ensmusg00000005357 (Slc1a6)

mus musculus

solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6

Filter your results

Mus musculus
Organism part
Showing 53 experiments:
image/svg+xml aorta circulatory system blood vessel brown adipose tissue white adipose tissue skin stomach duodenum pancreas spleen adrenal gland kidney colon small intestine caecum jejunum ileum esophagus gall bladder parotid gland submandibular gland lymph node parathyroid gland tongue Peyer’s patch prostate gland vas deferens epididymis testis seminal vesicle penis urinary bladder thymus femur bone marrow cartilage quadriceps femoris spinal cord lung diaphragm peripheral nervous system trachea hindlimb trigeminal nerve eye sciatic nerve intestinal mucosa liver heart brain skeletal muscle
Created with Highcharts 6.2.0adrenal glandcentral neural epitheliumepidermal ectodermhippocampusmammary glandolfactory epitheliumsmall intestineuterusaxillary lymph nodebronchuscorpora quadrigeminadiencephalonfloor plateheartintestinal mucosalateral prominence neural epitheliummedial prefrontal cortexmuscle tissuepancreasprostate glandstriatumthymuswhite adipose tissue
T
49 FANTOM5 project - adult
T
49 FANTOM5 project - neonate
T
49 FANTOM5 project - juvenile
T
49 FANTOM5 project - embryonic day 18
T
49 FANTOM5 project - embryonic day 17
T
49 FANTOM5 project - embryonic day 16
T
49 FANTOM5 project - embryonic day 15
T
49 FANTOM5 project - embryonic day 14
T
9 in 3 strains - DBA/2J
T
9 in 3 strains - CD1
T
9
T
49 FANTOM5 project - embryonic day 12
T
9 in 3 strains - C57BL/6
T
14 - embryonic day 10.5
T
49 FANTOM5 project - embryonic day 13
T
Mammalian Kaessmann
T
6
T
Vertebrates
T
4
T
14 - embryonic day 9.5
T
14 - embryonic day 8.5
T
4 Bonthuis et al - (CastEiJ X …
T
4 Bonthuis et al - (C57BL/6J X …
T
Developing gut
T
49 FANTOM5 project - embryonic day 11
T
3 Soumillon et al
T
3
T
Sun et al., 2020 - Organism part
T
Gregg et al - C57BL/6J
T
Gregg et al - (CAST/EiJ X C57BL/6J)F1
T
Gregg et al - (C57BL/6J X CAST/EiJ)F1
T
4 Bonthuis et al - CastEiJ
T
4 Bonthuis et al - C57BL/6J
T
Mernberger et al 2019 - Organism Part
T
49 FANTOM5 project - pregnant adult day …
T
49 FANTOM5 project - pregnant adult day …
T
2
T
Gregg et al - CAST/EiJ
T
Fat and muscle
T
49 FANTOM5 project - pregnant adult day …
T
49 FANTOM5 project - pregnant adult day …
T
49 FANTOM5 project - pregnant adult day …
T
49 FANTOM5 project - lactating adult …
T
49 FANTOM5 project - embryonic day 17.5
T
49 FANTOM5 project - embryonic day 14.5
T
49 FANTOM5 project - embryo
T
4 Bonthuis et al - Idaho derived wild …
P
Linscheid et al., 2021 - tissue - heart …
P
Duda et al., 2018 - organism part - …
P
Duda et al., 2018 - organism part - …
P
Linscheid et al. 2019 - organism part
P
Deshmukh et al., 2015 - organism part
P
Organism part - Huttlin et al
P
Proteomics
T
Transcriptomics
High
Medium
Low
Below cutoff
No data available

Filter your results

Kingdom
Species
Experiment type
Experimental variables
Regulation
Log2-fold changeSpeciesGene nameComparisonExperimental variablesExperiment name
Adjusted p-valueLog2-fold change
2.2272 × 10-25-8.2
Slc1a6'induced extraembryonic endoderm stem cell; grown in ES cell medium' vs 'mouse embryonic fibroblast; control'cell type, growth conditionOSKM induce extraembryonic endoderm stem (iXEN) cells in parallel to iPS cells
Adjusted p-valueLog2-fold change
3.129 × 10-7-7.2
Slc1a6'neural stem cell' vs 'niche cell'cell typeTranscription profiling by high throughput sequencing of three populations of primary dentate gyrus cells
Adjusted p-valueLog2-fold change
7.4977 × 10-24-6.5
Slc1a6'extraembryonic endoderm stem cell; grown in XEN cell medium' vs 'mouse embryonic fibroblast; control'cell type, growth conditionOSKM induce extraembryonic endoderm stem (iXEN) cells in parallel to iPS cells
Adjusted p-valueLog2-fold change
4.1739 × 10-25.1
Slc1a6'SMRT shRNA; CpG; 6 hour' vs 'none; none; 0 hour'RNA interference, stimulus, timeRNA-seq of Control and SMRT KD CD8α+ DCs at 0hr and 6hr CpG stimulation
Adjusted p-valueLog2-fold change
8.3374 × 10-12-4.8
Slc1a6'induced extraembryonic endoderm stem cell; grown in XEN cell medium' vs 'mouse embryonic fibroblast; control'cell type, growth conditionOSKM induce extraembryonic endoderm stem (iXEN) cells in parallel to iPS cells
Adjusted p-valueLog2-fold change
8.5279 × 10-3-4
Slc1a6'myeloid lineage restricted progenitor cell' vs 'long term hematopoietic stem cell' in 'Elp3fl/fl'cell type, genotypeRNA-seq of long-term hematopoietic stem cells and myeloid progenitors of control mice or mice conditionally deficient for Trp53 or Elp3 or both genes in the hematopoietic system
Adjusted p-valueLog2-fold change
5.2007 × 10-3-3.4
Slc1a6'neural progenitor cell' vs 'niche cell'cell typeTranscription profiling by high throughput sequencing of three populations of primary dentate gyrus cells
Adjusted p-valueLog2-fold change
1.806 × 10-3-3.3
Slc1a6'extraembryonic endoderm stem cell; grown in ES cell medium' vs 'mouse embryonic fibroblast; control'cell type, growth conditionOSKM induce extraembryonic endoderm stem (iXEN) cells in parallel to iPS cells
Adjusted p-valueLog2-fold change
1.6187 × 10-33
Slc1a6'Irx3 knockout' vs 'control' at '7 day'genetic modification, timeRNA-Seq of mouse Irx3-KO and Control ME3 cells on days 1 and 7 of adipogenic differentiation
Adjusted p-valueLog2-fold change
8.9042 × 10-332.9
Slc1a6'Duchenne muscular dystrophy' vs 'normal'diseaseRNA-seq comparison of immortalised myoblasts from dystrophic and WT mice
Adjusted p-valueLog2-fold change
2.3076 × 10-32.9
Slc1a6'AZD5069; 100 milligram per kilogram' vs 'none'compoundRNA-seq to investigate differentially expressed genes in KPC mouse PDAC treated with CSF-1R small molecule inhibitor AZD7507 and/or the CXCR2 small molecule inhibitor AZD5069
Adjusted p-valueLog2-fold change
4.8579 × 10-32.9
Slc1a6'AZD7507; AZD5069 (at same dosage); 100 milligram per kilogram' vs 'none'compoundRNA-seq to investigate differentially expressed genes in KPC mouse PDAC treated with CSF-1R small molecule inhibitor AZD7507 and/or the CXCR2 small molecule inhibitor AZD5069
Adjusted p-valueLog2-fold change
4.9758 × 10-14-2.8
Slc1a6'interferon gamma' vs 'dexamethasone; 100 nanomolar'compound, stimulusRNA-Seq of murine lung endothelial cells stimulated with IFN-gamma and dexamethasone
Adjusted p-valueLog2-fold change
1.8473 × 10-52.8
Slc1a6'15 day' vs '3 day'timeTranscription profiling time series of mouse embryonic chondrocyte differentiation
Adjusted p-valueLog2-fold change
7.7965 × 10-32.8
Slc1a6'osteosarcoma' vs 'control'disease, genotypeMouse Model of Clear Cell Sarcoma
Adjusted p-valueLog2-fold change
3.1586 × 10-42.6
Slc1a6'Id2_Id3_double knockout' vs 'wild type' in 'CD4+TCRb+CD8– cell; thymus'cell type, genotype, organism partTranscription profiling by high throughput sequencing of Id-proteins (Id2 and Id3) gene knockout cells
Adjusted p-valueLog2-fold change
4.7454 × 10-152.5
Slc1a6'neuron' vs 'differentiating progenitor'cell typeTranscription profiling by high throughput sequencing of proliferating neural stem cells, differentiating neurogenic progenitors and newborn neurons using a dual-reporter mouse line
Adjusted p-valueLog2-fold change
8.5959 × 10-32.5
Slc1a6'clear cell sarcoma; Rosa26CreER' vs 'control'disease, genotypeMouse Model of Clear Cell Sarcoma
Adjusted p-valueLog2-fold change
1.0863 × 10-2-2.5
Slc1a6'K-ras mutant/Wt1-null' vs 'wild type'genotypeTranscription profiling by array of wild type, K-ras mutant, Wt1-null, and double K-ras mutant/Wt1-null mouse embryonic fibroblasts
Adjusted p-valueLog2-fold change
2.5236 × 10-62.3
Slc1a6'12 day' vs '3 day'timeTranscription profiling time series of mouse embryonic chondrocyte differentiation
Adjusted p-valueLog2-fold change
1.7247 × 10-22.3
Slc1a6'clear cell sarcoma; TATCre' vs 'control'disease, genotypeMouse Model of Clear Cell Sarcoma
Adjusted p-valueLog2-fold change
2.1785 × 10-22.3
Slc1a6'Er1F/-' vs 'wild type genotype'genotypeRNA-Seq profiling of ERCC1-XPF DNA repair defect (Er1F/-) versus wild type (Er1F/+) macrophages
Adjusted p-valueLog2-fold change
1.321 × 10-2-2.2
Slc1a6'adenoviral vector expressing human ACE2' vs 'empty adenoviral vector'genotypeRNA-seq of SARS-CoV-2 infected lungs from mice sensitized for SARS-CoV-2 infection by Ad5-hACE2 transduction compared to non-sensitized mice
Adjusted p-valueLog2-fold change
7.8517 × 10-112.1
Slc1a6'Sall4 homozygous knockout' vs 'wild type genotype'genotypeRNA-Seq of Sall4 mutants in mouse embryonic stem cells
Adjusted p-valueLog2-fold change
5.4982 × 10-42.1
Slc1a6'Pkhd1Cre; Pkd2 F/F' vs 'wild type'genotypeNext Generation Sequencing of PKD2 mutant mice kidneys
Adjusted p-valueLog2-fold change
1.3459 × 10-3-2.1
Slc1a6'K-ras mutant' vs 'wild type'genotypeTranscription profiling by array of wild type, K-ras mutant, Wt1-null, and double K-ras mutant/Wt1-null mouse embryonic fibroblasts
Adjusted p-valueLog2-fold change
6.4414 × 10-3-2.1
Slc1a6'Trp53 knockout' vs 'wild type genotype' in 'Nutlin-3a; 10 micromolar'compound, phenotypeResidual tumor suppressor activities of tumorigenic p53 mutants enhance survival under chemotherapy
Adjusted p-valueLog2-fold change
9.6076 × 10-9-2
Slc1a6'induced neural stem cell' vs 'mouse embryonic fibroblast cell'cell typeGene expression profile of mouse induced neural stem cells
Adjusted p-valueLog2-fold change
7.9138 × 10-3-2
Slc1a6'Trp53 knockout' vs 'wild type genotype' in 'dimethyl sulfoxide; 0.1 microliter'compound, phenotypeResidual tumor suppressor activities of tumorigenic p53 mutants enhance survival under chemotherapy
Adjusted p-valueLog2-fold change
2.8181 × 10-2-1.9
Slc1a6'PolgD257A/D257A' vs 'wild type'genotypeTranscription profiling by array of cochlea from PolgD257A/D257A mice
Adjusted p-valueLog2-fold change
7.3913 × 10-121.8
Slc1a6'dexamethasone; 100 nanomolar' vs 'none'compound, stimulusRNA-Seq of murine lung endothelial cells stimulated with IFN-gamma and dexamethasone
Adjusted p-valueLog2-fold change
6.4316 × 10-81.8
Slc1a6'10 day' vs '0 day'ageTranscriptional profiling by array of mouse cerebellar cortex during postnatal development
Adjusted p-valueLog2-fold change
9.7985 × 10-4-1.8
Slc1a6'Dcrfx/fx;MisCre' vs 'wild type' in '5 day'age, genotypeTranscription profiling of testis from wild type mice and mice with a Sertoli-specific ablation of Dicer
Adjusted p-valueLog2-fold change
2.0026 × 10-2-1.7
Slc1a6'oxidized low density lipoprotein; 25 microgram per milliliter' vs 'none' in 'CD36 knockout'compound, genotypeQuantitative analysis of wild type and cd36-/- murine peritoneal macrophage transcriptomes
Adjusted p-valueLog2-fold change
1.592 × 10-5-1.6
Slc1a6'5,9-endoperoxy-cholest-7-en-3β,6α-diol' vs 'vehicle (cyclodextrin)'compound, timeArray results for differential gene expression in 661W, a mouse cone photoreceptor-derived cell line, comparing cells incubated with vehicle controls vs. those treated with either of two 7-dehdyrocholesterol-derived oxysterols or cholesterol
Adjusted p-valueLog2-fold change
3.696 × 10-51.6
Slc1a6'undifferentiated' vs 'differentiated; rosiglitazone' in 'A/J'phenotype, stimulus, strainRNA-seq of mouse subcutaneous SVF cells before and after differentiation with a brown fat differentiation cocktail
Adjusted p-valueLog2-fold change
1.6708 × 10-21.6
Slc1a6'Pkhd1Cre; Pkd2 F/F; miR-21null' vs 'wild type'genotypeNext Generation Sequencing of PKD2 mutant mice kidneys
Adjusted p-valueLog2-fold change
4.5124 × 10-6-1.5
Slc1a6'cholesterol' vs 'vehicle (cyclodextrin)'compound, timeArray results for differential gene expression in 661W, a mouse cone photoreceptor-derived cell line, comparing cells incubated with vehicle controls vs. those treated with either of two 7-dehdyrocholesterol-derived oxysterols or cholesterol
Adjusted p-valueLog2-fold change
1.29 × 10-51.5
Slc1a6'dexamethasone; 100 nanomolar; interferon gamma' vs 'none'compound, stimulusRNA-Seq of murine lung endothelial cells stimulated with IFN-gamma and dexamethasone
Adjusted p-valueLog2-fold change
6.1299 × 10-3-1.5
Slc1a6'heat-shocked at 42 degreeC' vs 'grown at 33 degreeC' in 'HdhQ111 knock-in'genotype, growth conditionTranscription profiling by array of mouse wild type and Htt mutant striatal cells upon heat shock
Adjusted p-valueLog2-fold change
1.529 × 10-2-1.5
Slc1a6'P19; transduced with NeuroD2 lentivirus' vs 'P19; control'cell line, treatmentGenetic and epigenetic determinants of neurogenesis and myogenesis [expression profiling]
Adjusted p-valueLog2-fold change
2.4625 × 10-81.4
Slc1a6'Sall4 -/-' vs 'wild type genotype'genotypeRNA-Seq of mouse embryonic stem cells in response to changes in Sall4
Adjusted p-valueLog2-fold change
4.7708 × 10-71.4
Slc1a6'Chikungunya virus; late stage encephalitis' vs 'mock infection'infect, timeTranscriptomic profiling of the brains of WNV and CHIKV infection-induced encephalitis in young mice after 2, 3 or 5 days post infection
Adjusted p-valueLog2-fold change
1.0367 × 10-51.4
Slc1a6'FusΔNLS/+' vs 'wild type genotype' at '12 hour'genotype, timeMutant FUS triggers age-dependent synaptic impairment in presymptomatic ALS-FUS mice (RNA-seq part2)
Adjusted p-valueLog2-fold change
1.2827 × 10-51.4
Slc1a6'9 day' vs '3 day'timeTranscription profiling time series of mouse embryonic chondrocyte differentiation
Adjusted p-valueLog2-fold change
7.4604 × 10-3-1.4
Slc1a6'Ink4a/Arf-/-; EGFRvIII' vs 'wild type genotype' in 'separate'genotype, growth conditionRNA-seq of wild-type and transformed Ink4a/Arf-/-; EGFRvIII neural stem cells in separate or co-culture conditions
Adjusted p-valueLog2-fold change
1.4867 × 10-21.4
Slc1a6'West Nile virus; early stage encephalitis' vs 'mock infection'infect, timeTranscriptomic profiling of the brains of WNV and CHIKV infection-induced encephalitis in young mice after 2, 3 or 5 days post infection
Adjusted p-valueLog2-fold change
2.3029 × 10-46-1.3
Slc1a6'etoposide; 2.5 micromolar' vs 'none' in 'wild type genotype'compound, genotypeRNA-seq of H2afj-ko and isogenic WT C57/Bl6-N mouse embryonic fibroblasts in proliferation and after etoposide-induced senescence.
Adjusted p-valueLog2-fold change
2.4071 × 10-27-1.3
Slc1a6'etoposide; 2.5 micromolar' vs 'none' in 'H2afj-∆7-KO'compound, genotypeRNA-seq of H2afj-ko and isogenic WT C57/Bl6-N mouse embryonic fibroblasts in proliferation and after etoposide-induced senescence.
Adjusted p-valueLog2-fold change
9.8168 × 10-51.3
Slc1a6'RAM siRNA' vs 'control' in 'polysomal RNA'RNA interference, protocolTranscription profiling by high throughput sequencing of mouse 46C embryonic stem cells transfected with RAM siRNA or control
Adjusted p-valueLog2-fold change
9.3699 × 10-3-1.3
Slc1a6'adult definitive erythroid cell' vs 'primitive erythroid cell' in 'reticulocyte'cell type, phenotypeTranscription profiling by array of differentiating primary primitive and definitive mouse red blood cells
Adjusted p-valueLog2-fold change
9.1458 × 10-3-1.2
Slc1a6'ductus arteriosis' vs 'aorta'organism partGene Profiling in Mouse Fetal Ductus Arteriosus
Adjusted p-valueLog2-fold change
3.6048 × 10-21.2
Slc1a6'neurosphere in differentiation medium; 1 day' vs 'neurosphere; 0 day' in 'Cstb knockout'genotype, growth condition, timeTranscriptome analysis of neurospheres derived from Cstb-KO mouse embryo brains during differentiation
Adjusted p-valueLog2-fold change
3.8566 × 10-111.1
Slc1a6'8.5 millimolar; methoxyacetic acid' vs 'none' at '24 hour'compound, timeTranscription profiling by array of mouse embryonic stem cells after treatment with 5-fluourouracil, methoxyacetic acid, monobutl phthalate, Penicillin G, retinoic acid or valproic acid
Adjusted p-valueLog2-fold change
4.3765 × 10-71.1
Slc1a6'3 day; myogenesis differentiation' vs ' 0 day; control' in '2C12-pMirn0'cell line, growth condition, timeEffect of Mirn378 overexpression on gene expression during C2C12 myogenic and BMP2-induced osteogenic differentiation
Adjusted p-valueLog2-fold change
3.7077 × 10-5-1.1
Slc1a6'seizure-preconditioning followed by intra-amygdala kainic acid' vs 'sham-preconditioning followed by intra-amygdala vehicle'clinical treatmentTranscription profiling by array of mice with epileptic tolerance
Adjusted p-valueLog2-fold change
4.2661 × 10-4-1.1
Slc1a6'total RNA; HRasV12 and c-Myc overexpression and Eif4e wild type' vs 'total RNA; wild type'fraction, genotypeRedefining the role of eIF4E dose in development, cancer, and protein synthesis
Adjusted p-valueLog2-fold change
8.2038 × 10-31.1
Slc1a6'proliferating progenitor' vs 'differentiating progenitor'cell typeTranscription profiling by high throughput sequencing of proliferating neural stem cells, differentiating neurogenic progenitors and newborn neurons using a dual-reporter mouse line
Adjusted p-valueLog2-fold change
1.6096 × 10-2-1.1
Slc1a6'17beta-estradiol' vs 'DMSO' in 'wild type'compound, genotypeTranscription profiling of mouse male embryos treated with DMSO or 17beta-estradiol in wild type or ERalpha knock outs to assess the toxic effects of oestrogen exposure in fetal testis
Adjusted p-valueLog2-fold change
4.6161 × 10-21.1
Slc1a6'undifferentiated' vs 'differentiated; rosiglitazone' in 'AKR/J'phenotype, stimulus, strainRNA-seq of mouse subcutaneous SVF cells before and after differentiation with a brown fat differentiation cocktail
Adjusted p-valueLog2-fold change
3.679 × 10-51
Slc1a6'shRNA p68/p72 knockdown; growing' vs 'control; growing' on 'Affymetrix Array MOE430A'RNA interference, developmental stageTranscription profiling of p68/72 deficient C2C12 cells to investigate the function of p68/p72 in muscle gene expression and skeletal C2C12 cell differentiation.
Adjusted p-valueLog2-fold change
1.0345 × 10-4-1
Slc1a6'Men1-null' vs 'wild type'genotypeDifferentially regulated genes in adipocytes derived from Men1-null vs WT mouse embryonic stem cells
Adjusted p-valueLog2-fold change
4.7309 × 10-31
Slc1a6'Id3 knockout' vs 'wild type' in 'Tet+CD24-CD44+NK1.1- Invariant natural killer T'cell type, genotypeEssential functions for ID proteins at multiple checkpoints in natural killer T cell development
Adjusted p-valueLog2-fold change
1.8573 × 10-21
Slc1a6'mock inoculated' at '150 day' vs 'none' at '0 day'infect, timeTranscription profiling by array of brains from mice infected with scrapie ME7
Adjusted p-valueLog2-fold change
3.2298 × 10-21
Slc1a6'undifferentiated' vs 'differentiated; rosiglitazone' in 'C57BL/6J'phenotype, stimulus, strainRNA-seq of mouse subcutaneous SVF cells before and after differentiation with a brown fat differentiation cocktail