ensmusg00000056220 (Pla2g4a)

mus musculus

phospholipase A2, group IVA (cytosolic, calcium-dependent)

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Mus musculus
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Log2-fold changeSpeciesGene nameComparisonExperimental variablesExperiment name
Adjusted p-valueLog2-fold change
6.1829 × 10-110-8.5
Pla2g4a'induced extraembryonic endoderm stem cell; grown in ES cell medium' vs 'mouse embryonic fibroblast; control'cell type, growth conditionOSKM induce extraembryonic endoderm stem (iXEN) cells in parallel to iPS cells
Adjusted p-valueLog2-fold change
3.9364 × 10-12-7.1
Pla2g4a'neuron' vs 'differentiating progenitor'cell typeTranscription profiling by high throughput sequencing of proliferating neural stem cells, differentiating neurogenic progenitors and newborn neurons using a dual-reporter mouse line
Adjusted p-valueLog2-fold change
7.127 × 10-114.6
Pla2g4a'10 day' vs '0 day'ageTranscription profiling of mouse embyronic stem cell line CGR8 during the first 10 days of differentiation into embryoid bodies
Adjusted p-valueLog2-fold change
9.1371 × 10-19-4.4
Pla2g4a'extraembryonic endoderm stem cell; grown in XEN cell medium' vs 'mouse embryonic fibroblast; control'cell type, growth conditionOSKM induce extraembryonic endoderm stem (iXEN) cells in parallel to iPS cells
Adjusted p-valueLog2-fold change
6.8731 × 10-37-4.2
Pla2g4a'extraembryonic endoderm stem cell; grown in ES cell medium' vs 'mouse embryonic fibroblast; control'cell type, growth conditionOSKM induce extraembryonic endoderm stem (iXEN) cells in parallel to iPS cells
Adjusted p-valueLog2-fold change
1.058 × 10-1044.1
Pla2g4a'tamoxifen induction at 2 months, wait 6 months' vs 'no tamoxifen induction' in 'basal cell of prostate epithelium; CK5-CreERT2 transgenic line'cell type, genotype, growth conditionTranscription profiling by high throughput sequencing of PIN/tumor lesions from basal or luminal origins at time points at which mice displayed similar histopathological phenotypes
Adjusted p-valueLog2-fold change
5.3383 × 10-364.1
Pla2g4a'hepatocyte-derived proliferative ducts (hepPDs)' vs 'biliary-derived proliferative ducts (bilDP)'cell typeTranscription profiling by high throughput sequencing of hepatocyte-derived progenitors cells in a mouse model of oval cell activation
Adjusted p-valueLog2-fold change
4.3973 × 10-21-3.9
Pla2g4a'cortical epithelial cell; Lin- Dapi-EpCAM+ CD31-UEA1-Ly51+ td-tomato+t vs 'medullary epithelial cell; Lin- Dapi-EpCAM+ CD31-UEA1+Ly51- td-tomato-'cell type, phenotypeThymic T-cell progenitor development is supported by membrane bound Kit ligand provided by a combined vascular endothelial and epithelial niche.
Adjusted p-valueLog2-fold change
6.888 × 10-53.7
Pla2g4a'Ubc9 overexpression' vs 'wild type genotype' in 'undifferentiated; none'genotype, growth condition, stimulusSUMOylation promotes survival and integration of neural stem cell grafts in stroke
Adjusted p-valueLog2-fold change
4.1421 × 10-233.6
Pla2g4a'adipose tissue specific Cnot1 knockout' vs 'wild type phenotype' in 'brown adipose tissue'organism part, phenotypeRNA-seq to identify the role of mRNA decay in mouse adipose tissues
Adjusted p-valueLog2-fold change
1.2748 × 10-1023.4
Pla2g4a'Salmonella enterica serovar Typhimurium' vs 'control' in 'bone marrow macrophage from 129P2 mouse strain'clinical information, infectGene expression profiles of mouse embryonic stem cell derived macrophages infected with Salmonella typhimurium
Adjusted p-valueLog2-fold change
2.29 × 10-333.4
Pla2g4a'Nippostrongylus brasiliensis' vs 'none'infectRNAseq of small intestinal epithelium extracted from mice infected with Nippostrongylus brasiliensis
Adjusted p-valueLog2-fold change
3.2368 × 10-73.4
Pla2g4a'conditional Kras and p53 mutation induced soft tissue sarcoma' vs 'normal'diseaseTranscription profiling by array of mouse soft tissue sarcoma samples induced by conditional mutations of Kras and p53 against healthy muscles from mice of the same genotype but no induced sarcoma
Adjusted p-valueLog2-fold change
1.3517 × 10-53.3
Pla2g4a'Ubc9 overexpression' vs 'wild type genotype' in 'undifferentiated; oxygen/glucose-deprivation followed by restoration of oxygen/glucose'genotype, growth condition, stimulusSUMOylation promotes survival and integration of neural stem cell grafts in stroke
Adjusted p-valueLog2-fold change
4.4625 × 10-193.2
Pla2g4a'high fat diet; 30 degree celsius' vs 'chow; 23 degree celsius' in 'brown adipose tissue'diet, organism part, temperatureRNA-seq of brown and white mouse adipose tissue at thermoneutrality and high-fat diet
Adjusted p-valueLog2-fold change
2.23 × 10-63.2
Pla2g4a'polarized with E coli lipopolysacharide and INF-gamma' vs 'untreated'compound, treatmentExpression data from polarized macrophages: effect of p53
Adjusted p-valueLog2-fold change
5.2186 × 10-403.1
Pla2g4a'tamoxifen induction at 2 months, wait 3 months' vs 'no tamoxifen induction' in 'basal cell of prostate epithelium; CK5-CreERT2 transgenic line'cell type, genotype, growth conditionTranscription profiling by high throughput sequencing of PIN/tumor lesions from basal or luminal origins at time points at which mice displayed similar histopathological phenotypes
Adjusted p-valueLog2-fold change
1.8611 × 10-123.1
Pla2g4a'26 day' vs '0 day'ageGene expression profile of mouse differentiating embryonic stem cells (day 0, 6, 16, and 26)
Adjusted p-valueLog2-fold change
5.0731 × 10-93.1
Pla2g4a'7 day' vs '0 day'ageTranscription profiling of mouse embyronic stem cell line CGR8 during the first 10 days of differentiation into embryoid bodies
Adjusted p-valueLog2-fold change
6.836 × 10-53.1
Pla2g4a'Ubc9 overexpression' vs 'wild type genotype' in 'differentiated; oxygen/glucose-deprivation followed by restoration of oxygen/glucose'genotype, growth condition, stimulusSUMOylation promotes survival and integration of neural stem cell grafts in stroke
Adjusted p-valueLog2-fold change
2.2248 × 10-17-3
Pla2g4a'brown adipose tissue' vs 'white adipose tissue' in 'chow; 23 degree celsius'diet, organism part, temperatureRNA-seq of brown and white mouse adipose tissue at thermoneutrality and high-fat diet
Adjusted p-valueLog2-fold change
1.5282 × 10-93
Pla2g4a'16 day' vs '0 day'ageGene expression profile of mouse differentiating embryonic stem cells (day 0, 6, 16, and 26)
Adjusted p-valueLog2-fold change
5.7296 × 10-232.9
Pla2g4a'tamoxifen induction at 2 months, wait 3 months' vs 'no tamoxifen induction' in 'luminal cell of prostate epithelium; Nkx3.1-CreERT2 targeted allele'cell type, genotype, growth conditionTranscription profiling by high throughput sequencing of PIN/tumor lesions from basal or luminal origins at time points at which mice displayed similar histopathological phenotypes
Adjusted p-valueLog2-fold change
1.3036 × 10-4-2.9
Pla2g4a'actinomycin D; 8 hour' vs 'none' in 'Cnot1 flox/flox'compound, genotype, timeRNA-seq of livers in control and Cnot1 tamoxifen-inducible liver-specific knockout mice
Adjusted p-valueLog2-fold change
6.9902 × 10-10-2.8
Pla2g4a'induced neural stem cell' vs 'mouse embryonic fibroblast cell'cell typeGene expression profile of mouse induced neural stem cells
Adjusted p-valueLog2-fold change
1.0034 × 10-5-2.8
Pla2g4a'renin-expression' vs 'control'phenotypeExpression data from mouse bone marrow cells expressing renin driven expression of green fluorescent protein.
Adjusted p-valueLog2-fold change
2.0297 × 10-162.7
Pla2g4a'tamoxifen induction at 2 months, wait 1 months' vs 'no tamoxifen induction' in 'luminal cell of prostate epithelium; Nkx3.1-CreERT2 targeted allele'cell type, genotype, growth conditionTranscription profiling by high throughput sequencing of PIN/tumor lesions from basal or luminal origins at time points at which mice displayed similar histopathological phenotypes
Adjusted p-valueLog2-fold change
2.9598 × 10-92.7
Pla2g4a'6 day; osteogenesis differentiation' vs ' 0 day; control' in '2C12-pMirn0'cell line, growth condition, timeEffect of Mirn378 overexpression on gene expression during C2C12 myogenic and BMP2-induced osteogenic differentiation
Adjusted p-valueLog2-fold change
3.107 × 10-32.7
Pla2g4a'Ubc9 overexpression' vs 'wild type genotype' in 'differentiated; none'genotype, growth condition, stimulusSUMOylation promotes survival and integration of neural stem cell grafts in stroke
Adjusted p-valueLog2-fold change
1.9733 × 10-272.6
Pla2g4a'lipopolysaccharide; 10 nanogram per milliliter' vs 'none' in 'Hoxb8-FL; wild type genotype'cell line, compound, genotypeBulk RNA-seq of wild type and MEF2A or MEF2C/D knockout mouse bone marrow macrophages under different stimulation conditions
Adjusted p-valueLog2-fold change
5.0091 × 10-172.6
Pla2g4a'Ink4a/Arf-/-; EGFRvIII' vs 'wild type genotype' in 'co-culture'genotype, growth conditionRNA-seq of wild-type and transformed Ink4a/Arf-/-; EGFRvIII neural stem cells in separate or co-culture conditions
Adjusted p-valueLog2-fold change
1.0415 × 10-92.6
Pla2g4a'6 day' vs '0 day'ageTranscription profiling of mouse embyronic stem cell line CGR8 during the first 10 days of differentiation into embryoid bodies
Adjusted p-valueLog2-fold change
2.0812 × 10-52.6
Pla2g4a'chemical hypoxia' vs 'control'growth conditionComparison of gene expression in whole blood of mice subjected to chemical hypoxia in vivo.
Adjusted p-valueLog2-fold change
3.009 × 10-4-2.6
Pla2g4a'MED23 knockout' vs 'wild type'genotypeMediator Med23-deficiency Enhances Neural Differentiation of Embryonic Stem Cells through Modulating BMP Signaling
Adjusted p-valueLog2-fold change
6.3435 × 10-4-2.6
Pla2g4a'acute graft vs. host disease; T-cell depleted bone marrow + T cells transplant' vs 'normal; T-cell depleted bone marrow transplant'disease, stimulusRNA-Seq of lymph node fibroblastic reticular cells isolated from bone marrow transplant recipient mice with or without acute Graft-versus-host disease on day 7 or untransplanted control mice
Adjusted p-valueLog2-fold change
9.5165 × 10-42.5
Pla2g4a'RAW264.7 macrophage cell line; control' vs 'bone marrow macrophage; control'cell type, growth conditionTranscription profiling of mouse bone marrow macrophages (BMM) compared to BMM co-cultured with 4T1.2 breast cancer cells, treated with tumour cell supernatant, or RAW macrophage cell line
Adjusted p-valueLog2-fold change
1.3857 × 10-32.5
Pla2g4a'megakaryocyte' vs 'hematopoietic stem cell'cell typeTranscription profiling by array of primary megakaryocytes (MEG) and erythroblasts (ERY) developed from murine fetal liver hematopoietic stem cells
Adjusted p-valueLog2-fold change
1.3934 × 10-3-2.5
Pla2g4a'old neuronal stem cells' vs 'young neuronal stem cells'ageA mechanism for the segregation of age in mammalian neural stem cells
Adjusted p-valueLog2-fold change
1.9192 × 10-32.5
Pla2g4a'induction of polymicrobial sepsis' vs 'control' at '24 hour' in '1.5 to 3 month mice'age, time, treatmentAged Mice are Unable to Mount an Effective Myeloid Response to Sepsis
Adjusted p-valueLog2-fold change
2.5523 × 10-32.5
Pla2g4a'unilateral ureteral obstruction' vs 'sham' in 'TIMP3 -/-'genotype, treatmentTIMP2 and TIMP3 have divergent roles in early renal tubulointerstitial injury
Adjusted p-valueLog2-fold change
2.5006 × 10-62.4
Pla2g4a'heart-specific Mdm2 knockout; 14 day' vs 'heart-specific Mdm2 knockout; 7 day'phenotype, timeTranscription profiling of heart tissue from mice with heart-specific knockout of p53 and Mdm2
Adjusted p-valueLog2-fold change
1.317 × 10-5-2.4
Pla2g4a'XBP1s overexpression' vs 'wild type genotype' in '4μ8C; 15 micromolar'compound, genotypeOverexpression of spliced XBP1 in in vitro Th2 cells, and comparison to 4u8c treatment
Adjusted p-valueLog2-fold change
9.0847 × 10-1172.2
Pla2g4a'Debaryomyces hansenii' at '6 hour' vs 'none' at '0 hour'stimulus, timeRNA seq of mouse bone marrow derived macrophages treated with Debaryomyces hansenii against untreated controls
Adjusted p-valueLog2-fold change
5.8302 × 10-72.2
Pla2g4a'heart-specific p53 and Mdm2 knockout; 7 day' vs 'heart-specific p53 and Mdm2 knockout; 1 day'phenotype, timeTranscription profiling of heart tissue from mice with heart-specific knockout of p53 and Mdm2
Adjusted p-valueLog2-fold change
1.7237 × 10-6-2.2
Pla2g4a'Tgfbeta inhibitor 20 micromolar' vs 'none'compoundExpression data from intestinal organoids altered for Tgfbeta signaling
Adjusted p-valueLog2-fold change
7.017 × 10-82.1
Pla2g4a'clear cell sarcoma; Rosa26CreER' vs 'control'disease, genotypeMouse Model of Clear Cell Sarcoma
Adjusted p-valueLog2-fold change
9.376 × 10-52.1
Pla2g4a'fetal definitive erythroid cell' vs 'primitive erythroid cell' in 'mix of orthochromatic and polychromatophilic erythroblast'cell type, phenotypeTranscription profiling by array of differentiating primary primitive and definitive mouse red blood cells
Adjusted p-valueLog2-fold change
5.2123 × 10-42.1
Pla2g4a'osteosarcoma' vs 'control'disease, genotypeMouse Model of Clear Cell Sarcoma
Adjusted p-valueLog2-fold change
2.5501 × 10-22.1
Pla2g4a'14 month; QH2; liver' vs '14 month; control; liver'age, compound, organism partCoenzyme Q10-dependent gene expression in SAMP1 mice tissues
Adjusted p-valueLog2-fold change
2.7871 × 10-92
Pla2g4a'M-CSF and FSL-1' at '3 day' vs 'none' at '0 day'compound, timeMicroarray profiling of polyploid macrophage progeny
Adjusted p-valueLog2-fold change
7.0809 × 10-72
Pla2g4a'Foxd3 knockout' vs 'control'phenotypeExpression data from embryonic stem cells differentiation
Adjusted p-valueLog2-fold change
4.2817 × 10-6-2
Pla2g4a'reduced expression of miR-25' vs 'wild type'phenotypeTranscription profiling by high throughput sequencing of wild type and miR-25 agomir or antagomir treated mice
Adjusted p-valueLog2-fold change
3.9045 × 10-52
Pla2g4a'adult definitive erythroid cell' vs 'primitive erythroid cell' in 'mix of orthochromatic and polychromatophilic erythroblast'cell type, phenotypeTranscription profiling by array of differentiating primary primitive and definitive mouse red blood cells
Adjusted p-valueLog2-fold change
8.0126 × 10-4-2
Pla2g4a'actinomycin D; 4 hour' vs 'none' in 'Cnot1 flox/flox'compound, genotype, timeRNA-seq of livers in control and Cnot1 tamoxifen-inducible liver-specific knockout mice
Adjusted p-valueLog2-fold change
3.3792 × 10-32
Pla2g4a'unilateral ureteral obstruction' vs 'sham' in 'TIMP2 -/-'genotype, treatmentTIMP2 and TIMP3 have divergent roles in early renal tubulointerstitial injury
Adjusted p-valueLog2-fold change
4.6168 × 10-2-2
Pla2g4a'24 hour' vs '4 hour'timeTranscription profiling of mouse rhythmic mRNA expression in the distal colon
Adjusted p-valueLog2-fold change
5.2287 × 10-981.9
Pla2g4a'co-cultured with hematopoietic stem cell for 9 days' vs 'non co-cultured for 9 days' in 'stromal cell; expressing AKT1'cell type, growth condition, phenotypeTranscription profiling by high throughput sequencing of murine bone marrow endothelial cells and bone marrow stroma, in vitro and in vivo, with and without hematopoietic stem cells co-culture
Adjusted p-valueLog2-fold change
1.5878 × 10-81.9
Pla2g4a'oxidized low density lipoprotein; 25 microgram per milliliter' vs 'none' in 'wild type genotype'compound, genotypeQuantitative analysis of wild type and cd36-/- murine peritoneal macrophage transcriptomes
Adjusted p-valueLog2-fold change
7.847 × 10-61.9
Pla2g4a'undifferentiated' vs 'differentiated; rosiglitazone' in 'AKR/J'phenotype, stimulus, strainRNA-seq of mouse subcutaneous SVF cells before and after differentiation with a brown fat differentiation cocktail
Adjusted p-valueLog2-fold change
1.7989 × 10-5-1.9
Pla2g4a'heart-specific Mdm2 knockout; 7 day' vs 'wild type phenotype'phenotype, timeTranscription profiling of heart tissue from mice with heart-specific knockout of p53 and Mdm2
Adjusted p-valueLog2-fold change
1.9312 × 10-41.9
Pla2g4a'upf3 knockout' vs 'wild type' in 'testis'cell type, genotypeUPF2 establishes testis-specific transcriptome enriched in transcripts with shorter 3’UTRs
Adjusted p-valueLog2-fold change
1.0614 × 10-31.9
Pla2g4a'human-Mfn2 T111A/S442A-overexpressing (Mfn2AA)' vs 'tet-off control' in '5 week; left ventricle'age, genotype, organism partTranscription profiling by high throughput sequencing of a mitofusin 2 (Mfn2) mutant in mouse
Adjusted p-valueLog2-fold change
1.9758 × 10-3-1.9
Pla2g4a'co-transplanted with NOD-scid IL2Rgamma null HSCs' vs 'co-transplanted with wild type HSCs'growth conditionRNA-seq of mouse wildtype HSCs purified from recipient mice co-transplanted with wildtype or different types of lymphoid cell deficient HSCs
Adjusted p-valueLog2-fold change
3.9813 × 10-31.9
Pla2g4a'p48-Cre;KrasG12D;Ela-Tgfa' vs 'wild type'genotypeTranscription profiling by array of pancreas from KrasG12D, Ela-Tgfa and KrasG12D Ela-Tgfa mice
Adjusted p-valueLog2-fold change
6.9801 × 10-31.9
Pla2g4a'Cbs knockout' vs 'wild type'genotypeGene expression profile of CD4-positive T cells from mouse Cbs knockout
Adjusted p-valueLog2-fold change
4.3855 × 10-21.9
Pla2g4a'ciliary neurotrophic factor' vs 'vehicle' at '1 day' on 'Affymetrix 430 2.0 Array'compound, timeGene expression profile of glial cells after treatment with ciliary neurotrophic factor
Adjusted p-valueLog2-fold change
7.6089 × 10-10-1.8
Pla2g4a'MEF2A knockout' vs 'wild type genotype' in 'Hoxb8-FL; lipopolysaccharide; 10 nanogram per milliliter'cell line, compound, genotypeBulk RNA-seq of wild type and MEF2A or MEF2C/D knockout mouse bone marrow macrophages under different stimulation conditions
Adjusted p-valueLog2-fold change
1.6283 × 10-91.8
Pla2g4a'Aire knockout' vs 'wild type' in 'cTEC'genotype, phenotypeTranscription profiling by high throughput sequencing of primary cTEC, mTEClo, and mTEChi harvested from wild type and Aire-deficient mice
Adjusted p-valueLog2-fold change
2.9761 × 10-81.8
Pla2g4a'3 day; osteogenesis differentiation' vs ' 0 day; control' in '2C12-pMirn0'cell line, growth condition, timeEffect of Mirn378 overexpression on gene expression during C2C12 myogenic and BMP2-induced osteogenic differentiation
Adjusted p-valueLog2-fold change
3.8263 × 10-81.8
Pla2g4a'6 day; osteogenesis differentiation' vs ' 0 day; control' in '2C12-pMirn378'cell line, growth condition, timeEffect of Mirn378 overexpression on gene expression during C2C12 myogenic and BMP2-induced osteogenic differentiation
Adjusted p-valueLog2-fold change
2.342 × 10-7-1.8
Pla2g4a'actinomycin D; 8 hour' vs 'none' in 'Alb-Cre-ERT2 / Cnot1 flox/flox'compound, genotype, timeRNA-seq of livers in control and Cnot1 tamoxifen-inducible liver-specific knockout mice
Adjusted p-valueLog2-fold change
3.0309 × 10-71.8
Pla2g4a'chronic pancreatitis' vs 'control'diseasePancreatic gene expression associated with cerulein induced chronic pancreatitis in mice
Adjusted p-valueLog2-fold change
5.0026 × 10-61.8
Pla2g4a'Salmonella enterica serovar Typhimurium' vs 'control' in 'derived macrophage from E14 Traf2 mutant cell line'clinical information, infectGene expression profiles of mouse embryonic stem cell derived macrophages infected with Salmonella typhimurium
Adjusted p-valueLog2-fold change
1.6989 × 10-51.8
Pla2g4a'clear cell sarcoma; TATCre' vs 'control'disease, genotypeMouse Model of Clear Cell Sarcoma
Adjusted p-valueLog2-fold change
4.8218 × 10-5-1.8
Pla2g4a'heart-specific p53 knockout; 7 day' vs 'wild type phenotype'phenotype, timeTranscription profiling of heart tissue from mice with heart-specific knockout of p53 and Mdm2
Adjusted p-valueLog2-fold change
2.1705 × 10-41.8
Pla2g4a'adult definitive erythroid cell' vs 'primitive erythroid cell' in 'basophilic erythroblast'cell type, phenotypeTranscription profiling by array of differentiating primary primitive and definitive mouse red blood cells
Adjusted p-valueLog2-fold change
8.813 × 10-41.8
Pla2g4a'fetal definitive erythroid cell' vs 'primitive erythroid cell' in 'basophilic erythroblast'cell type, phenotypeTranscription profiling by array of differentiating primary primitive and definitive mouse red blood cells
Adjusted p-valueLog2-fold change
3.0486 × 10-3-1.8
Pla2g4a'uterine-specific Tsc2-null' vs 'wild type' in 'intact'genotype, treatmentTranscription profiling by high throughput sequencing of uterine-specific Tsc2-null mice
Adjusted p-valueLog2-fold change
1.7611 × 10-2-1.8
Pla2g4a'polysomal RNA; HRasV12 and c-Myc overexpression and Eif4e wild type' vs 'polysomal RNA; wild type'fraction, genotypeRedefining the role of eIF4E dose in development, cancer, and protein synthesis
Adjusted p-valueLog2-fold change
2.1207 × 10-9-1.7
Pla2g4a'doxycycline-induced expression of NGN3' vs 'control' at '48 hour'time, treatmentTranscription profiling by array of mouse embryonic stem cells expressing the transcription factor NGN3 for 12 hours, 24 hours and 48 hours
Adjusted p-valueLog2-fold change
6.4359 × 10-81.7
Pla2g4a'Mycobacterium tuberculosis; C57BL/6J; 30 day' vs 'control; C57BL/6J; 0 day'infect, strain, timeTranscription profiling of mouse lung from C57BL6 and DBA2 parental strains and D2.B6-Chr7 and D2.B6-Chr19 congenic mice following aerosol infection with Mycobacterium tuberculosis for 30 and 70 days
Adjusted p-valueLog2-fold change
3.3465 × 10-71.7
Pla2g4a'Mycobacterium tuberculosis; C57BL/6J; 70 day' vs 'control; C57BL/6J; 0 day'infect, strain, timeTranscription profiling of mouse lung from C57BL6 and DBA2 parental strains and D2.B6-Chr7 and D2.B6-Chr19 congenic mice following aerosol infection with Mycobacterium tuberculosis for 30 and 70 days
Adjusted p-valueLog2-fold change
2.5396 × 10-61.7
Pla2g4a'Mycobacterium tuberculosis; DBA/2J congenic; 70 day' vs 'control; DBA/2J congenic; 0 day'infect, strain, timeTranscription profiling of mouse lung from C57BL6 and DBA2 parental strains and D2.B6-Chr7 and D2.B6-Chr19 congenic mice following aerosol infection with Mycobacterium tuberculosis for 30 and 70 days
Adjusted p-valueLog2-fold change
3.97 × 10-61.7
Pla2g4a'Porphyromonas gingivalis; normal' vs 'normal'infect, phenotypehyperlipidemia impaired innate response
Adjusted p-valueLog2-fold change
1.3291 × 10-51.7
Pla2g4a'Mycobacterium tuberculosis; DBA/2J congenic; 30 day' vs 'control; DBA/2J congenic; 0 day'infect, strain, timeTranscription profiling of mouse lung from C57BL6 and DBA2 parental strains and D2.B6-Chr7 and D2.B6-Chr19 congenic mice following aerosol infection with Mycobacterium tuberculosis for 30 and 70 days
Adjusted p-valueLog2-fold change
1.6425 × 10-51.7
Pla2g4a'30 days of tuberculosis' vs 'uninfected'disease, timeTranscription profiling by array of lungs from mice infected with tuberculosis
Adjusted p-valueLog2-fold change
3.7752 × 10-5-1.7
Pla2g4a'heart-specific p53 and Mdm2 knockout; 1 day' vs 'wild type phenotype'phenotype, timeTranscription profiling of heart tissue from mice with heart-specific knockout of p53 and Mdm2
Adjusted p-valueLog2-fold change
4.8404 × 10-31.7
Pla2g4a"Evi1-GFP positive" vs "Evi1-GFP negative"phenotypeWhole genome expression profiling of Evi1-GFP positive and negative murine hematopoietic stem cell sub-populations.
Adjusted p-valueLog2-fold change
4.9602 × 10-3-1.7
Pla2g4a'erythroblast' vs 'hematopoietic stem cell'cell typeTranscription profiling by array of primary megakaryocytes (MEG) and erythroblasts (ERY) developed from murine fetal liver hematopoietic stem cells
Adjusted p-valueLog2-fold change
3.9021 × 10-21.7
Pla2g4a'induction of polymicrobial sepsis' vs 'control' at '72 hour' in '1.5 to 3 month mice'age, time, treatmentAged Mice are Unable to Mount an Effective Myeloid Response to Sepsis
Adjusted p-valueLog2-fold change
1.2354 × 10-81.6
Pla2g4a'M-CSF' at '3 day' vs 'none' at '0 day'compound, timeMicroarray profiling of polyploid macrophage progeny
Adjusted p-valueLog2-fold change
1.1731 × 10-71.6
Pla2g4a'Sall4 homozygous knockout' vs 'wild type genotype'genotypeRNA-Seq of Sall4 mutants in mouse embryonic stem cells
Adjusted p-valueLog2-fold change
2.273 × 10-61.6
Pla2g4a'Mycobacterium tuberculosis; D2.B6-Chr19 congenic; 70 day' vs 'control; D2.B6-Chr19 congenic; 0 day'infect, strain, timeTranscription profiling of mouse lung from C57BL6 and DBA2 parental strains and D2.B6-Chr7 and D2.B6-Chr19 congenic mice following aerosol infection with Mycobacterium tuberculosis for 30 and 70 days
Adjusted p-valueLog2-fold change
1.0736 × 10-5-1.6
Pla2g4a'organoid culture without Noggin (ER medium)' vs 'organoid culture (ENR medium)' in 'none'growth condition, stimulusRNA-seq of small intestinal organoids treated with the control medium ENR (EGF, Noggin, R-spondin1) in the presence or absence of muscle supernatant
Adjusted p-valueLog2-fold change
2.6953 × 10-51.6
Pla2g4a'cardiac-specific constitutive expression of an activated Akt (caAkt)' vs 'wild type genotype'genotypeTranscription profiling by array of cardic ventricle tissues from mice with cardiac-specific constitutive expression of an activated Akt (caAkt) and wild-type controls to test whether Akt activation contributes to mitochondrial dysfunction in pathological cardiac hypertrophy
Adjusted p-valueLog2-fold change
6.7265 × 10-51.6
Pla2g4a'M-27; over-expressing IGF-IR' vs 'M-27; wild type'cell line, genotypeTranscription profiling of wild_type and IGF-I receptor over-expressing mouse lung carcinoma cells identifies a type I insulin like growth factor receptor regulated gene expression profile associated with an altered site-specificity of metastasis.
Adjusted p-valueLog2-fold change
7.8583 × 10-5-1.6
Pla2g4a'heart-specific p53 knockout; 28 day' vs 'wild type phenotype'phenotype, timeTranscription profiling of heart tissue from mice with heart-specific knockout of p53 and Mdm2
Adjusted p-valueLog2-fold change
1.215 × 10-41.6
Pla2g4a'Staphylococcus aureus Sanger476; 6 hour' vs 'none; 0 hour' in 'C57BL/6J'infect, strain, timeGene Expression-Based Classifiers Identify Staphylococcus aureus Infection in Mice and Humans
Adjusted p-valueLog2-fold change
3.885 × 10-4-1.6
Pla2g4a'V6.5; embryonic stem cell’ vs 'wild type; endothelial'cell line, cell type, genotypeCD47 Inhibits Self-renewal and Reprogramming by Regulating c-Myc and Other Stem Cell Transcription Factors
Adjusted p-valueLog2-fold change
3.9853 × 10-2-1.6
Pla2g4a'postnatal day 60' vs 'postnatal day 1' in 'insulin-expressing immature beta cell'cell type, developmental stageTranscription profiling by high throughput sequencing of murine beta cells at key stages of maturation
Adjusted p-valueLog2-fold change
4.274 × 10-91.5
Pla2g4a'West Nile virus; late stage encephalitis' vs 'mock infection'infect, timeTranscriptomic profiling of the brains of WNV and CHIKV infection-induced encephalitis in young mice after 2, 3 or 5 days post infection
Adjusted p-valueLog2-fold change
1.6835 × 10-71.5
Pla2g4a'M-CSF and FSL-1' at '6 day' vs 'none' at '0 day'compound, timeMicroarray profiling of polyploid macrophage progeny
Adjusted p-valueLog2-fold change
3.786 × 10-61.5
Pla2g4a'Mycobacterium tuberculosis; D2.B6-Chr19 congenic; 30 day' vs 'control; D2.B6-Chr19 congenic; 0 day'infect, strain, timeTranscription profiling of mouse lung from C57BL6 and DBA2 parental strains and D2.B6-Chr7 and D2.B6-Chr19 congenic mice following aerosol infection with Mycobacterium tuberculosis for 30 and 70 days
Adjusted p-valueLog2-fold change
4.0903 × 10-61.5
Pla2g4a'interferon gamma' vs 'none'compoundType I and II Interferon-Stimulated Genes in Murine Primary Bone Marrow Macrophages
Adjusted p-valueLog2-fold change
2.4589 × 10-5-1.5
Pla2g4a'21 day' vs '1 day'ageTranscriptional profilling of female mice liver as a function of age
Adjusted p-valueLog2-fold change
1.1641 × 10-4-1.5
Pla2g4a'144 hour after induction of differentiation' vs 'induction of differentiation'compound, sampling time pointExpression Profiling of Early Myogenesis - Affymetrix Dataset
Adjusted p-valueLog2-fold change
2.2104 × 10-41.5
Pla2g4a'Salmonella enterica serovar Typhimurium' vs 'control' in 'derived macrophage from E14 cell line'clinical information, infectGene expression profiles of mouse embryonic stem cell derived macrophages infected with Salmonella typhimurium
Adjusted p-valueLog2-fold change
5.1764 × 10-31.5
Pla2g4a'Ink4a/Arf-/-; EGFRvIII' vs 'wild type genotype' in 'separate'genotype, growth conditionRNA-seq of wild-type and transformed Ink4a/Arf-/-; EGFRvIII neural stem cells in separate or co-culture conditions
Adjusted p-valueLog2-fold change
1.4202 × 10-21.5
Pla2g4a'Hnf1a knock out' vs 'wild type'genotypeTranscription profiling of pancreatic islets from Hnf1a-deficient and wild type mice
Adjusted p-valueLog2-fold change
1.5018 × 10-21.5
Pla2g4a'Plasmodium chabaudi infection' vs 'no infection' in 'vaccination'infect, treatmentProtective vaccination against blood-stage malaria of Plasmodium chabaudi: differential gene expression in the liver of Balb/c mice towards the end of crisis phase
Adjusted p-valueLog2-fold change
3.0554 × 10-21.5
Pla2g4a'Mammary stem cell' vs 'Myoepithelial cell'cell typeTranscription profiling by array of mammary epithelium to identify genes which may be important for regulation of mammary stem cell function
Adjusted p-valueLog2-fold change
4.8692 × 10-21.5
Pla2g4a'aire knock out' vs 'wild type'genotypeTranscription profiling by array of mice mutant for aire
Adjusted p-valueLog2-fold change
1.0595 × 10-311.4
Pla2g4a'oxidized low density lipoprotein; 25 microgram per milliliter' vs 'none' in 'CD36 knockout'compound, genotypeQuantitative analysis of wild type and cd36-/- murine peritoneal macrophage transcriptomes
Adjusted p-valueLog2-fold change
6.837 × 10-9-1.4
Pla2g4a'organoid culture without Noggin (ER medium)' vs 'organoid culture (ENR medium)' in 'intestinal smooth muscle culture supernatant'growth condition, stimulusRNA-seq of small intestinal organoids treated with the control medium ENR (EGF, Noggin, R-spondin1) in the presence or absence of muscle supernatant
Adjusted p-valueLog2-fold change
6.103 × 10-71.4
Pla2g4a'Mycobacterium tuberculosis H37Rv' vs 'none' in 'TNF-alpha knockout'compound, genotype, infect4-week mouse comparative study on effect of neutralizing IL-17A, IL-17F and TNFa antibodies
Adjusted p-valueLog2-fold change
1.2965 × 10-6-1.4
Pla2g4a'osteoblast culture 27 day' vs '0 day'timeTranscription profiling by array of mouse primary neonatal osteoblasts to study the regulation of bone mineralisation
Adjusted p-valueLog2-fold change
2.1711 × 10-61.4
Pla2g4a'Lactobacillus acidophilus NCFM and Bifidobacterium bifidum Z9' vs 'control'infectTranscription profiling by array of mouse dendritic cells after infection with Bifidobacterium bifidum and Lactobacillus acidophilus
Adjusted p-valueLog2-fold change
2.7067 × 10-61.4
Pla2g4a'Staphylococcus aureus Sanger476; 12 hour' vs 'none; 0 hour' in 'C57BL/6J'infect, strain, timeGene Expression-Based Classifiers Identify Staphylococcus aureus Infection in Mice and Humans
Adjusted p-valueLog2-fold change
3.3084 × 10-6-1.4
Pla2g4a'doxorubicin; 17.5 milligram per kilogram body weight' vs 'vehicle' in 'scramble; podocyte'cell type, compound, genotypeTranscription profiling to identify the role of MOF in primary MEFs and differentiated podocytes in response to Adriamycin
Adjusted p-valueLog2-fold change
1.5506 × 10-5-1.4
Pla2g4a'extracellular vesicle; non-stimulated culture medium' vs 'none'sampling site, stimulusCellular and extracellular vesicle RNA sequence for E-cadherin-RFP EMT reporter system expressing mouse breast cancer cell line Py2T during EMT/MET
Adjusted p-valueLog2-fold change
1.7144 × 10-51.4
Pla2g4a'Reverbαflox/floxAlbCreERT2-' vs 'wild type genotype'genotypeAntibody-independent ChIP-sequencing and liver-targeted deletion redefine REVERBα repressor function - RNA-seq
Adjusted p-valueLog2-fold change
2.9263 × 10-51.4
Pla2g4a'Reverbαflox/floxAlbCreERT2+' vs 'wild type genotype'genotypeAntibody-independent ChIP-sequencing and liver-targeted deletion redefine REVERBα repressor function - RNA-seq
Adjusted p-valueLog2-fold change
1.6285 × 10-41.4
Pla2g4a'CCl4 and diethylnitrosamine' vs 'none' in 'wild type genotype'genotype, treatmentGene expression accompanying the promotion of hepatocellular carcinoma by intestinal microbiota and Tlr4 in mice.
Adjusted p-valueLog2-fold change
1.9016 × 10-4-1.4
Pla2g4a'TLR4 mutant' vs 'wild type genotype' in 'CCl4 and diethylnitrosamine'genotype, treatmentGene expression accompanying the promotion of hepatocellular carcinoma by intestinal microbiota and Tlr4 in mice.
Adjusted p-valueLog2-fold change
2.145 × 10-31.4
Pla2g4a'one year after pulmonary macrophage transplantation; Csf2rb-/-' vs 'untreated; Csf2rb-/-'clinical history, genotypeMouse GM-CSF-related alveolar macrophage genome-wide expression data
Adjusted p-valueLog2-fold change
2.5826 × 10-31.4
Pla2g4a'unilateral ureteral obstruction' vs 'sham' in 'wild type'genotype, treatmentTIMP2 and TIMP3 have divergent roles in early renal tubulointerstitial injury
Adjusted p-valueLog2-fold change
4.6285 × 10-3-1.4
Pla2g4a'total RNA; HRasV12 and c-Myc overexpression and Eif4e wild type' vs 'total RNA; wild type'fraction, genotypeRedefining the role of eIF4E dose in development, cancer, and protein synthesis
Adjusted p-valueLog2-fold change
5.0389 × 10-31.4
Pla2g4a'H9; undifferentiated 3factor-reprogrammed induced pluripotent stem cell' vs 'R1; undifferentiated embryonic stem cell' at '0 day'cell line, growth condition, timeNatural cardiogenesis-based template predicts cardiogenic potential of induced pluripotent stem cell lines
Adjusted p-valueLog2-fold change
2.8404 × 10-331.3
Pla2g4a'Debaryomyces hansenii' at '12 hour' vs 'none' at '0 hour'stimulus, timeRNA seq of mouse bone marrow derived macrophages treated with Debaryomyces hansenii against untreated controls
Adjusted p-valueLog2-fold change
4.0099 × 10-61.3
Pla2g4a'lipopolysaccharide; 10 nanogram per milliliter' vs 'none' in 'primary cell line; wild type genotype'cell line, compound, genotypeBulk RNA-seq of wild type and MEF2A or MEF2C/D knockout mouse bone marrow macrophages under different stimulation conditions
Adjusted p-valueLog2-fold change
6.2835 × 10-61.3
Pla2g4a'seizure-preconditioning followed by intra-amygdala kainic acid' vs 'sham-preconditioning followed by intra-amygdala vehicle'clinical treatmentTranscription profiling by array of mice with epileptic tolerance
Adjusted p-valueLog2-fold change
7.9017 × 10-61.3
Pla2g4a'ko cyld-/-' vs 'wild type'genotypeTranscription profiling by array of mouse liver with Cyld inactivation
Adjusted p-valueLog2-fold change
9.2164 × 10-6-1.3
Pla2g4a'osteoblast culture 9 day' vs '0 day'timeTranscription profiling by array of mouse primary neonatal osteoblasts to study the regulation of bone mineralisation
Adjusted p-valueLog2-fold change
2.6267 × 10-51.3
Pla2g4a'Porphyromonas gingivalis; hyperlipidemia' vs 'normal'infect, phenotypehyperlipidemia impaired innate response
Adjusted p-valueLog2-fold change
3.2602 × 10-51.3
Pla2g4a'Mycobacterium tuberculosis; D2.B6-Chr7 congenic; 70 day' vs 'control; D2.B6-Chr7 congenic; 0 day'infect, strain, timeTranscription profiling of mouse lung from C57BL6 and DBA2 parental strains and D2.B6-Chr7 and D2.B6-Chr19 congenic mice following aerosol infection with Mycobacterium tuberculosis for 30 and 70 days
Adjusted p-valueLog2-fold change
5.4584 × 10-51.3
Pla2g4a'7 days P. chabaudi infected' vs 'uninfected' in 'intact female'clinical information, disease, sex, timeTranscription profiling by array of mice infected with Plasmodium chabaudi after gonadectomization to investigate involvement of gonadal steroids
Adjusted p-valueLog2-fold change
2.3125 × 10-41.3
Pla2g4a'SARS coronavirus MA15; 4 day' vs 'mock' in 'CAST/EiJ'infect, strain, timeGenomic profiling of collaborative cross founder mouse strains infected with respiratory viruses to discover novel transcripts and infection-related strain-specific gene and isoform expression
Adjusted p-valueLog2-fold change
6.4999 × 10-41.3
Pla2g4a'2'-fucosyllactose supplementation' vs 'control' in '8 weeks post-ileocecal resection'diet, treatmentTranscriptomic characterization of the impact of 2'-fucosyllactose supplementation on intestinal adaptation following ileocecal resection.
Adjusted p-valueLog2-fold change
1.3235 × 10-31.3
Pla2g4a'1810027O10Rik knockout; gonad adipose tissue' vs 'wild type genotype; gonad adipose tissue'genotype, organism part, sampling siteRNAseq of coding RNA in the liver, spleen, kidney, abdominal muscle and gonadal adipose tissue of knock out mice and wild type controls.
Adjusted p-valueLog2-fold change
2.0738 × 10-2-1.3
Pla2g4a'PFI-1; 10 nanogram per milliliter' vs 'none' in 'primary cell line; wild type genotype'cell line, compound, genotypeBulk RNA-seq of wild type and MEF2A or MEF2C/D knockout mouse bone marrow macrophages under different stimulation conditions
Adjusted p-valueLog2-fold change
3.5368 × 10-21.3
Pla2g4a'Tfc knockout; normal' vs 'control'disease, genotypeGene expression in thymi of Tcf1 -/-, Tcf +/- or Tcf1 -/- mice with tumor.
Adjusted p-valueLog2-fold change
2.86 × 10-53-1.2
Pla2g4a'PF-04691502–resistant cell; 1 micromolar; PF-04691502' vs 'parental AKP cell; dimethyl sulfoxide'compound, phenotypeResistance to PI3K/mTOR inhibitor PF-04691502 in KRAS mutant colorectal cancer models reveals a sensitivity to combination with EGFR inhibition
Adjusted p-valueLog2-fold change
1.0175 × 10-171.2
Pla2g4a'SARS coronavirus MA15; 4 day' vs 'mock' in 'PWK/PhJ'infect, strain, timeGenomic profiling of collaborative cross founder mouse strains infected with respiratory viruses to discover novel transcripts and infection-related strain-specific gene and isoform expression
Adjusted p-valueLog2-fold change
3.7671 × 10-101.2
Pla2g4a'RBM20 antisense oligonucleotide' vs 'none' in 'Titin-N2B knockout'RNA interference, genotypeHeart RNA-seq of therapeutic RBM20 antisense oligonucleotide (ASO) treatment in a mouse model of heart failure with preserved ejection fraction (HFpEF)
Adjusted p-valueLog2-fold change
2.4612 × 10-91.2
Pla2g4a'Influenza A virus (A/Puerto Rico/8/1934(H1N1)); 2 day' vs 'mock' in 'NOD/ShiLtJ'infect, strain, timeGenomic profiling of collaborative cross founder mouse strains infected with respiratory viruses to discover novel transcripts and infection-related strain-specific gene and isoform expression
Adjusted p-valueLog2-fold change
9.5719 × 10-81.2
Pla2g4a'undifferentiated' vs 'differentiated; rosiglitazone' in '129S6sv/ev'phenotype, stimulus, strainRNA-seq of mouse subcutaneous SVF cells before and after differentiation with a brown fat differentiation cocktail
Adjusted p-valueLog2-fold change
9.5691 × 10-71.2
Pla2g4a'21 percent oxygen, 37 degree Celsius, 10 percent serum' vs 'none'growth conditionRNA sequencing of native and ex vivo cultured murine tail tendon fascicles
Adjusted p-valueLog2-fold change
1.634 × 10-61.2
Pla2g4a'acute myeloid leukemia' vs 'myeloproliferative disorder'diseaseTranscription profiling by high throughput sequencing of c-KIT+ splenocytes from murine acute myeloid leukemia and myeloproliferative neoplasm
Adjusted p-valueLog2-fold change
4.1134 × 10-61.2
Pla2g4a'wormy, worm left; Trichuris muris' vs 'control; non wormy' in 'caecum'environmental stress, infect, organism partRNA-seq of mouse intestinal mucosa to investigate infection by the parasitic nematode Trichuris muris
Adjusted p-valueLog2-fold change
4.7815 × 10-61.2
Pla2g4a'Chikungunya virus; late stage encephalitis' vs 'mock infection'infect, timeTranscriptomic profiling of the brains of WNV and CHIKV infection-induced encephalitis in young mice after 2, 3 or 5 days post infection
Adjusted p-valueLog2-fold change
1.3235 × 10-51.2
Pla2g4a'Bifidobacterium bifidum Z9' vs 'control'infectTranscription profiling by array of mouse dendritic cells after infection with Bifidobacterium bifidum and Lactobacillus acidophilus
Adjusted p-valueLog2-fold change
1.2187 × 10-41.2
Pla2g4a'cardiotoxin; 40 microliter' vs 'none' in 'wild type' at '12 day'compound, genotype, timeTranscription profiling by array of mouse skeletal muscle expressing CnAa or CnAb1 under the control of the MLC promoter after treatment with cardiotoxin
Adjusted p-valueLog2-fold change
1.3305 × 10-4-1.2
Pla2g4a'365 day' vs '1 day'ageTranscriptional profilling of female mice liver as a function of age
Adjusted p-valueLog2-fold change
1.958 × 10-41.2
Pla2g4a'α-GalCer; 2 microgram' vs 'none' in 'Cd1d homozyous knockout'compound, genotypeCD1d-dependent immune suppression mediated by regulatory B cells through modulations of iNKT cells
Adjusted p-valueLog2-fold change
2.9875 × 10-41.2
Pla2g4a'Mycobacterium tuberculosis; D2.B6-Chr7 congenic; 30 day' vs 'control; D2.B6-Chr7 congenic; 0 day'infect, strain, timeTranscription profiling of mouse lung from C57BL6 and DBA2 parental strains and D2.B6-Chr7 and D2.B6-Chr19 congenic mice following aerosol infection with Mycobacterium tuberculosis for 30 and 70 days
Adjusted p-valueLog2-fold change
3.1756 × 10-4-1.2
Pla2g4a'actinomycin D; 4 hour' vs 'none' in 'Alb-Cre-ERT2 / Cnot1 flox/flox'compound, genotype, timeRNA-seq of livers in control and Cnot1 tamoxifen-inducible liver-specific knockout mice
Adjusted p-valueLog2-fold change
5.195 × 10-41.2
Pla2g4a'lung carcinoma' vs 'normal' in 'lung cell'cell type, diseaseTranscriptome analysis of isolated stormal cells and tumor epithelial cells in mouse lung cancer by RNA-Seq
Adjusted p-valueLog2-fold change
1.0458 × 10-3-1.2
Pla2g4a'fasted' vs 're-fed' in 'db/db; Gabpa miRNA'RNA interference, diet, genotypeGene expression profiling of liver from C57BLKS/J and db/db 8 mice with an AAV harboring a control or GAbpa-specific miRNA under the LP1 promoter
Adjusted p-valueLog2-fold change
1.626 × 10-31.2
Pla2g4a'collagen sandwich' at '7 day' vs 'freshly isolated' at '0 day'growth condition, timeTranscription profiling of primary mouse hepatocytes under different culture conditions
Adjusted p-valueLog2-fold change
2.3763 × 10-31.2
Pla2g4a'130 week' vs '13 week' in 'liver'age, organism partTranscription profiling by array of liver, lung, spleen and kidney from young and old mice.
Adjusted p-valueLog2-fold change
5.1292 × 10-31.2
Pla2g4a'miR-155 overexpression' vs 'wild type genotype'genotypeExpression analysis of eu-miR-155 transgenic mice B-cells.
Adjusted p-valueLog2-fold change
5.7079 × 10-3-1.2
Pla2g4a'CAR deficient; ethanol and trans-resveratrol' vs 'wild type; ethanol and trans-resveratrol'genotype, treatmentNuclear receptor-mediated alleviation of alcoholic fatty liver by polyphenols contained in alcoholic beverages
Adjusted p-valueLog2-fold change
6.5588 × 10-31.2
Pla2g4a'Stella maternal / zygotic knockout' vs 'wild type genotype' in '1-cell embryo'developmental stage, genotypeTranscription profiling of wild type and Stella knockout oocytes, wild type and Stella maternal/zygotic knockout embryos to study to the role of Stella in early mouse development
Adjusted p-valueLog2-fold change
7.3354 × 10-31.2
Pla2g4a'Staphylococcus aureus Sanger476; 4 hour' vs 'none; 0 hour' in 'C57BL/6J'infect, strain, timeGene Expression-Based Classifiers Identify Staphylococcus aureus Infection in Mice and Humans
Adjusted p-valueLog2-fold change
8.15 × 10-3-1.2
Pla2g4a'stabilization-competent' vs 'stabilization-incompetent' in '23 day; secondary reprogramming cell'age, cell type, phenotypeTranscription profiling by high throughput sequencing in gene expresion profile of 4 SC clones and 4 SI clones at different time points defined a stabilization competency signiture
Adjusted p-valueLog2-fold change
1.3148 × 10-21.2
Pla2g4a'neurosphere in differentiation medium; 1 day' vs 'neurosphere; 0 day' in 'Cstb knockout'genotype, growth condition, timeTranscriptome analysis of neurospheres derived from Cstb-KO mouse embryo brains during differentiation
Adjusted p-valueLog2-fold change
1.7774 × 10-21.2
Pla2g4a'TAC surgery' vs 'sham surgery' in 'C57BL/6N'strain, treatmentTranscription profiling of left ventricular myocardium after sham or TAC surgery in BL/6N and BL/6J mice
Adjusted p-valueLog2-fold change
2.0708 × 10-21.2
Pla2g4a'lung carcinoma' vs 'normal' in 'Epcam+CD11b-CD11c- epithelial cell'cell type, diseaseTranscriptome analysis of isolated stormal cells and tumor epithelial cells in mouse lung cancer by RNA-Seq
Adjusted p-valueLog2-fold change
1.0941 × 10-131.1
Pla2g4a'SARS coronavirus MA15; 4 day' vs 'mock' in 'C57BL/6J'infect, strain, timeGenomic profiling of collaborative cross founder mouse strains infected with respiratory viruses to discover novel transcripts and infection-related strain-specific gene and isoform expression
Adjusted p-valueLog2-fold change
1.3636 × 10-131.1
Pla2g4a'SARS coronavirus MA15; 2 day' vs 'mock' in 'PWK/PhJ'infect, strain, timeGenomic profiling of collaborative cross founder mouse strains infected with respiratory viruses to discover novel transcripts and infection-related strain-specific gene and isoform expression
Adjusted p-valueLog2-fold change
3.6828 × 10-13-1.1
Pla2g4a'intestinal smooth muscle culture supernatant' vs 'none' in 'organoid culture (ENR medium)'growth condition, stimulusRNA-seq of small intestinal organoids treated with the control medium ENR (EGF, Noggin, R-spondin1) in the presence or absence of muscle supernatant
Adjusted p-valueLog2-fold change
4.4154 × 10-71.1
Pla2g4a'14 days P. chabaudi infected' vs 'uninfected' in 'gonadectomized female'clinical information, disease, sex, timeTranscription profiling by array of mice infected with Plasmodium chabaudi after gonadectomization to investigate involvement of gonadal steroids
Adjusted p-valueLog2-fold change
6.65 × 10-71.1
Pla2g4a'valproic acid; 1000 micromolar' vs 'none' at '4 day'compound, timeTranscription profiling by array of mouse embryonic multipotent stem cells treated with valproic acid, cyproconazole and hexaconazole
Adjusted p-valueLog2-fold change
3.2987 × 10-61.1
Pla2g4a'follicle stimulating hormone and epidermal growth factor' vs '293H control medium'growth conditionTranscription profiling by array of mouse cumulus cells after culture with growth differentiation factor 9 or follicle stimulating hormone and epidermal growth factor
Adjusted p-valueLog2-fold change
3.4558 × 10-6-1.1
Pla2g4a'3 day; myogenesis differentiation' vs ' 0 day; control' in '2C12-pMirn378'cell line, growth condition, timeEffect of Mirn378 overexpression on gene expression during C2C12 myogenic and BMP2-induced osteogenic differentiation
Adjusted p-valueLog2-fold change
3.9588 × 10-6-1.1
Pla2g4a'mutant MyoD expression' at '24 hour' vs 'control' at '24 hour'phenotype, timeTranscription profiling of mouse embryoic fibroblasts expressing wild type MyoD or its non-acetylatable version MyoD RRR to investigate how MyoD acetylation may contribute to differential gene activation.
Adjusted p-valueLog2-fold change
1.5048 × 10-51.1
Pla2g4a'lung carcinoma' vs 'normal' in 'CD11b+Ly6G+ neutrophil'cell type, diseaseTranscriptome analysis of isolated stormal cells and tumor epithelial cells in mouse lung cancer by RNA-Seq
Adjusted p-valueLog2-fold change
2.4665 × 10-51.1
Pla2g4a'3110043O21Rik knockout; spleen' vs 'wild type genotype; spleen'genotype, organism part, sampling siteRNAseq of coding RNA in the liver, spleen, kidney, abdominal muscle and gonadal adipose tissue of knock out mice and wild type controls.
Adjusted p-valueLog2-fold change
4.8831 × 10-51.1
Pla2g4a'Sall4 ZFC4mut' vs 'wild type genotype'genotypeRNA-Seq of Sall4 mutants in mouse embryonic stem cells
Adjusted p-valueLog2-fold change
1.0886 × 10-41.1
Pla2g4a'sham-preconditioning followed by intra-amygdala kainic acid' vs 'sham-preconditioning followed by intra-amygdala vehicle'clinical treatmentTranscription profiling by array of mice with epileptic tolerance
Adjusted p-valueLog2-fold change
1.1867 × 10-41.1
Pla2g4a'Ela-Tgfa' vs 'wild type'genotypeTranscription profiling by array of pancreas from KrasG12D, Ela-Tgfa and KrasG12D Ela-Tgfa mice
Adjusted p-valueLog2-fold change
1.4211 × 10-41.1
Pla2g4a'21 percent oxygen, 37 degree Celsius, no serum' vs 'none'growth conditionRNA sequencing of native and ex vivo cultured murine tail tendon fascicles
Adjusted p-valueLog2-fold change
1.5885 × 10-41.1
Pla2g4a'Yersinia pestis' vs 'control' in 'neutrophil'cell type, infect, sampling siteSpatially distinct neutrophil responses within the inflammatory lesions of pneumonic plague
Adjusted p-valueLog2-fold change
2.4828 × 10-41.1
Pla2g4a'transverse aortic constriction' vs 'sham transverse aortic constriction'treatmentTranscriptional profiling of mouse heat left ventricle after dfferential cardiac remodeling in preload versus afterload.
Adjusted p-valueLog2-fold change
2.8448 × 10-4-1.1
Pla2g4a'180 day' vs '1 day'ageTranscriptional profilling of female mice liver as a function of age
Adjusted p-valueLog2-fold change
2.9283 × 10-4-1.1
Pla2g4a'Zbtb10 knockdown' vs 'control' at '6 hour'genotype, timeRNA-seq of Zbtb10 Knockdown and Control cDC1 dendritic cells (Cd8+)
Adjusted p-valueLog2-fold change
2.9283 × 10-41.1
Pla2g4a'Crx knockout' vs 'control' at '6 zeitgeber'genotype, timeTranscriptome in 129sv and Crx-/- pineal gland at ZT (Zeitgeber time) 6 and ZT20
Adjusted p-valueLog2-fold change
3.7365 × 10-41.1
Pla2g4a'SARS coronavirus MA15; 10^4 PFU' vs 'none' at '2 day'stimulus, timeSM001: SARS CoV MA15 infection of C57Bl/6 mouse model – Data from 4 viral doses at 1, 2, 4 and 7 days post infection.
Adjusted p-valueLog2-fold change
4.0941 × 10-41.1
Pla2g4a'Het (Q175) knock-in' vs 'wild type' in 'white adipose tissue around gonad'genotype, organism partTranscriptome profiling in knock-in mouse models of Huntington's disease [AllelicSeries_6month_TissueSurvey_mRNA]
Adjusted p-valueLog2-fold change
5.1832 × 10-4-1.1
Pla2g4a'MyD88 homozygous knockout' vs 'wild type genotype' in 'TLR9 ligand CpG ODN (1826)'genotype, stimulusTranscription profiling by sequencing of murine MyD88 -/- and MyD88 +/+ mTECs stimulated with a TLR9 ligand
Adjusted p-valueLog2-fold change
5.4598 × 10-4-1.1
Pla2g4a'60 day' vs '1 day'ageTranscriptional profilling of female mice liver as a function of age
Adjusted p-valueLog2-fold change
6.2558 × 10-4-1.1
Pla2g4a'14 day' vs '1 day'ageTranscriptional profilling of female mice liver as a function of age
Adjusted p-valueLog2-fold change
8.6215 × 10-41.1
Pla2g4a'undifferentiated' vs 'differentiated; rosiglitazone' in 'A/J'phenotype, stimulus, strainRNA-seq of mouse subcutaneous SVF cells before and after differentiation with a brown fat differentiation cocktail
Adjusted p-valueLog2-fold change
1.4642 × 10-3-1.1
Pla2g4a'NFAT5 knock-out' vs 'wild type' in 'lipopolysaccharide'compound, genotypeTranscription profiling by array of mouse bone marrow derived macrophages mutant for NAT5 after treatment with lipopolysaccharide
Adjusted p-valueLog2-fold change
2.1901 × 10-3-1.1
Pla2g4a'untreated; Csf2rb-/-' vs 'untreated; wild type'clinical history, genotypeMouse GM-CSF-related alveolar macrophage genome-wide expression data
Adjusted p-valueLog2-fold change
2.2738 × 10-3-1.1
Pla2g4a'96 hour after induction of differentiation' vs 'induction of differentiation'compound, sampling time pointExpression Profiling of Early Myogenesis - Affymetrix Dataset
Adjusted p-valueLog2-fold change
2.7108 × 10-3-1.1
Pla2g4a'CAR deficient; ethanol' vs 'wild type; ethanol'genotype, treatmentNuclear receptor-mediated alleviation of alcoholic fatty liver by polyphenols contained in alcoholic beverages
Adjusted p-valueLog2-fold change
2.7868 × 10-3-1.1
Pla2g4a'730 day' vs '1 day'ageTranscriptional profilling of female mice liver as a function of age
Adjusted p-valueLog2-fold change
4.543 × 10-31.1
Pla2g4a'human-Mfn2 T111A/S442A-overexpressing (Mfn2AA)' vs 'wild type' in '5 week; left ventricle'age, genotype, organism partTranscription profiling by high throughput sequencing of a mitofusin 2 (Mfn2) mutant in mouse
Adjusted p-valueLog2-fold change
9.2032 × 10-31.1
Pla2g4a'bER knockout' vs 'wild type' in 'human chorionic gonadotropin; 5 International Unit'compound, genotypeLaser Capture Microdissection isolation of preovulatory granulosa cells from WT and bERKO ovaries
Adjusted p-valueLog2-fold change
9.7119 × 10-31.1
Pla2g4a'transgenic hepatic growth hormone and hepatocyte-specific deletion of JAK2' vs 'wild type genotype' in '40 week'age, genotypeHepatic Deletion of Janus Kinase 2 Counteracts Inflammation, Oxidative Stress and Liver Cancer Formation in Growth Hormone Transgenic Mice
Adjusted p-valueLog2-fold change
1.4552 × 10-21.1
Pla2g4a'HP1g knockdown' vs 'control' in 'embryoid body'developmental stage, genotypeTranscription profiling of mouse embryonic stem cell line CGR8 transfected with control shRNA and shRNA against HP1g in two different developmental stages
Adjusted p-valueLog2-fold change
1.8029 × 10-21.1
Pla2g4a'H-Ras expression; c-Myc activation' vs 'wild type'phenotypeRNA-seq of heart tissue from 15 day old mice 4 hours post MycER activation compared to wild type controls. RNA-seq of heart tissues from adult mice that have expressed oncogenic H-Ras for 4 weeks followed by MycER activation for 4 hours compared to MycER negative controls.
Adjusted p-valueLog2-fold change
1.8927 × 10-21.1
Pla2g4a'TRIM28(flox/flox):Mx1Cre' vs 'TRIM28(flox/flox)' in 'CD71(hi)TER119-'genotype, phenotypeTranscription profiling by high throughput sequencing of bone marrow immature erythroid cells from Trim28flox/flox:TgMx1Cre congenic mice
Adjusted p-valueLog2-fold change
2.1252 × 10-21.1
Pla2g4a'beta1-adrenoceptor overexpression, Crem knockout' vs 'wild type'genotypeTranscription profiling by array of CREM-knockout mice
Adjusted p-valueLog2-fold change
3.0524 × 10-2-1.1
Pla2g4a'FusΔNLS/+' vs 'wild type genotype' at '12 hour'genotype, timeMutant FUS triggers age-dependent synaptic impairment in presymptomatic ALS-FUS mice (RNA-seq part2)
Adjusted p-valueLog2-fold change
3.19 × 10-21.1
Pla2g4a'undifferentiated' vs 'differentiated; rosiglitazone' in 'SWR/J'phenotype, stimulus, strainRNA-seq of mouse subcutaneous SVF cells before and after differentiation with a brown fat differentiation cocktail
Adjusted p-valueLog2-fold change
4.7374 × 10-2-1.1
Pla2g4a'19BL; differentiated 3factor-reprogrammed induced pluripotent stem cell' vs 'R1; differentiated embryonic stem cell' at '11 day'cell line, growth condition, timeNatural cardiogenesis-based template predicts cardiogenic potential of induced pluripotent stem cell lines
Adjusted p-valueLog2-fold change
1.3353 × 10-31-1
Pla2g4a'Irx3 knockout' vs 'control' at '1 day'genetic modification, timeRNA-Seq of mouse Irx3-KO and Control ME3 cells on days 1 and 7 of adipogenic differentiation
Adjusted p-valueLog2-fold change
1.555 × 10-18-1
Pla2g4a'PF-04691502–resistant cell; 1 micromolar; PF-04691502 removed for 48 hours' vs 'parental AKP cell; dimethyl sulfoxide'compound, phenotypeResistance to PI3K/mTOR inhibitor PF-04691502 in KRAS mutant colorectal cancer models reveals a sensitivity to combination with EGFR inhibition
Adjusted p-valueLog2-fold change
2.6448 × 10-151
Pla2g4a'Helicobacter hepaticus' vs 'none' in 'wild type phenotype'infect, phenotypeWhole transcriptome profiling of the steady state and Hh-treated (8 hrs) Alpk1+/- (heterozygous) and Alpk1-/- (knockout) BMDMs using RNA-Sequencing approach
Adjusted p-valueLog2-fold change
6.4067 × 10-101
Pla2g4a'SARS coronavirus MA15; 2 day' vs 'mock' in 'C57BL/6J'infect, strain, timeGenomic profiling of collaborative cross founder mouse strains infected with respiratory viruses to discover novel transcripts and infection-related strain-specific gene and isoform expression
Adjusted p-valueLog2-fold change
1.6192 × 10-61
Pla2g4a'7 days P. chabaudi infected' vs 'uninfected' in 'gonadectomized female'clinical information, disease, sex, timeTranscription profiling by array of mice infected with Plasmodium chabaudi after gonadectomization to investigate involvement of gonadal steroids
Adjusted p-valueLog2-fold change
1.7955 × 10-61
Pla2g4a'Influenza A virus' vs 'mock' in 'interleukin-22'infect, stimulusTranscription profiling by array of pulmonary gene expression in response to interleukin-22 during severe influenza
Adjusted p-valueLog2-fold change
1.9165 × 10-51
Pla2g4a'Trim24 knockdown' vs 'wild type'genotypeTranscription profiling by high throughput sequencing of mouse embryonic stem cells following Trim24 and/or p53 knockdown
Adjusted p-valueLog2-fold change
2.7884 × 10-5-1
Pla2g4a'Gprc5a knockout' vs 'control'genotypeGene expression profile of lung epithelial cells cultured from normal tracheas of Gprc5a knockout and wild-type mice
Adjusted p-valueLog2-fold change
4.6665 × 10-51
Pla2g4a'lymphocytic choriomeningitis virus WE' vs 'normal'diseaseTranscription profiling by array of lymphocytic choriomeningitis virus-strain WE (LCMV-WE) infected mice versus naive mice.
Adjusted p-valueLog2-fold change
5.4904 × 10-51
Pla2g4a'wild type genoytpe; siRNA Keap1-1' vs 'wild type genotype; scrambled shRNA'RNA interference, compound, genotypeCharacterization of RA839, a non-covalent small-molecule binder to Keap1 and selective activator of Nrf2 signalling
Adjusted p-valueLog2-fold change
5.9439 × 10-5-1
Pla2g4a'Men1-null' vs 'wild type'genotypeDifferentially regulated genes in adipocytes derived from Men1-null vs WT mouse embryonic stem cells
Adjusted p-valueLog2-fold change
6.2533 × 10-5-1
Pla2g4a'mutant (Pdgfc-/-; Pdgfra GFP/+)' vs 'control'genotypeCerebral gene expression changes in Pdgfc and Pdgfra mutant
Adjusted p-valueLog2-fold change
6.3937 × 10-51
Pla2g4a'3110043O21Rik knockout; liver' vs 'wild type genotype; liver'genotype, organism part, sampling siteRNAseq of coding RNA in the liver, spleen, kidney, abdominal muscle and gonadal adipose tissue of knock out mice and wild type controls.
Adjusted p-valueLog2-fold change
7.349 × 10-5-1
Pla2g4a'acute oropharyngeal candidiasis' vs 'healthy' in wild type micecompound, disease, genotype, sexTranscription profiling by array of antibody blockade of IL-17-family cytokines in immunity to acute murine oral mucosal candidiasis
Adjusted p-valueLog2-fold change
9.7717 × 10-51
Pla2g4a'Panct1' vs 'non-targeting siRNA'RNA interferenceA combined RNAi and localization approach for dissecting long noncoding RNAs reveals a function of Panct1 in ES cells
Adjusted p-valueLog2-fold change
1.2798 × 10-4-1
Pla2g4a'doxycycline; 200 nanogram per milliliter; neoplasm; 5 day' vs 'none; normal; 0 day'compound, phenotype, timeRNA-seq of doxycycline induced tumor and residual mouse primary mammary epithelial cells grown in 3D cell cultures against non-induced controls
Adjusted p-valueLog2-fold change
2.497 × 10-4-1
Pla2g4a'prostaglandin E2; 1 micromolar' vs 'none' in 'primary cell line; wild type genotype'cell line, compound, genotypeBulk RNA-seq of wild type and MEF2A or MEF2C/D knockout mouse bone marrow macrophages under different stimulation conditions
Adjusted p-valueLog2-fold change
3.227 × 10-41
Pla2g4a'14 days P. chabaudi infected' vs 'uninfected' in 'intact male'clinical information, disease, sex, timeTranscription profiling by array of mice infected with Plasmodium chabaudi after gonadectomization to investigate involvement of gonadal steroids
Adjusted p-valueLog2-fold change
3.8806 × 10-41
Pla2g4a'Sall4 ZFC1-2Δ' vs 'wild type genotype'genotypeRNA-Seq of Sall4 mutants in mouse embryonic stem cells
Adjusted p-valueLog2-fold change
8.2814 × 10-4-1
Pla2g4a'postnatal day 21; hindlimb' vs 'embryonic day 17.5; whole forelimb and hindlimb'age, organism partExpression data from skeletal muscle satellite cells at different development stages
Adjusted p-valueLog2-fold change
9.3267 × 10-41
Pla2g4a'SARS coronavirus MA15; 10^4 PFU' vs 'none' at '4 day'stimulus, timeSM001: SARS CoV MA15 infection of C57Bl/6 mouse model – Data from 4 viral doses at 1, 2, 4 and 7 days post infection.
Adjusted p-valueLog2-fold change
1.0973 × 10-31
Pla2g4a'ABIN1[D485N] knock-in' vs 'wild type genotype' in 'classical monocyte'cell type, genotypeRNA-seq of inflammatory monocytes, patrolling monocytes and neutrophils in wild type and ABIN1[D485N] mice
Adjusted p-valueLog2-fold change
1.1739 × 10-3-1
Pla2g4a'side population cells' vs 'main population cells' in 'muscle'cell type, organism partGene expression of side population and main population cells, isolated from adult murine skeletal muscle and bone marrow
Adjusted p-valueLog2-fold change
1.5578 × 10-31
Pla2g4a'Influenza A virus (A/Puerto Rico/8/1934(H1N1)); 4 day' vs 'mock' in 'C57BL/6J'infect, strain, timeGenomic profiling of collaborative cross founder mouse strains infected with respiratory viruses to discover novel transcripts and infection-related strain-specific gene and isoform expression
Adjusted p-valueLog2-fold change
1.7156 × 10-31
Pla2g4a'Lactobacillus acidophilus NCFM' vs 'control'infectTranscription profiling by array of mouse dendritic cells after infection with Bifidobacterium bifidum and Lactobacillus acidophilus
Adjusted p-valueLog2-fold change
2.0487 × 10-3-1
Pla2g4a'NFAT5 knock-out' vs 'wild type' in 'none'compound, genotypeTranscription profiling by array of mouse bone marrow derived macrophages mutant for NAT5 after treatment with lipopolysaccharide
Adjusted p-valueLog2-fold change
2.5156 × 10-3-1
Pla2g4a'CAR deficient; ethanol and ellagic acid' vs 'wild type; ethanol and ellagic acid'genotype, treatmentNuclear receptor-mediated alleviation of alcoholic fatty liver by polyphenols contained in alcoholic beverages
Adjusted p-valueLog2-fold change
2.6213 × 10-3-1
Pla2g4a'90 day' vs '1 day'ageTranscriptional profilling of female mice liver as a function of age
Adjusted p-valueLog2-fold change
5.706 × 10-31
Pla2g4a'Crx knockout' vs 'control' at '20 zeitgeber'genotype, timeTranscriptome in 129sv and Crx-/- pineal gland at ZT (Zeitgeber time) 6 and ZT20
Adjusted p-valueLog2-fold change
6.3915 × 10-3-1
Pla2g4a'total RNA; HRasV12 and c-Myc overexpression and Eif4e heterozygous knockout' vs 'total RNA; wild type'fraction, genotypeRedefining the role of eIF4E dose in development, cancer, and protein synthesis
Adjusted p-valueLog2-fold change
2.0837 × 10-2-1
Pla2g4a'Pcl2 knockdown' vs 'control'genotypeGene expression profile in mouse embryonic stem cells in which endogenous Pcl2 expression was stably knocked down using short hairpin RNA
Adjusted p-valueLog2-fold change
2.1493 × 10-2-1
Pla2g4a'Rb^{lox/lox}; p130^{lox/lox}; p107+/-' vs 'wild type'genotypeTranscription profiling by array of livers from the mouse model of human hepatocellular carcinoma
Adjusted p-valueLog2-fold change
3.2708 × 10-21
Pla2g4a'Cnot3 knockout' vs 'wild type'phenotypeRNA-seq of mouse islets from Ins1-cre driven Cnot3 KO and control islets
Adjusted p-valueLog2-fold change
4.6713 × 10-21
Pla2g4a'19BL; differentiated 3factor-reprogrammed induced pluripotent stem cell' vs 'R1; differentiated embryonic stem cell' at '5 day'cell line, growth condition, timeNatural cardiogenesis-based template predicts cardiogenic potential of induced pluripotent stem cell lines
Adjusted p-valueLog2-fold change
4.716 × 10-21
Pla2g4a'Stella knockout' vs 'wild type genotype' in 'oocyte'developmental stage, genotypeTranscription profiling of wild type and Stella knockout oocytes, wild type and Stella maternal/zygotic knockout embryos to study to the role of Stella in early mouse development
Adjusted p-valueLog2-fold change
4.8117 × 10-21
Pla2g4a'adipose tissue specific Cnot1 knockout' vs 'wild type phenotype' in 'inguinal fat pad'organism part, phenotypeRNA-seq to identify the role of mRNA decay in mouse adipose tissues