ensmusg00000027077 (Smtnl1)

mus musculus

smoothelin-like 1

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Mus musculus
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Showing 26 experiments:
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Created with Highcharts 6.2.0arcuate nucleus of hypothalamusbronchuscaecumcentral neural epitheliumcolondorsal control neural epitheliumepidermal ectodermhead mesenchymehippocampal formationileumkidneylateral prominence neural epitheliumlungmaxillary archmedial prefrontal cortexmuscle tissueolfactory bulbolfactory pitskeletal muscle tissuestriatumtestistracheawhite adipose tissue
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9 in 3 strains - CD1
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9 in 3 strains - C57BL/6
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9 in 3 strains - DBA/2J
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Mammalian Kaessmann
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Vertebrates
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Developing gut
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14 - embryonic day 8.5
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14 - embryonic day 10.5
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Gregg et al - C57BL/6J
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Gregg et al - (CAST/EiJ X C57BL/6J)F1
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Gregg et al - (C57BL/6J X CAST/EiJ)F1
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3 Soumillon et al
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2
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14 - embryonic day 9.5
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4 Bonthuis et al - CastEiJ
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4 Bonthuis et al - C57BL/6J
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4 Bonthuis et al - (CastEiJ X …
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4 Bonthuis et al - (C57BL/6J X …
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Mernberger et al 2019 - Organism Part
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Fat and muscle
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Sun et al., 2020 - Organism part
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Gregg et al - CAST/EiJ
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4 Bonthuis et al - Idaho derived wild …
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Proteomics
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Transcriptomics
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-1
-9.2
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10.9
Display log2-fold change
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Log2-fold changeSpeciesGene nameComparisonExperimental variablesExperiment name
Adjusted p-valueLog2-fold change
4.6618 × 10-210.9
Smtnl1'soticlestat; 30 milligram per kilogram' vs 'none' in 'astrocyte; none'cell type, compound, diseaseRNA-seq profiling of three distinct cell populations in a murine model of epilepsia with and without drug treatment
Adjusted p-valueLog2-fold change
4.5615 × 10-23-9.2
Smtnl1'myeloid lineage restricted progenitor cell' vs 'long term hematopoietic stem cell' in 'Elp3fl/fl'cell type, genotypeRNA-seq of long-term hematopoietic stem cells and myeloid progenitors of control mice or mice conditionally deficient for Trp53 or Elp3 or both genes in the hematopoietic system
Adjusted p-valueLog2-fold change
8.4733 × 10-46.5
Smtnl1'AZD7507; AZD5069 (at same dosage); 100 milligram per kilogram' vs 'none'compoundRNA-seq to investigate differentially expressed genes in KPC mouse PDAC treated with CSF-1R small molecule inhibitor AZD7507 and/or the CXCR2 small molecule inhibitor AZD5069
Adjusted p-valueLog2-fold change
3.4754 × 10-6-5.8
Smtnl1'70 week' vs '6 week' in 'none; none;age, irradiatePericyte induced reprogramming of the bone marrow microenvironment drives stem and cancer cell quiescence
Adjusted p-valueLog2-fold change
1.8192 × 10-5-5.3
Smtnl1'clear cell sarcoma; TATCre' vs 'control'disease, genotypeMouse Model of Clear Cell Sarcoma
Adjusted p-valueLog2-fold change
3.2319 × 10-6-4.7
Smtnl1'clear cell sarcoma; Rosa26CreER' vs 'control'disease, genotypeMouse Model of Clear Cell Sarcoma
Adjusted p-valueLog2-fold change
1.4057 × 10-5-4.7
Smtnl1'osteosarcoma' vs 'control'disease, genotypeMouse Model of Clear Cell Sarcoma
Adjusted p-valueLog2-fold change
8.5568 × 10-8-4.1
Smtnl1'conditional Kras and p53 mutation induced soft tissue sarcoma' vs 'normal'diseaseTranscription profiling by array of mouse soft tissue sarcoma samples induced by conditional mutations of Kras and p53 against healthy muscles from mice of the same genotype but no induced sarcoma
Adjusted p-valueLog2-fold change
3.7463 × 10-7-3.8
Smtnl1'adult definitive erythroid cell' vs 'primitive erythroid cell' in 'mix of orthochromatic and polychromatophilic erythroblast'cell type, phenotypeTranscription profiling by array of differentiating primary primitive and definitive mouse red blood cells
Adjusted p-valueLog2-fold change
1.7137 × 10-6-3.5
Smtnl1'heterozygous RYR1 mutant' vs 'RYR1 wild type' in 'embryonic day 14.5'developmental stage, genotypeMicroarrays of mouse embryonic limb skeletal muscle at days E14.5 and E18.5 lacking the RYR1 or Cav1.1 Ca2+ channels
Adjusted p-valueLog2-fold change
2.5568 × 10-7-3.3
Smtnl1'carcinoma' vs 'normal'diseaseGene expression profile between normal mouse skin and carcinomas arising in the skin of RbF/F;K14creERTM;p107-/- mouse
Adjusted p-valueLog2-fold change
3.578 × 10-7-3.3
Smtnl1'synovial sarcoma' vs 'control'disease, genotypeMouse Model of Clear Cell Sarcoma
Adjusted p-valueLog2-fold change
5.6965 × 10-63.3
Smtnl1'SARS coronavirus MA15; 4 day' vs 'mock' in 'A/J'infect, strain, timeGenomic profiling of collaborative cross founder mouse strains infected with respiratory viruses to discover novel transcripts and infection-related strain-specific gene and isoform expression
Adjusted p-valueLog2-fold change
4.527 × 10-2-3.3
Smtnl1'30 month' vs '5 month' in 'male'age, block, sexExpression data from tail skin in young (5 months) and old (30 months) CB6F1 mice
Adjusted p-valueLog2-fold change
5.1576 × 10-53.2
Smtnl1'PGC-1 beta knock in' vs 'wild type'genotypeTranscription profiling by array of skeletal muscle from PGC-1 beta transgenic mice
Adjusted p-valueLog2-fold change
1.9979 × 10-4-3.2
Smtnl1'fetal definitive erythroid cell' vs 'primitive erythroid cell' in 'mix of orthochromatic and polychromatophilic erythroblast'cell type, phenotypeTranscription profiling by array of differentiating primary primitive and definitive mouse red blood cells
Adjusted p-valueLog2-fold change
8.478 × 10-43.2
Smtnl1'Salmonella enterica serovar Typhimurium' vs 'control' in 'derived macrophage from E14 cell line'clinical information, infectGene expression profiles of mouse embryonic stem cell derived macrophages infected with Salmonella typhimurium
Adjusted p-valueLog2-fold change
1.316 × 10-21-3.1
Smtnl1'Setd5 homozygous (null) knockout' vs 'Setd5 heterozygous knockout'genotypeTranscriptional profiling of Setd5 heterozygous and knockout mouse embryonic stem cells
Adjusted p-valueLog2-fold change
8.2149 × 10-6-3.1
Smtnl1'Irx3 knockout' vs 'control' at '7 day'genetic modification, timeRNA-Seq of mouse Irx3-KO and Control ME3 cells on days 1 and 7 of adipogenic differentiation
Adjusted p-valueLog2-fold change
6.9222 × 10-5-2.9
Smtnl1'homozygous RYR1 mutant' vs 'RYR1 wild type' in 'embryonic day 14.5'developmental stage, genotypeMicroarrays of mouse embryonic limb skeletal muscle at days E14.5 and E18.5 lacking the RYR1 or Cav1.1 Ca2+ channels
Adjusted p-valueLog2-fold change
6.4382 × 10-3-2.9
Smtnl1'synovial sarcoma' vs 'normal'diseaseTranscription profiling by array of tumors excised from conditional mouse model of synovial sarcoma compared to skeletal muscle from wild type mice
Adjusted p-valueLog2-fold change
2.8226 × 10-6-2.8
Smtnl1'homozygous Cav1.1 mutant' vs 'Cav1.1 wild type' in 'embryonic day 18.5'developmental stage, genotypeMicroarrays of mouse embryonic limb skeletal muscle at days E14.5 and E18.5 lacking the RYR1 or Cav1.1 Ca2+ channels
Adjusted p-valueLog2-fold change
4.7933 × 10-6-2.8
Smtnl1'homozygous RYR1 mutant' vs 'RYR1 wild type' in 'embryonic day 18.5'developmental stage, genotypeMicroarrays of mouse embryonic limb skeletal muscle at days E14.5 and E18.5 lacking the RYR1 or Cav1.1 Ca2+ channels
Adjusted p-valueLog2-fold change
2.4675 × 10-52.8
Smtnl1'embryonic day 16.5' vs 'embryonic day 11.5'developmental stageGene expression profile of diaphragm morphogenesis at different developmental stages
Adjusted p-valueLog2-fold change
7.957 × 10-42.7
Smtnl1'Triple knockout (Zfp36-/-, TNFR1-/-, TNFR2-/-)' vs 'wild type'genotypeTranscription profiling by high throughput sequencing of douple (TNFR1-/-/TNFR2-/-) and triple (Zfp36-/-/TNFR1-/-/TNFR2-/-) knockout mouse spleens
Adjusted p-valueLog2-fold change
6.5702 × 10-52.6
Smtnl1'Alkbh1-/-' vs 'wild type'genotypeTranscription profiling by array of wild type and Alkbh1 knock out mouse embyronic stem cells
Adjusted p-valueLog2-fold change
1.1254 × 10-32.6
Smtnl1'stabilization-competent' vs 'stabilization-incompetent' in '23 day; secondary reprogramming cell'age, cell type, phenotypeTranscription profiling by high throughput sequencing in gene expresion profile of 4 SC clones and 4 SI clones at different time points defined a stabilization competency signiture
Adjusted p-valueLog2-fold change
1.3007 × 10-2-2.3
Smtnl1'adult definitive erythroid cell' vs 'primitive erythroid cell' in 'reticulocyte'cell type, phenotypeTranscription profiling by array of differentiating primary primitive and definitive mouse red blood cells
Adjusted p-valueLog2-fold change
1.5338 × 10-3-2.2
Smtnl1'Duchenne muscular dystrophy' vs 'normal'diseaseRNA-seq comparison of immortalised myoblasts from dystrophic and WT mice
Adjusted p-valueLog2-fold change
9.5158 × 10-11-2
Smtnl1'NOD allele at SNP rs50454566' vs 'wild type genotype'genotypeRNA-Seq of mouse embryonic stem cells derived from genetically diverse inbred mouse strains with varying alleles at Lifr gene
Adjusted p-valueLog2-fold change
1.8664 × 10-181.9
Smtnl1'PH3 homozygous knockout' vs 'wild type phenotype'phenotypePHF3 binds RNA polymerase II via the SPOC domain and regulates transcription of neuronal genes - Mouse Embryonic Stem Cell RNAseq
Adjusted p-valueLog2-fold change
1.8631 × 10-21.9
Smtnl1'hematopoietic stem cell and hematopoietic multipotent progenitor cell' vs 'common myeloid progenitor'cell typeTranscription profiling by high throughput sequencing between multipotent hematopoietic stem progenitor cells LS+K) and myeloid committed cells (LS−K) of the mouse bone marrow
Adjusted p-valueLog2-fold change
1.8833 × 10-21.9
Smtnl1'SARS coronavirus MA15; 2 day' vs 'mock' in 'C57BL/6J'infect, strain, timeGenomic profiling of collaborative cross founder mouse strains infected with respiratory viruses to discover novel transcripts and infection-related strain-specific gene and isoform expression
Adjusted p-valueLog2-fold change
2.2728 × 10-51.8
Smtnl1'Aire knockout' vs 'wild type' in 'cTEC'genotype, phenotypeTranscription profiling by high throughput sequencing of primary cTEC, mTEClo, and mTEChi harvested from wild type and Aire-deficient mice
Adjusted p-valueLog2-fold change
4.519 × 10-4-1.8
Smtnl1'adult definitive erythroid cell' vs 'primitive erythroid cell' in 'basophilic erythroblast'cell type, phenotypeTranscription profiling by array of differentiating primary primitive and definitive mouse red blood cells
Adjusted p-valueLog2-fold change
7.6236 × 10-31.8
Smtnl1'masseter muscle' vs 'tibialis anterior'organism partTranscription profiling of mouse masseter and tibialis anterior muscles to determine expression differences between muscle groups
Adjusted p-valueLog2-fold change
8.5619 × 10-31.8
Smtnl1'SARS coronavirus MA15; 2 day' vs 'mock' in '129S1/SvImJ'infect, strain, timeGenomic profiling of collaborative cross founder mouse strains infected with respiratory viruses to discover novel transcripts and infection-related strain-specific gene and isoform expression
Adjusted p-valueLog2-fold change
1.6507 × 10-21.7
Smtnl1'stabilization-competent' vs 'stabilization-incompetent' in '22 day; secondary reprogramming cell'age, cell type, phenotypeTranscription profiling by high throughput sequencing in gene expresion profile of 4 SC clones and 4 SI clones at different time points defined a stabilization competency signiture
Adjusted p-valueLog2-fold change
1.7315 × 10-21.7
Smtnl1'Influenza A virus (A/Puerto Rico/8/1934(H1N1)); 4 day' vs 'mock' in '129S1/SvImJ'infect, strain, timeGenomic profiling of collaborative cross founder mouse strains infected with respiratory viruses to discover novel transcripts and infection-related strain-specific gene and isoform expression
Adjusted p-valueLog2-fold change
7.9032 × 10-10-1.6
Smtnl1'Sall4 homozygous knockout' vs 'wild type genotype'genotypeRNA-Seq of Sall4 mutants in mouse embryonic stem cells
Adjusted p-valueLog2-fold change
1.1934 × 10-4-1.6
Smtnl1'induced neuronal cell' vs 'pluripotent embryonic stem cell'phenotypeTranscription profiling by high throughput sequencing of retinoic acid-differentiated neuronal cells compared to nondifferentiated pluripotent embryonic stem cells
Adjusted p-valueLog2-fold change
3.0853 × 10-21.6
Smtnl1'brown adipose tissue' vs 'white adipose tissue' in 'high fat diet; 30 degree celsius'diet, organism part, temperatureRNA-seq of brown and white mouse adipose tissue at thermoneutrality and high-fat diet
Adjusted p-valueLog2-fold change
3.8948 × 10-21.6
Smtnl1'low-protein/high-carbohydrate diet' vs 'western diet'dietGene expression analysis of subcutaneous adipose tissue in mice fed with a low-protein/high carbohydrate diet
Adjusted p-valueLog2-fold change
3.7277 × 10-4-1.5
Smtnl1'fetal definitive erythroid cell' vs 'primitive erythroid cell' in 'basophilic erythroblast'cell type, phenotypeTranscription profiling by array of differentiating primary primitive and definitive mouse red blood cells
Adjusted p-valueLog2-fold change
2.632 × 10-21.5
Smtnl1'Influenza A virus (A/Puerto Rico/8/1934(H1N1)); 2 day' vs 'mock' in 'CAST/EiJ'infect, strain, timeGenomic profiling of collaborative cross founder mouse strains infected with respiratory viruses to discover novel transcripts and infection-related strain-specific gene and isoform expression
Adjusted p-valueLog2-fold change
4.8182 × 10-21.5
Smtnl1'Influenza A virus (A/Puerto Rico/8/1934(H1N1)); 2 day' vs 'mock' in '129S1/SvImJ'infect, strain, timeGenomic profiling of collaborative cross founder mouse strains infected with respiratory viruses to discover novel transcripts and infection-related strain-specific gene and isoform expression
Adjusted p-valueLog2-fold change
4.6532 × 10-7-1.4
Smtnl1'Sall4 -/-' vs 'wild type genotype'genotypeRNA-Seq of mouse embryonic stem cells in response to changes in Sall4
Adjusted p-valueLog2-fold change
7.3342 × 10-41.4
Smtnl1'8 month; GSL30 overexpression; medial gastrocnemius' vs '8 month; wild type; medial gastrocnemius'age, genotype, organism partTranscription profiling of muscles from mice with genetically modified muscle glycogen content to study the impact of glycogen content on gene expression.
Adjusted p-valueLog2-fold change
4.627 × 10-21.4
Smtnl1'S6K1 knockout' vs 'wild type' in 'white adipose tissue'genotype, organism partTranscription profiling of mouse long-lived S6K1 -/- strain females compared to wild types
Adjusted p-valueLog2-fold change
1.0175 × 10-41.3
Smtnl1'Pcbp2 knockout' vs 'wild type genotype'genotypeTranscription profiling by RNA-seq of fetal liver from poly(C) binding protein 2 (Pcbp2) knockout mice
Adjusted p-valueLog2-fold change
2.1486 × 10-2-1.2
Smtnl1'PolgD257A/D257A' vs 'wild type'genotypeTranscription profiling by array of cochlea from PolgD257A/D257A mice
Adjusted p-valueLog2-fold change
3.557 × 10-21.2
Smtnl1'stabilization-competent' vs 'stabilization-incompetent' in '21 day; secondary reprogramming cell'age, cell type, phenotypeTranscription profiling by high throughput sequencing in gene expresion profile of 4 SC clones and 4 SI clones at different time points defined a stabilization competency signiture
Adjusted p-valueLog2-fold change
7.8943 × 10-5-1.1
Smtnl1'3 day' vs '0 day'ageTranscription profiling of mouse embyronic stem cell line CGR8 during the first 10 days of differentiation into embryoid bodies
Adjusted p-valueLog2-fold change
4.7538 × 10-4-1.1
Smtnl1'dinitrofluorobenzene' vs 'control' in 'Cnr1 -/- /Cnr2 -/-'compound, genotypeTranscription profiling of mouse Cannabinoid receptor double knockouts (Cnr1 -/- /Cnr2 -/-) in CHS model to investigate cutaneous contact hypersensitivity
Adjusted p-valueLog2-fold change
7.8037 × 10-4-1.1
Smtnl1'PolgD257A knockout' vs 'control'genotypeGene expression profile of gastrocnemius muscle from D257A mice
Adjusted p-valueLog2-fold change
3.6093 × 10-3-1.1
Smtnl1'calorie restricted diet' vs 'normal diet' at '15 month'age, dietTranscription profiling by array of cochleae from mice fed a calorie-restricted diet
Adjusted p-valueLog2-fold change
6.0354 × 10-3-1.1
Smtnl1'fetal definitive erythroid cell' vs 'primitive erythroid cell' in 'proerythroblast'cell type, phenotypeTranscription profiling by array of differentiating primary primitive and definitive mouse red blood cells
Adjusted p-valueLog2-fold change
2.0217 × 10-5-1
Smtnl1'TUT4 deficiency; TUT7 knockout' vs 'wild type'phenotypeMicroarray profiling of mouse pachytene cells deficient for UPF2 or both TUT4 and TUT7
Adjusted p-valueLog2-fold change
3.6511 × 10-5-1
Smtnl1'10 day' vs '0 day'ageTranscription profiling of mouse embyronic stem cell line CGR8 during the first 10 days of differentiation into embryoid bodies
Adjusted p-valueLog2-fold change
5.5725 × 10-5-1
Smtnl1'6 day' vs '0 day'ageTranscription profiling of mouse embyronic stem cell line CGR8 during the first 10 days of differentiation into embryoid bodies
Adjusted p-valueLog2-fold change
6.1035 × 10-5-1
Smtnl1'2 day' vs '0 day'ageTranscription profiling of mouse embyronic stem cell line CGR8 during the first 10 days of differentiation into embryoid bodies
Adjusted p-valueLog2-fold change
3.0598 × 10-4-1
Smtnl1'Cbfb knockout' vs 'control of Cbfb knockout'genotypeTranscription profiling by array of Mus musculus expressing Cbfb-MYH11
Adjusted p-valueLog2-fold change
4.9723 × 10-3-1
Smtnl1'Mettl6 knockout clone D1' vs 'wild type genotype'genotypeMETTL6 is a tRNA m3C methyltransferase that regulates translation and tumor cell proliferation
Adjusted p-valueLog2-fold change
6.1824 × 10-31
Smtnl1'UV' vs 'sham' in 'DMSO' at '6 hour'irradiate, timeTranscription profiling by array of mouse dorsal skin exposed to UV radiation vs controls in mice treated with DMSO or selective tyrosine kinase inhibitor AG825
Adjusted p-valueLog2-fold change
8.5298 × 10-3-1
Smtnl1'adult definitive erythroid cell' vs 'primitive erythroid cell' in 'proerythroblast'cell type, phenotypeTranscription profiling by array of differentiating primary primitive and definitive mouse red blood cells
Adjusted p-valueLog2-fold change
1.8087 × 10-2-1
Smtnl1'acute graft vs. host disease' vs 'normal'compound, diseaseTranscription profiling by array of murine thymus medulla in the absence and presence of acute graft-versus-host disease
Adjusted p-valueLog2-fold change
1.874 × 10-21
Smtnl1'Cbfb+/MYH11' vs 'control of Cbfb+/MYH11'genotypeTranscription profiling by array of Mus musculus expressing Cbfb-MYH11