
Adjusted p-valueLog2-fold change
9.072 × 10-8-1.3
Dusp1'14 days P. chabaudi infected' vs 'uninfected' in 'gonadectomized female'clinical information, disease, sex, timeTranscription profiling by array of mice infected with Plasmodium chabaudi after gonadectomization to investigate involvement of gonadal steroids
Adjusted p-valueLog2-fold change
1.5617 × 10-7-1.3
Dusp1'anti-CD3/anti-CD28' vs 'none' in 'FOXP3 overexpression'genotype, stimulusTranscription profiling by array of FOXP3 overexpression in resting and activated mouse CD4+ T cells
Adjusted p-valueLog2-fold change
4.6655 × 10-71.3
Dusp1'anti-CD3/CSA' vs 'anti-CD3' in 'cyclosporine-resistant'phenotype, treatmentActivating CD8 T cell clones via the T cell receptor complex in the absence and presence of cyclosporine A
Adjusted p-valueLog2-fold change
3.0352 × 10-61.3
Dusp1'osteoblast culture 27 day' vs '0 day'timeTranscription profiling by array of mouse primary neonatal osteoblasts to study the regulation of bone mineralisation
Adjusted p-valueLog2-fold change
7.9276 × 10-6-1.3
Dusp1'Elp3fl/fl Trp53fl/fl vav-iCreT/+' vs 'Elp3fl/fl vav-iCreT/+' in 'myeloid lineage restricted progenitor cell'cell type, genotypeRNA-seq of long-term hematopoietic stem cells and myeloid progenitors of control mice or mice conditionally deficient for Trp53 or Elp3 or both genes in the hematopoietic system
Adjusted p-valueLog2-fold change
3.0882 × 10-51.3
Dusp1'postnatal day 21; hindlimb' vs 'embryonic day 17.5; whole forelimb and hindlimb'age, organism partExpression data from skeletal muscle satellite cells at different development stages
Adjusted p-valueLog2-fold change
3.4432 × 10-51.3
Dusp1'adult definitive erythroid cell' vs 'primitive erythroid cell' in 'basophilic erythroblast'cell type, phenotypeTranscription profiling by array of differentiating primary primitive and definitive mouse red blood cells
Adjusted p-valueLog2-fold change
8.3949 × 10-51.3
Dusp1'pre-B acute lymphoblastic leukemia 8093; nilotinib; 3 day' vs 'pre-B acute lymphoblastic leukemia 8093; nilotinib; 0 day'cell type, compound, timeDrug tolerance development of mouse Bcr/Abl pre-B ALL cells on irradiated MEFs
Adjusted p-valueLog2-fold change
1.3712 × 10-4-1.3
Dusp1'dominant active mutant DREAM transgenic' vs 'wild type'genotypeTranscription profiling by array of hippocampus from transgenic mice expressing a Ca2+-insensitive/CREB-independent dominant active mutant DREAM
Adjusted p-valueLog2-fold change
2.4682 × 10-41.3
Dusp1'confluent monolayer on collagen' at '1 day' vs 'freshly isolated' at '0 day'growth condition, timeTranscription profiling of primary mouse hepatocytes under different culture conditions
Adjusted p-valueLog2-fold change
2.7452 × 10-41.3
Dusp1'collagen sandwich' at '3 day' vs 'freshly isolated' at '0 day'growth condition, timeTranscription profiling of primary mouse hepatocytes under different culture conditions
Adjusted p-valueLog2-fold change
2.7693 × 10-41.3
Dusp1'phosgene - carbonyl chloride' at '1 hour' vs 'none' at '0 hour'compound, timeTranscription profiling of lung from mouse exposed to carbonyl chloride (phosgene) for different lengths of time to investigate the molecular mechanism of phosgene-induced lung injury
Adjusted p-valueLog2-fold change
3.1674 × 10-41.3
Dusp1'Escherichia coli O18:K1:H7; 2 hour' vs 'none; 0 hour' in 'C57BL/6J'infect, strain, timeGene Expression-Based Classifiers Identify Staphylococcus aureus Infection in Mice and Humans
Adjusted p-valueLog2-fold change
3.2913 × 10-4-1.3
Dusp1'co-culture' vs 'separate' in 'Ink4a/Arf-/-; EGFRvIII'genotype, growth conditionRNA-seq of wild-type and transformed Ink4a/Arf-/-; EGFRvIII neural stem cells in separate or co-culture conditions
Adjusted p-valueLog2-fold change
3.757 × 10-41.3
Dusp1'0.5 hour after induction of differentiation' vs 'induction of differentiation'compound, sampling time pointExpression Profiling of Early Myogenesis - Affymetrix Dataset
Adjusted p-valueLog2-fold change
4.5518 × 10-41.3
Dusp1'calorie restricted diet' vs 'normal diet' at '15 month'age, dietTranscription profiling by array of cochleae from mice fed a calorie-restricted diet
Adjusted p-valueLog2-fold change
1.4851 × 10-31.3
Dusp1'db/db' vs 'wild type genotype' in 'control miRNA; re-fed'RNA interference, diet, genotypeGene expression profiling of liver from C57BLKS/J and db/db 8 mice with an AAV harboring a control or GAbpa-specific miRNA under the LP1 promoter
Adjusted p-valueLog2-fold change
2.1664 × 10-3-1.3
Dusp1'R6/2 transgenic' vs 'wild type' in '12 week; striatum'age, genotype, organism partTranscription profiling by high throughput sequencing in wild type and R6/2 mutant mouse cortex and striatum at 8 and 12 weeks.
Adjusted p-valueLog2-fold change
2.9257 × 10-31.3
Dusp1'Staphylococcus aureus Sanger476; 2 hour' vs 'none; 0 hour' in 'C3H/HeJ'infect, strain, timeGene Expression-Based Classifiers Identify Staphylococcus aureus Infection in Mice and Humans
Adjusted p-valueLog2-fold change
5.2328 × 10-3-1.3
Dusp1'CFTR-; male; BALB' vs 'wild type; male; BALB'genotype, sex, strainTranscription profiling of lung from a mouse model of cystic fibrosis fromB6 and Balb strains vs wild type littermates to determine strain specific differences
Adjusted p-valueLog2-fold change
6.3053 × 10-3-1.3
Dusp1'expanded on HUVEC and m5GF in the presence of mD1R for 7 days' vs 'control'treatmentExpression data from cultured c-Kit+Sca-1+Lin- (KSL)cells
Adjusted p-valueLog2-fold change
8.0487 × 10-31.3
Dusp1'mPIN (mouse prostatic intraepithelial neoplasia)' vs 'normal'diseaseTranscription profiling by array of ventral prostates of wild type and p110 beta transgenic mice to investigate prostate cancer
Adjusted p-valueLog2-fold change
9.1325 × 10-31.3
Dusp1'follicle stimulating hormone and epidermal growth factor' vs '293H control medium'growth conditionTranscription profiling by array of mouse cumulus cells after culture with growth differentiation factor 9 or follicle stimulating hormone and epidermal growth factor
Adjusted p-valueLog2-fold change
1.4028 × 10-2-1.3
Dusp1'infarct and border region of left ventricle 5 days post-myocardial infarction; MRL/MpJ' vs 'left ventricle at baseline (no myocardial infarction) in the same region as the infarct in post-myocardial infarction hearts; MRL/MpJ'clinical information, strainExpression data from C57BL/6J and MRL/MpJ hearts following acute myocardial infarction
Adjusted p-valueLog2-fold change
1.9874 × 10-21.3
Dusp1'clear cell sarcoma; Rosa26CreER' vs 'control'disease, genotypeMouse Model of Clear Cell Sarcoma
Adjusted p-valueLog2-fold change
2.2623 × 10-2-1.3
Dusp1'promyelocyte' vs 'hemopoietic stem cell'cell typeGene expression data from mouse hemopoietic stem cells (LSKs), promyelocytes, myelocytes and granulocytes.
Adjusted p-valueLog2-fold change
2.4099 × 10-21.3
Dusp1'induction of polymicrobial sepsis' vs 'control' at '24 hour' in '20 to 24 month mice'age, time, treatmentAged Mice are Unable to Mount an Effective Myeloid Response to Sepsis
Adjusted p-valueLog2-fold change
2.9353 × 10-21.3
Dusp1'mutant MyoD expression' at '12 hour' vs 'control' at '12 hour'phenotype, timeTranscription profiling of mouse embryoic fibroblasts expressing wild type MyoD or its non-acetylatable version MyoD RRR to investigate how MyoD acetylation may contribute to differential gene activation.
Adjusted p-valueLog2-fold change
4.6213 × 10-2-1.3
Dusp1'ICG-001 and PHA665752' vs 'DMSO'compoundTranscription profiling by array of mammospheres derived from tumors of mice harboring Wnt/Met signaling mutations treated Wnt and MET pathway inhibitors
Adjusted p-valueLog2-fold change
4.9595 × 10-2-1.3
Dusp1'Cebpa L/L mutant' vs 'wild type'genotypeTranscription profiling by array of mouse LSK hematopoietic stem cells from Cebpa K/K, K/L, and L/L knock-in mutants
Adjusted p-valueLog2-fold change
2.4628 × 10-67-1.2
Dusp1'Debaryomyces hansenii' at '12 hour' vs 'none' at '0 hour'stimulus, timeRNA seq of mouse bone marrow derived macrophages treated with Debaryomyces hansenii against untreated controls
Adjusted p-valueLog2-fold change
7.7268 × 10-35-1.2
Dusp1'Follicular B cell' vs 'Pre-B cell' in 'wild type genotype; MHC II-positive'cell type, genotype, phenotypeEffect of MHC II expression in pro-B cells: Pre-B cells and follicular B cells from wild-type and MHC II conditional mice
Adjusted p-valueLog2-fold change
5.6043 × 10-291.2
Dusp1'PF-04691502–resistant cell; 1 micromolar; PF-04691502 removed for 48 hours' vs 'parental AKP cell; dimethyl sulfoxide'compound, phenotypeResistance to PI3K/mTOR inhibitor PF-04691502 in KRAS mutant colorectal cancer models reveals a sensitivity to combination with EGFR inhibition
Adjusted p-valueLog2-fold change
7.2831 × 10-20-1.2
Dusp1'Abcc8-/-' vs 'wild type genotype' in 'high fat; female'diet, genotype, sexEffects of increased intracellular calcium and overnutrition on pancreatic beta cell transcriptome
Adjusted p-valueLog2-fold change
4.826 × 10-171.2
Dusp1'overexpression of miR-25' vs 'wild type'phenotypeTranscription profiling by high throughput sequencing of wild type and miR-25 agomir or antagomir treated mice
Adjusted p-valueLog2-fold change
4.6834 × 10-151.2
Dusp1'postnatal day 60' vs 'postnatal day 1' in 'insulin-expressing immature beta cell'cell type, developmental stageTranscription profiling by high throughput sequencing of murine beta cells at key stages of maturation
Adjusted p-valueLog2-fold change
3.8659 × 10-8-1.2
Dusp1'21 percent oxygen, 37 degree Celsius, 10 percent serum' vs 'none'growth conditionRNA sequencing of native and ex vivo cultured murine tail tendon fascicles
Adjusted p-valueLog2-fold change
7.069 × 10-7-1.2
Dusp1'R6/2 transgenic' vs 'wild type' in '12 week; brain cortex'age, genotype, organism partTranscription profiling by high throughput sequencing in wild type and R6/2 mutant mouse cortex and striatum at 8 and 12 weeks.
Adjusted p-valueLog2-fold change
2.4096 × 10-61.2
Dusp1'Porphyromonas gingivalis; hyperlipidemia' vs 'normal'infect, phenotypehyperlipidemia impaired innate response
Adjusted p-valueLog2-fold change
6.1832 × 10-61.2
Dusp1'West Nile virus; late stage encephalitis' vs 'mock infection'infect, timeTranscriptomic profiling of the brains of WNV and CHIKV infection-induced encephalitis in young mice after 2, 3 or 5 days post infection
Adjusted p-valueLog2-fold change
1.2279 × 10-51.2
Dusp1'West Nile virus; late stage encephalitis' vs 'early stage encephalitis'infect, timeTranscriptomic profiling of the brains of WNV and CHIKV infection-induced encephalitis in young mice after 2, 3 or 5 days post infection
Adjusted p-valueLog2-fold change
1.4362 × 10-5-1.2
Dusp1'9 day' vs '3 day'timeTranscription profiling time series of mouse embryonic chondrocyte differentiation
Adjusted p-valueLog2-fold change
3.3266 × 10-5-1.2
Dusp1'M-CSF and FSL-1' at '6 day' vs 'none' at '0 day'compound, timeMicroarray profiling of polyploid macrophage progeny
Adjusted p-valueLog2-fold change
3.8597 × 10-5-1.2
Dusp1'14 days P. chabaudi infected' vs 'uninfected' in 'intact male'clinical information, disease, sex, timeTranscription profiling by array of mice infected with Plasmodium chabaudi after gonadectomization to investigate involvement of gonadal steroids
Adjusted p-valueLog2-fold change
6.8437 × 10-5-1.2
Dusp1'homozygous RYR1 mutant' vs 'RYR1 wild type' in 'embryonic day 14.5'developmental stage, genotypeMicroarrays of mouse embryonic limb skeletal muscle at days E14.5 and E18.5 lacking the RYR1 or Cav1.1 Ca2+ channels
Adjusted p-valueLog2-fold change
1.6442 × 10-41.2
Dusp1'subconfluent monolayer on collagen' at '2 day' vs 'freshly isolated' at '0 day'growth condition, timeTranscription profiling of primary mouse hepatocytes under different culture conditions
Adjusted p-valueLog2-fold change
1.6612 × 10-4-1.2
Dusp1'100 unit per milliliter interferon gamma' vs 'DMSO'compoundDissecting primary (translation independent) from secondary (translation dependent) IFN-mediated differential gene expression
Adjusted p-valueLog2-fold change
2.4402 × 10-41.2
Dusp1'subconfluent monolayer on collagen' at '5 day' vs 'freshly isolated' at '0 day'growth condition, timeTranscription profiling of primary mouse hepatocytes under different culture conditions
Adjusted p-valueLog2-fold change
2.5542 × 10-4-1.2
Dusp1'Il10-/-' vs 'wild type genotype' in 'none'compound, genotypeRNA-seq analysis of colonic intestinal epithelial cells (IECs) isolated from naive wild-type C57BL/6 mice, DSS-treated wild-type C57BL/6 mice, Il10-/- C57BL/6 mice and Il10-/- C57BL/6 mice with IEC-specific Rabgef1 deletion
Adjusted p-valueLog2-fold change
4.3325 × 10-41.2
Dusp1'Rb;E2f8 knock-out' vs 'wild type'genotypeExpression data from WT, E2f8 KO, Rb KO and Rb;E2f8 DKO spleen Ter19+CD71high sorted cells
Adjusted p-valueLog2-fold change
4.4461 × 10-41.2
Dusp1'Rorc homozygous knockout' vs 'wild type phenotype' in 'methotrexate; first dose 120 milligram per kilogram; second dose 60 milligram per kilogram' at '1 day'compound, phenotype, stimulus, timeRNA-seq of mouse crypts to investigate Rorc gamma t-deficient mice tissue repair compared to wild type controls
Adjusted p-valueLog2-fold change
5.2598 × 10-4-1.2
Dusp1'high fat diet' vs 'chow diet' in 'SHP knockout'genotype, growth conditionTranscription profiling of small heterodimer partner deficiency (SHP) knockout mice heart
Adjusted p-valueLog2-fold change
5.6633 × 10-41.2
Dusp1'confluent monolayer on collagen' at '2 day' vs 'freshly isolated' at '0 day'growth condition, timeTranscription profiling of primary mouse hepatocytes under different culture conditions
Adjusted p-valueLog2-fold change
7.294 × 10-41.2
Dusp1'serrated polyp' vs 'normal surrounding (distal) cecum'clinical informationInterplay of host microbiota, genetic perturbations, and inflammation promote local development of intestinal neoplasms in mice
Adjusted p-valueLog2-fold change
7.599 × 10-4-1.2
Dusp1'swimming twice a day' at '4 week' vs 'control'time, treatmentTranscription profiling of heart ventricles from mice that have cardiac hypertrophy induced by swimming training
Adjusted p-valueLog2-fold change
7.6887 × 10-41.2
Dusp1'heat-shocked at 42 degreeC' vs 'grown at 33 degreeC' in 'wild type'genotype, growth conditionTranscription profiling by array of mouse wild type and Htt mutant striatal cells upon heat shock
Adjusted p-valueLog2-fold change
8.2065 × 10-41.2
Dusp1'recombinant human interleukin-2; 100 unit per milliliter; 6 hour' vs 'control; 0 hour'compound, timeTranscription profiling by array of mouse CTLL-2 cell line treated with recombinant human interleukin-2
Adjusted p-valueLog2-fold change
1.2381 × 10-3-1.2
Dusp1'methionine- and choline-deficient, high fat diet mixed with 0.1% metformin' vs 'normal'dietExpression data from mouse liver treated with metformin
Adjusted p-valueLog2-fold change
5.3971 × 10-3-1.2
Dusp1'conditional Kras and p53 mutation induced soft tissue sarcoma' vs 'normal'diseaseTranscription profiling by array of mouse soft tissue sarcoma samples induced by conditional mutations of Kras and p53 against healthy muscles from mice of the same genotype but no induced sarcoma
Adjusted p-valueLog2-fold change
1.3174 × 10-21.2
Dusp1'cecal ligation and puncture surgery' vs 'sham surgery' in 'PPTA knockout'clinical treatment, genotypeGene expression profile in lung tissue 8 h after inducing polymicrobial sepsis in preprotachykinin-A (PPTA) knockout mice and wild type
Adjusted p-valueLog2-fold change
1.6769 × 10-21.2
Dusp1'Chromogranin A knockout' vs 'wild type genotype'genotypeLiver gene expression from chromogranin A knockout mice (Mahapatra et al. 2005) vs. wild-type mice
Adjusted p-valueLog2-fold change
1.7427 × 10-2-1.2
Dusp1'2.8 microgram per day adrenocorticotropic hormone' vs 'none'compoundTranscription profiling by array of mouse kidneys after chronic adrenocorticotropic hormone treatment
Adjusted p-valueLog2-fold change
1.8623 × 10-2-1.2
Dusp1'2,3-Benzofuran; 240 milligram per kilogram; corn oil' vs 'none; ; corn oil'compound, treatmentTranscription profiling by array of Mus musculus liver tissue after exposure to various carcinogenic chemicals
Adjusted p-valueLog2-fold change
2.5189 × 10-2-1.2
Dusp1'essential fatty acid deficient' vs 'control'dietLiver mRNA microarray study for mice treated with various diets
Adjusted p-valueLog2-fold change
2.8384 × 10-21.2
Dusp1'Ezh2 knockout' vs 'control'genotypeExpression profiling of secondary wild type (WT) and Ezh2-null murine MLL-AF9 AML
Adjusted p-valueLog2-fold change
3.6979 × 10-2-1.2
Dusp1'Cebpa K/K mutant' vs 'wild type'genotypeTranscription profiling by array of mouse LSK hematopoietic stem cells from Cebpa K/K, K/L, and L/L knock-in mutants
Adjusted p-valueLog2-fold change
4.3755 × 10-2-1.2
Dusp1'polysomal RNA; HRasV12 and c-Myc overexpression and Eif4e heterozygous knockout' vs 'polysomal RNA; wild type'fraction, genotypeRedefining the role of eIF4E dose in development, cancer, and protein synthesis
Adjusted p-valueLog2-fold change
4.4803 × 10-21.2
Dusp1'S6K1 knockout' vs 'wild type' in 'liver'genotype, organism partTranscription profiling of mouse long-lived S6K1 -/- strain females compared to wild types
Adjusted p-valueLog2-fold change
2.2776 × 10-221.1
Dusp1'nuclear translocation of Mbd3b' at '48 hour' vs 'none' at '0 hour'stimulus, timeTranscription profiling by RNA-seq during NuRD complex induction in mouse embryonic stem cells
Adjusted p-valueLog2-fold change
6.9942 × 10-18-1.1
Dusp1'induced neuronal cell' vs 'pluripotent embryonic stem cell'phenotypeTranscription profiling by high throughput sequencing of retinoic acid-differentiated neuronal cells compared to nondifferentiated pluripotent embryonic stem cells
Adjusted p-valueLog2-fold change
3.7745 × 10-12-1.1
Dusp1'Ffar3 knockout' vs 'wild type'genotypeTranscription profiling by high throughput sequencing of pancreatic islets isolated from free fatty acid receptor 3 knockout (Ffar3 KO) and wild type (Ffar3 WT) male mice
Adjusted p-valueLog2-fold change
6.4625 × 10-11-1.1
Dusp1'none; XPF knockout' vs 'all-trans-retinoic acid; 10 micromolar; wild type genotype'compound, genotypeRNA-seq of mouse DNA repair endonuclease XPF knock out versus wild type and versus trans retinoic acid (tRA) treated wild type
Adjusted p-valueLog2-fold change
6.8688 × 10-10-1.1
Dusp1'non-pregnant' vs 'pregnant'clinical informationRNA-seq of pancreatic islets from pregnant mice
Adjusted p-valueLog2-fold change
1.3819 × 10-71.1
Dusp1'tamoxifen induction at 2 months, wait 6 months' vs 'no tamoxifen induction' in 'basal cell of prostate epithelium; CK5-CreERT2 transgenic line'cell type, genotype, growth conditionTranscription profiling by high throughput sequencing of PIN/tumor lesions from basal or luminal origins at time points at which mice displayed similar histopathological phenotypes
Adjusted p-valueLog2-fold change
1.5711 × 10-71.1
Dusp1'Kit ligand; wasp knockout' vs 'Kit ligand; wild type'compound, genotypeTranscription profiling of bone marrow–derived mast cells from WASP-deficient mice after stimulation with kit ligand
Adjusted p-valueLog2-fold change
1.5016 × 10-6-1.1
Dusp1'6 day' vs '0 day'ageTranscription profiling of mouse embyronic stem cell line CGR8 during the first 10 days of differentiation into embryoid bodies
Adjusted p-valueLog2-fold change
1.2617 × 10-51.1
Dusp1'Bcl6 +/+ BCR-ABL1-transformed B cell precursors; STI571 treated' vs 'Bcl6 +/+ BCR-ABL1-transformed B cell precursors; untreated'cell type, treatmentGene expression data of BCR-ABL1 transformed B cell precursors from BCL6 wild-type and BCL6 knockout mice
Adjusted p-valueLog2-fold change
1.413 × 10-51.1
Dusp1'Runx1 knockdown; none' vs 'wild type; none'genotype, stimulusTranscription profiling by array of Mouse erythro-leukaemia cells during differentiation to investigate the influence of Runx1 transcription factor
Adjusted p-valueLog2-fold change
2.0116 × 10-51.1
Dusp1'Panct1' vs 'non-targeting siRNA'RNA interferenceA combined RNAi and localization approach for dissecting long noncoding RNAs reveals a function of Panct1 in ES cells
Adjusted p-valueLog2-fold change
2.4955 × 10-5-1.1
Dusp1'MED23 knockout' vs 'wild type'genotypeMediator Med23-deficiency Enhances Neural Differentiation of Embryonic Stem Cells through Modulating BMP Signaling
Adjusted p-valueLog2-fold change
3.6444 × 10-51.1
Dusp1'shRNA mediated Brd4 knockdown' vs 'control shRNA'treatmentExpression Data For BRD4 Inhibition
Adjusted p-valueLog2-fold change
7.5868 × 10-51.1
Dusp1'phosgene - carbonyl chloride' at '4 hour' vs 'air' at '4 hour'compound, timeTranscription profiling of lung from mouse exposed to carbonyl chloride (phosgene) for different lengths of time to investigate the molecular mechanism of phosgene-induced lung injury
Adjusted p-valueLog2-fold change
1.1189 × 10-41.1
Dusp1'UV' vs 'sham' in 'DMSO' at '6 hour'irradiate, timeTranscription profiling by array of mouse dorsal skin exposed to UV radiation vs controls in mice treated with DMSO or selective tyrosine kinase inhibitor AG825
Adjusted p-valueLog2-fold change
1.2277 × 10-4-1.1
Dusp1'wild type; ethanol and ellagic acid' vs 'wild type; control'genotype, treatmentNuclear receptor-mediated alleviation of alcoholic fatty liver by polyphenols contained in alcoholic beverages
Adjusted p-valueLog2-fold change
1.6187 × 10-4-1.1
Dusp1'cut nerve; 7 day' vs 'none'injury, protocol, timeChanges in the coding/non-coding transcriptome and DNA methylome that define the Schwann cell repair phenotype after nerve injury
Adjusted p-valueLog2-fold change
1.9017 × 10-41.1
Dusp1'mutant MyoD expression' at '6 hour' vs 'control' at '6 hour'phenotype, timeTranscription profiling of mouse embryoic fibroblasts expressing wild type MyoD or its non-acetylatable version MyoD RRR to investigate how MyoD acetylation may contribute to differential gene activation.
Adjusted p-valueLog2-fold change
2.7137 × 10-4-1.1
Dusp1'chlorpyrifos; 0.5 milligram per kilogram per day; tgHuPON1Q192' vs 'chlorpyrifos; 0.5 milligram per kilogram per day; wild type'compound, genotypeTranscription profiling by array of mouse cerebellum mutant for Pon1 after treatment with chlorpyrifos
Adjusted p-valueLog2-fold change
3.6998 × 10-4-1.1
Dusp1'14 days P. chabaudi infected' vs 'uninfected' in 'intact female'clinical information, disease, sex, timeTranscription profiling by array of mice infected with Plasmodium chabaudi after gonadectomization to investigate involvement of gonadal steroids
Adjusted p-valueLog2-fold change
5.2576 × 10-4-1.1
Dusp1'Il10-/-; Rabgef1 IEC-KO' vs 'wild type genotype' in 'none'compound, genotypeRNA-seq analysis of colonic intestinal epithelial cells (IECs) isolated from naive wild-type C57BL/6 mice, DSS-treated wild-type C57BL/6 mice, Il10-/- C57BL/6 mice and Il10-/- C57BL/6 mice with IEC-specific Rabgef1 deletion
Adjusted p-valueLog2-fold change
6.6156 × 10-41.1
Dusp1'E2f8 knock-out' vs 'wild type'genotypeExpression data from WT, E2f8 KO, Rb KO and Rb;E2f8 DKO spleen Ter19+CD71high sorted cells
Adjusted p-valueLog2-fold change
7.5758 × 10-4-1.1
Dusp1'artesunate and chloroquine (at same dosage); 30 milligram per kilogram' at '10 day' vs 'none' at '7 day' in 'Plasmodium berghei ANKA'compound, infect, sampling time pointRNA-seq analysis of anti-malarial drug chemotherapy of murine experimental Cerebral Malaria (ECM)
Adjusted p-valueLog2-fold change
1.5105 × 10-3-1.1
Dusp1'organoid culture without Noggin (ER medium)' vs 'organoid culture (ENR medium)' in 'none'growth condition, stimulusRNA-seq of small intestinal organoids treated with the control medium ENR (EGF, Noggin, R-spondin1) in the presence or absence of muscle supernatant
Adjusted p-valueLog2-fold change
1.9223 × 10-31.1
Dusp1'0.5 day' vs '0 day' on 'Affymetrix Mouse430A_2 Array'timeTranscription profiling of murine R1 embryonic stem cells differentiating into embryoid bodies over a time-course to study changes in transcription during stem cell differentiation
Adjusted p-valueLog2-fold change
2.148 × 10-3-1.1
Dusp1'interleukin-1 beta (Mus musculus)' at '1 hour' vs 'control' at '1 hour'stimulus, timeGenome-wide comparison between IL-17 and combined TNF-alpha/ IL-17 induced genes in primary murine hepatocytes
Adjusted p-valueLog2-fold change
2.4913 × 10-3-1.1
Dusp1'conditional UPF2 knockout; 36 hour after partial hepatechtomy' vs 'control; 36 hour after partial hepatechtomy'genotype, sampling timeTranscription profiling of livers of adult UPF2 null mice in response to partial hepatechtomy
Adjusted p-valueLog2-fold change
2.899 × 10-31.1
Dusp1'Tgfb1 heterozygote; 0.1 Gray' at '4 week' vs 'wild type; 0.1 Gray' at '4 week'genotype, irradiate, timeGene expression profile in Tgfb1 heterozygote and wild type mouse mammay glands, after whole body exposure to an acute dose of 10cGy ionizing radiation
Adjusted p-valueLog2-fold change
4.0841 × 10-31.1
Dusp1'cecal ligation and puncture surgery' vs 'sham surgery' in 'wild type'clinical treatment, genotypeGene expression profile in lung tissue 8 h after inducing polymicrobial sepsis in preprotachykinin-A (PPTA) knockout mice and wild type
Adjusted p-valueLog2-fold change
4.2864 × 10-31.1
Dusp1'oxygen/glucose-deprivation followed by restoration of oxygen/glucose' vs 'none' in 'wild type genotype; undifferentiated'genotype, growth condition, stimulusSUMOylation promotes survival and integration of neural stem cell grafts in stroke
Adjusted p-valueLog2-fold change
5.7324 × 10-3-1.1
Dusp1'scrapie ME7 inoculated' at '90 day' vs 'none' at '0 day'infect, timeTranscription profiling by array of brains from mice infected with scrapie ME7
Adjusted p-valueLog2-fold change
6.1007 × 10-31.1
Dusp1'Chromogranin A knockout' vs 'wild type genotype'genotypeTranscription profiling by array of adreanal gland samples from chromogranin A knockout mice vs wild-type controls
Adjusted p-valueLog2-fold change
6.8977 × 10-3-1.1
Dusp1'CD34+ keratinocyte' vs 'CD34-keratinocyte'cell typeAkt signalling leads to stem cell activation and promotes tumour development in epidermis.
Adjusted p-valueLog2-fold change
8.1279 × 10-31.1
Dusp1'CpG ODN' vs 'PBS' at '24 hour'compound, timeTranscription profiling by array of mouse vaginal samples following adjuvant treatment
Adjusted p-valueLog2-fold change
8.7539 × 10-3-1.1
Dusp1'Mycobacterium tuberculosis; D2.B6-Chr7 congenic; 70 day' vs 'control; D2.B6-Chr7 congenic; 0 day'infect, strain, timeTranscription profiling of mouse lung from C57BL6 and DBA2 parental strains and D2.B6-Chr7 and D2.B6-Chr19 congenic mice following aerosol infection with Mycobacterium tuberculosis for 30 and 70 days
Adjusted p-valueLog2-fold change
1.689 × 10-2-1.1
Dusp1'hepatocyte-specific Pten and Tgfbr2 knockout' vs 'wild type'genotypeHepatocyte-specific knockout of Pten and of Pten and Tgfbr2 in mice
Adjusted p-valueLog2-fold change
2.496 × 10-2-1.1
Dusp1'L-Pex5 knock-out' vs 'wild type'genotypeTranscription profiling by array of liver from L-Pex5 knock-out mice
Adjusted p-valueLog2-fold change
2.6497 × 10-21.1
Dusp1'Alb-Cre;HIF1dPA/HIF2dPA' vs 'Alb-Cre'genotypeTranscription profiling by array of mice with liver-specific expression of hypoxia inducible factor, or inactivated von Hippel-Lindau tumor suppressor
Adjusted p-valueLog2-fold change
2.8938 × 10-21.1
Dusp1'Alb-Cre;HIF2dPA' vs 'Alb-Cre'genotypeTranscription profiling by array of mice with liver-specific expression of hypoxia inducible factor, or inactivated von Hippel-Lindau tumor suppressor
Adjusted p-valueLog2-fold change
2.9553 × 10-21.1
Dusp1'recombinant human interleukin-2; 100 unit per milliliter; 10 hour' vs 'control; 0 hour'compound, timeTranscription profiling by array of mouse CTLL-2 cell line treated with recombinant human interleukin-2
Adjusted p-valueLog2-fold change
3.7371 × 10-21.1
Dusp1'Elk/Sap double knockout; stimulated with plate-bound alphaCD3 for 30 min' vs 'Elk/Sap double knockout; none'genotype, stimulusGene expression analysis of double positive T cells from different genotypes, unstimulated or stimulated with plate-bound alphaCD3 for 30 min
Adjusted p-valueLog2-fold change
3.9475 × 10-2-1.1
Dusp1'control mice [Gp130f/f]; cecal ligation and puncture' vs 'control mice [Gp130f/f]; control'genotype, treatmentHepatic acute phase proteins control innate immune responses during infection by promoting myeloid derived suppressor cell function
Adjusted p-valueLog2-fold change
4.143 × 10-21.1
Dusp1'UV' vs 'sham' in 'AG825' at '6 hour'irradiate, timeTranscription profiling by array of mouse dorsal skin exposed to UV radiation vs controls in mice treated with DMSO or selective tyrosine kinase inhibitor AG825
Adjusted p-valueLog2-fold change
4.4041 × 10-21.1
Dusp1'Albumin Cre+/-;Hnf4a fl/fl' vs 'wild type genotype'genotypeTranscription profiling by array of liver-specific Hnf4alpha knock-out mice
Adjusted p-valueLog2-fold change
4.8695 × 10-21.1
Dusp1'KDM4C knock-down' vs 'wild type genotype' in 'mixed-lineage leukemia'clinical history, genotypeTargeting epigenetic networks mediated by Prmt1 and Kdm4c in acute myeloid leukemia
Adjusted p-valueLog2-fold change
5.481 × 10-421
Dusp1'Mettl6 knockout clone D1' vs 'wild type genotype'genotypeMETTL6 is a tRNA m3C methyltransferase that regulates translation and tumor cell proliferation
Adjusted p-valueLog2-fold change
1.1077 × 10-201
Dusp1'129S1 allele at SNP rs50454566' vs 'wild type genotype'genotypeRNA-Seq of mouse embryonic stem cells derived from genetically diverse inbred mouse strains with varying alleles at Lifr gene
Adjusted p-valueLog2-fold change
8.8484 × 10-151
Dusp1'8.5 millimolar; methoxyacetic acid' vs 'none' at '24 hour'compound, timeTranscription profiling by array of mouse embryonic stem cells after treatment with 5-fluourouracil, methoxyacetic acid, monobutl phthalate, Penicillin G, retinoic acid or valproic acid
Adjusted p-valueLog2-fold change
5.4209 × 10-91
Dusp1'trans-tympanically injected with Hemophilus influenza' vs 'control'treatmentOtitis Media Impact on Middle Ear
Adjusted p-valueLog2-fold change
2.327 × 10-71
Dusp1'26 day' vs '0 day'ageGene expression profile of mouse differentiating embryonic stem cells (day 0, 6, 16, and 26)
Adjusted p-valueLog2-fold change
3.4301 × 10-7-1
Dusp1'CD36 knockout' vs 'wild type genotype' in 'oxidized low density lipoprotein; 25 microgram per milliliter'compound, genotypeQuantitative analysis of wild type and cd36-/- murine peritoneal macrophage transcriptomes
Adjusted p-valueLog2-fold change
1.7831 × 10-6-1
Dusp1'7 days P. chabaudi infected' vs 'uninfected' in 'gonadectomized female'clinical information, disease, sex, timeTranscription profiling by array of mice infected with Plasmodium chabaudi after gonadectomization to investigate involvement of gonadal steroids
Adjusted p-valueLog2-fold change
2.1026 × 10-6-1
Dusp1'5 day' vs '0 day'ageTranscription profiling of mouse embyronic stem cell line CGR8 during the first 10 days of differentiation into embryoid bodies
Adjusted p-valueLog2-fold change
4.5535 × 10-6-1
Dusp1'mutant MyoD expression' at '12 hour' vs 'wild type MyoD expression' at '0 hour'phenotype, timeTranscription profiling of mouse embryoic fibroblasts expressing wild type MyoD or its non-acetylatable version MyoD RRR to investigate how MyoD acetylation may contribute to differential gene activation.
Adjusted p-valueLog2-fold change
1.4495 × 10-51
Dusp1'MEF; transduced with NeuroD2 lentivirus' vs 'MEF; control'cell line, treatmentGenetic and epigenetic determinants of neurogenesis and myogenesis [expression profiling]
Adjusted p-valueLog2-fold change
2.8925 × 10-5-1
Dusp1'Id2_Id3_double knockout' vs 'wild type' in 'CD4+TCRb+CD8– cell; thymus'cell type, genotype, organism partTranscription profiling by high throughput sequencing of Id-proteins (Id2 and Id3) gene knockout cells
Adjusted p-valueLog2-fold change
3.2712 × 10-5-1
Dusp1'14 days P. chabaudi infected' vs 'uninfected' in 'gonadectomized male'clinical information, disease, sex, timeTranscription profiling by array of mice infected with Plasmodium chabaudi after gonadectomization to investigate involvement of gonadal steroids
Adjusted p-valueLog2-fold change
4.4582 × 10-5-1
Dusp1'HDM allergen; IL-13 knockout' vs 'PBS control; IL-13 knockout' on 'Affymetrix MOE430A Array'compound, genotypeTranscription profiling of wild type and IL13 knock out mice treated with allergen vs. control to investigate the IL13 role in allergic asthma
Adjusted p-valueLog2-fold change
4.6369 × 10-51
Dusp1'Porphyromonas gingivalis; normal' vs 'normal'infect, phenotypehyperlipidemia impaired innate response
Adjusted p-valueLog2-fold change
4.6506 × 10-51
Dusp1'estradiol' at '14 hour' vs 'none' at '0 hour'compound, timeTranscription profiling by array of G1E cells during time course treatment with estradiol.
Adjusted p-valueLog2-fold change
7.7527 × 10-5-1
Dusp1'heterozygous RYR1 mutant' vs 'RYR1 wild type' in 'embryonic day 14.5'developmental stage, genotypeMicroarrays of mouse embryonic limb skeletal muscle at days E14.5 and E18.5 lacking the RYR1 or Cav1.1 Ca2+ channels
Adjusted p-valueLog2-fold change
9.8544 × 10-51
Dusp1'7-ketocholesterol' vs 'vehicle (cyclodextrin)'compound, timeArray results for differential gene expression in 661W, a mouse cone photoreceptor-derived cell line, comparing cells incubated with vehicle controls vs. those treated with either of two 7-dehdyrocholesterol-derived oxysterols or cholesterol
Adjusted p-valueLog2-fold change
3.7693 × 10-4-1
Dusp1'heart-specific p53 and Mdm2 knockout; 7 day' vs 'heart-specific p53 and Mdm2 knockout; 1 day'phenotype, timeTranscription profiling of heart tissue from mice with heart-specific knockout of p53 and Mdm2
Adjusted p-valueLog2-fold change
4.4961 × 10-4-1
Dusp1'transplanted secondary tumors' vs 'normal' in 'kidney'clinical information, organism partPremature termination of in vivo reprogramming leads to cancer development through altered epigenetic regulation [array]
Adjusted p-valueLog2-fold change
4.6639 × 10-41
Dusp1'confluent monolayer on collagen' at '3 day' vs 'freshly isolated' at '0 day'growth condition, timeTranscription profiling of primary mouse hepatocytes under different culture conditions
Adjusted p-valueLog2-fold change
4.7029 × 10-4-1
Dusp1'smoke; 3000 microgram' vs 'control; 0 microgram' in 'wild type' at 'after 5 month exposure and 1 day post-exposure'compound, genotype, sampling time pointTranscription profiling by array of Nrf2 knockout mice exposed to cigarette smoke
Adjusted p-valueLog2-fold change
5.6392 × 10-41
Dusp1'0.75 day' vs '0 day' on 'Affymetrix Mouse430A_2 Array'timeTranscription profiling of murine R1 embryonic stem cells differentiating into embryoid bodies over a time-course to study changes in transcription during stem cell differentiation
Adjusted p-valueLog2-fold change
5.87 × 10-41
Dusp1'confluent monolayer on collagen' at '5 day' vs 'freshly isolated' at '0 day'growth condition, timeTranscription profiling of primary mouse hepatocytes under different culture conditions
Adjusted p-valueLog2-fold change
5.9419 × 10-41
Dusp1'subconfluent monolayer on collagen' at '7 day' vs 'freshly isolated' at '0 day'growth condition, timeTranscription profiling of primary mouse hepatocytes under different culture conditions
Adjusted p-valueLog2-fold change
6.7509 × 10-41
Dusp1'tristetrapolin knockout' vs 'wild type' in 'actinomycin D' at '90 minute'compound, genotype, timeTranscription profiling by array of fibroblasts from TTP knock out mice
Adjusted p-valueLog2-fold change
7.4966 × 10-4-1
Dusp1'neurosphere in differentiation medium; 1 day' vs 'neurosphere; 0 day' in 'wild type genotype'genotype, growth condition, timeTranscriptome analysis of neurospheres derived from Cstb-KO mouse embryo brains during differentiation
Adjusted p-valueLog2-fold change
7.8336 × 10-4-1
Dusp1'smoke; 2250 microgram' vs 'control; 0 microgram' in 'wild type' at 'after 5 month exposure and 1 day post-exposure'compound, genotype, sampling time pointTranscription profiling by array of Nrf2 knockout mice exposed to cigarette smoke
Adjusted p-valueLog2-fold change
1.0323 × 10-31
Dusp1'subconfluent monolayer on collagen' at '3 day' vs 'freshly isolated' at '0 day'growth condition, timeTranscription profiling of primary mouse hepatocytes under different culture conditions
Adjusted p-valueLog2-fold change
1.2473 × 10-31
Dusp1'phosgene - carbonyl chloride' at '8 hour' vs 'air' at '8 hour'compound, timeTranscription profiling of lung from mouse exposed to carbonyl chloride (phosgene) for different lengths of time to investigate the molecular mechanism of phosgene-induced lung injury
Adjusted p-valueLog2-fold change
1.7001 × 10-3-1
Dusp1'smoke; 2250 microgram' vs 'control; 0 microgram' in 'Nrf2 knockout' at 'after 2 month exposure'compound, genotype, sampling time pointTranscription profiling by array of Nrf2 knockout mice exposed to cigarette smoke
Adjusted p-valueLog2-fold change
2.137 × 10-31
Dusp1'hepatocyte-derived proliferative ducts (hepPDs)' vs 'biliary-derived proliferative ducts (bilDP)'cell typeTranscription profiling by high throughput sequencing of hepatocyte-derived progenitors cells in a mouse model of oval cell activation
Adjusted p-valueLog2-fold change
2.197 × 10-3-1
Dusp1'SMAD2; TGF beta 1; 5 nanogram per milliliter' vs 'SMAD2; vehicle; 5 nanogram per milliliter'RNA interference, compoundtranscription profiling by array mouse mammary epithelial cells treated with TGF-beta to induce epithelial-to-mesenchymal transition
Adjusted p-valueLog2-fold change
2.8916 × 10-31
Dusp1'SHP knockout' vs 'wild type' in 'chow diet'genotype, growth conditionTranscription profiling of small heterodimer partner deficiency (SHP) knockout mice heart
Adjusted p-valueLog2-fold change
4.2222 × 10-31
Dusp1'CpG ODN' vs 'PBS' at '4 hour'compound, timeTranscription profiling by array of mouse vaginal samples following adjuvant treatment
Adjusted p-valueLog2-fold change
4.3402 × 10-31
Dusp1'actinomycin D; 8 hour' vs 'none' in 'Cnot1 flox/flox'compound, genotype, timeRNA-seq of livers in control and Cnot1 tamoxifen-inducible liver-specific knockout mice
Adjusted p-valueLog2-fold change
4.3521 × 10-3-1
Dusp1'10 nanogram per milliliter; TGF-beta1' vs 'none' in 'multipotent progenitor' at '24 hour'cell type, compound, timeDynamic Gene Expression Response to TGF-b Stimulation in Multipotent Progenitors and Common Dendritic Cell Progenitors
Adjusted p-valueLog2-fold change
4.4611 × 10-31
Dusp1'E14_STAT3_ER; leukemia inhibitor factor; 10000 unit per milliliter' vs 'E14_STAT3_ER; none; 'cell line, compoundTranscription profiling of mouse embryonic stem cells to identify genes regulated by STAT3 and NANOG, known differentiation inhibitors
Adjusted p-valueLog2-fold change
4.4811 × 10-31
Dusp1'gamma radiation; 8 Gray' vs 'none' in 'Lgr5-Cre-ERT2; Il22-/-'genotype, irradiateRNA Seq of colonic Lgr5+ epithelial stem cells in Il22+/+ and Il22-/- mice during homeostasis and 24h after irradiation with 8 Gy
Adjusted p-valueLog2-fold change
6.3158 × 10-3-1
Dusp1'B4053; RML infected' at '6 week' vs 'B4053; uninfected' at '6 week'strain, time, treatmentTranscription profiling of mouse brain infected with prions in eight mouse-prion strain combinations in a systems approach to the study of prion disease
Adjusted p-valueLog2-fold change
8.3671 × 10-31
Dusp1'brown adipose tissue' vs 'white adipose tissue' in 'chow; 23 degree celsius'diet, organism part, temperatureRNA-seq of brown and white mouse adipose tissue at thermoneutrality and high-fat diet
Adjusted p-valueLog2-fold change
9.1046 × 10-31
Dusp1'control; 36 hour after partial hepatechtomy' vs 'control; before partial hepatechtomy'genotype, sampling timeTranscription profiling of livers of adult UPF2 null mice in response to partial hepatechtomy
Adjusted p-valueLog2-fold change
1.1318 × 10-21
Dusp1'anti-mPDL1; anti-mCTLA4; 10 milligram per kilogram' vs 'none' at '7 day'compound, timeRNAseq of tumor samples from CT26 syngeneic mouse treated with a PD-L1 and CTLA-4 immunotherapy combination
Adjusted p-valueLog2-fold change
1.5133 × 10-2-1
Dusp1'chlorpyrifos; 0.5 milligram per kilogram per day; tgHuPON1Q192' vs 'DMSO; ; tgHuPON1Q192'compound, genotypeTranscription profiling by array of mouse cerebellum mutant for Pon1 after treatment with chlorpyrifos
Adjusted p-valueLog2-fold change
1.5352 × 10-2-1
Dusp1'Stat5a (Stat5abnull/Stat5b-)' vs 'wild type' at 'pregnancy'genotype, sampling time pointTranscription profiling by high throughput sequencing of mouse wild type and Stat5-mutant mammary tissues at parturition and early pregnancy
Adjusted p-valueLog2-fold change
1.8412 × 10-21
Dusp1'Gabpa miRNA' vs 'control miRNA' in 'db/db; re-fed'RNA interference, diet, genotypeGene expression profiling of liver from C57BLKS/J and db/db 8 mice with an AAV harboring a control or GAbpa-specific miRNA under the LP1 promoter
Adjusted p-valueLog2-fold change
2.3156 × 10-2-1
Dusp1'liver-specific Pit1 knockout' vs 'wild type genotype' in 'high fat diet'diet, genotypeTranscription profiling by array of liver tissues from mice with liver-specific knockout of Pit1 and wild-type littermates fed with either a high-fat diet or chow control diet
Adjusted p-valueLog2-fold change
2.9324 × 10-21
Dusp1'5-aza-2'-deoxycytidine; 5 micromolar' vs 'none'compoundTranscription profiling by array of mouse primary dermal fibroblasts after treatment with 5-aza-2'-deoxycytidine
Adjusted p-valueLog2-fold change
3.4384 × 10-21
Dusp1'tape stripping' vs 'control'treatmentTranscription profiling by array of mouse dorsal skin after tape stripping and treatment with winged bean extract.
Adjusted p-valueLog2-fold change
4.5885 × 10-21
Dusp1'NEMO knockout' vs 'wild type'genotypeTNFR1 controls apoptosis and chronic liver disease in hepatocyte-specific IKKγ (Nemo) mice.
Synonym
erp, 3CH134, mkp-1, MKP1, Ptpn16
Ortholog
Gene ontology
InterPro
Ensembl gene
Ensembl transcript
Ensembl protein
Entrez
UniProt
MGI ID (Mouse)
MGI description
Gene biotype
Design element
1448830_at, 10449289, 4417323, 17342642, 4711471, X61940_s_at, 4417291, 1454277_at, 5236163, Msa.40398.0_s_at, 10449284, 4926931, 17342650, 4776376, 5516053, 4870707, 5393121, ILMN_2622983, 104598_at, 4404494, A_55_P2027678, ILMN_2416897, 4357068, 5132063
Reactome pathway ID