ensmusg00000022801 (Lrch3)

mus musculus

leucine-rich repeats and calponin homology (CH) domain containing 3

Filter your results

Mus musculus
Organism part
Showing 54 experiments:
image/svg+xml aorta circulatory system blood vessel brown adipose tissue white adipose tissue skin stomach duodenum pancreas spleen adrenal gland kidney colon small intestine caecum jejunum ileum esophagus gall bladder parotid gland submandibular gland lymph node parathyroid gland tongue Peyer’s patch prostate gland vas deferens epididymis testis seminal vesicle penis urinary bladder thymus femur bone marrow cartilage quadriceps femoris spinal cord lung diaphragm peripheral nervous system trachea hindlimb trigeminal nerve eye sciatic nerve intestinal mucosa liver heart brain skeletal muscle
Created with Highcharts 6.2.0adrenal glandcaudal brain neural epitheliumdorsal control neural epitheliumhead mesenchymelateral prominence neural epitheliummuscle (biceps femoris)preoptic areastriatumwhite adipose tissueaxillary lymph nodebraincolondentate gyrus of hippocampal formationepidermal ectodermeyeball of camera-type eyehippocampal formationintestinal mucosamammary glandmedial prefrontal cortexolfactory bulboviductsaliva-secreting glandsmall intestinethymusuterus
T
49 FANTOM5 project - adult
T
49 FANTOM5 project - neonate
T
49 FANTOM5 project - juvenile
T
49 FANTOM5 project - embryonic day 18
T
49 FANTOM5 project - embryonic day 17
T
49 FANTOM5 project - embryonic day 16
T
49 FANTOM5 project - embryonic day 15
T
49 FANTOM5 project - embryonic day 14
T
9 in 3 strains - DBA/2J
T
9 in 3 strains - CD1
T
9
T
49 FANTOM5 project - embryonic day 12
T
9 in 3 strains - C57BL/6
T
14 - embryonic day 10.5
T
49 FANTOM5 project - embryonic day 13
T
Mammalian Kaessmann
T
6
T
Vertebrates
T
4
T
14 - embryonic day 9.5
T
14 - embryonic day 8.5
T
4 Bonthuis et al - CastEiJ
T
4 Bonthuis et al - (CastEiJ X …
T
4 Bonthuis et al - (C57BL/6J X …
T
Fat and muscle
T
Developing gut
T
49 FANTOM5 project - embryonic day 11
T
3 Soumillon et al
T
3
T
Sun et al., 2020 - Organism part
T
Gregg et al - CAST/EiJ
T
Gregg et al - C57BL/6J
T
Gregg et al - (CAST/EiJ X C57BL/6J)F1
T
Gregg et al - (C57BL/6J X CAST/EiJ)F1
T
4 Bonthuis et al - C57BL/6J
T
Mernberger et al 2019 - Organism Part
T
49 FANTOM5 project - pregnant adult day …
T
49 FANTOM5 project - pregnant adult day …
T
2
T
49 FANTOM5 project - pregnant adult day …
T
49 FANTOM5 project - pregnant adult day …
T
49 FANTOM5 project - pregnant adult day …
T
49 FANTOM5 project - lactating adult …
T
49 FANTOM5 project - embryonic day 17.5
T
49 FANTOM5 project - embryonic day 14.5
T
49 FANTOM5 project - embryo
T
4 Bonthuis et al - Idaho derived wild …
P
Organism part - Geiger et al
P
Organism part - Huttlin et al
P
Linscheid et al., 2021 - tissue - heart …
P
Huttlin et al., 2010 - tissues - brain, …
P
Linscheid et al. 2019 - organism part
P
Organism part - Malmstrom et al - , , …
P
Deshmukh et al., 2015 - organism part
P
Proteomics
T
Transcriptomics
High
Medium
Low
Below cutoff
No data available

Filter your results

Kingdom
Species
Experiment type
Experimental variables
Regulation
-1
-2.4
1
1.7
Display log2-fold change
Download results
Log2-fold changeSpeciesGene nameComparisonExperimental variablesExperiment name
Adjusted p-valueLog2-fold change
4.7455 × 10-7-2.4
Lrch3'AZD5069; 100 milligram per kilogram' vs 'none'compoundRNA-seq to investigate differentially expressed genes in KPC mouse PDAC treated with CSF-1R small molecule inhibitor AZD7507 and/or the CXCR2 small molecule inhibitor AZD5069
Adjusted p-valueLog2-fold change
5.0507 × 10-3-2.1
Lrch3'induced extraembryonic endoderm stem cell; grown in XEN cell medium' vs 'mouse embryonic fibroblast; control'cell type, growth conditionOSKM induce extraembryonic endoderm stem (iXEN) cells in parallel to iPS cells
Adjusted p-valueLog2-fold change
9.5399 × 10-4-2
Lrch3'heat-shocked at 42 degreeC' vs 'grown at 33 degreeC' in 'HdhQ111 knock-in'genotype, growth conditionTranscription profiling by array of mouse wild type and Htt mutant striatal cells upon heat shock
Adjusted p-valueLog2-fold change
6.1994 × 10-4-1.9
Lrch3'clear cell sarcoma; TATCre' vs 'control'disease, genotypeMouse Model of Clear Cell Sarcoma
Adjusted p-valueLog2-fold change
9.5084 × 10-26-1.8
Lrch3'extraembryonic endoderm stem cell; grown in XEN cell medium' vs 'mouse embryonic fibroblast; control'cell type, growth conditionOSKM induce extraembryonic endoderm stem (iXEN) cells in parallel to iPS cells
Adjusted p-valueLog2-fold change
4.3467 × 10-7-1.8
Lrch3'reduced expression of miR-25' vs 'wild type'phenotypeTranscription profiling by high throughput sequencing of wild type and miR-25 agomir or antagomir treated mice
Adjusted p-valueLog2-fold change
1.608 × 10-5-1.8
Lrch3'colitis' at '19 day' vs 'normal' at '0 day'disease, timeTemporal transcriptomic changes during DSS colitis development and resolution.
Adjusted p-valueLog2-fold change
6.1644 × 10-81.7
Lrch3'confluent monolayer on collagen' at '7 day' vs 'freshly isolated' at '0 day'growth condition, timeTranscription profiling of primary mouse hepatocytes under different culture conditions
Adjusted p-valueLog2-fold change
2.6074 × 10-3-1.7
Lrch3'2'-fucosyllactose supplementation' vs 'control' in '8 weeks post-ileocecal resection'diet, treatmentTranscriptomic characterization of the impact of 2'-fucosyllactose supplementation on intestinal adaptation following ileocecal resection.
Adjusted p-valueLog2-fold change
4.0597 × 10-2-1.7
Lrch3'carboplatin; 30 milligram per kilogram' vs 'none' in '14 week; none'age, irradiatePericyte induced reprogramming of the bone marrow microenvironment drives stem and cancer cell quiescence
Adjusted p-valueLog2-fold change
3.2691 × 10-5-1.6
Lrch3'normobaric hypoxia' vs 'control'growth conditionComparison of gene expression in whole blood of mice subjected to normobaric hypoxia in vivo.
Adjusted p-valueLog2-fold change
2.002 × 10-25-1.5
Lrch3'doxorubicin; 17.5 milligram per kilogram body weight' vs 'vehicle' in 'scramble; podocyte'cell type, compound, genotypeTranscription profiling to identify the role of MOF in primary MEFs and differentiated podocytes in response to Adriamycin
Adjusted p-valueLog2-fold change
1.7949 × 10-201.5
Lrch3'Helicobacter hepaticus' vs 'none' in 'Alpk1 homozygous knockout'infect, phenotypeWhole transcriptome profiling of the steady state and Hh-treated (8 hrs) Alpk1+/- (heterozygous) and Alpk1-/- (knockout) BMDMs using RNA-Sequencing approach
Adjusted p-valueLog2-fold change
3.86 × 10-81.4
Lrch3'Reverbαflox/floxAlbCreERT2+' vs 'wild type genotype'genotypeAntibody-independent ChIP-sequencing and liver-targeted deletion redefine REVERBα repressor function - RNA-seq
Adjusted p-valueLog2-fold change
8.6668 × 10-3-1.4
Lrch3'Mycobacterium tuberculosis H37Rv' vs 'none'infectThe global transcriptome of whole lungs extracted from M. tuberculosis infected C57BL6 mice
Adjusted p-valueLog2-fold change
9.2559 × 10-3-1.4
Lrch3'adult definitive erythroid cell' vs 'primitive erythroid cell' in 'mix of orthochromatic and polychromatophilic erythroblast'cell type, phenotypeTranscription profiling by array of differentiating primary primitive and definitive mouse red blood cells
Adjusted p-valueLog2-fold change
6.0362 × 10-10-1.3
Lrch3'carcinoma' vs 'normal'diseaseGene expression profile between normal mouse skin and carcinomas arising in the skin of RbF/F;K14creERTM;p107-/- mouse
Adjusted p-valueLog2-fold change
3.153 × 10-81.3
Lrch3'neurosphere in differentiation medium; 5 day' vs 'neurosphere; 0 day' in 'Cstb knockout'genotype, growth condition, timeTranscriptome analysis of neurospheres derived from Cstb-KO mouse embryo brains during differentiation
Adjusted p-valueLog2-fold change
7.1004 × 10-81.3
Lrch3'6 day; osteogenesis differentiation' vs ' 0 day; control' in '2C12-pMirn378'cell line, growth condition, timeEffect of Mirn378 overexpression on gene expression during C2C12 myogenic and BMP2-induced osteogenic differentiation
Adjusted p-valueLog2-fold change
4.5168 × 10-6-1.3
Lrch3'fear conditioning' vs 'none'stimulusGene-expression changes in neurons active during contextual fear conditioning compared to controls left in the homecage
Adjusted p-valueLog2-fold change
7.4804 × 10-61.3
Lrch3'lipopolysaccharide; 10 nanogram per milliliter' vs 'none' in 'Hoxb8-FL; wild type genotype'cell line, compound, genotypeBulk RNA-seq of wild type and MEF2A or MEF2C/D knockout mouse bone marrow macrophages under different stimulation conditions
Adjusted p-valueLog2-fold change
1.2788 × 10-2-1.3
Lrch3'eIF6+/-' vs 'wild type genotype'genotypeRNA-seq of liver biopsies of eIF6 wild type and eIF6 heterozygous mice
Adjusted p-valueLog2-fold change
5.1356 × 10-181.2
Lrch3'lipopolysaccharide; 10 nanogram per milliliter' vs 'none' in 'primary cell line; wild type genotype'cell line, compound, genotypeBulk RNA-seq of wild type and MEF2A or MEF2C/D knockout mouse bone marrow macrophages under different stimulation conditions
Adjusted p-valueLog2-fold change
2.0187 × 10-14-1.2
Lrch3'diphtheria toxin; 30 nanogram per gram' vs 'none'stimulusRNA-seq of mouse brain tissue repopulating microglia in response to traumatic brain injury
Adjusted p-valueLog2-fold change
1.5633 × 10-71.2
Lrch3'3 day; osteogenesis differentiation' vs ' 0 day; control' in '2C12-pMirn0'cell line, growth condition, timeEffect of Mirn378 overexpression on gene expression during C2C12 myogenic and BMP2-induced osteogenic differentiation
Adjusted p-valueLog2-fold change
3.4873 × 10-61.2
Lrch3'confluent monolayer on collagen' at '5 day' vs 'freshly isolated' at '0 day'growth condition, timeTranscription profiling of primary mouse hepatocytes under different culture conditions
Adjusted p-valueLog2-fold change
1.2749 × 10-5-1.2
Lrch3'colitis' at '12 day' vs 'normal' at '0 day'disease, timeTemporal transcriptomic changes during DSS colitis development and resolution.
Adjusted p-valueLog2-fold change
3.3173 × 10-41.2
Lrch3'liver-specific Cnot1 knockout' vs 'wild type'phenotypeRoles of mRNA decay in liver development
Adjusted p-valueLog2-fold change
3.7865 × 10-4-1.2
Lrch3'MEF2A knockout' vs 'wild type genotype' in 'Hoxb8-FL; lipopolysaccharide; 10 nanogram per milliliter'cell line, compound, genotypeBulk RNA-seq of wild type and MEF2A or MEF2C/D knockout mouse bone marrow macrophages under different stimulation conditions
Adjusted p-valueLog2-fold change
6.1156 × 10-41.2
Lrch3'hepatocyte-derived proliferative ducts (hepPDs)' vs 'hepatocyte'cell typeTranscription profiling by high throughput sequencing of hepatocyte-derived progenitors cells in a mouse model of oval cell activation
Adjusted p-valueLog2-fold change
8.6305 × 10-101.1
Lrch3'Alb-Cre-ERT2 / Cnot1 flox/flox' vs 'Cnot1 flox/flox' in 'none'compound, genotype, timeRNA-seq of livers in control and Cnot1 tamoxifen-inducible liver-specific knockout mice
Adjusted p-valueLog2-fold change
1.8529 × 10-71.1
Lrch3'3 day; osteogenesis differentiation' vs ' 0 day; control' in '2C12-pMirn378'cell line, growth condition, timeEffect of Mirn378 overexpression on gene expression during C2C12 myogenic and BMP2-induced osteogenic differentiation
Adjusted p-valueLog2-fold change
9.2511 × 10-71.1
Lrch3'6 day; osteogenesis differentiation' vs ' 0 day; control' in '2C12-pMirn0'cell line, growth condition, timeEffect of Mirn378 overexpression on gene expression during C2C12 myogenic and BMP2-induced osteogenic differentiation
Adjusted p-valueLog2-fold change
2.324 × 10-61.1
Lrch3'Reverbαflox/floxAlbCreERT2-' vs 'wild type genotype'genotypeAntibody-independent ChIP-sequencing and liver-targeted deletion redefine REVERBα repressor function - RNA-seq
Adjusted p-valueLog2-fold change
2.5209 × 10-5-1.1
Lrch3'1810027O10Rik knockout; abdominal muscle' vs 'wild type genotype; abdominal muscle'genotype, organism part, sampling siteRNAseq of coding RNA in the liver, spleen, kidney, abdominal muscle and gonadal adipose tissue of knock out mice and wild type controls.
Adjusted p-valueLog2-fold change
9.456 × 10-51.1
Lrch3'neurosphere in differentiation medium; 1 day' vs 'neurosphere; 0 day' in 'Cstb knockout'genotype, growth condition, timeTranscriptome analysis of neurospheres derived from Cstb-KO mouse embryo brains during differentiation
Adjusted p-valueLog2-fold change
1.8121 × 10-41.1
Lrch3'Helicobacter hepaticus' vs 'none' in 'wild type phenotype'infect, phenotypeWhole transcriptome profiling of the steady state and Hh-treated (8 hrs) Alpk1+/- (heterozygous) and Alpk1-/- (knockout) BMDMs using RNA-Sequencing approach
Adjusted p-valueLog2-fold change
2.0015 × 10-3-1.1
Lrch3'heat-shocked at 42 degreeC' vs 'grown at 33 degreeC' in 'wild type'genotype, growth conditionTranscription profiling by array of mouse wild type and Htt mutant striatal cells upon heat shock
Adjusted p-valueLog2-fold change
2.8358 × 10-31.1
Lrch3'chemical hypoxia' vs 'control'growth conditionComparison of gene expression in whole blood of mice subjected to chemical hypoxia in vivo.
Adjusted p-valueLog2-fold change
6.8476 × 10-3-1.1
Lrch3'9V/null' vs 'wild type' in 'saline; lung'compound, genotype, organism partGaucher Disease: Transcriptome Analyses Using Microarray or mRNA Sequencing in a Mouse Model Treated with velaglucerase alfa or imiglucerase [RNA-Seq]
Adjusted p-valueLog2-fold change
9.7419 × 10-3-1.1
Lrch3'neuronal stem cell; positive staining for GFP and prominin' vs 'astrocyte; positive staining for GFP'cell type, phenotypeTranscription profiling by array of adult neural stem cells (hGFAP-GFP+/prominin1+ cells) compared to parenchymal astrocytes that are not neurogenic (hGFAP-GFP+ cells from the diencephalon)
Adjusted p-valueLog2-fold change
2.6753 × 10-23-1
Lrch3'α-GalCer; 2 microgram' vs 'none' in 'Cd1d homozyous knockout'compound, genotypeCD1d-dependent immune suppression mediated by regulatory B cells through modulations of iNKT cells
Adjusted p-valueLog2-fold change
1.4812 × 10-10-1
Lrch3'cerium oxide nanoparticles; 1 day differentiated; 25 microgram per milliliter' vs 'none; 1 day differentiated'compound, developmental stageRNA-seq of C17.2 neuronal progenitor cells exposed to cerium oxide nanoparticles during cell differentiation
Adjusted p-valueLog2-fold change
1.1442 × 10-51
Lrch3'confluent monolayer on collagen' at '3 day' vs 'freshly isolated' at '0 day'growth condition, timeTranscription profiling of primary mouse hepatocytes under different culture conditions
Adjusted p-valueLog2-fold change
1.473 × 10-5-1
Lrch3'mutant MyoD expression' at '24 hour' vs 'control' at '24 hour'phenotype, timeTranscription profiling of mouse embryoic fibroblasts expressing wild type MyoD or its non-acetylatable version MyoD RRR to investigate how MyoD acetylation may contribute to differential gene activation.
Adjusted p-valueLog2-fold change
8.5483 × 10-41
Lrch3'subconfluent monolayer on collagen' at '7 day' vs 'freshly isolated' at '0 day'growth condition, timeTranscription profiling of primary mouse hepatocytes under different culture conditions
Adjusted p-valueLog2-fold change
3.9625 × 10-3-1
Lrch3'ABIN1[D485N] knock-in' vs 'wild type genotype' in 'classical monocyte'cell type, genotypeRNA-seq of inflammatory monocytes, patrolling monocytes and neutrophils in wild type and ABIN1[D485N] mice
Adjusted p-valueLog2-fold change
6.2158 × 10-31
Lrch3'Ckit negative' vs 'Ckit positive'cell typeGene expression profile of c-kit positive and c-kit negative cells
Adjusted p-valueLog2-fold change
3.3204 × 10-2-1
Lrch3'5 week' vs '1 week' in 'Jak2+/V617F; CRISPR/Cas9 mediated knockout of Dnmt3a'genotype, timeRNA-seq of Jak2VF LSK cells transduced with Dnmt3a-Cas9-GFP lentivirus vs. emp-Cas9-GFP controls one week and five weeks post methylcellulose plating
Synonym
2210409B11Rik, LOC385628
Ortholog
Gene ontology
InterPro
Ensembl gene
Ensembl transcript
Ensembl protein
Entrez
UniProt
MGI ID (Mouse)
MGI description
Gene biotype
Design element
5412864, 5608232, 5414789, A_55_P2113944, 4857006, 1454756_at, 5508825, 4758456, 4832084, 5173043, 4715909, 4588656, 5209753, 5062141, 4507087, 5402863, 5088153, 5289416, 4891562, 17324932, ILMN_2478746, 4503780, 4991512, 4449155, A_52_P242751, 5564098, 10435162, 4660994, 4800143, 4983810, 5608963, 5166339, ILMN_2537726, 5403261, 5460632, 114564_at, 4812523, 5353973, 4668039, 5342044, 110326_at, 4458400, 5106355, 4613640, 4419619, 4674962, 5211314