ensmusg00000049929 (Lpar4)

mus musculus

lysophosphatidic acid receptor 4

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Mus musculus
Organism part
Showing 45 experiments:
Created with Highcharts 6.2.0adrenal glandaxillary lymph nodebronchuscentral neural epitheliumcorpora quadrigeminadifferentiated myotubeepididymisforelimbhippocampal formationintestinal mucosalateral prominence neural epitheliummandibular archmedulla oblongatanon-floor plate neural epitheliumolfactory pitpituitary glandskeletal muscle tissuestomachtestisurinary bladdervomeronasal organzone of skin
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49 FANTOM5 project - neonate
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49 FANTOM5 project - embryonic day 18
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49 FANTOM5 project - embryonic day 17
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49 FANTOM5 project - embryonic day 16
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49 FANTOM5 project - embryonic day 15
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49 FANTOM5 project - embryonic day 14
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49 FANTOM5 project - embryonic day 12
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49 FANTOM5 project - adult
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14 - embryonic day 10.5
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49 FANTOM5 project - embryonic day 13
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9 in 3 strains - DBA/2J
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9
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49 FANTOM5 project - juvenile
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9 in 3 strains - CD1
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6
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9 in 3 strains - C57BL/6
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4
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14 - embryonic day 9.5
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14 - embryonic day 8.5
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Developing gut
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49 FANTOM5 project - embryonic day 11
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3
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Sun et al., 2020 - Organism part
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Gregg et al - CAST/EiJ
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Gregg et al - C57BL/6J
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Gregg et al - (CAST/EiJ X C57BL/6J)F1
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Gregg et al - (C57BL/6J X CAST/EiJ)F1
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4 Bonthuis et al - (CastEiJ X …
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4 Bonthuis et al - (C57BL/6J X …
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Mernberger et al 2019 - Organism Part
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Mammalian Kaessmann
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Fat and muscle
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2
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4 Bonthuis et al - CastEiJ
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4 Bonthuis et al - C57BL/6J
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49 FANTOM5 project - pregnant adult day …
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49 FANTOM5 project - pregnant adult day …
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49 FANTOM5 project - pregnant adult day …
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49 FANTOM5 project - lactating adult …
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49 FANTOM5 project - embryonic day 17.5
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49 FANTOM5 project - embryonic day 14.5
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49 FANTOM5 project - embryo
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3 Soumillon et al
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4 Bonthuis et al - Idaho derived wild …
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Deshmukh et al., 2015 - organism part
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Proteomics
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Transcriptomics
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Display log2-fold change
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Log2-fold changeSpeciesGene nameComparisonExperimental variablesExperiment name
Adjusted p-valueLog2-fold change
1.9595 × 10-91-9
Lpar4'induced extraembryonic endoderm stem cell; grown in ES cell medium' vs 'mouse embryonic fibroblast; control'cell type, growth conditionOSKM induce extraembryonic endoderm stem (iXEN) cells in parallel to iPS cells
Adjusted p-valueLog2-fold change
3.7059 × 10-3-7.8
Lpar4'2 Gray; total body irradiation' vs 'none'irradiateRNA-seq on hematopoietic stem cells sorted from mice 1 month after they were irradiated (2Gy total body irradiation = IR) or not (non irradiated = NIR)
Adjusted p-valueLog2-fold change
7.305 × 10-7-6.6
Lpar4'Sox17.Epi' vs 'Sox17.Endo'genotypeTranscription profiling by high throughput sequencing of Sox17.Epi and Endo cells from mouse embryos
Adjusted p-valueLog2-fold change
4.2615 × 10-5-5.8
Lpar4'70 week' vs '6 week' in 'none; none;age, irradiatePericyte induced reprogramming of the bone marrow microenvironment drives stem and cancer cell quiescence
Adjusted p-valueLog2-fold change
1.0187 × 10-6-4.5
Lpar4'acute graft vs. host disease; T-cell depleted bone marrow + T cells transplant' vs 'normal; T-cell depleted bone marrow transplant'disease, stimulusRNA-Seq of lymph node fibroblastic reticular cells isolated from bone marrow transplant recipient mice with or without acute Graft-versus-host disease on day 7 or untransplanted control mice
Adjusted p-valueLog2-fold change
7.9009 × 10-19-4.4
Lpar4'extraembryonic endoderm stem cell; grown in ES cell medium' vs 'mouse embryonic fibroblast; control'cell type, growth conditionOSKM induce extraembryonic endoderm stem (iXEN) cells in parallel to iPS cells
Adjusted p-valueLog2-fold change
1.3195 × 10-16-4.3
Lpar4'extraembryonic endoderm stem cell; grown in XEN cell medium' vs 'mouse embryonic fibroblast; control'cell type, growth conditionOSKM induce extraembryonic endoderm stem (iXEN) cells in parallel to iPS cells
00
Log2-fold change
3.9
Lpar4'Irx3 knockout' vs 'control' at '1 day'genetic modification, timeRNA-Seq of mouse Irx3-KO and Control ME3 cells on days 1 and 7 of adipogenic differentiation
Adjusted p-valueLog2-fold change
2.032 × 10-10-3.7
Lpar4'MEF; transduced with NeuroD2 lentivirus' vs 'MEF; control'cell line, treatmentGenetic and epigenetic determinants of neurogenesis and myogenesis [expression profiling]
Adjusted p-valueLog2-fold change
1.8357 × 10-1493.6
Lpar4'Irx3 knockout' vs 'control' at '7 day'genetic modification, timeRNA-Seq of mouse Irx3-KO and Control ME3 cells on days 1 and 7 of adipogenic differentiation
Adjusted p-valueLog2-fold change
6.2295 × 10-53.6
Lpar4'tumor' vs 'normal' in 'kidney'clinical information, organism partPremature termination of in vivo reprogramming leads to cancer development through altered epigenetic regulation [array]
Adjusted p-valueLog2-fold change
1.665 × 10-73.4
Lpar4'2 day' vs '0 day'ageTranscription profiling of mouse embyronic stem cell line CGR8 during the first 10 days of differentiation into embryoid bodies
Adjusted p-valueLog2-fold change
3.2958 × 10-53.4
Lpar4'Ckit negative' vs 'Ckit positive'cell typeGene expression profile of c-kit positive and c-kit negative cells
Adjusted p-valueLog2-fold change
5.2724 × 10-93.3
Lpar4'6 day; osteogenesis differentiation' vs ' 0 day; control' in '2C12-pMirn0'cell line, growth condition, timeEffect of Mirn378 overexpression on gene expression during C2C12 myogenic and BMP2-induced osteogenic differentiation
Adjusted p-valueLog2-fold change
5.6704 × 10-83.3
Lpar4'transplanted secondary tumors' vs 'normal' in 'kidney'clinical information, organism partPremature termination of in vivo reprogramming leads to cancer development through altered epigenetic regulation [array]
Adjusted p-valueLog2-fold change
3.4592 × 10-3-3.2
Lpar4'chemical hypoxia' vs 'control'growth conditionComparison of gene expression in whole blood of mice subjected to chemical hypoxia in vivo.
Adjusted p-valueLog2-fold change
4.7386 × 10-32-3.1
Lpar4'Influenza A virus' vs 'none'infectRNA-seq of mouse alveolar macrophages from control and Influenza A virus infected animals
Adjusted p-valueLog2-fold change
4.3934 × 10-5-3.1
Lpar4'postnatal day 60' vs 'postnatal day 1' in 'insulin-expressing immature beta cell'cell type, developmental stageTranscription profiling by high throughput sequencing of murine beta cells at key stages of maturation
Adjusted p-valueLog2-fold change
2.2132 × 10-4-3.1
Lpar4'P60; insulin-expressing mature beta cells' vs 'E16.5; insulin-expressing nascent beta cells'age, cell typeTranscriptional profiling of nascent and mature pancreatic beta cells
Adjusted p-valueLog2-fold change
1.9822 × 10-5-3
Lpar4'myeloid lineage restricted progenitor cell' vs 'long term hematopoietic stem cell' in 'Elp3fl/fl'cell type, genotypeRNA-seq of long-term hematopoietic stem cells and myeloid progenitors of control mice or mice conditionally deficient for Trp53 or Elp3 or both genes in the hematopoietic system
Adjusted p-valueLog2-fold change
1.6972 × 10-2-3
Lpar4'induced extraembryonic endoderm stem cell; grown in XEN cell medium' vs 'mouse embryonic fibroblast; control'cell type, growth conditionOSKM induce extraembryonic endoderm stem (iXEN) cells in parallel to iPS cells
Adjusted p-valueLog2-fold change
1.0128 × 10-3-2.9
Lpar4'AZD5069; 100 milligram per kilogram' vs 'none'compoundRNA-seq to investigate differentially expressed genes in KPC mouse PDAC treated with CSF-1R small molecule inhibitor AZD7507 and/or the CXCR2 small molecule inhibitor AZD5069
Adjusted p-valueLog2-fold change
2.2808 × 10-6-2.8
Lpar4'Lkb1 -/- Pten-/-' vs 'wild type'genotypeLoss of Lkb1 and Pten Leads to Lung Squamous Cell Carcinoma with Elevated Pdl1 Expression: Epithelial Cells
Adjusted p-valueLog2-fold change
1.0557 × 10-32.8
Lpar4'tumor' vs 'normal' in 'liver'clinical information, organism partPremature termination of in vivo reprogramming leads to cancer development through altered epigenetic regulation [array]
Adjusted p-valueLog2-fold change
1.2331 × 10-22.8
Lpar4'ICG-001 and PHA665752' vs 'DMSO'compoundTranscription profiling by array of mammospheres derived from tumors of mice harboring Wnt/Met signaling mutations treated Wnt and MET pathway inhibitors
Adjusted p-valueLog2-fold change
4.6061 × 10-82.7
Lpar4'ABIN1[D485N] knock-in' vs 'wild type genotype' in 'non-classical monocyte'cell type, genotypeRNA-seq of inflammatory monocytes, patrolling monocytes and neutrophils in wild type and ABIN1[D485N] mice
Adjusted p-valueLog2-fold change
2.9094 × 10-62.7
Lpar4'1 day' vs '0 day'ageTranscription profiling of mouse embyronic stem cell line CGR8 during the first 10 days of differentiation into embryoid bodies
Adjusted p-valueLog2-fold change
2.6512 × 10-462.6
Lpar4'Sall4 homozygous knockout' vs 'wild type genotype'genotypeRNA-Seq of Sall4 mutants in mouse embryonic stem cells
Adjusted p-valueLog2-fold change
3.1746 × 10-7-2.6
Lpar4'clear cell sarcoma; Rosa26CreER' vs 'control'disease, genotypeMouse Model of Clear Cell Sarcoma
Adjusted p-valueLog2-fold change
1.0358 × 10-742.4
Lpar4'Mettl6 knockout clone D1' vs 'wild type genotype'genotypeMETTL6 is a tRNA m3C methyltransferase that regulates translation and tumor cell proliferation
Adjusted p-valueLog2-fold change
4.1467 × 10-82.4
Lpar4'3 day; osteogenesis differentiation' vs ' 0 day; control' in '2C12-pMirn0'cell line, growth condition, timeEffect of Mirn378 overexpression on gene expression during C2C12 myogenic and BMP2-induced osteogenic differentiation
Adjusted p-valueLog2-fold change
5.3676 × 10-32.4
Lpar4'hepatocyte-derived proliferative ducts (hepPDs)' vs 'biliary-derived proliferative ducts (bilDP)'cell typeTranscription profiling by high throughput sequencing of hepatocyte-derived progenitors cells in a mouse model of oval cell activation
Adjusted p-valueLog2-fold change
2.2536 × 10-702.3
Lpar4'Mettl6 knockout clone G6' vs 'wild type genotype'genotypeMETTL6 is a tRNA m3C methyltransferase that regulates translation and tumor cell proliferation
Adjusted p-valueLog2-fold change
4.4874 × 10-52.3
Lpar4'3 day' vs '0 day'ageTranscription profiling of mouse embyronic stem cell line CGR8 during the first 10 days of differentiation into embryoid bodies
Adjusted p-valueLog2-fold change
2.1389 × 10-3-2.3
Lpar4'tamoxifen induction at 2 months, wait 1 months' vs 'no tamoxifen induction' in 'luminal cell of prostate epithelium; Nkx3.1-CreERT2 targeted allele'cell type, genotype, growth conditionTranscription profiling by high throughput sequencing of PIN/tumor lesions from basal or luminal origins at time points at which mice displayed similar histopathological phenotypes
Adjusted p-valueLog2-fold change
1.2503 × 10-22.3
Lpar4'colitis' at '8 day' vs 'normal' at '0 day'disease, timeTemporal transcriptomic changes during DSS colitis development and resolution.
Adjusted p-valueLog2-fold change
4.6944 × 10-182.2
Lpar4'Sall4 -/-' vs 'wild type genotype'genotypeRNA-Seq of mouse embryonic stem cells in response to changes in Sall4
Adjusted p-valueLog2-fold change
6.3817 × 10-102.2
Lpar4'undifferentiated' vs 'differentiated; rosiglitazone' in 'AKR/J'phenotype, stimulus, strainRNA-seq of mouse subcutaneous SVF cells before and after differentiation with a brown fat differentiation cocktail
Adjusted p-valueLog2-fold change
2.5046 × 10-3-2.2
Lpar4'Kras G12D' vs 'wild type'genotypeLoss of Lkb1 and Pten Leads to Lung Squamous Cell Carcinoma with Elevated Pdl1 Expression: Epithelial Cells
Adjusted p-valueLog2-fold change
1.6019 × 10-6-2.1
Lpar4'730 day' vs '1 day'ageTranscriptional profilling of female mice liver as a function of age
Adjusted p-valueLog2-fold change
1.1422 × 10-5-2.1
Lpar4'SARS coronavirus MA15; 2 day' vs 'mock' in 'PWK/PhJ'infect, strain, timeGenomic profiling of collaborative cross founder mouse strains infected with respiratory viruses to discover novel transcripts and infection-related strain-specific gene and isoform expression
Adjusted p-valueLog2-fold change
1.2327 × 10-5-2.1
Lpar4'transgenic C3(1)-SV40Tag; 20 week' vs 'wild type; 8 week'age, genotypePrevention of mammary tumor progression by silencing HoxA1 via intraductal injection of nanoparticle-formulated siRNA
Adjusted p-valueLog2-fold change
1.8342 × 10-32.1
Lpar4"Evi1-GFP positive" vs "Evi1-GFP negative"phenotypeWhole genome expression profiling of Evi1-GFP positive and negative murine hematopoietic stem cell sub-populations.
Adjusted p-valueLog2-fold change
2.7419 × 10-222
Lpar4'undifferentiated' vs 'differentiated; rosiglitazone' in 'F1.B6x129'phenotype, stimulus, strainRNA-seq of mouse subcutaneous SVF cells before and after differentiation with a brown fat differentiation cocktail
Adjusted p-valueLog2-fold change
2.4559 × 10-62
Lpar4'6 day' vs '0 day'ageTranscription profiling of mouse embyronic stem cell line CGR8 during the first 10 days of differentiation into embryoid bodies
Adjusted p-valueLog2-fold change
2.6644 × 10-6-2
Lpar4'365 day' vs '1 day'ageTranscriptional profilling of female mice liver as a function of age
Adjusted p-valueLog2-fold change
3.7778 × 10-4-2
Lpar4'total RNA; HRasV12 and c-Myc overexpression and Eif4e wild type' vs 'total RNA; wild type'fraction, genotypeRedefining the role of eIF4E dose in development, cancer, and protein synthesis
Adjusted p-valueLog2-fold change
3.8935 × 10-3-2
Lpar4'Pcl2 knockdown' vs 'control'genotypeGene expression profile in mouse embryonic stem cells in which endogenous Pcl2 expression was stably knocked down using short hairpin RNA
Adjusted p-valueLog2-fold change
1.3381 × 10-22
Lpar4'hematopoietic stem cell and hematopoietic multipotent progenitor cell' vs 'common myeloid progenitor'cell typeTranscription profiling by high throughput sequencing between multipotent hematopoietic stem progenitor cells LS+K) and myeloid committed cells (LS−K) of the mouse bone marrow
Adjusted p-valueLog2-fold change
3.5236 × 10-6-1.9
Lpar4'180 day' vs '1 day'ageTranscriptional profilling of female mice liver as a function of age
Adjusted p-valueLog2-fold change
3.4227 × 10-3-1.9
Lpar4'lung carcinoma' vs 'normal' in 'Epcam+CD11b-CD11c- epithelial cell'cell type, diseaseTranscriptome analysis of isolated stormal cells and tumor epithelial cells in mouse lung cancer by RNA-Seq
Adjusted p-valueLog2-fold change
1.7774 × 10-31-1.8
Lpar4'neuron' vs 'differentiating progenitor'cell typeTranscription profiling by high throughput sequencing of proliferating neural stem cells, differentiating neurogenic progenitors and newborn neurons using a dual-reporter mouse line
Adjusted p-valueLog2-fold change
4.0177 × 10-111.8
Lpar4'undifferentiated' vs 'differentiated; rosiglitazone' in 'F1.129xB6'phenotype, stimulus, strainRNA-seq of mouse subcutaneous SVF cells before and after differentiation with a brown fat differentiation cocktail
Adjusted p-valueLog2-fold change
2.1708 × 10-91.8
Lpar4'6 day; osteogenesis differentiation' vs ' 0 day; control' in '2C12-pMirn378'cell line, growth condition, timeEffect of Mirn378 overexpression on gene expression during C2C12 myogenic and BMP2-induced osteogenic differentiation
Adjusted p-valueLog2-fold change
7.8188 × 10-91.8
Lpar4'undifferentiated' vs 'differentiated; rosiglitazone' in 'A/J'phenotype, stimulus, strainRNA-seq of mouse subcutaneous SVF cells before and after differentiation with a brown fat differentiation cocktail
Adjusted p-valueLog2-fold change
5.471 × 10-6-1.8
Lpar4'90 day' vs '1 day'ageTranscriptional profilling of female mice liver as a function of age
Adjusted p-valueLog2-fold change
1.4912 × 10-4-1.8
Lpar4'doxycycline; 200 nanogram per milliliter; neoplasm; 5 day' vs 'none; normal; 0 day'compound, phenotype, timeRNA-seq of doxycycline induced tumor and residual mouse primary mammary epithelial cells grown in 3D cell cultures against non-induced controls
Adjusted p-valueLog2-fold change
1.5604 × 10-2-1.8
Lpar4'lung carcinoma' vs 'normal' in 'lung cell'cell type, diseaseTranscriptome analysis of isolated stormal cells and tumor epithelial cells in mouse lung cancer by RNA-Seq
Adjusted p-valueLog2-fold change
9.7839 × 10-201.7
Lpar4'Sall4 ZFC4mut' vs 'wild type genotype'genotypeRNA-Seq of Sall4 mutants in mouse embryonic stem cells
Adjusted p-valueLog2-fold change
1.6087 × 10-91.7
Lpar4'undifferentiated' vs 'differentiated; rosiglitazone' in '129S6sv/ev'phenotype, stimulus, strainRNA-seq of mouse subcutaneous SVF cells before and after differentiation with a brown fat differentiation cocktail
Adjusted p-valueLog2-fold change
8.7201 × 10-8-1.7
Lpar4'5-aza-2'-deoxycytidine; 5 micromolar' vs 'none'compoundTranscription profiling by array of mouse primary dermal fibroblasts after treatment with 5-aza-2'-deoxycytidine
Adjusted p-valueLog2-fold change
2.7172 × 10-5-1.7
Lpar4'60 day' vs '1 day'ageTranscriptional profilling of female mice liver as a function of age
Adjusted p-valueLog2-fold change
2.9739 × 10-5-1.7
Lpar4'21 day' vs '1 day'ageTranscriptional profilling of female mice liver as a function of age
Adjusted p-valueLog2-fold change
6.4838 × 10-41.7
Lpar4'Salmonella enterica serovar Typhimurium' vs 'control' in 'bone marrow macrophage from 129P2 mouse strain'clinical information, infectGene expression profiles of mouse embryonic stem cell derived macrophages infected with Salmonella typhimurium
Adjusted p-valueLog2-fold change
1.4815 × 10-21.7
Lpar4'V6.5; embryonic stem cell’ vs 'wild type; endothelial'cell line, cell type, genotypeCD47 Inhibits Self-renewal and Reprogramming by Regulating c-Myc and Other Stem Cell Transcription Factors
Adjusted p-valueLog2-fold change
1.6082 × 10-21.7
Lpar4'5 day; Ad-VEGF-A164' vs '0 day; control'time, treatmentTranscription profiling by array of stromal-based signatures for the classification of gastric cance
Adjusted p-valueLog2-fold change
2.5237 × 10-2-1.7
Lpar4'neuronal stem cell; positive staining for GFP and prominin' vs 'astrocyte; positive staining for GFP'cell type, phenotypeTranscription profiling by array of adult neural stem cells (hGFAP-GFP+/prominin1+ cells) compared to parenchymal astrocytes that are not neurogenic (hGFAP-GFP+ cells from the diencephalon)
Adjusted p-valueLog2-fold change
1.0574 × 10-5-1.6
Lpar4'retinoic acid' vs 'none' in 'embryoid body' at '6 day'age, compound, phenotypeTranscription profiling of mouse embryonic stem cell line Sox1Tv2 during neuronal differentiation
Adjusted p-valueLog2-fold change
1.8454 × 10-5-1.6
Lpar4'30 day' vs '1 day'ageTranscriptional profilling of female mice liver as a function of age
Adjusted p-valueLog2-fold change
6.252 × 10-51.6
Lpar4'7 day' vs '0 day'ageTranscription profiling of mouse embyronic stem cell line CGR8 during the first 10 days of differentiation into embryoid bodies
Adjusted p-valueLog2-fold change
5.2903 × 10-4-1.6
Lpar4'cycloheximide' vs 'DMSO'compoundDissecting primary (translation independent) from secondary (translation dependent) IFN-mediated differential gene expression
Adjusted p-valueLog2-fold change
1.2802 × 10-3-1.6
Lpar4'Insm1-expressing endocrine progenitor cell' vs 'Insm1-lacking endocrine progenitor cell' in 'embryonic day 15.5'cell type, developmental stageTranscriptional regulation of endocrine cell differentiation by Insm1
Adjusted p-valueLog2-fold change
4.9822 × 10-31.6
Lpar4'carotid body' vs 'adrenal medulla'organism partExpression profile of mouse carotid body and adrenal medulla [RNA-Seq]
Adjusted p-valueLog2-fold change
1.4851 × 10-2-1.6
Lpar4'human chorionic gonadotropin; 5 International Unit' vs 'none' in 'wild type'compound, genotypeLaser Capture Microdissection isolation of preovulatory granulosa cells from WT and bERKO ovaries
Adjusted p-valueLog2-fold change
2.1363 × 10-2-1.6
Lpar4'30 month' vs '5 month' in 'male'age, block, sexExpression data from tail skin in young (5 months) and old (30 months) CB6F1 mice
Adjusted p-valueLog2-fold change
1.2909 × 10-5-1.5
Lpar4'acute oropharyngeal candidiasis' vs 'healthy' in wild type micecompound, disease, genotype, sexTranscription profiling by array of antibody blockade of IL-17-family cytokines in immunity to acute murine oral mucosal candidiasis
Adjusted p-valueLog2-fold change
1.2407 × 10-4-1.5
Lpar4'T-cell depleted bone marrow transplant' vs 'none' in 'normal'disease, stimulusRNA-Seq of lymph node fibroblastic reticular cells isolated from bone marrow transplant recipient mice with or without acute Graft-versus-host disease on day 7 or untransplanted control mice
Adjusted p-valueLog2-fold change
5.6168 × 10-4-1.5
Lpar4'Tbx5;Nkx2-5 knockout' vs 'wild type'genotypeTranscription profiling by array of tbx5, nkx2-5 or both transcription factor knockouts during early heart formation in mouse
Adjusted p-valueLog2-fold change
1.1832 × 10-3-1.5
Lpar4'SARS coronavirus MA15; 4 day' vs 'mock' in 'A/J'infect, strain, timeGenomic profiling of collaborative cross founder mouse strains infected with respiratory viruses to discover novel transcripts and infection-related strain-specific gene and isoform expression
Adjusted p-valueLog2-fold change
5.2517 × 10-3-1.5
Lpar4'15 day' vs '0 day'ageTime course analysis of the cardiac transcriptome in the neonatal period
Adjusted p-valueLog2-fold change
9.078 × 10-3-1.5
Lpar4'Ngn3-expressing cell' vs 'Ngn3-null cell'cell typeTranscriptional profiling of Ngn3-dependent pancreatic endocrine differentiation at E15.5
Adjusted p-valueLog2-fold change
6.0387 × 10-8-1.4
Lpar4'IRAK1BP1 KO' vs 'wild type' in 'TNFα'genotype, treatmentIdentification of TNFα-induced genes that are IRAK1BP1 dependent
Adjusted p-valueLog2-fold change
7.737 × 10-7-1.4
Lpar4'NrlGFP positive' vs 'NrlGFP negative'phenotypeTranscription profiling by array of photoreceptor precursor cells selected via cell surface antigen expression.
Adjusted p-valueLog2-fold change
7.8175 × 10-5-1.4
Lpar4'SARS coronavirus MA15; 4 day' vs 'mock' in 'PWK/PhJ'infect, strain, timeGenomic profiling of collaborative cross founder mouse strains infected with respiratory viruses to discover novel transcripts and infection-related strain-specific gene and isoform expression
Adjusted p-valueLog2-fold change
2.8683 × 10-4-1.4
Lpar4'hypobaric hypoxia' vs 'control'growth conditionComparison of gene expression in whole blood of mice subjected to hypobaric hypoxia at Mt. Everest in vivo.
Adjusted p-valueLog2-fold change
1.2181 × 10-31.4
Lpar4'shRNA mediated depletion of TUNA' vs 'control' at '6 day'time, treatmentTranscriptome Analysis of LincRNA TUNA Knockdown in Mouse Embryonic Stem Cells
Adjusted p-valueLog2-fold change
3.6989 × 10-3-1.4
Lpar4'Mycobacterium tuberculosis H37Rv' vs 'none'infectThe global transcriptome of whole lungs extracted from M. tuberculosis infected C57BL6 mice
Adjusted p-valueLog2-fold change
1.8085 × 10-2-1.4
Lpar4'polysomal RNA; HRasV12 and c-Myc overexpression and Eif4e wild type' vs 'polysomal RNA; wild type'fraction, genotypeRedefining the role of eIF4E dose in development, cancer, and protein synthesis
Adjusted p-valueLog2-fold change
1.8821 × 10-21.4
Lpar4'Tumor Necrosis Factor' vs 'none'stimulusTranscription profiling by high throughput sequencing of CD8 single positive thymocytes from F5 Rag1KO TCR transgenic mice stimulated with tumor necrosis factor
Adjusted p-valueLog2-fold change
3.9558 × 10-21.4
Lpar4'glioma' vs 'normal'diseaseGene expression profile between glioma associated macrophages and normal brain tissue associated macrophages
Adjusted p-valueLog2-fold change
6.5505 × 10-9-1.3
Lpar4'IRAK1BP1 KO' vs 'wild type' in 'none'genotype, treatmentIdentification of TNFα-induced genes that are IRAK1BP1 dependent
Adjusted p-valueLog2-fold change
2.1876 × 10-81.3
Lpar4'6 day; myogenesis differentiation' vs ' 0 day; control' in '2C12-pMirn378'cell line, growth condition, timeEffect of Mirn378 overexpression on gene expression during C2C12 myogenic and BMP2-induced osteogenic differentiation
Adjusted p-valueLog2-fold change
4.4995 × 10-81.3
Lpar4'3 day; osteogenesis differentiation' vs ' 0 day; control' in '2C12-pMirn378'cell line, growth condition, timeEffect of Mirn378 overexpression on gene expression during C2C12 myogenic and BMP2-induced osteogenic differentiation
Adjusted p-valueLog2-fold change
5.0428 × 10-61.3
Lpar4'6 day; myogenesis differentiation' vs ' 0 day; control' in '2C12-pMirn0'cell line, growth condition, timeEffect of Mirn378 overexpression on gene expression during C2C12 myogenic and BMP2-induced osteogenic differentiation
Adjusted p-valueLog2-fold change
7.9382 × 10-61.3
Lpar4'liver containing B16-F10 tumor' vs 'normal'sampling siteEndothelial inhibition of the glycolytic activator PFKFB3 induces tumor vessel normalization, impairs metastasis and improves chemotherapy
Adjusted p-valueLog2-fold change
3.2623 × 10-41.3
Lpar4'10 day' vs '0 day'ageTranscription profiling of mouse embyronic stem cell line CGR8 during the first 10 days of differentiation into embryoid bodies
Adjusted p-valueLog2-fold change
5.0487 × 10-41.3
Lpar4'5 day' vs '0 day'ageTranscription profiling of mouse embyronic stem cell line CGR8 during the first 10 days of differentiation into embryoid bodies
Adjusted p-valueLog2-fold change
8.6684 × 10-4-1.3
Lpar4'48 hour; leukemia inhibitory factor; 500 picomolar' vs '48 hour; none' at '48.42 hour'age, compound, timeTranscription profiling of mouse embryonic stem cell line CGR8 treated with Leukemia Inhibitory Factor (LIF) to identify LIF-dependent genes and early differentiation markers
Adjusted p-valueLog2-fold change
4.4151 × 10-31.3
Lpar4'adipose tissue specific Cnot1 knockout' vs 'wild type phenotype' in 'brown adipose tissue'organism part, phenotypeRNA-seq to identify the role of mRNA decay in mouse adipose tissues
Adjusted p-valueLog2-fold change
6.1462 × 10-3-1.3
Lpar4'48 hour; leukemia inhibitory factor; 500 picomolar' vs '48 hour; none' at '48 hour'age, compound, timeTranscription profiling of mouse embryonic stem cell line CGR8 treated with Leukemia Inhibitory Factor (LIF) to identify LIF-dependent genes and early differentiation markers
Adjusted p-valueLog2-fold change
1.4706 × 10-2-1.3
Lpar4'total RNA; HRasV12 and c-Myc overexpression and Eif4e heterozygous knockout' vs 'total RNA; wild type'fraction, genotypeRedefining the role of eIF4E dose in development, cancer, and protein synthesis
Adjusted p-valueLog2-fold change
1.7112 × 10-21.3
Lpar4'anti-mPDL1; anti-mCTLA4; 10 milligram per kilogram' vs 'none' at '7 day'compound, timeRNAseq of tumor samples from CT26 syngeneic mouse treated with a PD-L1 and CTLA-4 immunotherapy combination
Adjusted p-valueLog2-fold change
2.518 × 10-21.3
Lpar4'20 day; Ad-VEGF-A164' vs '0 day; control'time, treatmentTranscription profiling by array of stromal-based signatures for the classification of gastric cance
Adjusted p-valueLog2-fold change
4.701 × 10-51.2
Lpar4'7-ketocholesterol' vs 'vehicle (cyclodextrin)'compound, timeArray results for differential gene expression in 661W, a mouse cone photoreceptor-derived cell line, comparing cells incubated with vehicle controls vs. those treated with either of two 7-dehdyrocholesterol-derived oxysterols or cholesterol
Adjusted p-valueLog2-fold change
1.7937 × 10-4-1.2
Lpar4'trypsinized and mock FACS sorted' vs 'untreated'treatmentExpression data from mammary epithelial cells harvested from 8-9 week old C3H female mice - various isolation conditions
Adjusted p-valueLog2-fold change
2.0785 × 10-4-1.2
Lpar4'doxycycline; 200 nanogram per milliliter; neoplasm; 12 day' vs 'none; normal; 0 day'compound, phenotype, timeRNA-seq of doxycycline induced tumor and residual mouse primary mammary epithelial cells grown in 3D cell cultures against non-induced controls
Adjusted p-valueLog2-fold change
4.8433 × 10-4-1.2
Lpar4'untreated; Csf2rb-/-' vs 'untreated; wild type'clinical history, genotypeMouse GM-CSF-related alveolar macrophage genome-wide expression data
Adjusted p-valueLog2-fold change
7.5151 × 10-4-1.2
Lpar4'SARS coronavirus MA15; 2 day' vs 'mock' in 'WSB/EiJ'infect, strain, timeGenomic profiling of collaborative cross founder mouse strains infected with respiratory viruses to discover novel transcripts and infection-related strain-specific gene and isoform expression
Adjusted p-valueLog2-fold change
6.9278 × 10-3-1.2
Lpar4'neurogenin-3-expressing endocrine progenitor cell' vs 'neurogenin-3-lacking pancreatic progenitor cell' at 'embryonic day 15.5'cell type, developmental stageTranscription profiling by high throughput sequencing of murine beta cells at key stages of maturation
Adjusted p-valueLog2-fold change
2.0953 × 10-2-1.2
Lpar4'H-Ras expression; c-Myc activation' vs 'wild type'phenotypeRNA-seq of heart tissue from 15 day old mice 4 hours post MycER activation compared to wild type controls. RNA-seq of heart tissues from adult mice that have expressed oncogenic H-Ras for 4 weeks followed by MycER activation for 4 hours compared to MycER negative controls.
Adjusted p-valueLog2-fold change
3.5717 × 10-2-1.2
Lpar4'wounded skin; PKC alpha-/-' vs 'wounded skin; wild type genotype'clinical history, genotypeAltered dermal architecture in PKCα-/- skin
Adjusted p-valueLog2-fold change
4.1073 × 10-21.2
Lpar4'embryoid body' vs 'embryonic stem cell' on 'Affymetrix GeneChip Array MOE430B'developmental stageGene expression profile of J1 embryonic stem cells and J1 embryoid bodies
Adjusted p-valueLog2-fold change
1.3061 × 10-6-1.1
Lpar4'West Nile virus; late stage encephalitis' vs 'mock infection'infect, timeTranscriptomic profiling of the brains of WNV and CHIKV infection-induced encephalitis in young mice after 2, 3 or 5 days post infection
Adjusted p-valueLog2-fold change
3.1072 × 10-5-1.1
Lpar4'shRNA mediated Brd4 knockdown' vs 'control shRNA'treatmentExpression Data For BRD4 Inhibition
Adjusted p-valueLog2-fold change
2.3017 × 10-41.1
Lpar4'Mxd1 knockdown by siRNA' vs 'wild type' at '3 day'phenotype, time3' RNA-seq of differentiating (brown) mouse subcutaneous SVF cells upon knockdown of Zfp521, Fhl1, or Mxd1
Adjusted p-valueLog2-fold change
4.5713 × 10-41.1
Lpar4'conditional Kras and p53 mutation induced soft tissue sarcoma' vs 'normal'diseaseTranscription profiling by array of mouse soft tissue sarcoma samples induced by conditional mutations of Kras and p53 against healthy muscles from mice of the same genotype but no induced sarcoma
Adjusted p-valueLog2-fold change
8.7221 × 10-4-1.1
Lpar4'14 day' vs '1 day'ageTranscriptional profilling of female mice liver as a function of age
Adjusted p-valueLog2-fold change
1.2376 × 10-3-1.1
Lpar4'Influenza A virus (A/Puerto Rico/8/1934(H1N1)); 4 day' vs 'mock' in 'WSB/EiJ'infect, strain, timeGenomic profiling of collaborative cross founder mouse strains infected with respiratory viruses to discover novel transcripts and infection-related strain-specific gene and isoform expression
Adjusted p-valueLog2-fold change
1.7482 × 10-31.1
Lpar4'Fhl1 knockdown by siRNA' vs 'wild type' at '3 day'phenotype, time3' RNA-seq of differentiating (brown) mouse subcutaneous SVF cells upon knockdown of Zfp521, Fhl1, or Mxd1
Adjusted p-valueLog2-fold change
2.0561 × 10-31.1
Lpar4'undifferentiated' vs 'differentiated; rosiglitazone' in 'C57BL/6J'phenotype, stimulus, strainRNA-seq of mouse subcutaneous SVF cells before and after differentiation with a brown fat differentiation cocktail
Adjusted p-valueLog2-fold change
2.3479 × 10-31.1
Lpar4'4 day' vs '0 day'ageTranscription profiling of mouse embyronic stem cell line CGR8 during the first 10 days of differentiation into embryoid bodies
Adjusted p-valueLog2-fold change
3.1525 × 10-3-1.1
Lpar4'Drosha -/-' vs 'wild type genotype'genotypeRNA-seq of mouse ES cells with conditional Drosha knockout against wild type controls to identify pri-miRNAs
Adjusted p-valueLog2-fold change
1.841 × 10-21.1
Lpar4'p53 null mutant; plagL2 vector' vs 'p53 null mutant; empty vector'genotypeTranscription profiling by array of mouse primary neural stem cells mutant for p53 after infection with retrovirus expressing PLAGL2
Adjusted p-valueLog2-fold change
2.077 × 10-21.1
Lpar4'undifferentiated' vs 'differentiated; rosiglitazone' in 'SWR/J'phenotype, stimulus, strainRNA-seq of mouse subcutaneous SVF cells before and after differentiation with a brown fat differentiation cocktail
Adjusted p-valueLog2-fold change
2.2803 × 10-2-1.1
Lpar4'damaged by neuropathy' vs 'control'sampling siteTranscriptional profiling of damaged and adjacent but intact dorsal root ganglia neurons against DRG cells from contralacteral control regions from mice with neuropathy
Adjusted p-valueLog2-fold change
3.0172 × 10-21.1
Lpar4'carcinoma' vs 'normal'diseaseExpression data from (mouse) normal lung fibroblasts and carcinoma-associated fibroblasts
Adjusted p-valueLog2-fold change
6.871 × 10-7-1
Lpar4'26 day' vs '0 day'ageGene expression profile of mouse differentiating embryonic stem cells (day 0, 6, 16, and 26)
Adjusted p-valueLog2-fold change
1.4444 × 10-61
Lpar4'3 day; myogenesis differentiation' vs ' 0 day; control' in '2C12-pMirn0'cell line, growth condition, timeEffect of Mirn378 overexpression on gene expression during C2C12 myogenic and BMP2-induced osteogenic differentiation
Adjusted p-valueLog2-fold change
1.098 × 10-51
Lpar4"tunicamycin; 2 microgram per milliliter" vs "DMSO" in "C57BL/6J x 129S1Sv/ImJ F1 cross"compound, strainTranscription profiling by high throughput sequencing of mouse embryonic fibroblasts treated with tunicamycin to study the transcriptional response to endoplasmic reticulum stress
Adjusted p-valueLog2-fold change
3.6409 × 10-41
Lpar4'Crx knockout' vs 'control' at '6 zeitgeber'genotype, timeTranscriptome in 129sv and Crx-/- pineal gland at ZT (Zeitgeber time) 6 and ZT20
Adjusted p-valueLog2-fold change
9.8283 × 10-4-1
Lpar4'subarachnoid hemorrhage' vs 'normal'diseaseTranscription profiling by array of the effect of SAH on brain cells in white matter region of mice
Adjusted p-valueLog2-fold change
1.6318 × 10-3-1
Lpar4'chronic cystitis' vs 'none' in 'C57/Bl6'disease, strainChronic cystitis microarray comparing C3H/HeN and C57BL/6 bladder gene expression
Adjusted p-valueLog2-fold change
2.0064 × 10-31
Lpar4'anti-IL-17A and anti-IL-17F treatment' vs 'no treatment' in 'wild type mice with acute oropharyngeal candidiasis'compound, disease, genotype, sexTranscription profiling by array of antibody blockade of IL-17-family cytokines in immunity to acute murine oral mucosal candidiasis
Adjusted p-valueLog2-fold change
2.3065 × 10-3-1
Lpar4'co-culture' vs 'separate' in 'wild type genotype'genotype, growth conditionRNA-seq of wild-type and transformed Ink4a/Arf-/-; EGFRvIII neural stem cells in separate or co-culture conditions
Adjusted p-valueLog2-fold change
5.2111 × 10-3-1
Lpar4'brown adipose tissue' vs 'white adipose tissue' in 'high fat diet; 30 degree celsius'diet, organism part, temperatureRNA-seq of brown and white mouse adipose tissue at thermoneutrality and high-fat diet
Adjusted p-valueLog2-fold change
7.313 × 10-3-1
Lpar4'9V/null' vs 'wild type' in 'saline; lung'compound, genotype, organism partGaucher Disease: Transcriptome Analyses Using Microarray or mRNA Sequencing in a Mouse Model Treated with velaglucerase alfa or imiglucerase [RNA-Seq]
Adjusted p-valueLog2-fold change
1.0646 × 10-2-1
Lpar4'brown adipose tissue' vs 'white adipose tissue' in 'chow; 23 degree celsius'diet, organism part, temperatureRNA-seq of brown and white mouse adipose tissue at thermoneutrality and high-fat diet
Adjusted p-valueLog2-fold change
1.1043 × 10-2-1
Lpar4'Influenza A virus (A/Puerto Rico/8/1934(H1N1)); 2 day' vs 'mock' in '129S1/SvImJ'infect, strain, timeGenomic profiling of collaborative cross founder mouse strains infected with respiratory viruses to discover novel transcripts and infection-related strain-specific gene and isoform expression
Adjusted p-valueLog2-fold change
1.4112 × 10-2-1
Lpar4'acute oropharyngeal candidiasis wild type mice'; female' vs 'healthy wild type genotype mice'compound, disease, genotype, sexTranscription profiling by array of antibody blockade of IL-17-family cytokines in immunity to acute murine oral mucosal candidiasis
Adjusted p-valueLog2-fold change
1.4945 × 10-21
Lpar4'Mxd1 knockdown by siRNA' vs 'wild type' at '1 day'phenotype, time3' RNA-seq of differentiating (brown) mouse subcutaneous SVF cells upon knockdown of Zfp521, Fhl1, or Mxd1
Adjusted p-valueLog2-fold change
1.495 × 10-2-1
Lpar4'mechanical stress induced by fluid flow; skin' vs 'control; skin' on 'Affymetrix Array MOE430B'environmental stress, organism parttranscription profiling by array of phenotypic responses to mechanical stress in fibroblasts from tendon, cornea and skin.