ensmusg00000039356 (Exosc2)

mus musculus

exosome component 2

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Mus musculus
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Showing 53 experiments:
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Created with Highcharts 6.2.0adrenal glandcentral neural epitheliumepidermal ectodermhippocampusmammary glandolfactory epitheliumsmall intestineuterusaxillary lymph nodebronchuscorpora quadrigeminadiencephalonfloor plateheartintestinal mucosalateral prominence neural epitheliummedial prefrontal cortexmuscle tissuepancreasprostate glandstriatumthymuswhite adipose tissue
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49 FANTOM5 project - adult
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49 FANTOM5 project - neonate
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49 FANTOM5 project - juvenile
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49 FANTOM5 project - embryonic day 18
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49 FANTOM5 project - embryonic day 17
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49 FANTOM5 project - embryonic day 16
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49 FANTOM5 project - embryonic day 15
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49 FANTOM5 project - embryonic day 14
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9 in 3 strains - DBA/2J
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9 in 3 strains - CD1
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9
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49 FANTOM5 project - embryonic day 12
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9 in 3 strains - C57BL/6
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14 - embryonic day 10.5
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49 FANTOM5 project - embryonic day 13
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Mammalian Kaessmann
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Vertebrates
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14 - embryonic day 9.5
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14 - embryonic day 8.5
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4 Bonthuis et al - (CastEiJ X …
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4 Bonthuis et al - (C57BL/6J X …
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Developing gut
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49 FANTOM5 project - embryonic day 11
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3 Soumillon et al
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3
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Sun et al., 2020 - Organism part
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Gregg et al - C57BL/6J
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Gregg et al - (CAST/EiJ X C57BL/6J)F1
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Gregg et al - (C57BL/6J X CAST/EiJ)F1
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4 Bonthuis et al - CastEiJ
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4 Bonthuis et al - C57BL/6J
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Mernberger et al 2019 - Organism Part
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49 FANTOM5 project - pregnant adult day …
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49 FANTOM5 project - pregnant adult day …
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2
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Gregg et al - CAST/EiJ
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Fat and muscle
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49 FANTOM5 project - pregnant adult day …
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49 FANTOM5 project - pregnant adult day …
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49 FANTOM5 project - pregnant adult day …
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49 FANTOM5 project - lactating adult …
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49 FANTOM5 project - embryonic day 17.5
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49 FANTOM5 project - embryonic day 14.5
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49 FANTOM5 project - embryo
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4 Bonthuis et al - Idaho derived wild …
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Linscheid et al., 2021 - tissue - heart …
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Duda et al., 2018 - organism part - …
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Duda et al., 2018 - organism part - …
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Linscheid et al. 2019 - organism part
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Deshmukh et al., 2015 - organism part
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Organism part - Huttlin et al
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Proteomics
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Log2-fold changeSpeciesGene nameComparisonExperimental variablesExperiment name
Adjusted p-valueLog2-fold change
1.3454 × 10-6-2.6
Exosc2'granulocyte' vs 'hemopoietic stem cell'cell typeGene expression data from mouse hemopoietic stem cells (LSKs), promyelocytes, myelocytes and granulocytes.
Adjusted p-valueLog2-fold change
1.816 × 10-1352.3
Exosc2'α-GalCer; 2 microgram' vs 'none' in 'Cd1d homozyous knockout'compound, genotypeCD1d-dependent immune suppression mediated by regulatory B cells through modulations of iNKT cells
Adjusted p-valueLog2-fold change
4.1469 × 10-92.3
Exosc2'Kit ligand' vs 'none' in 'wasp knockout'compound, genotypeTranscription profiling of bone marrow–derived mast cells from WASP-deficient mice after stimulation with kit ligand
Adjusted p-valueLog2-fold change
6.2092 × 10-6-2
Exosc2'alpha-amanitin; maternal Ring1-Rnf+' vs 'none; maternal Ring1-Rnf+'compound, genotypePolycomb function during oogenesis is required for mouse early embryonic development (2-cell embryos)
Adjusted p-valueLog2-fold change
2.3121 × 10-34-1.9
Exosc2'3D culture' vs '2D culture'growth conditionmRNA-seq of mouse salivary gland cancer cells cultured in adherent or non-adherent culture
Adjusted p-valueLog2-fold change
8.1082 × 10-5-1.9
Exosc2'myelocyte' vs 'hemopoietic stem cell'cell typeGene expression data from mouse hemopoietic stem cells (LSKs), promyelocytes, myelocytes and granulocytes.
Adjusted p-valueLog2-fold change
1.3635 × 10-41.9
Exosc2'recombinant human interleukin-2; 100 unit per milliliter; 12 hour' vs 'control; 0 hour'compound, timeTranscription profiling by array of mouse CTLL-2 cell line treated with recombinant human interleukin-2
Adjusted p-valueLog2-fold change
1.7786 × 10-41.9
Exosc2'recombinant human interleukin-2; 100 unit per milliliter; 10 hour' vs 'control; 0 hour'compound, timeTranscription profiling by array of mouse CTLL-2 cell line treated with recombinant human interleukin-2
Adjusted p-valueLog2-fold change
7.7823 × 10-191.8
Exosc2'lipopolysaccharide; 10 nanogram per milliliter' vs 'none' in 'Hoxb8-FL; MEF2A knockout'cell line, compound, genotypeBulk RNA-seq of wild type and MEF2A or MEF2C/D knockout mouse bone marrow macrophages under different stimulation conditions
Adjusted p-valueLog2-fold change
5.7281 × 10-161.8
Exosc2'epithelium-specific Apc knockout' vs 'wild type'phenotypeRNAseq of murine small intestinal tissue following epithelium-specific deletion of Bcl9/9l +/- Apc +/- mutant B-catenin
Adjusted p-valueLog2-fold change
3.3305 × 10-391.7
Exosc2'LDB1 knock-down with Ldb1 delta 4/5 construct' vs 'control shRNA'RNA interferenceRole of LDB1 in the transition from chromatin looping to transcription activation
Adjusted p-valueLog2-fold change
3.3509 × 10-191.7
Exosc2'epithelium-specific mutant beta-catenin expression' vs 'wild type'phenotypeRNAseq of murine small intestinal tissue following epithelium-specific deletion of Bcl9/9l +/- Apc +/- mutant B-catenin
Adjusted p-valueLog2-fold change
9.6031 × 10-151.6
Exosc2'epithelium-specific Apc; Bcl9; Bcl9l knockout' vs 'wild type'phenotypeRNAseq of murine small intestinal tissue following epithelium-specific deletion of Bcl9/9l +/- Apc +/- mutant B-catenin
Adjusted p-valueLog2-fold change
1.0491 × 10-81.6
Exosc2'carcinoma' vs 'normal'diseaseGene expression profile between normal mouse skin and carcinomas arising in the skin of RbF/F;K14creERTM;p107-/- mouse
Adjusted p-valueLog2-fold change
1.467 × 10-6-1.6
Exosc2'12 day' vs '5 day' in 'doxycycline; 200 nanogram per milliliter; neoplasm'compound, phenotype, timeRNA-seq of doxycycline induced tumor and residual mouse primary mammary epithelial cells grown in 3D cell cultures against non-induced controls
Adjusted p-valueLog2-fold change
4.0017 × 10-6-1.5
Exosc2'pre-B acute lymphoblastic leukemia 8093; nilotinib; 3 day' vs 'pre-B acute lymphoblastic leukemia 8093; nilotinib; 0 day'cell type, compound, timeDrug tolerance development of mouse Bcr/Abl pre-B ALL cells on irradiated MEFs
Adjusted p-valueLog2-fold change
5.2276 × 10-51.5
Exosc2'stabilization-competent' vs 'stabilization-incompetent' in '23 day; secondary reprogramming cell'age, cell type, phenotypeTranscription profiling by high throughput sequencing in gene expresion profile of 4 SC clones and 4 SI clones at different time points defined a stabilization competency signiture
Adjusted p-valueLog2-fold change
2.0428 × 10-41.5
Exosc2'recombinant human interleukin-2; 100 unit per milliliter; 16 hour' vs 'control; 0 hour'compound, timeTranscription profiling by array of mouse CTLL-2 cell line treated with recombinant human interleukin-2
Adjusted p-valueLog2-fold change
1.9187 × 10-31.5
Exosc2'fetal definitive erythroid cell' vs 'primitive erythroid cell' in 'mix of orthochromatic and polychromatophilic erythroblast'cell type, phenotypeTranscription profiling by array of differentiating primary primitive and definitive mouse red blood cells
Adjusted p-valueLog2-fold change
3.5965 × 10-42-1.4
Exosc2'etoposide; 2.5 micromolar' vs 'none' in 'wild type genotype'compound, genotypeRNA-seq of H2afj-ko and isogenic WT C57/Bl6-N mouse embryonic fibroblasts in proliferation and after etoposide-induced senescence.
Adjusted p-valueLog2-fold change
7.2586 × 10-371.4
Exosc2'α-GalCer; 2 microgram' vs 'none' in 'wild type genotype'compound, genotypeCD1d-dependent immune suppression mediated by regulatory B cells through modulations of iNKT cells
Adjusted p-valueLog2-fold change
1.6963 × 10-91.4
Exosc2'undifferentiated' vs 'differentiated; rosiglitazone' in '129S6sv/ev'phenotype, stimulus, strainRNA-seq of mouse subcutaneous SVF cells before and after differentiation with a brown fat differentiation cocktail
Adjusted p-valueLog2-fold change
1.4925 × 10-81.4
Exosc2'Kit ligand' vs 'none' in 'wild type'compound, genotypeTranscription profiling of bone marrow–derived mast cells from WASP-deficient mice after stimulation with kit ligand
Adjusted p-valueLog2-fold change
2.6408 × 10-8-1.4
Exosc2'Helicobacter hepaticus' vs 'none' in 'Alpk1 homozygous knockout'infect, phenotypeWhole transcriptome profiling of the steady state and Hh-treated (8 hrs) Alpk1+/- (heterozygous) and Alpk1-/- (knockout) BMDMs using RNA-Sequencing approach
Adjusted p-valueLog2-fold change
9.0754 × 10-8-1.4
Exosc2'10 day' vs '0 day'ageTranscription profiling of mouse embyronic stem cell line CGR8 during the first 10 days of differentiation into embryoid bodies
Adjusted p-valueLog2-fold change
2.1222 × 10-41.4
Exosc2'recombinant human interleukin-2; 100 unit per milliliter; 8 hour' vs 'control; 0 hour'compound, timeTranscription profiling by array of mouse CTLL-2 cell line treated with recombinant human interleukin-2
Adjusted p-valueLog2-fold change
9.7841 × 10-41.4
Exosc2'RAW264.7 macrophage cell line; control' vs 'bone marrow macrophage; control'cell type, growth conditionTranscription profiling of mouse bone marrow macrophages (BMM) compared to BMM co-cultured with 4T1.2 breast cancer cells, treated with tumour cell supernatant, or RAW macrophage cell line
Adjusted p-valueLog2-fold change
4.8491 × 10-31.4
Exosc2'V6.5; embryonic stem cell’ vs 'wild type; endothelial'cell line, cell type, genotypeCD47 Inhibits Self-renewal and Reprogramming by Regulating c-Myc and Other Stem Cell Transcription Factors
Adjusted p-valueLog2-fold change
1.8283 × 10-8-1.3
Exosc2'3 day; osteogenesis differentiation' vs ' 0 day; control' in '2C12-pMirn378'cell line, growth condition, timeEffect of Mirn378 overexpression on gene expression during C2C12 myogenic and BMP2-induced osteogenic differentiation
Adjusted p-valueLog2-fold change
8.9936 × 10-7-1.3
Exosc2'Bcl6 +/+ BCR-ABL1-transformed B cell precursors; STI571 treated' vs 'Bcl6 +/+ BCR-ABL1-transformed B cell precursors; untreated'cell type, treatmentGene expression data of BCR-ABL1 transformed B cell precursors from BCL6 wild-type and BCL6 knockout mice
Adjusted p-valueLog2-fold change
1.5295 × 10-5-1.3
Exosc2'isotype-control; 150 micrograms' vs 'none' in 'methotrexate; first dose 120 milligram per kilogram; second dose 60 milligram per kilogram; wild type phenotype' at '1 day'compound, phenotype, stimulus, timeRNA-seq of mouse crypts to investigate Rorc gamma t-deficient mice tissue repair compared to wild type controls
Adjusted p-valueLog2-fold change
2.5169 × 10-41.3
Exosc2'dox-induced over-expression of oncogenes for 5 days' vs 'untreated control'phenotypeTemporal Transcriptional Profiling in response to cMYC and KrasG12D Expression and Inactivation in In Vitro Cultured Primary Mammary Epithelial Cells of Adult Virgin Mice
Adjusted p-valueLog2-fold change
4.185 × 10-4-1.3
Exosc2'Bcl6 -/- BCR-ABL1-transformed B cell precursors; STI571 treated' vs 'Bcl6 -/- BCR-ABL1-transformed B cell precursors; untreated'cell type, treatmentGene expression data of BCR-ABL1 transformed B cell precursors from BCL6 wild-type and BCL6 knockout mice
Adjusted p-valueLog2-fold change
7.7789 × 10-41.3
Exosc2'undifferentiated' vs 'differentiated; rosiglitazone' in 'SWR/J'phenotype, stimulus, strainRNA-seq of mouse subcutaneous SVF cells before and after differentiation with a brown fat differentiation cocktail
Adjusted p-valueLog2-fold change
2.0057 × 10-3-1.3
Exosc2'Tbx5;Nkx2-5 knockout' vs 'wild type'genotypeTranscription profiling by array of tbx5, nkx2-5 or both transcription factor knockouts during early heart formation in mouse
Adjusted p-valueLog2-fold change
5.1472 × 10-31.3
Exosc2'undifferentiated' vs 'differentiated; rosiglitazone' in 'AKR/J'phenotype, stimulus, strainRNA-seq of mouse subcutaneous SVF cells before and after differentiation with a brown fat differentiation cocktail
Adjusted p-valueLog2-fold change
1.7772 × 10-101.2
Exosc2'undifferentiated' vs 'differentiated; rosiglitazone' in 'F1.129xB6'phenotype, stimulus, strainRNA-seq of mouse subcutaneous SVF cells before and after differentiation with a brown fat differentiation cocktail
Adjusted p-valueLog2-fold change
3.9793 × 10-8-1.2
Exosc2'6 day; myogenesis differentiation' vs ' 0 day; control' in '2C12-pMirn378'cell line, growth condition, timeEffect of Mirn378 overexpression on gene expression during C2C12 myogenic and BMP2-induced osteogenic differentiation
Adjusted p-valueLog2-fold change
6.4403 × 10-8-1.2
Exosc2'3 day; myogenesis differentiation' vs ' 0 day; control' in '2C12-pMirn378'cell line, growth condition, timeEffect of Mirn378 overexpression on gene expression during C2C12 myogenic and BMP2-induced osteogenic differentiation
Adjusted p-valueLog2-fold change
9.5803 × 10-81.2
Exosc2'acute graft vs. host disease; T-cell depleted bone marrow + T cells transplant' vs 'normal; T-cell depleted bone marrow transplant'disease, stimulusRNA-Seq of lymph node fibroblastic reticular cells isolated from bone marrow transplant recipient mice with or without acute Graft-versus-host disease on day 7 or untransplanted control mice
Adjusted p-valueLog2-fold change
1.7912 × 10-7-1.2
Exosc2'7 day' vs '0 day'ageTranscription profiling of mouse embyronic stem cell line CGR8 during the first 10 days of differentiation into embryoid bodies
Adjusted p-valueLog2-fold change
3.9431 × 10-7-1.2
Exosc2'mutant MyoD expression' at '24 hour' vs 'wild type MyoD expression' at '0 hour'phenotype, timeTranscription profiling of mouse embryoic fibroblasts expressing wild type MyoD or its non-acetylatable version MyoD RRR to investigate how MyoD acetylation may contribute to differential gene activation.
Adjusted p-valueLog2-fold change
1.9564 × 10-6-1.2
Exosc2'neurosphere in differentiation medium; 5 day' vs 'neurosphere; 0 day' in 'wild type genotype'genotype, growth condition, timeTranscriptome analysis of neurospheres derived from Cstb-KO mouse embryo brains during differentiation
Adjusted p-valueLog2-fold change
1.3179 × 10-51.2
Exosc2'CCl4 and diethylnitrosamine' vs 'none' in 'wild type genotype'genotype, treatmentGene expression accompanying the promotion of hepatocellular carcinoma by intestinal microbiota and Tlr4 in mice.
Adjusted p-valueLog2-fold change
2.6631 × 10-41.2
Exosc2'MEF2A knockout' vs 'wild type genotype' in 'Hoxb8-FL; lipopolysaccharide; 10 nanogram per milliliter'cell line, compound, genotypeBulk RNA-seq of wild type and MEF2A or MEF2C/D knockout mouse bone marrow macrophages under different stimulation conditions
Adjusted p-valueLog2-fold change
3.8696 × 10-41.2
Exosc2'recombinant human interleukin-2; 100 unit per milliliter; 6 hour' vs 'control; 0 hour'compound, timeTranscription profiling by array of mouse CTLL-2 cell line treated with recombinant human interleukin-2
Adjusted p-valueLog2-fold change
8.922 × 10-4-1.2
Exosc2'actinomycin D; 8 hour' vs 'none' in 'Cnot1 flox/flox'compound, genotype, timeRNA-seq of livers in control and Cnot1 tamoxifen-inducible liver-specific knockout mice
Adjusted p-valueLog2-fold change
2.3133 × 10-2-1.2
Exosc2'fetal definitive erythroid cell' vs 'primitive erythroid cell' in 'basophilic erythroblast'cell type, phenotypeTranscription profiling by array of differentiating primary primitive and definitive mouse red blood cells
Adjusted p-valueLog2-fold change
3.7463 × 10-2-1.2
Exosc2'megakaryocyte' vs 'hematopoietic stem cell'cell typeTranscription profiling by array of primary megakaryocytes (MEG) and erythroblasts (ERY) developed from murine fetal liver hematopoietic stem cells
Adjusted p-valueLog2-fold change
6.4119 × 10-17-1.1
Exosc2'etoposide; 2.5 micromolar' vs 'none' in 'H2afj-∆7-KO'compound, genotypeRNA-seq of H2afj-ko and isogenic WT C57/Bl6-N mouse embryonic fibroblasts in proliferation and after etoposide-induced senescence.
Adjusted p-valueLog2-fold change
1.4034 × 10-8-1.1
Exosc2'neurosphere in differentiation medium; 12 day' vs 'neurosphere; 0 day' in 'wild type genotype'genotype, growth condition, timeTranscriptome analysis of neurospheres derived from Cstb-KO mouse embryo brains during differentiation
Adjusted p-valueLog2-fold change
5.66 × 10-8-1.1
Exosc2'neurosphere in differentiation medium; 12 day' vs 'neurosphere; 0 day' in 'Cstb knockout'genotype, growth condition, timeTranscriptome analysis of neurospheres derived from Cstb-KO mouse embryo brains during differentiation
Adjusted p-valueLog2-fold change
8.1757 × 10-8-1.1
Exosc2'tape stripping and oral administration of winged bean extract' vs 'tape stripping'treatmentTranscription profiling by array of mouse dorsal skin after tape stripping and treatment with winged bean extract.
Adjusted p-valueLog2-fold change
1.4097 × 10-71.1
Exosc2'Kit ligand; wasp knockout' vs 'Kit ligand; wild type'compound, genotypeTranscription profiling of bone marrow–derived mast cells from WASP-deficient mice after stimulation with kit ligand
Adjusted p-valueLog2-fold change
1.4951 × 10-71.1
Exosc2'wormy, worm left; Trichuris muris' vs 'control; non wormy' in 'caecum'environmental stress, infect, organism partRNA-seq of mouse intestinal mucosa to investigate infection by the parasitic nematode Trichuris muris
Adjusted p-valueLog2-fold change
4.7313 × 10-71.1
Exosc2'induced neural stem cell' vs 'mouse embryonic fibroblast cell'cell typeGene expression profile of mouse induced neural stem cells
Adjusted p-valueLog2-fold change
8.3957 × 10-7-1.1
Exosc2'6 day; myogenesis differentiation' vs ' 0 day; control' in '2C12-pMirn0'cell line, growth condition, timeEffect of Mirn378 overexpression on gene expression during C2C12 myogenic and BMP2-induced osteogenic differentiation
Adjusted p-valueLog2-fold change
1.5198 × 10-6-1.1
Exosc2'neurosphere in differentiation medium; 1 day' vs 'neurosphere; 0 day' in 'Cstb knockout'genotype, growth condition, timeTranscriptome analysis of neurospheres derived from Cstb-KO mouse embryo brains during differentiation
Adjusted p-valueLog2-fold change
1.4855 × 10-41.1
Exosc2'recombinant human interleukin-2; 100 unit per milliliter; 4 hour' vs 'control; 0 hour'compound, timeTranscription profiling by array of mouse CTLL-2 cell line treated with recombinant human interleukin-2
Adjusted p-valueLog2-fold change
7.6377 × 10-41.1
Exosc2'Rb;E2f8 knock-out' vs 'wild type'genotypeExpression data from WT, E2f8 KO, Rb KO and Rb;E2f8 DKO spleen Ter19+CD71high sorted cells
Adjusted p-valueLog2-fold change
1.7112 × 10-3-1.1
Exosc2'anti-IL-22; 150 micrograms' vs 'none' in 'methotrexate; first dose 120 milligram per kilogram; second dose 60 milligram per kilogram; wild type phenotype' at '1 day'compound, phenotype, stimulus, timeRNA-seq of mouse crypts to investigate Rorc gamma t-deficient mice tissue repair compared to wild type controls
Adjusted p-valueLog2-fold change
3.934 × 10-31.1
Exosc2'H-Ras expression; c-Myc activation' vs 'wild type'phenotypeRNA-seq of heart tissue from 15 day old mice 4 hours post MycER activation compared to wild type controls. RNA-seq of heart tissues from adult mice that have expressed oncogenic H-Ras for 4 weeks followed by MycER activation for 4 hours compared to MycER negative controls.
Adjusted p-valueLog2-fold change
3.5011 × 10-7-1
Exosc2'3 day; myogenesis differentiation' vs ' 0 day; control' in '2C12-pMirn0'cell line, growth condition, timeEffect of Mirn378 overexpression on gene expression during C2C12 myogenic and BMP2-induced osteogenic differentiation
Adjusted p-valueLog2-fold change
4.2708 × 10-7-1
Exosc2'6 day' vs '0 day'ageTranscription profiling of mouse embyronic stem cell line CGR8 during the first 10 days of differentiation into embryoid bodies
Adjusted p-valueLog2-fold change
1.0502 × 10-6-1
Exosc2'3 day; osteogenesis differentiation' vs ' 0 day; control' in '2C12-pMirn0'cell line, growth condition, timeEffect of Mirn378 overexpression on gene expression during C2C12 myogenic and BMP2-induced osteogenic differentiation
Adjusted p-valueLog2-fold change
7.8784 × 10-61
Exosc2'c-Myc activation' vs 'wild type'phenotypeRNA-seq of heart tissue from 15 day old mice 4 hours post MycER activation compared to wild type controls. RNA-seq of heart tissues from adult mice that have expressed oncogenic H-Ras for 4 weeks followed by MycER activation for 4 hours compared to MycER negative controls.
Adjusted p-valueLog2-fold change
3.8138 × 10-5-1
Exosc2'Helicobacter hepaticus' vs 'none' in 'wild type phenotype'infect, phenotypeWhole transcriptome profiling of the steady state and Hh-treated (8 hrs) Alpk1+/- (heterozygous) and Alpk1-/- (knockout) BMDMs using RNA-Sequencing approach
Adjusted p-valueLog2-fold change
4.9607 × 10-51
Exosc2'Kin-' vs 'wild type' in 'cAMP' at '24 hour'compound, genotype, timeTranscription profiling by array of mouse S49 cells mutant for Kin after treatment with cAMP
Adjusted p-valueLog2-fold change
1.1009 × 10-4-1
Exosc2'lipopolysaccharide; 10 nanogram per milliliter and prostaglandin E2; 1 micromolar' vs 'none' in 'primary cell line; MEF2C/D knockout'cell line, compound, genotypeBulk RNA-seq of wild type and MEF2A or MEF2C/D knockout mouse bone marrow macrophages under different stimulation conditions
Adjusted p-valueLog2-fold change
1.2975 × 10-41
Exosc2'undifferentiated' vs 'differentiated; rosiglitazone' in 'F1.B6x129'phenotype, stimulus, strainRNA-seq of mouse subcutaneous SVF cells before and after differentiation with a brown fat differentiation cocktail
Adjusted p-valueLog2-fold change
2.1553 × 10-4-1
Exosc2'KDM4C knock-down' vs 'wild type genotype' in 'mixed-lineage leukemia'clinical history, genotypeTargeting epigenetic networks mediated by Prmt1 and Kdm4c in acute myeloid leukemia
Adjusted p-valueLog2-fold change
2.694 × 10-4-1
Exosc2'XBP1s overexpression' vs 'wild type genotype' in '4μ8C; 15 micromolar'compound, genotypeOverexpression of spliced XBP1 in in vitro Th2 cells, and comparison to 4u8c treatment
Adjusted p-valueLog2-fold change
5.8811 × 10-41
Exosc2'transgenic C3(1)-SV40Tag; 20 week' vs 'wild type; 8 week'age, genotypePrevention of mammary tumor progression by silencing HoxA1 via intraductal injection of nanoparticle-formulated siRNA
Adjusted p-valueLog2-fold change
9.4627 × 10-41
Exosc2'adult definitive erythroid cell' vs 'primitive erythroid cell' in 'mix of orthochromatic and polychromatophilic erythroblast'cell type, phenotypeTranscription profiling by array of differentiating primary primitive and definitive mouse red blood cells
Adjusted p-valueLog2-fold change
9.1879 × 10-31
Exosc2'AhCre Apc Floxed Cited1 knockout' vs 'control'genotypeCited-1 deficiency suppresses intestinal tumorigenesis through the repression of the Wnt pathway- evidence for the just right model of Wnt mediated tumorigenesis
Adjusted p-valueLog2-fold change
9.3379 × 10-31
Exosc2'stabilization-competent' vs 'stabilization-incompetent' in '22 day; secondary reprogramming cell'age, cell type, phenotypeTranscription profiling by high throughput sequencing in gene expresion profile of 4 SC clones and 4 SI clones at different time points defined a stabilization competency signiture
Adjusted p-valueLog2-fold change
1.6378 × 10-21
Exosc2'ABIN1[D485N] knock-in' vs 'wild type genotype' in 'classical monocyte'cell type, genotypeRNA-seq of inflammatory monocytes, patrolling monocytes and neutrophils in wild type and ABIN1[D485N] mice
Adjusted p-valueLog2-fold change
2.0772 × 10-21
Exosc2'Sox17.Epi' vs 'Sox17.Endo'genotypeTranscription profiling by high throughput sequencing of Sox17.Epi and Endo cells from mouse embryos