ensmusg00000028788 (Ptp4a2)

mus musculus

protein tyrosine phosphatase 4a2

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Mus musculus
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Showing 6 experiments:
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Mammalian Kaessmann
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9 in 3 strains - DBA/2J
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9 in 3 strains - CD1
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9 in 3 strains - C57BL/6
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3 Soumillon et al
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Proteomics
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Transcriptomics
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Display log2-fold change
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Log2-fold changeSpeciesGene nameComparisonExperimental variablesExperiment name
Adjusted p-valueLog2-fold change
1.2276 × 10-31.9
Ptp4a2'fetal definitive erythroid cell' vs 'primitive erythroid cell' in 'reticulocyte'cell type, phenotypeTranscription profiling by array of differentiating primary primitive and definitive mouse red blood cells
Adjusted p-valueLog2-fold change
6.7335 × 10-31.8
Ptp4a2'unilateral ureteral obstruction' vs 'sham' in 'TIMP3 -/-'genotype, treatmentTIMP2 and TIMP3 have divergent roles in early renal tubulointerstitial injury
Adjusted p-valueLog2-fold change
3.6896 × 10-201.7
Ptp4a2'acute graft vs. host disease; T-cell depleted bone marrow + T cells transplant' vs 'normal; T-cell depleted bone marrow transplant'disease, stimulusRNA-Seq of lymph node fibroblastic reticular cells isolated from bone marrow transplant recipient mice with or without acute Graft-versus-host disease on day 7 or untransplanted control mice
Adjusted p-valueLog2-fold change
1.059 × 10-5-1.5
Ptp4a2'shRNA mediated Brd4 knockdown' vs 'control shRNA'treatmentExpression Data For BRD4 Inhibition
Adjusted p-valueLog2-fold change
1.079 × 10-21.5
Ptp4a2'unilateral ureteral obstruction' vs 'sham' in 'TIMP2 -/-'genotype, treatmentTIMP2 and TIMP3 have divergent roles in early renal tubulointerstitial injury
Adjusted p-valueLog2-fold change
1.7911 × 10-2-1.5
Ptp4a2'Tetrafluororethane; 50000 part per million; air' vs 'none; ; air'compound, treatmentTranscription profiling by array of Mus musculus liver tissue after exposure to various carcinogenic chemicals
Adjusted p-valueLog2-fold change
5.087 × 10-6-1.4
Ptp4a2'PGC-1 beta knock in' vs 'wild type'genotypeTranscription profiling by array of skeletal muscle from PGC-1 beta transgenic mice
Adjusted p-valueLog2-fold change
3.3685 × 10-5-1.4
Ptp4a2'Kin-' vs 'wild type' in 'cAMP' at '24 hour'compound, genotype, timeTranscription profiling by array of mouse S49 cells mutant for Kin after treatment with cAMP
Adjusted p-valueLog2-fold change
5.8142 × 10-31.4
Ptp4a2'induction of polymicrobial sepsis' vs 'control' at '24 hour' in '1.5 to 3 month mice'age, time, treatmentAged Mice are Unable to Mount an Effective Myeloid Response to Sepsis
Adjusted p-valueLog2-fold change
1.068 × 10-21.4
Ptp4a2'adult definitive erythroid cell' vs 'primitive erythroid cell' in 'reticulocyte'cell type, phenotypeTranscription profiling by array of differentiating primary primitive and definitive mouse red blood cells
Adjusted p-valueLog2-fold change
1.6107 × 10-21.4
Ptp4a2'AUY922; 100 nanomolar' vs 'DMSO; 0.1 percent' in 'wild type'compound, genotypeIdentification of targets regulated by MLL1 in response to HSP90 inhibitors
Adjusted p-valueLog2-fold change
2.5632 × 10-21.4
Ptp4a2'erythroblast' vs 'hematopoietic stem cell'cell typeTranscription profiling by array of primary megakaryocytes (MEG) and erythroblasts (ERY) developed from murine fetal liver hematopoietic stem cells
Adjusted p-valueLog2-fold change
2.3116 × 10-181.3
Ptp4a2'LDB1 knock-down with full-length Ldb1 construct' vs 'control shRNA'RNA interferenceRole of LDB1 in the transition from chromatin looping to transcription activation
Adjusted p-valueLog2-fold change
3.0875 × 10-51.3
Ptp4a2'hypobaric hypoxia' vs 'control'growth conditionComparison of gene expression in whole blood of mice subjected to hypobaric hypoxia at Mt. Everest in vivo.
Adjusted p-valueLog2-fold change
4.1984 × 10-5-1.3
Ptp4a2'clear cell sarcoma; Rosa26CreER' vs 'control'disease, genotypeMouse Model of Clear Cell Sarcoma
Adjusted p-valueLog2-fold change
4.6425 × 10-21.3
Ptp4a2'megakaryocyte' vs 'hematopoietic stem cell'cell typeTranscription profiling by array of primary megakaryocytes (MEG) and erythroblasts (ERY) developed from murine fetal liver hematopoietic stem cells
Adjusted p-valueLog2-fold change
2.4836 × 10-7-1.2
Ptp4a2'conditional Kras and p53 mutation induced soft tissue sarcoma' vs 'normal'diseaseTranscription profiling by array of mouse soft tissue sarcoma samples induced by conditional mutations of Kras and p53 against healthy muscles from mice of the same genotype but no induced sarcoma
Adjusted p-valueLog2-fold change
8.7604 × 10-6-1.2
Ptp4a2'polarized with E coli lipopolysacharide and INF-gamma' vs 'untreated'compound, treatmentExpression data from polarized macrophages: effect of p53
Adjusted p-valueLog2-fold change
7.2702 × 10-3-1.2
Ptp4a2'synovial sarcoma' vs 'normal'diseaseTranscription profiling by array of tumors excised from conditional mouse model of synovial sarcoma compared to skeletal muscle from wild type mice
Adjusted p-valueLog2-fold change
2.4702 × 10-21.2
Ptp4a2'4 hours after hCG treatment' vs 'control' in 'wild type'genotype, treatmentThe ISWI ATPase Snf2L is required for superovulation and regulates Fgl2 in differentiating mouse granulosa cells
Adjusted p-valueLog2-fold change
7.25 × 10-1121.1
Ptp4a2'tamoxifen induction at 2 months, wait 3 months' vs 'no tamoxifen induction' in 'luminal cell of prostate epithelium; Nkx3.1-CreERT2 targeted allele'cell type, genotype, growth conditionTranscription profiling by high throughput sequencing of PIN/tumor lesions from basal or luminal origins at time points at which mice displayed similar histopathological phenotypes
Adjusted p-valueLog2-fold change
4.1292 × 10-71.1
Ptp4a2'mutant MyoD expression' at '12 hour' vs 'wild type MyoD expression' at '0 hour'phenotype, timeTranscription profiling of mouse embryoic fibroblasts expressing wild type MyoD or its non-acetylatable version MyoD RRR to investigate how MyoD acetylation may contribute to differential gene activation.
Adjusted p-valueLog2-fold change
5.6983 × 10-61.1
Ptp4a2'mutant MyoD expression' at '24 hour' vs 'wild type MyoD expression' at '0 hour'phenotype, timeTranscription profiling of mouse embryoic fibroblasts expressing wild type MyoD or its non-acetylatable version MyoD RRR to investigate how MyoD acetylation may contribute to differential gene activation.
Adjusted p-valueLog2-fold change
1.0565 × 10-4-1.1
Ptp4a2'AZD5069; 100 milligram per kilogram' vs 'none'compoundRNA-seq to investigate differentially expressed genes in KPC mouse PDAC treated with CSF-1R small molecule inhibitor AZD7507 and/or the CXCR2 small molecule inhibitor AZD5069
Adjusted p-valueLog2-fold change
4.2073 × 10-41.1
Ptp4a2'normobaric hypoxia' vs 'control'growth conditionComparison of gene expression in whole blood of mice subjected to normobaric hypoxia in vivo.
Adjusted p-valueLog2-fold change
1.0393 × 10-3-1.1
Ptp4a2'clear cell sarcoma; TATCre' vs 'control'disease, genotypeMouse Model of Clear Cell Sarcoma
Adjusted p-valueLog2-fold change
2.7652 × 10-3-1.1
Ptp4a2'colitis' at '8 day' vs 'normal' at '0 day'disease, timeTemporal transcriptomic changes during DSS colitis development and resolution.
Adjusted p-valueLog2-fold change
3.082 × 10-31.1
Ptp4a2'induction of polymicrobial sepsis' vs 'control' at '24 hour' in '20 to 24 month mice'age, time, treatmentAged Mice are Unable to Mount an Effective Myeloid Response to Sepsis
Adjusted p-valueLog2-fold change
6.659 × 10-3-1.1
Ptp4a2'Mxd1 knockdown by siRNA' vs 'wild type' at '1 day'phenotype, time3' RNA-seq of differentiating (brown) mouse subcutaneous SVF cells upon knockdown of Zfp521, Fhl1, or Mxd1
Adjusted p-valueLog2-fold change
2.6311 × 10-16-1
Ptp4a2'liver-specific Cnot3 knockout' vs 'wild type'phenotypeRoles of mRNA decay in liver development
Adjusted p-valueLog2-fold change
6.8231 × 10-13-1
Ptp4a2'MyD88 homozygous knockout' vs 'wild type genotype' in 'TLR9 ligand CpG ODN (1826)'genotype, stimulusTranscription profiling by sequencing of murine MyD88 -/- and MyD88 +/+ mTECs stimulated with a TLR9 ligand
Adjusted p-valueLog2-fold change
1.1376 × 10-51
Ptp4a2'10 day' vs '0 day'ageTranscription profiling of mouse embyronic stem cell line CGR8 during the first 10 days of differentiation into embryoid bodies
Adjusted p-valueLog2-fold change
1.2178 × 10-51
Ptp4a2'7 day' vs '0 day'ageTranscription profiling of mouse embyronic stem cell line CGR8 during the first 10 days of differentiation into embryoid bodies
Adjusted p-valueLog2-fold change
3.9118 × 10-5-1
Ptp4a2'Lactobacillus acidophilus NCFM and Bifidobacterium bifidum Z9' vs 'control'infectTranscription profiling by array of mouse dendritic cells after infection with Bifidobacterium bifidum and Lactobacillus acidophilus
Adjusted p-valueLog2-fold change
2.802 × 10-41
Ptp4a2'Plasmodium chabaudi infection' vs 'no infection' in 'adjuvant only'infect, treatmentProtective vaccination against blood-stage malaria of Plasmodium chabaudi: differential gene expression in the liver of Balb/c mice towards the end of crisis phase
Adjusted p-valueLog2-fold change
4.1029 × 10-41
Ptp4a2'doxycicline-mediated expression of c-Jun' vs 'control'phenotypeTranscription profiling by array of mouse whole bone marrow after c-Jun induction
Adjusted p-valueLog2-fold change
1.4207 × 10-3-1
Ptp4a2'Yersinia pestis' vs 'control' in 'neutrophil'cell type, infect, sampling siteSpatially distinct neutrophil responses within the inflammatory lesions of pneumonic plague
Adjusted p-valueLog2-fold change
4.9908 × 10-31
Ptp4a2'Alb-Cre;HIF1dPA/HIF2dPA' vs 'Alb-Cre'genotypeTranscription profiling by array of mice with liver-specific expression of hypoxia inducible factor, or inactivated von Hippel-Lindau tumor suppressor
Adjusted p-valueLog2-fold change
6.5689 × 10-3-1
Ptp4a2'Sox17.Epi' vs 'Sox17.Endo'genotypeTranscription profiling by high throughput sequencing of Sox17.Epi and Endo cells from mouse embryos