ensmusg00000019558 (Slc6a8)

mus musculus

solute carrier family 6 (neurotransmitter transporter, creatine), member 8

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Mus musculus
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Showing 1 experiment:
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Log2-fold changeSpeciesGene nameComparisonExperimental variablesExperiment name
Adjusted p-valueLog2-fold change
1.9251 × 10-14-4.7
Slc6a8'acute graft vs. host disease; T-cell depleted bone marrow + T cells transplant' vs 'normal; T-cell depleted bone marrow transplant'disease, stimulusRNA-Seq of lymph node fibroblastic reticular cells isolated from bone marrow transplant recipient mice with or without acute Graft-versus-host disease on day 7 or untransplanted control mice
Adjusted p-valueLog2-fold change
5.8798 × 10-964.6
Slc6a8'Influenza A virus' vs 'none'infectRNA-seq of mouse alveolar macrophages from control and Influenza A virus infected animals
Adjusted p-valueLog2-fold change
2.474 × 10-4-3.6
Slc6a8'70 week' vs '6 week' in 'none; none;age, irradiatePericyte induced reprogramming of the bone marrow microenvironment drives stem and cancer cell quiescence
Adjusted p-valueLog2-fold change
1.6456 × 10-133.2
Slc6a8'Id2_Id3_double knockout' vs 'wild type' in 'CD4+TCRb+CD8– cell; thymus'cell type, genotype, organism partTranscription profiling by high throughput sequencing of Id-proteins (Id2 and Id3) gene knockout cells
Adjusted p-valueLog2-fold change
1.1524 × 10-4-2.8
Slc6a8"muscularis externa layer of small intestine" vs "lamina propria of small intestine" in "YFP positive"organism part, phenotypeBulk RNA-sequencing of self-maintaining versus monocyte-replaced gut macrophages
Adjusted p-valueLog2-fold change
3.6092 × 10-442.6
Slc6a8'Alb-Cre-ERT2 / Cnot1 flox/flox' vs 'Cnot1 flox/flox' in 'none'compound, genotype, timeRNA-seq of livers in control and Cnot1 tamoxifen-inducible liver-specific knockout mice
Adjusted p-valueLog2-fold change
2.4171 × 10-442.5
Slc6a8'P60; insulin-expressing mature beta cells' vs 'E16.5; insulin-expressing nascent beta cells'age, cell typeTranscriptional profiling of nascent and mature pancreatic beta cells
Adjusted p-valueLog2-fold change
2.1958 × 10-5-2.5
Slc6a8'colitis' at '8 day' vs 'normal' at '0 day'disease, timeTemporal transcriptomic changes during DSS colitis development and resolution.
Adjusted p-valueLog2-fold change
9.4451 × 10-3-2.5
Slc6a8'adult definitive erythroid cell' vs 'primitive erythroid cell' in 'proerythroblast'cell type, phenotypeTranscription profiling by array of differentiating primary primitive and definitive mouse red blood cells
Adjusted p-valueLog2-fold change
3.2865 × 10-52.4
Slc6a8'Plasmodium chabaudi infection' vs 'no infection' in 'adjuvant only'infect, treatmentProtective vaccination against blood-stage malaria of Plasmodium chabaudi: differential gene expression in the liver of Balb/c mice towards the end of crisis phase
Adjusted p-valueLog2-fold change
1.7208 × 10-42.4
Slc6a8'hepatocyte-specific Pten and Tgfbr2 knockout' vs 'wild type'genotypeHepatocyte-specific knockout of Pten and of Pten and Tgfbr2 in mice
Adjusted p-valueLog2-fold change
2.7154 × 10-22.4
Slc6a8'glioma' vs 'normal'diseaseGene expression profile between glioma associated macrophages and normal brain tissue associated macrophages
Adjusted p-valueLog2-fold change
3.9265 × 10-22.4
Slc6a8'expanded on HUVEC and m5GF in the presence of mD1R for 7 days' vs 'control'treatmentExpression data from cultured c-Kit+Sca-1+Lin- (KSL)cells
Adjusted p-valueLog2-fold change
1.3857 × 10-342.3
Slc6a8'Adjuvant System 03' at '8 hour' vs 'none'compound, timeRNA-Seq of RAW 264.7 cells stimulated with the AS03 adjuvant after 4 and 8 hours
Adjusted p-valueLog2-fold change
3.1783 × 10-42.3
Slc6a8'Taf10-/-' vs 'wild type'genotypeTranscription profiling by array of liver from Taf10 knock out mice
Adjusted p-valueLog2-fold change
1.6548 × 10-342.2
Slc6a8'Adjuvant System 03' at '4 hour' vs 'none'compound, timeRNA-Seq of RAW 264.7 cells stimulated with the AS03 adjuvant after 4 and 8 hours
Adjusted p-valueLog2-fold change
7.0181 × 10-9-2.2
Slc6a8'clear cell sarcoma; TATCre' vs 'control'disease, genotypeMouse Model of Clear Cell Sarcoma
Adjusted p-valueLog2-fold change
1.4423 × 10-42.2
Slc6a8'untreated; Csf2rb-/-' vs 'untreated; wild type'clinical history, genotypeMouse GM-CSF-related alveolar macrophage genome-wide expression data
Adjusted p-valueLog2-fold change
2.1214 × 10-672.1
Slc6a8'tamoxifen induction at 2 months, wait 3 months' vs 'no tamoxifen induction' in 'basal cell of prostate epithelium; CK5-CreERT2 transgenic line'cell type, genotype, growth conditionTranscription profiling by high throughput sequencing of PIN/tumor lesions from basal or luminal origins at time points at which mice displayed similar histopathological phenotypes
Adjusted p-valueLog2-fold change
1.1055 × 10-232.1
Slc6a8'neurosphere in differentiation medium; 12 day' vs 'neurosphere; 0 day' in 'wild type genotype'genotype, growth condition, timeTranscriptome analysis of neurospheres derived from Cstb-KO mouse embryo brains during differentiation
Adjusted p-valueLog2-fold change
1.764 × 10-52.1
Slc6a8'Rb^{lox/lox}; p130^{lox/lox}; p107+/-' vs 'wild type'genotypeTranscription profiling by array of livers from the mouse model of human hepatocellular carcinoma
Adjusted p-valueLog2-fold change
9.6734 × 10-32.1
Slc6a8'human chorionic gonadotropin; 5 International Unit' vs 'none' in 'bER knockout'compound, genotypeLaser Capture Microdissection isolation of preovulatory granulosa cells from WT and bERKO ovaries
Adjusted p-valueLog2-fold change
9.4668 × 10-202
Slc6a8'liver-specific Cnot1 knockout' vs 'wild type'phenotypeRoles of mRNA decay in liver development
Adjusted p-valueLog2-fold change
3.233 × 10-72
Slc6a8'adipose tissue specific Cnot1 knockout' vs 'wild type phenotype' in 'inguinal fat pad'organism part, phenotypeRNA-seq to identify the role of mRNA decay in mouse adipose tissues
Adjusted p-valueLog2-fold change
1.3751 × 10-42
Slc6a8'PTEN null' vs 'wild type genotype'genotypeRNA seq of prostate gland from WT, PTEN pc -/- and PTEN pc-/-;P53 -/- mice
Adjusted p-valueLog2-fold change
5.3678 × 10-4-2
Slc6a8"muscularis externa layer of small intestine" vs "lamina propria of small intestine" in "YFP negative"organism part, phenotypeBulk RNA-sequencing of self-maintaining versus monocyte-replaced gut macrophages
Adjusted p-valueLog2-fold change
1.9953 × 10-841.9
Slc6a8'tamoxifen induction at 2 months, wait 3 months' vs 'no tamoxifen induction' in 'luminal cell of prostate epithelium; Nkx3.1-CreERT2 targeted allele'cell type, genotype, growth conditionTranscription profiling by high throughput sequencing of PIN/tumor lesions from basal or luminal origins at time points at which mice displayed similar histopathological phenotypes
Adjusted p-valueLog2-fold change
8.8031 × 10-351.9
Slc6a8'tamoxifen induction at 2 months, wait 6 months' vs 'no tamoxifen induction' in 'basal cell of prostate epithelium; CK5-CreERT2 transgenic line'cell type, genotype, growth conditionTranscription profiling by high throughput sequencing of PIN/tumor lesions from basal or luminal origins at time points at which mice displayed similar histopathological phenotypes
Adjusted p-valueLog2-fold change
1.7834 × 10-131.9
Slc6a8'3110043O21Rik knockout; spleen' vs 'wild type genotype; spleen'genotype, organism part, sampling siteRNAseq of coding RNA in the liver, spleen, kidney, abdominal muscle and gonadal adipose tissue of knock out mice and wild type controls.
Adjusted p-valueLog2-fold change
7.9083 × 10-81.9
Slc6a8'uterine-specific Tsc2-null' vs 'wild type' in 'intact'genotype, treatmentTranscription profiling by high throughput sequencing of uterine-specific Tsc2-null mice
Adjusted p-valueLog2-fold change
1.0767 × 10-2-1.9
Slc6a8'subventicular zone of the lateral ventricle' vs 'cerebellum'organism partExpression data from adult Shh-responding astroglia cells in mice
Adjusted p-valueLog2-fold change
1.5321 × 10-2-1.9
Slc6a8'bone marrow macrophage; co-cultured with breast cancer cell line 4T1.2' vs 'bone marrow macrophage; control'cell type, growth conditionTranscription profiling of mouse bone marrow macrophages (BMM) compared to BMM co-cultured with 4T1.2 breast cancer cells, treated with tumour cell supernatant, or RAW macrophage cell line
Adjusted p-valueLog2-fold change
9.2256 × 10-311.8
Slc6a8'high fat diet' vs 'normal chow' in '28 week; ReverbαFlox2-6AdipoCre-'age, diet, genotypeTissue-autonomous regulation of adipose expansion by core clock protein REVERBα
Adjusted p-valueLog2-fold change
3.0094 × 10-49-1.7
Slc6a8'Setd5 homozygous (null) knockout' vs 'Setd5 heterozygous knockout'genotypeTranscriptional profiling of Setd5 heterozygous and knockout mouse embryonic stem cells
Adjusted p-valueLog2-fold change
7.8229 × 10-151.7
Slc6a8'neurosphere in differentiation medium; 12 day' vs 'neurosphere; 0 day' in 'Cstb knockout'genotype, growth condition, timeTranscriptome analysis of neurospheres derived from Cstb-KO mouse embryo brains during differentiation
Adjusted p-valueLog2-fold change
4.0591 × 10-91.7
Slc6a8'adipose tissue specific Cnot1 knockout' vs 'wild type phenotype' in 'brown adipose tissue'organism part, phenotypeRNA-seq to identify the role of mRNA decay in mouse adipose tissues
Adjusted p-valueLog2-fold change
7.0676 × 10-6-1.7
Slc6a8'transplanted secondary tumors' vs 'normal' in 'kidney'clinical information, organism partPremature termination of in vivo reprogramming leads to cancer development through altered epigenetic regulation [array]
Adjusted p-valueLog2-fold change
3.5369 × 10-31.7
Slc6a8'Macrophage of F4/80+, CD11b+, CD11c-+; obese leptin-deficient' vs 'Macrophage of F4/80+, CD11b+, CD11c-+; control'cell type, genotypeExpression data from mouse adipose tissue macrophage
Adjusted p-valueLog2-fold change
3.2956 × 10-21.7
Slc6a8'4 hours after hCG treatment' vs 'control' in 'Snfl2 Ex6DEL'genotype, treatmentThe ISWI ATPase Snf2L is required for superovulation and regulates Fgl2 in differentiating mouse granulosa cells
Adjusted p-valueLog2-fold change
1.6716 × 10-731.6
Slc6a8'interferon gamma; 10 nanogram per milliliter and interleukin-13; 10 nanogram per milliliter' vs 'none'compoundRNAseq of small intestinal organoids from mice treated with the cytokines IFNG, IL-13 and IL-22 for 24 hours
Adjusted p-valueLog2-fold change
4.1589 × 10-711.6
Slc6a8'interleukin-13 (Mus musculus); 10 nanogram per milliliter' vs 'none'compoundRNAseq of small intestinal organoids from mice treated with the cytokines IFNG, IL-13 and IL-22 for 24 hours
Adjusted p-valueLog2-fold change
4.5399 × 10-251.6
Slc6a8'liver-specific Cnot3 knockout' vs 'wild type'phenotypeRoles of mRNA decay in liver development
Adjusted p-valueLog2-fold change
1.7188 × 10-121.6
Slc6a8'undifferentiated' vs 'differentiated; rosiglitazone' in 'A/J'phenotype, stimulus, strainRNA-seq of mouse subcutaneous SVF cells before and after differentiation with a brown fat differentiation cocktail
Adjusted p-valueLog2-fold change
2.8526 × 10-61.6
Slc6a8'Ercc1 knock out' vs 'wild type'genotypeTranscription profiling by array of liver from mice mutant for Ercc1
Adjusted p-valueLog2-fold change
2.659 × 10-31.6
Slc6a8'Plasmodium chabaudi infection' vs 'no infection' in 'vaccination'infect, treatmentProtective vaccination against blood-stage malaria of Plasmodium chabaudi: differential gene expression in the liver of Balb/c mice towards the end of crisis phase
Adjusted p-valueLog2-fold change
1.7568 × 10-21.6
Slc6a8'4 hours after hCG treatment' vs 'control' in 'wild type'genotype, treatmentThe ISWI ATPase Snf2L is required for superovulation and regulates Fgl2 in differentiating mouse granulosa cells
Adjusted p-valueLog2-fold change
2.4173 × 10-141.5
Slc6a8'tamoxifen induction at 2 months, wait 1 months' vs 'no tamoxifen induction' in 'luminal cell of prostate epithelium; Nkx3.1-CreERT2 targeted allele'cell type, genotype, growth conditionTranscription profiling by high throughput sequencing of PIN/tumor lesions from basal or luminal origins at time points at which mice displayed similar histopathological phenotypes
Adjusted p-valueLog2-fold change
2.069 × 10-6-1.5
Slc6a8'lipopolysaccharide; 10 nanogram per milliliter and prostaglandin E2; 1 micromolar and interferon beta; 100 units per milliliter' vs 'none' in 'primary cell line; wild type genotype'cell line, compound, genotypeBulk RNA-seq of wild type and MEF2A or MEF2C/D knockout mouse bone marrow macrophages under different stimulation conditions
Adjusted p-valueLog2-fold change
2.668 × 10-61.5
Slc6a8'neurosphere in differentiation medium; 5 day' vs 'neurosphere; 0 day' in 'wild type genotype'genotype, growth condition, timeTranscriptome analysis of neurospheres derived from Cstb-KO mouse embryo brains during differentiation
Adjusted p-valueLog2-fold change
5.2021 × 10-61.5
Slc6a8'ko cyld-/-' vs 'wild type'genotypeTranscription profiling by array of mouse liver with Cyld inactivation
Adjusted p-valueLog2-fold change
6.638 × 10-61.5
Slc6a8'2.5 milligram per milliliter; Fibrinogen' at '12 hour' vs 'none'compound, timeTranscription profiling by array of adult mouse neural stem cell differentiation after 3 and 12 hours of fibrinogen treatment
Adjusted p-valueLog2-fold change
2.0628 × 10-51.5
Slc6a8'Alkbh1-/-' vs 'wild type'genotypeTranscription profiling by array of wild type and Alkbh1 knock out mouse embyronic stem cells
Adjusted p-valueLog2-fold change
2.1466 × 10-5-1.5
Slc6a8'wild type; mature luminal' vs 'wild type; MaSC/basal'cell type, genotypeExpression data from sorted control and Pygo2-null mouse mammary stem/basal cells
Adjusted p-valueLog2-fold change
4.6182 × 10-41.5
Slc6a8'brown adipose tissue' vs 'white adipose tissue' in 'chow; 23 degree celsius'diet, organism part, temperatureRNA-seq of brown and white mouse adipose tissue at thermoneutrality and high-fat diet
Adjusted p-valueLog2-fold change
7.2818 × 10-41.5
Slc6a8'Sox17.Epi' vs 'Sox17.Endo'genotypeTranscription profiling by high throughput sequencing of Sox17.Epi and Endo cells from mouse embryos
Adjusted p-valueLog2-fold change
7.4769 × 10-41.5
Slc6a8'upf3 knockout' vs 'wild type' in 'testis'cell type, genotypeUPF2 establishes testis-specific transcriptome enriched in transcripts with shorter 3’UTRs
Adjusted p-valueLog2-fold change
4.8004 × 10-221.4
Slc6a8'TGFβ, 5 nanogram per milliliter' vs 'none'sampling site, stimulusCellular and extracellular vesicle RNA sequence for E-cadherin-RFP EMT reporter system expressing mouse breast cancer cell line Py2T during EMT/MET
Adjusted p-valueLog2-fold change
1.9548 × 10-191.4
Slc6a8'Helicobacter hepaticus' vs 'none' in 'wild type phenotype'infect, phenotypeWhole transcriptome profiling of the steady state and Hh-treated (8 hrs) Alpk1+/- (heterozygous) and Alpk1-/- (knockout) BMDMs using RNA-Sequencing approach
Adjusted p-valueLog2-fold change
9.4413 × 10-81.4
Slc6a8'lipopolysaccharide; 10 nanogram per milliliter' vs 'none' in 'Hoxb8-FL; MEF2A knockout'cell line, compound, genotypeBulk RNA-seq of wild type and MEF2A or MEF2C/D knockout mouse bone marrow macrophages under different stimulation conditions
Adjusted p-valueLog2-fold change
1.2153 × 10-51.4
Slc6a8'methionine- and choline-deficient, high fat diet mixed with 0.1% metformin' vs 'normal'dietExpression data from mouse liver treated with metformin
Adjusted p-valueLog2-fold change
4.485 × 10-51.4
Slc6a8'5 nanogram per milliliter; TGFbeta1' vs 'none' at '24 hour'compound, timeTranscription profiling by array of mouse hepatocytes following treatment with growth factor beta 1 in a time series
Adjusted p-valueLog2-fold change
1.0095 × 10-41.4
Slc6a8'pre-B acute lymphoblastic leukemia 8093; nilotinib; 3 day' vs 'pre-B acute lymphoblastic leukemia 8093; nilotinib; 0 day'cell type, compound, timeDrug tolerance development of mouse Bcr/Abl pre-B ALL cells on irradiated MEFs
Adjusted p-valueLog2-fold change
3.138 × 10-41.4
Slc6a8'NEMO knockout' vs 'wild type'genotypeTNFR1 controls apoptosis and chronic liver disease in hepatocyte-specific IKKγ (Nemo) mice.
Adjusted p-valueLog2-fold change
2.2284 × 10-351.3
Slc6a8'doxorubicin; 17.5 milligram per kilogram body weight' vs 'vehicle' in 'scramble; podocyte'cell type, compound, genotypeTranscription profiling to identify the role of MOF in primary MEFs and differentiated podocytes in response to Adriamycin
Adjusted p-valueLog2-fold change
1.8033 × 10-101.3
Slc6a8'lung carcinoma' vs 'normal' in 'lung cell'cell type, diseaseTranscriptome analysis of isolated stormal cells and tumor epithelial cells in mouse lung cancer by RNA-Seq
Adjusted p-valueLog2-fold change
1.6637 × 10-61.3
Slc6a8'sham-preconditioning followed by intra-amygdala kainic acid' vs 'sham-preconditioning followed by intra-amygdala vehicle'clinical treatmentTranscription profiling by array of mice with epileptic tolerance
Adjusted p-valueLog2-fold change
7.2424 × 10-61.3
Slc6a8'confluent monolayer on collagen' at '7 day' vs 'freshly isolated' at '0 day'growth condition, timeTranscription profiling of primary mouse hepatocytes under different culture conditions
Adjusted p-valueLog2-fold change
7.7909 × 10-6-1.3
Slc6a8'synovial sarcoma' vs 'control'disease, genotypeMouse Model of Clear Cell Sarcoma
Adjusted p-valueLog2-fold change
2.8398 × 10-51.3
Slc6a8'methionine- and choline-deficient, high fat diet' vs 'normal'dietExpression data from mouse liver treated with metformin
Adjusted p-valueLog2-fold change
3.2702 × 10-51.3
Slc6a8'Mkl1-RFP with a mutated SRF-interaction site' vs 'full length Mkl1-RFP'genotypeTranscription profiling by array of HC11 mammary epithelial cell strains stably expressing different variants of the transcriptional regulator megakaryoblastic leukemia-1 (Mkl1)
Adjusted p-valueLog2-fold change
7.2106 × 10-5-1.3
Slc6a8'alpha-amanitin; maternal Ring1-Rnf+' vs 'none; maternal Ring1-Rnf+'compound, genotypePolycomb function during oogenesis is required for mouse early embryonic development (2-cell embryos)
Adjusted p-valueLog2-fold change
3.9817 × 10-41.3
Slc6a8'Pten knockout' vs 'wild type' at '15 month'genotype, timeTranscription profiling by array of Pten knockout liver cells of mouse
Adjusted p-valueLog2-fold change
5.736 × 10-41.3
Slc6a8'antibiotics, CCl4 and diethylnitrosamine' vs 'none' in 'wild type genotype'genotype, treatmentGene expression accompanying the promotion of hepatocellular carcinoma by intestinal microbiota and Tlr4 in mice.
Adjusted p-valueLog2-fold change
7.9068 × 10-41.3
Slc6a8'hepatocyte-specific Pten knockout' vs 'wild type'genotypeHepatocyte-specific knockout of Pten and of Pten and Tgfbr2 in mice
Adjusted p-valueLog2-fold change
1.0667 × 10-31.3
Slc6a8'high fat diet; 30 degree celsius' vs 'chow; 23 degree celsius' in 'white adipose tissue'diet, organism part, temperatureRNA-seq of brown and white mouse adipose tissue at thermoneutrality and high-fat diet
Adjusted p-valueLog2-fold change
1.5154 × 10-3-1.3
Slc6a8'2'-fucosyllactose supplementation' vs 'control' in '8 weeks post-ileocecal resection'diet, treatmentTranscriptomic characterization of the impact of 2'-fucosyllactose supplementation on intestinal adaptation following ileocecal resection.
Adjusted p-valueLog2-fold change
3.343 × 10-3-1.3
Slc6a8'HP1g knockdown' vs 'control' in 'embryoid body'developmental stage, genotypeTranscription profiling of mouse embryonic stem cell line CGR8 transfected with control shRNA and shRNA against HP1g in two different developmental stages
Adjusted p-valueLog2-fold change
1.1233 × 10-211.2
Slc6a8'high fat diet' vs 'normal chow' in '28 week; ReverbαFlox2-6AdipoCre+'age, diet, genotypeTissue-autonomous regulation of adipose expansion by core clock protein REVERBα
Adjusted p-valueLog2-fold change
1.9591 × 10-181.2
Slc6a8'Helicobacter hepaticus' vs 'none' in 'Alpk1 homozygous knockout'infect, phenotypeWhole transcriptome profiling of the steady state and Hh-treated (8 hrs) Alpk1+/- (heterozygous) and Alpk1-/- (knockout) BMDMs using RNA-Sequencing approach
Adjusted p-valueLog2-fold change
3.6428 × 10-121.2
Slc6a8'undifferentiated' vs 'differentiated; rosiglitazone' in '129S6sv/ev'phenotype, stimulus, strainRNA-seq of mouse subcutaneous SVF cells before and after differentiation with a brown fat differentiation cocktail
Adjusted p-valueLog2-fold change
1.4144 × 10-101.2
Slc6a8'undifferentiated' vs 'differentiated; rosiglitazone' in 'F1.129xB6'phenotype, stimulus, strainRNA-seq of mouse subcutaneous SVF cells before and after differentiation with a brown fat differentiation cocktail
Adjusted p-valueLog2-fold change
2.2961 × 10-8-1.2
Slc6a8'BAG6 homozygous knockout' vs 'wild type genotype'genotypeTranscription profiling of B16V mouse melanoma cells after BAG6 knockout to study impacts on extracellular vesicle mRNA cargo
Adjusted p-valueLog2-fold change
2.023 × 10-7-1.2
Slc6a8'Il10-/-; Rabgef1 IEC-KO' vs 'wild type genotype' in 'none'compound, genotypeRNA-seq analysis of colonic intestinal epithelial cells (IECs) isolated from naive wild-type C57BL/6 mice, DSS-treated wild-type C57BL/6 mice, Il10-/- C57BL/6 mice and Il10-/- C57BL/6 mice with IEC-specific Rabgef1 deletion
Adjusted p-valueLog2-fold change
2.7893 × 10-71.2
Slc6a8'seizure-preconditioning followed by intra-amygdala kainic acid' vs 'sham-preconditioning followed by intra-amygdala vehicle'clinical treatmentTranscription profiling by array of mice with epileptic tolerance
Adjusted p-valueLog2-fold change
4.0008 × 10-71.2
Slc6a8'Tumor Necrosis Factor' vs 'none'stimulusTranscription profiling by high throughput sequencing of CD8 single positive thymocytes from F5 Rag1KO TCR transgenic mice stimulated with tumor necrosis factor
Adjusted p-valueLog2-fold change
2.4974 × 10-61.2
Slc6a8'Gata3 knock out' vs 'wild type'genotypeTranscription profiling by array of Gata3 knock-out mice
Adjusted p-valueLog2-fold change
3.5045 × 10-61.2
Slc6a8'follicle stimulating hormone and epidermal growth factor' vs '293H control medium'growth conditionTranscription profiling by array of mouse cumulus cells after culture with growth differentiation factor 9 or follicle stimulating hormone and epidermal growth factor
Adjusted p-valueLog2-fold change
1.336 × 10-51.2
Slc6a8'undifferentiated' vs 'differentiated; rosiglitazone' in 'AKR/J'phenotype, stimulus, strainRNA-seq of mouse subcutaneous SVF cells before and after differentiation with a brown fat differentiation cocktail
Adjusted p-valueLog2-fold change
1.6282 × 10-51.2
Slc6a8'lipopolysaccharide' vs 'none' in 'bone marrow; wild type'cell type, compound, genotypeTranscription profiling by high throughput sequencing of spleens of GPR34 knockout and wild type mice
Adjusted p-valueLog2-fold change
1.2701 × 10-41.2
Slc6a8'control mice [Gp130f/f]; cecal ligation and puncture' vs 'control mice [Gp130f/f]; control'genotype, treatmentHepatic acute phase proteins control innate immune responses during infection by promoting myeloid derived suppressor cell function
Adjusted p-valueLog2-fold change
1.4715 × 10-41.2
Slc6a8'gamma radiation; 8 Gray' vs 'none' in 'Lgr5-Cre-ERT2; Il22-/-'genotype, irradiateRNA Seq of colonic Lgr5+ epithelial stem cells in Il22+/+ and Il22-/- mice during homeostasis and 24h after irradiation with 8 Gy
Adjusted p-valueLog2-fold change
1.5449 × 10-41.2
Slc6a8'non-pregnant' vs 'pregnant'clinical informationRNA-seq of pancreatic islets from pregnant mice
Adjusted p-valueLog2-fold change
3.244 × 10-4-1.2
Slc6a8'conditional Kras and p53 mutation induced soft tissue sarcoma' vs 'normal'diseaseTranscription profiling by array of mouse soft tissue sarcoma samples induced by conditional mutations of Kras and p53 against healthy muscles from mice of the same genotype but no induced sarcoma
Adjusted p-valueLog2-fold change
3.4496 × 10-4-1.2
Slc6a8'Zbtb10 knockdown' vs 'control' at '6 hour'genotype, timeRNA-seq of Zbtb10 Knockdown and Control cDC1 dendritic cells (Cd8+)
Adjusted p-valueLog2-fold change
3.6324 × 10-4-1.2
Slc6a8'lipopolysaccharide; 100 nanogram per milliliter and interferon gamma 20 nanogram per milliliter' vs 'none'stimulusTranscriptional profiling in macrophages in stimulated and unstimulated conditions.
Adjusted p-valueLog2-fold change
3.6878 × 10-4-1.2
Slc6a8'polarized with E coli lipopolysacharide and INF-gamma' vs 'untreated'compound, treatmentExpression data from polarized macrophages: effect of p53
Adjusted p-valueLog2-fold change
3.7213 × 10-41.2
Slc6a8'actinomycin D; 8 hour' vs 'none' in 'Cnot1 flox/flox'compound, genotype, timeRNA-seq of livers in control and Cnot1 tamoxifen-inducible liver-specific knockout mice
Adjusted p-valueLog2-fold change
1.1956 × 10-31.2
Slc6a8'NEMO-TNFR1 double knockout' vs 'wild type'genotypeTNFR1 controls apoptosis and chronic liver disease in hepatocyte-specific IKKγ (Nemo) mice.
Adjusted p-valueLog2-fold change
4.2504 × 10-31.2
Slc6a8'lung carcinoma' vs 'normal' in 'CD11b+Ly6G+ neutrophil'cell type, diseaseTranscriptome analysis of isolated stormal cells and tumor epithelial cells in mouse lung cancer by RNA-Seq
Adjusted p-valueLog2-fold change
1.0921 × 10-2-1.2
Slc6a8'SARS coronavirus MA15 E protein mutant Δ5' vs 'mock'infectHost responses contributing to the attenuation of severe acute respiratory syndrome coronaviruses missing E protein domains
Adjusted p-valueLog2-fold change
1.2314 × 10-21.2
Slc6a8'human chorionic gonadotropin; 5 International Unit' vs 'none' in 'wild type'compound, genotypeLaser Capture Microdissection isolation of preovulatory granulosa cells from WT and bERKO ovaries
Adjusted p-valueLog2-fold change
2.0208 × 10-28-1.1
Slc6a8'LDB1 knock-down with Ldb1 delta 4/5 construct' vs 'control shRNA'RNA interferenceRole of LDB1 in the transition from chromatin looping to transcription activation
Adjusted p-valueLog2-fold change
1.8459 × 10-6-1.1
Slc6a8'induced neural stem cell' vs 'mouse embryonic fibroblast cell'cell typeGene expression profile of mouse induced neural stem cells
Adjusted p-valueLog2-fold change
3.2542 × 10-61.1
Slc6a8'Tgfbeta inhibitor 20 micromolar' vs 'none'compoundExpression data from intestinal organoids altered for Tgfbeta signaling
Adjusted p-valueLog2-fold change
6.0442 × 10-6-1.1
Slc6a8'Influenza A virus' vs 'mock' in 'interleukin-22'infect, stimulusTranscription profiling by array of pulmonary gene expression in response to interleukin-22 during severe influenza
Adjusted p-valueLog2-fold change
3.741 × 10-51.1
Slc6a8'2.5 milligram per milliliter; Fibrinogen' at '3 hour' vs 'none'compound, timeTranscription profiling by array of adult mouse neural stem cell differentiation after 3 and 12 hours of fibrinogen treatment
Adjusted p-valueLog2-fold change
5.6616 × 10-51.1
Slc6a8'undifferentiated' vs 'differentiated; rosiglitazone' in 'F1.B6x129'phenotype, stimulus, strainRNA-seq of mouse subcutaneous SVF cells before and after differentiation with a brown fat differentiation cocktail
Adjusted p-valueLog2-fold change
1.2572 × 10-41.1
Slc6a8'collagen sandwich' at '3 day' vs 'freshly isolated' at '0 day'growth condition, timeTranscription profiling of primary mouse hepatocytes under different culture conditions
Adjusted p-valueLog2-fold change
1.5868 × 10-41.1
Slc6a8'subconfluent monolayer on collagen' at '7 day' vs 'freshly isolated' at '0 day'growth condition, timeTranscription profiling of primary mouse hepatocytes under different culture conditions
Adjusted p-valueLog2-fold change
2.0183 × 10-41.1
Slc6a8'TGF-beta; 15 nanogram per milliliter' vs 'control'compoundTGF beta Dosage Experiment
Adjusted p-valueLog2-fold change
2.3263 × 10-41.1
Slc6a8'lipopolysaccharide; 10 nanogram per milliliter' vs 'none' in 'Hoxb8-FL; wild type genotype'cell line, compound, genotypeBulk RNA-seq of wild type and MEF2A or MEF2C/D knockout mouse bone marrow macrophages under different stimulation conditions
Adjusted p-valueLog2-fold change
3.6894 × 10-41.1
Slc6a8'CCl4 and diethylnitrosamine' vs 'none' in 'wild type genotype'genotype, treatmentGene expression accompanying the promotion of hepatocellular carcinoma by intestinal microbiota and Tlr4 in mice.
Adjusted p-valueLog2-fold change
1.2535 × 10-3-1.1
Slc6a8'synovial sarcoma' vs 'normal'diseaseTranscription profiling by array of tumors excised from conditional mouse model of synovial sarcoma compared to skeletal muscle from wild type mice
Adjusted p-valueLog2-fold change
2.4377 × 10-3-1.1
Slc6a8'liver-specific Pit1 knockout' vs 'wild type genotype' in 'high fat diet'diet, genotypeTranscription profiling by array of liver tissues from mice with liver-specific knockout of Pit1 and wild-type littermates fed with either a high-fat diet or chow control diet
Adjusted p-valueLog2-fold change
2.8749 × 10-3-1.1
Slc6a8'inh-alpha/Tag transgenic' vs 'wild type' in 'none'compound, genotypeNovel genes involved in the pathophysiology of gonadotropin-dependent adrenocortical tumorigenesis in mice.
Adjusted p-valueLog2-fold change
3.884 × 10-31.1
Slc6a8'Salmonella enterica serovar Typhimurium' vs 'control' in 'derived macrophage from E14 Traf2 mutant cell line'clinical information, infectGene expression profiles of mouse embryonic stem cell derived macrophages infected with Salmonella typhimurium
Adjusted p-valueLog2-fold change
6.1117 × 10-3-1.1
Slc6a8'tumor' vs 'normal' in 'kidney'clinical information, organism partPremature termination of in vivo reprogramming leads to cancer development through altered epigenetic regulation [array]
Adjusted p-valueLog2-fold change
1.3407 × 10-2-1.1
Slc6a8'heat-shocked at 42 degreeC' vs 'grown at 33 degreeC' in 'HdhQ111 knock-in'genotype, growth conditionTranscription profiling by array of mouse wild type and Htt mutant striatal cells upon heat shock
Adjusted p-valueLog2-fold change
1.5753 × 10-21.1
Slc6a8'S6K1 knockout' vs 'wild type' in 'liver'genotype, organism partTranscription profiling of mouse long-lived S6K1 -/- strain females compared to wild types
Adjusted p-valueLog2-fold change
1.5905 × 10-2-1.1
Slc6a8'Runx3 knockout' vs 'wild type genotype' in 'IL-2'compound, genotypeRunx3 function in splenic NK cells (IL-2 or IL-15)
Adjusted p-valueLog2-fold change
1.5948 × 10-21.1
Slc6a8'streptozotocin; 30 milligram per kilogram' vs 'vehicle'compoundRNA-seq of islet, FACS- sorted CD45+Ly6C-CD11B+CD11C+F4/80+ cells from C57bl6/J male mice that were treated with low dose streptozotocin (STZ) or acetate buffer
Adjusted p-valueLog2-fold change
3.2772 × 10-2-1.1
Slc6a8'damaged by neuropathy' vs 'control'sampling siteTranscriptional profiling of damaged and adjacent but intact dorsal root ganglia neurons against DRG cells from contralacteral control regions from mice with neuropathy
Adjusted p-valueLog2-fold change
3.6976 × 10-2-1.1
Slc6a8'one year after pulmonary macrophage transplantation; Csf2rb-/-' vs 'untreated; Csf2rb-/-'clinical history, genotypeMouse GM-CSF-related alveolar macrophage genome-wide expression data
Adjusted p-valueLog2-fold change
4.7441 × 10-21.1
Slc6a8'one year after pulmonary macrophage transplantation; Csf2rb-/-' vs 'untreated; wild type'clinical history, genotypeMouse GM-CSF-related alveolar macrophage genome-wide expression data
Adjusted p-valueLog2-fold change
1.7281 × 10-121
Slc6a8'intestinal smooth muscle culture supernatant' vs 'none' in 'organoid culture without Noggin (ER medium)'growth condition, stimulusRNA-seq of small intestinal organoids treated with the control medium ENR (EGF, Noggin, R-spondin1) in the presence or absence of muscle supernatant
Adjusted p-valueLog2-fold change
1.7566 × 10-91
Slc6a8'undifferentiated' vs 'differentiated; rosiglitazone' in 'C57BL/6J'phenotype, stimulus, strainRNA-seq of mouse subcutaneous SVF cells before and after differentiation with a brown fat differentiation cocktail
Adjusted p-valueLog2-fold change
2.6656 × 10-81
Slc6a8'3110043O21Rik knockout; liver' vs 'wild type genotype; liver'genotype, organism part, sampling siteRNAseq of coding RNA in the liver, spleen, kidney, abdominal muscle and gonadal adipose tissue of knock out mice and wild type controls.
Adjusted p-valueLog2-fold change
8.1547 × 10-8-1
Slc6a8'Kit ligand; wasp knockout' vs 'Kit ligand; wild type'compound, genotypeTranscription profiling of bone marrow–derived mast cells from WASP-deficient mice after stimulation with kit ligand
Adjusted p-valueLog2-fold change
1.1969 × 10-71
Slc6a8'gamma radiation; 8 Gray' vs 'none' in 'Lgr5-Cre-ERT2'genotype, irradiateRNA Seq of colonic Lgr5+ epithelial stem cells in Il22+/+ and Il22-/- mice during homeostasis and 24h after irradiation with 8 Gy
Adjusted p-valueLog2-fold change
5.0913 × 10-71
Slc6a8'undifferentiated' vs 'differentiated; rosiglitazone' in 'SWR/J'phenotype, stimulus, strainRNA-seq of mouse subcutaneous SVF cells before and after differentiation with a brown fat differentiation cocktail
Adjusted p-valueLog2-fold change
1.0122 × 10-61
Slc6a8'uterine-specific Tsc2-null' vs 'wild type' in 'oopherectomized'genotype, treatmentTranscription profiling by high throughput sequencing of uterine-specific Tsc2-null mice
Adjusted p-valueLog2-fold change
3.4575 × 10-6-1
Slc6a8'colitis' at '19 day' vs 'normal' at '0 day'disease, timeTemporal transcriptomic changes during DSS colitis development and resolution.
Adjusted p-valueLog2-fold change
5.8408 × 10-61
Slc6a8'Abcc8-/-' vs 'wild type genotype' in 'high fat; female'diet, genotype, sexEffects of increased intracellular calcium and overnutrition on pancreatic beta cell transcriptome
Adjusted p-valueLog2-fold change
7.2401 × 10-61
Slc6a8'HDAC1 knock out' vs 'wild type'genotypeTranscription profiling by array of embryonic stem cells from wild type and histone deacetylase 1 (HDAC1) knock out mice
Adjusted p-valueLog2-fold change
1.0529 × 10-5-1
Slc6a8'extraembryonic endoderm stem cell; grown in XEN cell medium' vs 'mouse embryonic fibroblast; control'cell type, growth conditionOSKM induce extraembryonic endoderm stem (iXEN) cells in parallel to iPS cells
Adjusted p-valueLog2-fold change
2.0725 × 10-5-1
Slc6a8'dinitrofluorobenzene' vs 'control' in 'Cnr1 -/- /Cnr2 -/-'compound, genotypeTranscription profiling of mouse Cannabinoid receptor double knockouts (Cnr1 -/- /Cnr2 -/-) in CHS model to investigate cutaneous contact hypersensitivity
Adjusted p-valueLog2-fold change
2.3725 × 10-5-1
Slc6a8'dinitrofluorobenzene' vs 'control' in 'wild type'compound, genotypeTranscription profiling of mouse Cannabinoid receptor double knockouts (Cnr1 -/- /Cnr2 -/-) in CHS model to investigate cutaneous contact hypersensitivity
Adjusted p-valueLog2-fold change
3.391 × 10-51
Slc6a8'Staphylococcus aureus Sanger476; 2 hour' vs 'none; 0 hour' in 'C57BL/6J'infect, strain, timeGene Expression-Based Classifiers Identify Staphylococcus aureus Infection in Mice and Humans
Adjusted p-valueLog2-fold change
3.8794 × 10-51
Slc6a8'12.5 days post conception, pregnant' vs 'non-pregnant'clinical informationTranscription profiling by array of pancreatic islets from pregnant mice
Adjusted p-valueLog2-fold change
6.9234 × 10-51
Slc6a8'collagen sandwich' at '2 day' vs 'freshly isolated' at '0 day'growth condition, timeTranscription profiling of primary mouse hepatocytes under different culture conditions
Adjusted p-valueLog2-fold change
7.3594 × 10-5-1
Slc6a8'MEF; transduced with MyoD lentivirus' vs 'MEF; control'cell line, treatmentGenetic and epigenetic determinants of neurogenesis and myogenesis [expression profiling]
Adjusted p-valueLog2-fold change
7.6385 × 10-51
Slc6a8'Egr2 and Egr3 knockout' vs 'Egr2-GFP knockin; Egr2-GFP high' in 'CD4-positive T cell'cell type, genotype, phenotypeRNAseq analysis of CD4 and CD8 T cells in response to vaccinia virus infection
Adjusted p-valueLog2-fold change
1.1882 × 10-41
Slc6a8'collagen sandwich' at '7 day' vs 'freshly isolated' at '0 day'growth condition, timeTranscription profiling of primary mouse hepatocytes under different culture conditions
Adjusted p-valueLog2-fold change
1.551 × 10-4-1
Slc6a8'MEF; transduced with NeuroD2 lentivirus' vs 'MEF; control'cell line, treatmentGenetic and epigenetic determinants of neurogenesis and myogenesis [expression profiling]
Adjusted p-valueLog2-fold change
1.6963 × 10-4-1
Slc6a8'oral hard palate epithelium' vs 'tail skin epithelium'organism partTranscriptional profiling of mouse oral and skin epithelium to study their intrinsic difference in global gene expression
Adjusted p-valueLog2-fold change
3.8341 × 10-4-1
Slc6a8'epithelium-specific Apc knockout' vs 'wild type'phenotypeRNAseq of murine small intestinal tissue following epithelium-specific deletion of Bcl9/9l +/- Apc +/- mutant B-catenin
Adjusted p-valueLog2-fold change
4.3599 × 10-41
Slc6a8'neurosphere in differentiation medium; 5 day' vs 'neurosphere; 0 day' in 'Cstb knockout'genotype, growth condition, timeTranscriptome analysis of neurospheres derived from Cstb-KO mouse embryo brains during differentiation
Adjusted p-valueLog2-fold change
1.1295 × 10-3-1
Slc6a8'90 day' vs '1 day'ageTranscriptional profilling of female mice liver as a function of age
Adjusted p-valueLog2-fold change
1.1391 × 10-3-1
Slc6a8'730 day' vs '1 day'ageTranscriptional profilling of female mice liver as a function of age
Adjusted p-valueLog2-fold change
3.1763 × 10-31
Slc6a8'cetrorelix; 3 milligram per kilogram' vs 'none' in 'inh-alpha/Tag transgenic'compound, genotypeNovel genes involved in the pathophysiology of gonadotropin-dependent adrenocortical tumorigenesis in mice.
Adjusted p-valueLog2-fold change
3.3104 × 10-31
Slc6a8'atherogenic rodent' vs 'control'dietLiver mRNA microarray study for mice treated with various diets
Adjusted p-valueLog2-fold change
1.5441 × 10-21
Slc6a8'Alb-Cre;VHLf/f' vs 'Alb-Cre'genotypeTranscription profiling by array of mice with liver-specific expression of hypoxia inducible factor, or inactivated von Hippel-Lindau tumor suppressor
Adjusted p-valueLog2-fold change
1.7658 × 10-2-1
Slc6a8'Fam208a homozygous mutant' vs 'wild type'block, genotypeThe epigenetic modifier Fam208a is required to maintain epiblast cell potency
Adjusted p-valueLog2-fold change
2.19 × 10-21
Slc6a8'lung carcinoma' vs 'normal' in 'Epcam+CD11b-CD11c- epithelial cell'cell type, diseaseTranscriptome analysis of isolated stormal cells and tumor epithelial cells in mouse lung cancer by RNA-Seq
Synonym
CRT, Creat
Ortholog
ENSPTRG00000042890 (Felis catus), ENSPTRG00000022405 (Canis familiaris), ENSTNIG00000002127 (Ciona intestinalis), ENSACAG00000008691 (Anolis carolinensis), ENSOARG00020024643 (Salmo salar), ENSOANG00000010213 (Ornithorhynchus anatinus), ENSGGOG00000034957 (Gorilla gorilla), ENSPPYG00000020849 (Pongo abelii), SLC6A8 (Sus scrofa), ENSGGOG00000039278 (Gorilla gorilla), Slc6a8 (Rattus norvegicus), SLC6A8 (Macaca mulatta), ENSMODG00000008271 (Monodelphis domestica), ENSPTRG00000050829 (Pan troglodytes), ENSG00000273554 (Homo sapiens), ENSPTRG00000044981 (Ciona intestinalis), ENSTNIG00000002857 (Salmo salar), SLC6A8 (Equus caballus), ENSPTRG00000043055 (Salmo salar), SLC6A8 (Homo sapiens), ENSGGOG00000004977 (Gorilla gorilla), ENSOCUG00000039313 (Oryctolagus cuniculus), ENSCING00000023838 (Ciona intestinalis), slc6a8 (Danio rerio), slc6a8 (Xenopus tropicalis), ENSDNOG00000034957 (Dasypus novemcinctus), SLC6A8 (Bos taurus), ENSCSAG00000006918 (Chlorocebus sabaeus), ENSPTRG00000048840 (Canis familiaris), ENSGGOG00000041742 (Gorilla gorilla), ENSOCUG00000026260 (Oryctolagus cuniculus), ENSPANG00000010089 (Papio anubis)
Gene ontology
InterPro
Ensembl gene
Ensembl transcript
Ensembl protein
Entrez
UniProt
MGI ID (Mouse)
MGI description
Gene biotype
Design element
4977240, 5339717, 17535607, 5325250, ILMN_2605212, 5576156, 5352336, 4517633, 5272173, 5558016, 4999637, 5575481, 95625_at, 5349762, 1448596_at, A_55_P2000553, 4895764, 4767240, 5354392, 5343624, 4711802, 10600210, 4737581, 4747528, 5330373, 4606172, 5570863, 5229677, 5037848, 4669889, 1417116_at, aa230405_s_at, 5234294, 4574976, 4733141, 4815710, 4889997, 4707603, 5514349, 117239_at, 5592848, 5504033, 4475988, 5085312, A_51_P450829, 4747760
Reactome pathway ID