-8.5 | | Ache | '5 week' vs '1 week' in 'Jak2+/V617F; CRISPR/Cas9 mediated knockout of Dnmt3a' | genotype, time | RNA-seq of Jak2VF LSK cells transduced with Dnmt3a-Cas9-GFP lentivirus vs. emp-Cas9-GFP controls one week and five weeks post methylcellulose plating |
6.3 | | Ache | 'extraembryonic endoderm stem cell; grown in ES cell medium' vs 'mouse embryonic fibroblast; control' | cell type, growth condition | OSKM induce extraembryonic endoderm stem (iXEN) cells in parallel to iPS cells |
-5.6 | | Ache | 'acute graft vs. host disease; T-cell depleted bone marrow + T cells transplant' vs 'normal; T-cell depleted bone marrow transplant' | disease, stimulus | RNA-Seq of lymph node fibroblastic reticular cells isolated from bone marrow transplant recipient mice with or without acute Graft-versus-host disease on day 7 or untransplanted control mice |
-5.5 | | Ache | 'undifferentiated' vs 'differentiated; rosiglitazone' in '129S6sv/ev' | phenotype, stimulus, strain | RNA-seq of mouse subcutaneous SVF cells before and after differentiation with a brown fat differentiation cocktail |
5.5 | | Ache | 'induced extraembryonic endoderm stem cell; grown in ES cell medium' vs 'mouse embryonic fibroblast; control' | cell type, growth condition | OSKM induce extraembryonic endoderm stem (iXEN) cells in parallel to iPS cells |
-5 | | Ache | 'undifferentiated' vs 'differentiated; rosiglitazone' in 'F1.129xB6' | phenotype, stimulus, strain | RNA-seq of mouse subcutaneous SVF cells before and after differentiation with a brown fat differentiation cocktail |
-4.8 | | Ache | 'osteosarcoma' vs 'control' | disease, genotype | Mouse Model of Clear Cell Sarcoma |
4.6 | | Ache | 'Stat5abfl/fl;MMTV-Cre' vs 'wild type' at 'pregnancy' | genotype, sampling time point | Transcription profiling by high throughput sequencing of mouse wild type and Stat5-mutant mammary tissues at parturition and early pregnancy |
4.6 | | Ache | 'tamoxifen induction at 2 months, wait 1 months' vs 'no tamoxifen induction' in 'luminal cell of prostate epithelium; Nkx3.1-CreERT2 targeted allele' | cell type, genotype, growth condition | Transcription profiling by high throughput sequencing of PIN/tumor lesions from basal or luminal origins at time points at which mice displayed similar histopathological phenotypes |
-4.5 | | Ache | 'undifferentiated' vs 'differentiated; rosiglitazone' in 'A/J' | phenotype, stimulus, strain | RNA-seq of mouse subcutaneous SVF cells before and after differentiation with a brown fat differentiation cocktail |
-4.3 | | Ache | 'undifferentiated' vs 'differentiated; rosiglitazone' in 'F1.B6x129' | phenotype, stimulus, strain | RNA-seq of mouse subcutaneous SVF cells before and after differentiation with a brown fat differentiation cocktail |
-4.3 | | Ache | 'clear cell sarcoma; TATCre' vs 'control' | disease, genotype | Mouse Model of Clear Cell Sarcoma |
4.2 | | Ache | 'extracellular vesicle; non-stimulated culture medium' vs 'none' | sampling site, stimulus | Cellular and extracellular vesicle RNA sequence for E-cadherin-RFP EMT reporter system expressing mouse breast cancer cell line Py2T during EMT/MET |
-4.1 | | Ache | 'undifferentiated' vs 'differentiated; rosiglitazone' in 'SWR/J' | phenotype, stimulus, strain | RNA-seq of mouse subcutaneous SVF cells before and after differentiation with a brown fat differentiation cocktail |
4.1 | | Ache | 'etoposide; 2.5 micromolar' vs 'none' in 'H2afj-∆7-KO' | compound, genotype | RNA-seq of H2afj-ko and isogenic WT C57/Bl6-N mouse embryonic fibroblasts in proliferation and after etoposide-induced senescence. |
3.9 | | Ache | 'megakaryocyte' vs 'hematopoietic stem cell' | cell type | Transcription profiling by array of primary megakaryocytes (MEG) and erythroblasts (ERY) developed from murine fetal liver hematopoietic stem cells |
3.9 | | Ache | 'tamoxifen induction at 2 months, wait 3 months' vs 'no tamoxifen induction' in 'basal cell of prostate epithelium; CK5-CreERT2 transgenic line' | cell type, genotype, growth condition | Transcription profiling by high throughput sequencing of PIN/tumor lesions from basal or luminal origins at time points at which mice displayed similar histopathological phenotypes |
3.7 | | Ache | 'etoposide; 2.5 micromolar' vs 'none' in 'wild type genotype' | compound, genotype | RNA-seq of H2afj-ko and isogenic WT C57/Bl6-N mouse embryonic fibroblasts in proliferation and after etoposide-induced senescence. |
3.7 | | Ache | 'AR3 transgenic' vs 'wild type' | genotype | Expression data from AR3 transgenic and wild-type mouse prostates |
-3.5 | | Ache | 'neural stem cell' vs 'niche cell' | cell type | Transcription profiling by high throughput sequencing of three populations of primary dentate gyrus cells |
3.3 | | Ache | 'postnatal day 60' vs 'postnatal day 1' in 'insulin-expressing immature beta cell' | cell type, developmental stage | Transcription profiling by high throughput sequencing of murine beta cells at key stages of maturation |
3.3 | | Ache | 'erythroblast' vs 'hematopoietic stem cell' | cell type | Transcription profiling by array of primary megakaryocytes (MEG) and erythroblasts (ERY) developed from murine fetal liver hematopoietic stem cells |
3.2 | | Ache | 'wild type; mature luminal' vs 'wild type; MaSC/basal' | cell type, genotype | Expression data from sorted control and Pygo2-null mouse mammary stem/basal cells |
-3.1 | | Ache | 'undifferentiated' vs 'differentiated; rosiglitazone' in 'AKR/J' | phenotype, stimulus, strain | RNA-seq of mouse subcutaneous SVF cells before and after differentiation with a brown fat differentiation cocktail |
3 | | Ache | 'LDB1 knock-down with full-length Ldb1 construct' vs 'control shRNA' | RNA interference | Role of LDB1 in the transition from chromatin looping to transcription activation |
3 | | Ache | 'Triple knockout (Zfp36-/-, TNFR1-/-, TNFR2-/-)' vs 'wild type' | genotype | Transcription profiling by high throughput sequencing of douple (TNFR1-/-/TNFR2-/-) and triple (Zfp36-/-/TNFR1-/-/TNFR2-/-) knockout mouse spleens |
-3 | | Ache | 'undifferentiated' vs 'differentiated; rosiglitazone' in 'C57BL/6J' | phenotype, stimulus, strain | RNA-seq of mouse subcutaneous SVF cells before and after differentiation with a brown fat differentiation cocktail |
2.9 | | Ache | 'extraembryonic endoderm stem cell; grown in XEN cell medium' vs 'mouse embryonic fibroblast; control' | cell type, growth condition | OSKM induce extraembryonic endoderm stem (iXEN) cells in parallel to iPS cells |
2.8 | | Ache | 'co-cultured with hematopoietic stem cell for 9 days' vs 'non co-cultured for 9 days' in 'stromal cell; expressing AKT1' | cell type, growth condition, phenotype | Transcription profiling by high throughput sequencing of murine bone marrow endothelial cells and bone marrow stroma, in vitro and in vivo, with and without hematopoietic stem cells co-culture |
2.8 | | Ache | 'estradiol' at '30 hour' vs 'none' at '0 hour' | compound, time | Transcription profiling by array of G1E cells during time course treatment with estradiol. |
2.8 | | Ache | 'myeloid lineage restricted progenitor cell' vs 'long term hematopoietic stem cell' in 'Elp3fl/fl' | cell type, genotype | RNA-seq of long-term hematopoietic stem cells and myeloid progenitors of control mice or mice conditionally deficient for Trp53 or Elp3 or both genes in the hematopoietic system |
2.8 | | Ache | 'tamoxifen induction at 2 months, wait 3 months' vs 'no tamoxifen induction' in 'luminal cell of prostate epithelium; Nkx3.1-CreERT2 targeted allele' | cell type, genotype, growth condition | Transcription profiling by high throughput sequencing of PIN/tumor lesions from basal or luminal origins at time points at which mice displayed similar histopathological phenotypes |
2.6 | | Ache | 'interleukin-22 (Mus Musculus); 10 nanogram per milliliter' vs 'none' | compound | RNAseq of small intestinal organoids from mice treated with the cytokines IFNG, IL-13 and IL-22 for 24 hours |
2.6 | | Ache | 'Stat5b (Stat5abnull/Stat5a-)' vs 'wild type' at 'pregnancy' | genotype, sampling time point | Transcription profiling by high throughput sequencing of mouse wild type and Stat5-mutant mammary tissues at parturition and early pregnancy |
2.6 | | Ache | 'estradiol' at '21 hour' vs 'none' at '0 hour' | compound, time | Transcription profiling by array of G1E cells during time course treatment with estradiol. |
2.6 | | Ache | 'induced extraembryonic endoderm stem cell; grown in XEN cell medium' vs 'mouse embryonic fibroblast; control' | cell type, growth condition | OSKM induce extraembryonic endoderm stem (iXEN) cells in parallel to iPS cells |
-2.6 | | Ache | 'Tet2 knockout' vs 'wild type' in 'hematopoietic stem cell' | cell type, genotype | Transcription profiling by high throughput sequencing of bone marrow stem and progenitor cells from Tet2 depleted mice |
2.5 | | Ache | 'neurosphere in differentiation medium; 12 day' vs 'neurosphere; 0 day' in 'Cstb knockout' | genotype, growth condition, time | Transcriptome analysis of neurospheres derived from Cstb-KO mouse embryo brains during differentiation |
2.5 | | Ache | 'doxorubicin; 17.5 milligram per kilogram body weight' vs 'vehicle' in 'scramble; podocyte' | cell type, compound, genotype | Transcription profiling to identify the role of MOF in primary MEFs and differentiated podocytes in response to Adriamycin |
-2.5 | | Ache | 'XBP1s overexpression' vs 'wild type genotype' in '4μ8C; 15 micromolar' | compound, genotype | Overexpression of spliced XBP1 in in vitro Th2 cells, and comparison to 4u8c treatment |
-2.4 | | Ache | 'Salmonella enterica serovar Typhimurium' vs 'control' in 'bone marrow macrophage from 129P2 mouse strain' | clinical information, infect | Gene expression profiles of mouse embryonic stem cell derived macrophages infected with Salmonella typhimurium |
-2.4 | | Ache | 'Lgr6-positive hair follicle/sebaceous gland cell' vs 'basal keratinocyte' | cell type | Transcription profiling of Lgr6+ keratinocyte populations in the epidermis and hair follicle |
2.3 | | Ache | "muscularis externa layer of small intestine" vs "lamina propria of small intestine" in "YFP negative" | organism part, phenotype | Bulk RNA-sequencing of self-maintaining versus monocyte-replaced gut macrophages |
-2.3 | | Ache | 'co-transplanted with NOD-scid IL2Rgamma null HSCs' vs 'co-transplanted with wild type HSCs' | growth condition | RNA-seq of mouse wildtype HSCs purified from recipient mice co-transplanted with wildtype or different types of lymphoid cell deficient HSCs |
2.2 | | Ache | 'interferon gamma; 10 nanogram per milliliter and interleukin-22; 10 nanogram per milliliter' vs 'none' | compound | RNAseq of small intestinal organoids from mice treated with the cytokines IFNG, IL-13 and IL-22 for 24 hours |
-2.2 | | Ache | 'germ free C57BL/6' vs 'specific pathogen free C57BL/6' in 'wild type genotype' | genotype, strain | RNA sequencing of primary isolated unstimulated murine splenic cDC from specific pathogen free (SPF), Germ Free (GF) and Interferon alpha/beta receptor 1 (Ifnar) knock out mice. |
2 | | Ache | 'actinomycin D; 8 hour' vs 'none' in 'Cnot1 flox/flox' | compound, genotype, time | RNA-seq of livers in control and Cnot1 tamoxifen-inducible liver-specific knockout mice |
1.9 | | Ache | 'Ts1Rhr; KRASG12D' vs 'wild type genotype' | genotype | RNA-Seq of murine trisomic B cell precursors expressing KRAS_G12D |
-1.9 | | Ache | '90 day' vs '1 day' | age | Transcriptional profilling of female mice liver as a function of age |
-1.9 | | Ache | '30 day' vs '1 day' | age | Transcriptional profilling of female mice liver as a function of age |
1.9 | | Ache | 'co-cultured with hematopoietic stem cell for 9 days' vs 'non co-cultured for 9 days' in 'endothelial cell; expressing AKT1' | cell type, growth condition, phenotype | Transcription profiling by high throughput sequencing of murine bone marrow endothelial cells and bone marrow stroma, in vitro and in vivo, with and without hematopoietic stem cells co-culture |
1.9 | | Ache | 'estradiol' at '14 hour' vs 'none' at '0 hour' | compound, time | Transcription profiling by array of G1E cells during time course treatment with estradiol. |
1.9 | | Ache | 'AZD5069; 100 milligram per kilogram' vs 'none' | compound | RNA-seq to investigate differentially expressed genes in KPC mouse PDAC treated with CSF-1R small molecule inhibitor AZD7507 and/or the CXCR2 small molecule inhibitor AZD5069 |
-1.8 | | Ache | 'Irgm1 knockout' vs 'wild type genotype' in 'bone marrow' | genotype, organism part | RNA-Seq of bone marrow derived macophages (BMDMs) and brain tissue isolated from wild type and Irgm1 knockout mice |
-1.8 | | Ache | '730 day' vs '1 day' | age | Transcriptional profilling of female mice liver as a function of age |
-1.8 | | Ache | '365 day' vs '1 day' | age | Transcriptional profilling of female mice liver as a function of age |
-1.8 | | Ache | '60 day' vs '1 day' | age | Transcriptional profilling of female mice liver as a function of age |
-1.8 | | Ache | 'lung carcinoma' vs 'normal' in 'CD11b+Ly6G+ neutrophil' | cell type, disease | Transcriptome analysis of isolated stormal cells and tumor epithelial cells in mouse lung cancer by RNA-Seq |
1.7 | | Ache | 'LDB1 knock-down with Ldb1 delta 4/5 construct' vs 'control shRNA' | RNA interference | Role of LDB1 in the transition from chromatin looping to transcription activation |
1.7 | | Ache | 'neuron' vs 'differentiating progenitor' | cell type | Transcription profiling by high throughput sequencing of proliferating neural stem cells, differentiating neurogenic progenitors and newborn neurons using a dual-reporter mouse line |
-1.7 | | Ache | '21 day' vs '1 day' | age | Transcriptional profilling of female mice liver as a function of age |
-1.7 | | Ache | '180 day' vs '1 day' | age | Transcriptional profilling of female mice liver as a function of age |
1.7 | | Ache | 'interferon gamma; 10 nanogram per milliliter and interleukin-13; 10 nanogram per milliliter' vs 'none' | compound | RNAseq of small intestinal organoids from mice treated with the cytokines IFNG, IL-13 and IL-22 for 24 hours |
-1.7 | | Ache | 'glioblastoma multiforme' vs 'normal' | disease | Analysis of the expression profiles of glioma-associated microglia/macrophages and naive control cells in Mus musculus. |
-1.7 | | Ache | 'Ifnar1 knockout' vs 'wild type genotype' in 'specific pathogen free C57BL/6' | genotype, strain | RNA sequencing of primary isolated unstimulated murine splenic cDC from specific pathogen free (SPF), Germ Free (GF) and Interferon alpha/beta receptor 1 (Ifnar) knock out mice. |
1.7 | | Ache | 'Cbs knockout' vs 'wild type' | genotype | Gene expression profile of CD4-positive T cells from mouse Cbs knockout |
-1.7 | | Ache | 'Pbcas4 knockdown' vs 'scramble control' | RNA interference | Genome-wide effects of Pbcas4 knockdown |
1.6 | | Ache | 'LDB1 knock-down' vs 'control shRNA' | RNA interference | Role of LDB1 in the transition from chromatin looping to transcription activation |
1.6 | | Ache | 'beta cell specific Pax6 knockout' vs 'wild type' | phenotype | RNA-Seq of pancreatic islets from beta cell-specific Pax6 knockout mice |
1.6 | | Ache | 'transplanted secondary tumors' vs 'normal' in 'kidney' | clinical information, organism part | Premature termination of in vivo reprogramming leads to cancer development through altered epigenetic regulation [array] |
-1.5 | | Ache | '14 day' vs '1 day' | age | Transcriptional profilling of female mice liver as a function of age |
1.5 | | Ache | 'reduced expression of miR-25' vs 'wild type' | phenotype | Transcription profiling by high throughput sequencing of wild type and miR-25 agomir or antagomir treated mice |
1.5 | | Ache | 'Abcc8-/-' vs 'wild type genotype' in 'normal; male' | diet, genotype, sex | Effects of increased intracellular calcium and overnutrition on pancreatic beta cell transcriptome |
-1.5 | | Ache | 'no limb muscle' vs 'wild type' | phenotype | Transcription profiling by array of TS23 humerus tissue from muscle-less mutant (splotch-delayed) mice and control littermates to identify differentially expressed genes between muscle-less and control embryonic (TS23) humerus tissue, in order to determine mechanosensitive genes that impact skeletal development |
1.5 | | Ache | 'inhibitor of kappaB kinase beta constitutively active' vs 'wild type' | phenotype | Transcription profiling by array of primary murine cardiomyocytes with and without expression of constitutively active IKK2 |
1.5 | | Ache | 'neurosphere in differentiation medium; 12 day' vs 'neurosphere; 0 day' in 'wild type genotype' | genotype, growth condition, time | Transcriptome analysis of neurospheres derived from Cstb-KO mouse embryo brains during differentiation |
-1.4 | | Ache | 'Runx1 P1-GFP::P2-hCD4/-' vs 'wild type' | genotype | RUNX1B expression distinguishes megakaryocytic and erythroid lineage fate in adult hematopoiesis |
-1.4 | | Ache | 'K14-Cre-ERT2 / CK1α fl/fl; 4-hydroxytamoxifen; none; 14 day' vs 'K14-Cre-ERT2; none; none' | genotype, irradiate, time | Ablation of casein kinase 1 in keratinocytes induces p53-dependent hyperpigmentation of the skin |
-1.4 | | Ache | 'α-GalCer; 2 microgram' vs 'none' in 'wild type genotype' | compound, genotype | CD1d-dependent immune suppression mediated by regulatory B cells through modulations of iNKT cells |
1.3 | | Ache | 'Runx1 knockdown; none' vs 'wild type; none' | genotype, stimulus | Transcription profiling by array of Mouse erythro-leukaemia cells during differentiation to investigate the influence of Runx1 transcription factor |
-1.3 | | Ache | 'T-cell depleted bone marrow transplant' vs 'none' in 'normal' | disease, stimulus | RNA-Seq of lymph node fibroblastic reticular cells isolated from bone marrow transplant recipient mice with or without acute Graft-versus-host disease on day 7 or untransplanted control mice |
-1.3 | | Ache | 'status epilepticus' vs 'none' in 'astrocyte; soticlestat; 30 milligram per kilogram' | cell type, compound, disease | RNA-seq profiling of three distinct cell populations in a murine model of epilepsia with and without drug treatment |
-1.3 | | Ache | 'induced neuronal cell' vs 'pluripotent embryonic stem cell' | phenotype | Transcription profiling by high throughput sequencing of retinoic acid-differentiated neuronal cells compared to nondifferentiated pluripotent embryonic stem cells |
-1.3 | | Ache | 'acute myeloid leukemia' vs 'myeloproliferative disorder' | disease | Transcription profiling by high throughput sequencing of c-KIT+ splenocytes from murine acute myeloid leukemia and myeloproliferative neoplasm |
-1.2 | | Ache | 'nmf205, Gcn2 double mutant' vs 'wild type' | genotype | Transcription profiling by high throughput sequencing in cerebellum of mouse Gcn2 -/-, nmf205-/- and nmf205-/-;Gcn2-/- |
-1.2 | | Ache | 'Pkhd1Cre; Pkd2 F/F' vs 'wild type' | genotype | Next Generation Sequencing of PKD2 mutant mice kidneys |
1.2 | | Ache | 'Cnot3 knockout' vs 'wild type' | phenotype | RNA-seq of mouse islets from Ins1-cre driven Cnot3 KO and control islets |
1.2 | | Ache | 'Zfx fl/y CreER; infected with control retrovirus with GFP selectable marker' vs 'wild type; infected with control retrovirus with GFP selectable marker' | genotype, treatment | Effect of genetic Zfx deletion on Myc induced gene expression in bone marrrow myeloid progenitors |
1.2 | | Ache | 'prostaglandin E2; 1 micromolar' vs 'none' in 'primary cell line; wild type genotype' | cell line, compound, genotype | Bulk RNA-seq of wild type and MEF2A or MEF2C/D knockout mouse bone marrow macrophages under different stimulation conditions |
1.1 | | Ache | 'sorafenib treatment' vs 'DMSO control' in 'Ba/F3-ITD cells' | compound | Transcription profiling by array of murine Ba/F3-ITD cells treated with DMSO or sorafenib |
1.1 | | Ache | 'estradiol' at '7 hour' vs 'none' at '0 hour' | compound, time | Transcription profiling by array of G1E cells during time course treatment with estradiol. |
1.1 | | Ache | 'Follicular B cell' vs 'Pre-B cell' in 'wild type genotype; MHC II-positive' | cell type, genotype, phenotype | Effect of MHC II expression in pro-B cells: Pre-B cells and follicular B cells from wild-type and MHC II conditional mice |
-1.1 | | Ache | 'M-CSF' at '6 day' vs 'none' at '0 day' | compound, time | Microarray profiling of polyploid macrophage progeny |
-1.1 | | Ache | 'CD2AP-/-' vs 'wild type genotype' in 'renal glomerular mesangial cell' | cell type, genotype | Transcription profiling by array of three major cell types of the glomerulus (podocytes, mesangial cells and endothelial cells) from CD2AP-/- mutant mice and normal controls |
-1 | | Ache | 'M-CSF and FSL-1' at '6 day' vs 'none' at '0 day' | compound, time | Microarray profiling of polyploid macrophage progeny |
1 | | Ache | 'NHD13 mutant' vs 'wild type' | genotype | Myelodysplastic syndrome: NUP98-HoxD13 (NHD13) expression effect on hematopoietic stem cells |
-1 | | Ache | 'Het (Q175) knock-in' vs 'wild type' in 'brown adipose tissue' | genotype, organism part | Transcriptome profiling in knock-in mouse models of Huntington's disease [AllelicSeries_6month_TissueSurvey_mRNA] |
1 | | Ache | 'epithelium-specific Apc knockout' vs 'wild type' | phenotype | RNAseq of murine small intestinal tissue following epithelium-specific deletion of Bcl9/9l +/- Apc +/- mutant B-catenin |
